IL69465A - Dna expression vector capable of replication in saccharomyces cerevisiae and containing a glycolytic promoter of said yeast - Google Patents

Dna expression vector capable of replication in saccharomyces cerevisiae and containing a glycolytic promoter of said yeast

Info

Publication number
IL69465A
IL69465A IL69465A IL6946583A IL69465A IL 69465 A IL69465 A IL 69465A IL 69465 A IL69465 A IL 69465A IL 6946583 A IL6946583 A IL 6946583A IL 69465 A IL69465 A IL 69465A
Authority
IL
Israel
Prior art keywords
replication
yeast
expression vector
saccharomyces cerevisiae
dna expression
Prior art date
Application number
IL69465A
Other languages
English (en)
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/408,099 external-priority patent/US4599311A/en
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to IL9273483A priority Critical patent/IL92734A/en
Priority to IL92734A priority patent/IL92734A0/xx
Publication of IL69465A publication Critical patent/IL69465A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL69465A 1982-08-13 1983-08-10 Dna expression vector capable of replication in saccharomyces cerevisiae and containing a glycolytic promoter of said yeast IL69465A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL9273483A IL92734A (en) 1982-08-13 1983-08-10 Methods for the production of alpha-1-antitrypsin protease inhibitors of human mammals and polypeptides produced by them
IL92734A IL92734A0 (en) 1982-08-13 1989-12-15 Methods for producing polypeptides having protease inhibitor activity and polypeptides produced thereby

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/408,099 US4599311A (en) 1982-08-13 1982-08-13 Glycolytic promotersfor regulated protein expression: protease inhibitor
US48940683A 1983-04-28 1983-04-28

Publications (1)

Publication Number Publication Date
IL69465A true IL69465A (en) 1993-02-21

Family

ID=27020145

Family Applications (1)

Application Number Title Priority Date Filing Date
IL69465A IL69465A (en) 1982-08-13 1983-08-10 Dna expression vector capable of replication in saccharomyces cerevisiae and containing a glycolytic promoter of said yeast

Country Status (5)

Country Link
EP (1) EP0103409B1 (fr)
JP (3) JP2509163B2 (fr)
AU (3) AU577259B2 (fr)
DE (2) DE3382821T2 (fr)
IL (1) IL69465A (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE895961A (fr) * 1983-02-21 1983-06-16 Wallone Region Procede de preparation d'un clone bacterien produisant de 1'alpha 1-antitrypsine humaine
CA1341302C (fr) * 1983-02-22 2001-10-09 Rae Lyn Burke Systemes d'expression de la levure avec vecteurs ayant des promoteurs de gapdh ou pyk et synthese de proteine etrangere
ZA8410063B (en) * 1984-01-30 1985-10-30 Smith Kline Rit Expression of human alpha-1-antitrypsin in yeast
ATE102250T1 (de) * 1984-05-11 1994-03-15 Chiron Corp Erhoehte hefetranskription unter verwendung einer hybridkonstruktion der promotorregion.
US5422267A (en) * 1984-05-22 1995-06-06 Robert R. Yocum Industrial yeast comprising an integrated glucoamylase gene
EP0169114B1 (fr) * 1984-06-19 1991-01-16 Transgene S.A. Dérivés de l'alpha 1-antitrypsine humaine et procédé pour leur préparation
FR2565983B1 (fr) * 1984-06-19 1988-01-15 Transgene Sa Derives de l'a1-antitrypsine humaine et procede pour leur preparation
FR2582001B2 (fr) * 1985-05-15 1988-04-29 Transgene Sa Nouveaux derives de l'a1-antitrypsine humaine, composition et reactif biologique les contenant
US5187263A (en) * 1984-10-12 1993-02-16 Zymogenetics, Inc. Expression of biologically active PDGE analogs in eucaryotic cells
EP0487116B1 (fr) * 1984-10-12 1999-12-29 ZymoGenetics, Inc. Analogues biologiquement actifs d'un facteur de croissance provenant de plaquettes sanguines dans des cellules eucaryotiques
US5498600A (en) * 1984-10-12 1996-03-12 Zymogenetics, Inc. Biologically active mosaic proteins
US6291662B1 (en) 1984-12-05 2001-09-18 Amgen Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences
IL77227A (en) * 1984-12-06 1992-08-18 Synergen Biolog Inc Recombinant methods for production of serine protease inhibitors and methods for isolation of same
AU591474B2 (en) * 1984-12-06 1989-12-07 Amgen, Inc. Serine protease inhibitors and methods for isolation of same
EP0188312A3 (fr) * 1985-01-07 1988-01-13 Celltech Limited Procédé de production d'une protéine
EP0189784B1 (fr) * 1985-01-18 1989-11-08 G.D. Searle & Co. Inhibiteur naturel humain de collagénases
KR940010862B1 (ko) * 1985-02-05 1994-11-18 씨네겐 바이오로지칼즈, 인코포레이티드 유용한 메탈로프로테이나제 억제제 씨퀀스 재조합 벡터계의 제조를 위한 dna 재조합 방법
US5045633A (en) * 1985-02-25 1991-09-03 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US4683294A (en) * 1985-04-03 1987-07-28 Smith Kline Rit, S.A. Process for the extraction and purification of proteins from culture media producing them
AU5954486A (en) * 1985-05-21 1986-12-24 Biotechnica International Inc. Yeast expressing gluocoamylase
GB8521496D0 (en) * 1985-08-29 1985-10-02 Ciba Geigy Ag Repressible yeast promoters
NZ218148A (en) * 1985-11-08 1989-06-28 Smithkline Beckman Corp E.coli expression vector coding for alpha-1-antitrypsin
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
JP2656944B2 (ja) * 1987-04-30 1997-09-24 クーパー ラボラトリーズ タンパク質性治療剤のエアロゾール化
DE3854256T2 (de) * 1987-06-06 1996-02-01 Omnigene Inc Expressionsvektor für hefe.
DE68928124T2 (de) 1988-09-02 1997-10-16 Chiron Corp., Emeryville, Calif. Makrophagenabgeleiteter entzündungsmediator(mip-2)
DE69032025T2 (de) * 1989-02-23 1998-05-20 Blood Res Center Menschlicher elastase-inhibitor
US5663299A (en) * 1989-02-23 1997-09-02 Center For Blood Research, Inc. Human monocyte elastase inhibitor
JPH0739329B2 (ja) * 1989-03-13 1995-05-01 味の素株式会社 植物の開花を制御する方法及び植物の開花制御剤
KR960701899A (ko) * 1989-11-17 1996-03-28 안네 제케르 인자 viii:c활성을 갖는 단백질 복합체 및 그의 제조
JPH0617699U (ja) * 1992-04-07 1994-03-08 ササキ金属有限会社 衣類乾燥機
EP0752853B1 (fr) 1993-03-10 2005-09-21 Smithkline Beecham Corporation Phosphodiesterase du cerveau humain
US5514653A (en) * 1994-09-09 1996-05-07 Washington University Method of blocking the SEC receptor
GB2318732A (en) 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
AUPP263498A0 (en) * 1998-03-27 1998-04-23 Walter And Eliza Hall Institute Of Medical Research, The Novel therapeutic molecules and uses therefor
DE10101962B4 (de) * 2001-01-17 2006-07-27 Tad Pharma Gmbh DNA-Sequenz mit regulatorischen Bereichen zur Expression von Proteinen
EP1685160A1 (fr) * 2003-11-10 2006-08-02 Arriva-Prometic Inc. Preparation seche de alpha 1-antitrypsine humaine obtenue par recombinaison
EP1737499A4 (fr) * 2004-03-09 2009-07-22 Arriva Pharmaceuticals Inc Traitement de la bronchopneumopathie chronique obstructive par inhalation a faible dose d'inhibiteur de protease
EP1739179A1 (fr) 2005-06-30 2007-01-03 Octapharma AG Transfection stable exempt de sérum et production des protéines recombinantes humaines dans des lignées cellulaires humaines
EP2258855A1 (fr) 2009-05-28 2010-12-08 Universität für Bodenkultur Wien Séquences d'expression
WO2012178102A2 (fr) 2011-06-24 2012-12-27 The Regents Of The Unversity Of Colorado, A Body Corporate Compositions, procédés et utilisations de molécules de fusion de l'alpha-1 antitrypsine
EP2764016B1 (fr) 2011-10-07 2019-03-13 Lonza Ltd Promoteur régulable
US8951752B2 (en) 2011-10-20 2015-02-10 University Of Iowa Research Foundation N-demethyase genes and uses thereof
EP2861740A1 (fr) 2012-06-15 2015-04-22 University of Iowa Research Foundation Promoteurs sensibles à la caféine et gènes régulateurs
US9150870B2 (en) 2013-03-15 2015-10-06 Lonza Ltd. Constitutive promoter
DK2970994T3 (da) 2013-03-15 2019-10-28 Lonza Ag Konstitutiv promotor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4615974A (en) * 1981-08-25 1986-10-07 Celltech Limited Yeast expression vectors
AU561343B2 (en) * 1981-10-19 1987-05-07 Genentech Inc. Human immune interferon by recombinant dna
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
EP0114777B1 (fr) * 1983-01-21 1990-08-01 Transgene S.A. Nouveaux vecteurs d'expression et leur application à la préparation d'une protéine ayant l'activité de l'antitrypsine-alpha 1 humaine
BE895961A (fr) * 1983-02-21 1983-06-16 Wallone Region Procede de preparation d'un clone bacterien produisant de 1'alpha 1-antitrypsine humaine
CA1341302C (fr) * 1983-02-22 2001-10-09 Rae Lyn Burke Systemes d'expression de la levure avec vecteurs ayant des promoteurs de gapdh ou pyk et synthese de proteine etrangere
JPS60186290A (ja) * 1983-08-10 1985-09-21 チモ−ジエネテイツクス　インコ−ポレ−テツド アルフア−１−アンチトリプシンを細菌に表現させる方法

Also Published As

Publication number Publication date
EP0103409A3 (en) 1986-06-11
AU577259B2 (en) 1988-09-22
JP2694134B2 (ja) 1997-12-24
AU3304893A (en) 1993-05-06
DE3382658T2 (de) 1993-06-03
EP0103409A2 (fr) 1984-03-21
AU658973B2 (en) 1995-05-04
EP0103409B1 (fr) 1993-02-10
DE3382821D1 (de) 1998-03-12
JP2991670B2 (ja) 1999-12-20
DE3382658D1 (en) 1993-03-25
JP2509163B2 (ja) 1996-06-19
JPH08224092A (ja) 1996-09-03
AU1870088A (en) 1988-12-01
DE3382821T2 (de) 1998-07-09
AU1770083A (en) 1984-02-16
JPS5991886A (ja) 1984-05-26
JPH1045799A (ja) 1998-02-17

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Legal Events

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EXP Patent expired