IL71435A - Immunoassay method,reagents,test kit and test device for determining iodothyronines in biological fluids - Google Patents

Immunoassay method,reagents,test kit and test device for determining iodothyronines in biological fluids

Info

Publication number: IL71435A
Authority: IL; Israel
Prior art keywords: iodothyronines; determining; enzyme; immunoassay method; reagents
Prior art date: 1983-07-05

Application number

IL71435A

Other languages

English (en)

Other versions

IL71435A0 (en

Original Assignee

Miles Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-07-05

Filing date

1984-04-03

Publication date

1987-10-20

1984-04-03 Application filed by Miles Lab filed Critical Miles Lab

1984-07-31 Publication of IL71435A0 publication Critical patent/IL71435A0/xx

1987-10-20 Publication of IL71435A publication Critical patent/IL71435A/xx

Links

VSWSDTLXDWESGZ-AWEZNQCLSA-N (2s)-3-[4-(4-hydroxyphenoxy)phenyl]-2-(iodoamino)propanoic acid Chemical class C1=CC(C[C@@H](C(=O)O)NI)=CC=C1OC1=CC=C(O)C=C1 VSWSDTLXDWESGZ-AWEZNQCLSA-N 0.000 title abstract 4
238000003018 immunoassay Methods 0.000 title abstract 3
239000013060 biological fluid Substances 0.000 title abstract 2
239000003153 chemical reaction reagent Substances 0.000 title abstract 2
102000004190 Enzymes Human genes 0.000 abstract 3
108090000790 Enzymes Proteins 0.000 abstract 3
102000009488 Thyroxine-Binding Proteins Human genes 0.000 abstract 2
108010048889 Thyroxine-Binding Proteins Proteins 0.000 abstract 2
CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 abstract 2
XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 abstract 1
230000027455 binding Effects 0.000 abstract 1
239000002981 blocking agent Substances 0.000 abstract 1
238000006555 catalytic reaction Methods 0.000 abstract 1
239000005515 coenzyme Substances 0.000 abstract 1
230000009137 competitive binding Effects 0.000 abstract 1
-1 e.g. Chemical compound 0.000 abstract 1
239000002532 enzyme inhibitor Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
210000002966 serum Anatomy 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1
229940034208 thyroxine Drugs 0.000 abstract 1
XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/97—Test strip or test slide
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Food Science & Technology (AREA)
General Physics & Mathematics (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Pathology (AREA)
Endocrinology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Peptides Or Proteins (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Steroid Compounds (AREA)

IL71435A 1983-07-05 1984-04-03 Immunoassay method,reagents,test kit and test device for determining iodothyronines in biological fluids IL71435A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/510,814 US4622293A (en)	1983-07-05	1983-07-05	Iodothyronine immunoassays employing HMS as TBP blocking agent

Publications (2)

Publication Number	Publication Date
IL71435A0 IL71435A0 (en)	1984-07-31
IL71435A true IL71435A (en)	1987-10-20

Family

ID=24032316

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL71435A IL71435A (en)	1983-07-05	1984-04-03	Immunoassay method,reagents,test kit and test device for determining iodothyronines in biological fluids

Country Status (12)

Country	Link
US (1)	US4622293A (de)
EP (1)	EP0133464B1 (de)
JP (1)	JPS6038654A (de)
AT (1)	ATE24971T1 (de)
AU (1)	AU545412B2 (de)
CA (1)	CA1225024A (de)
DE (1)	DE3462072D1 (de)
DK (1)	DK160335C (de)
ES (1)	ES8604694A1 (de)
IE (1)	IE55677B1 (de)
IL (1)	IL71435A (de)
NO (1)	NO163586C (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0165669A1 (de) *	1984-05-04	1985-12-27	Corning Glass Works	Methode zur Messung freien Ligands
DE3650437T2 (de) *	1985-10-04	1996-04-18	Diagnostic Products Corp	Verfahren zum Messen von Freiliganden in biologischen Flüssigkeiten.
US5102786A (en) *	1987-05-21	1992-04-07	Pb Diagnostic Systems, Inc.	Biological diagnostic assay system
EP0312897A1 (de) *	1987-10-21	1989-04-26	Abbott Laboratories	Thyroid-Hormon-Test und Furosemid verwendendes Reagenssystem
US5256575A (en) *	1988-12-22	1993-10-26	Syntex (U.S.A.) Inc.	Geminal diphenyl derivatives and their use in immunoassays
US5063165A (en) *	1988-12-22	1991-11-05	Syntex (U.S.A.) Inc.	Geminal diphenyl derivatives and their use in immunoassays
US5210017A (en) *	1990-11-19	1993-05-11	Genentech, Inc.	Ligand-mediated immunofunctional hormone binding protein assay method
US5593844A (en) *	1990-11-19	1997-01-14	Genentech, Inc.	Ligand-mediated immunofunctional hormone binding protein assay method
US6326154B1 (en)	1990-11-19	2001-12-04	Genentech, Inc.	Ligand-mediated immunofunctional hormone binding protein assay method
DE4103167A1 (de) *	1991-02-02	1992-08-06	Boehringer Mannheim Gmbh	Diphenylmethanderivate, verfahren zu deren herstellung und ihre verwendung zur verdraengung von jodthyroninen von diesen bindenden proteinen
US7141436B2 (en) *	1999-11-03	2006-11-28	Science And Technology Corp.	Immunoassay and reagents and kits for performing the same
US20070243632A1 (en)	2003-07-08	2007-10-18	Coller Barry S	Methods for measuring platelet reactivity of patients that have received drug eluting stents
ATE536889T1 (de)	2003-07-08	2011-12-15	Accumetrics Inc	Kontrollierte thrombozyten-aktivierung zur überwachung der behandlung von adp-antagonisten
WO2007040559A2 (en) *	2004-11-17	2007-04-12	Bioveris	Electrochemiluminescent assay
US20060275841A1 (en) *	2004-12-20	2006-12-07	Martin Blankfard	Assay method and apparatus with reduced sample matrix effects

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3928553A (en) *	1972-03-23	1975-12-23	Univ New York	Radioimmunoassay method for triiodothyronine and thyroxine
US3911096A (en) *	1972-06-23	1975-10-07	Professional Staff Ass Of The	Radioimmunoassay for measurement of thyroxine (T{HD 4{B ) and triiodothyonine (T{HD 3{B ) in blood serum
CA1050425A (en) *	1975-06-26	1979-03-13	Mallinckrodt	Radioimmunoassay methods for the determination of l-triiodothyronine and thyroxine
CA1183450A (en) *	1980-10-30	1985-03-05	Alfred C. Greenquist	Homogeneous specific binding assay device and method
US4468469A (en) *	1981-11-04	1984-08-28	Miles Laboratories, Inc.	Substituted phenylacetic acids and salts as TBP blocking agents in iodothyronine immunoassays

1983
- 1983-07-05 US US06/510,814 patent/US4622293A/en not_active Expired - Fee Related
1984
- 1984-04-03 IL IL71435A patent/IL71435A/xx not_active IP Right Cessation
- 1984-04-04 CA CA000451292A patent/CA1225024A/en not_active Expired
- 1984-04-12 AU AU26776/84A patent/AU545412B2/en not_active Ceased
- 1984-06-21 NO NO842519A patent/NO163586C/no unknown
- 1984-06-25 AT AT84107264T patent/ATE24971T1/de not_active IP Right Cessation
- 1984-06-25 EP EP84107264A patent/EP0133464B1/de not_active Expired
- 1984-06-25 DE DE8484107264T patent/DE3462072D1/de not_active Expired
- 1984-07-04 ES ES534023A patent/ES8604694A1/es not_active Expired
- 1984-07-04 IE IE1702/84A patent/IE55677B1/en not_active IP Right Cessation
- 1984-07-04 DK DK328584A patent/DK160335C/da not_active IP Right Cessation
- 1984-07-04 JP JP59137416A patent/JPS6038654A/ja active Pending

Also Published As

Publication number	Publication date
IL71435A0 (en)	1984-07-31
ES8604694A1 (es)	1986-02-01
DK160335C (da)	1991-07-29
NO163586C (no)	1990-06-20
IE55677B1 (en)	1990-12-19
CA1225024A (en)	1987-08-04
JPS6038654A (ja)	1985-02-28
AU2677684A (en)	1985-01-10
DE3462072D1 (en)	1987-02-19
ATE24971T1 (de)	1987-01-15
AU545412B2 (en)	1985-07-11
EP0133464B1 (de)	1987-01-14
DK160335B (da)	1991-02-25
DK328584A (da)	1985-01-06
NO842519L (no)	1985-01-07
EP0133464A1 (de)	1985-02-27
NO163586B (no)	1990-03-12
ES534023A0 (es)	1986-02-01
IE841702L (en)	1985-01-05
US4622293A (en)	1986-11-11
DK328584D0 (da)	1984-07-04

Legal Events

Date	Code	Title	Description
1998-10-30	KB	Patent renewed
2003-01-12	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL71435A0 (en)	1984-07-31	Immunoassay method,reagents,test kit and test device for determining iodothyronines in biological fluids
DK104093D0 (da)	1993-09-17	Fremgangsmaade til bestemmelse af collagen-fragmenter i legemsvaesker, test-kit og midler til udoevelse af fremgangsmaaden og anvendelse af fremgangsmaaden til diagnosticering af lidelser associeret til collagen-metabolismen
LV10538A (lv)	1995-02-20	Imunologiski saistamas vielas noteiksanas panemiens biologiska skidruma un diagnostikas lidzeklis
IE822628L (en)	1983-05-04	Fenclofenac as tbp blocking agent in iodothyroneine¹immunoassays
TW348216B (en)	1998-12-21	Method for the determination of urinary protein and creatinine
ATE47231T1 (de)	1989-10-15	Verfahren zur bestimmung eines partners einer immunreaktion sowie reagens zur durchfuehrung dieses verfahrens.
ATE12010T1 (de)	1985-03-15	Verfahren zur bestimmung von antigen-antikoerper- reaktionen und reagens hierfuer.
EP0348211A3 (en)	1990-11-28	Visual discrimination qualitative enzyme assay
DK0495625T3 (da)	1997-10-06	Assay til bestemmelse af niveauerne af frit IGF-I, IGF-II og GH i legemsvæsker.
EP0753743A3 (de)	1998-07-08	Vitamin-D-Bestimmung
DK0696642T3 (da)	2002-10-28	Fremgangsmåde til påvisning af forstyrrelser i protein C/protein S-systemet
ATE79678T1 (de)	1992-09-15	Bestimmung von monokinen.
DK0402997T3 (da)	1994-10-31	Fremgangsmåde til bestemmelse af nukleinsyre
ATE80463T1 (de)	1992-09-15	Verfahren und testtraeger zur bestimmung eines analyten.
FI854627A7 (fi)	1986-05-24	Menetelmä ja reagenssi plasmassa, seerumissa tai kokoveressä olevan vapaan tyroksiinin kvantitatiiviseksi määrittämiseksi.
SE7905266L (sv)	1979-12-16	Forfarande och testanordning for bestemning av karbamidhalten i vetskor
ATE63166T1 (de)	1991-05-15	Verfahren zur immunologischen bestimmung von aminen, monoklonale antikoerper und testsatz zur durchfuehrung des verfahrens.
DE3863270D1 (de)	1991-07-18	Immuntest.
DK0408542T3 (da)	1996-01-22	Fremgangsmåde til bestemmelse af antigener og/eller antistoffer i humane legemsvæsker samt test-kit til udøvelse af fremgangsmåden
ATE80741T1 (de)	1992-10-15	Diagnosetestverfahren fuer schweinedysenterie.
Yamamoto et al.	1985	Immunoenzymometric assay for insulin involving column chromatography and insulin immobilized on Sepharose.
BE900911A (fr)	1985-04-26	Procede de diagnostic d'infections.
NO881998L (no)	1988-11-09	Fremgangsmaate til kvantitativ bestemmelse av serumproteiner i kroppsvaesker og middel til gjennomfoering av fremgangsmaaten.
ATE193376T1 (de)	2000-06-15	Verfahren zur immunologischen bestimmung von proteinen, kit zur durchführung des verfahrens und für ein solches verfahren geeignete teströhrchen
JPH07146293A (ja)	1995-06-06	免疫測定法