IL72082A - Cyclic pentapeptides displaying somatostatin antagonism and their preparation - Google Patents

Cyclic pentapeptides displaying somatostatin antagonism and their preparation

Info

Publication number: IL72082A
Authority: IL; Israel
Prior art keywords: somatostatin; antagonism; displaying; preparation; cyclic pentapeptides
Prior art date: 1983-06-06

Application number

IL72082A

Other languages

English (en)

Original Assignee

Univ Tulane

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-06-06

Filing date

1984-06-12

Publication date

1987-12-31

1984-06-12 Application filed by Univ Tulane filed Critical Univ Tulane

1987-12-31 Publication of IL72082A publication Critical patent/IL72082A/xx

Links

102000005157 Somatostatin Human genes 0.000 title abstract 2
108010056088 Somatostatin Proteins 0.000 title abstract 2
125000004122 cyclic group Chemical group 0.000 title abstract 2
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 2
229960000553 somatostatin Drugs 0.000 title abstract 2
230000008485 antagonism Effects 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
102000051325 Glucagon Human genes 0.000 abstract 1
108060003199 Glucagon Proteins 0.000 abstract 1
102000018997 Growth Hormone Human genes 0.000 abstract 1
108010051696 Growth Hormone Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
229960004666 glucagon Drugs 0.000 abstract 1
MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
239000000122 growth hormone Substances 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/16—Somatostatin; related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

IL72082A 1983-06-06 1984-06-12 Cyclic pentapeptides displaying somatostatin antagonism and their preparation IL72082A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/501,321 US4505897A (en)	1983-04-18	1983-06-06	Cyclic pentapeptides displaying somatostatin antagonism and method of treatment of mammals therewith

Publications (1)

Publication Number	Publication Date
IL72082A true IL72082A (en)	1987-12-31

Family

ID=23993046

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL72082A IL72082A (en)	1983-06-06	1984-06-12	Cyclic pentapeptides displaying somatostatin antagonism and their preparation

Country Status (11)

Country	Link
US (1)	US4505897A (de)
EP (2)	EP0127899B1 (de)
JP (1)	JPS60501505A (de)
AT (1)	ATE30326T1 (de)
AU (1)	AU596784B2 (de)
CA (1)	CA1236451A (de)
DE (1)	DE3466879D1 (de)
IL (1)	IL72082A (de)
NZ (1)	NZ208376A (de)
WO (1)	WO1984004916A1 (de)
ZA (1)	ZA844222B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4748153A (en) *	1985-04-29	1988-05-31	Merck & Co., Inc.	Compounds having somatostatin-like activity useful as local anti-inflammatory agents
US4585755A (en) *	1985-04-29	1986-04-29	Merck & Co., Inc.	Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents
US4612366A (en) *	1985-06-17	1986-09-16	Merck & Co., Inc.	Cyclic hexapeptide somatostatin analogs
US4880778A (en) *	1986-05-12	1989-11-14	Eastman Kodak Company	Combinations having synergistic growth hormone releasing activity and methods for use thereof
DE3726517A1 (de) *	1986-08-18	1988-03-03	Sandoz Ag	Nasale zusammensetzungen, welche octreotid enthalten
US4839344A (en) *	1987-06-12	1989-06-13	Eastman Kodak Company	Polypeptide compounds having growth hormone releasing activity
US4880777A (en) *	1987-09-01	1989-11-14	Eastman Kodak Company	Synthetic peptides having growth hormone releasing activity
AU637316B2 (en) *	1988-01-28	1993-05-27	Eastman Kodak Company	Polypeptide compounds having growth hormone releasing activity
US5662525A (en) *	1989-11-20	1997-09-02	Briggs; Rick A.	Participatory water play apparatus
CA2032559C (en) *	1989-12-28	2001-11-06	Kiyofumi Ishikawa	Endothelin antagonistic cyclic pentapeptides
US6183722B1 (en)	1991-11-27	2001-02-06	Diatide, Inc.	Somatostatin analogs
MY147327A (en) *	1995-06-29	2012-11-30	Novartis Ag	Somatostatin peptides
US5849293A (en) *	1996-01-11	1998-12-15	Cornell Research Foundation, Inc.	Use of human transferrin in controlling insulin levels
JPH09328499A (ja) *	1996-02-20	1997-12-22	American Cyanamid Co	純粋なソマトスタチンアンタゴニストおよびその使用方法
IT1283134B1 (it) *	1996-07-08	1998-04-07	Dox Al Italia Spa	Derivati sintetici e semisintetici di somatostatine utili nella stimolazione della crescita corporea, in particolare in
JPH10251296A (ja) *	1997-03-06	1998-09-22	American Cyanamid Co	ソマトスタチン拮抗薬として有用なペプチド
CN1367793A (zh) *	1999-06-04	2002-09-04	研究及应用科学协会股份有限公司	神经调节肽b和生长抑素受体拮抗剂
US6903074B1 (en)	1999-06-04	2005-06-07	Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.	Neuromedin b and somatostatin receptor agonists
GB0018891D0 (en) *	2000-08-01	2000-09-20	Novartis Ag	Organic compounds
US6786830B2 (en)	2002-06-28	2004-09-07	Koala Corporation	Modular water play structure
US8017575B2 (en) *	2004-12-15	2011-09-13	Wilfred Wayne Lautt	Treatment of insulin resistance by modulating somatostatin using somatostatin receptor antagonists
US9604151B2 (en)	2014-10-30	2017-03-28	Charles E. DeCaro	Water amusement device
US10758831B2 (en)	2014-11-17	2020-09-01	Whitewater West Industries Ltd.	Interactive play center with interactive elements and consequence elements
US10576388B2 (en)	2016-11-14	2020-03-03	Whitewater West Industries Ltd.	Play center using structural monoliths for water delivery capabilities

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4101721A (en) *	1976-12-09	1978-07-18	Wisconsin Alumni Research Foundation	Solid phase synthesis of protected peptides
NZ195303A (en) *	1979-10-31	1984-10-19	Merck & Co Inc	Cyclic hexapeptide somatostatin analogues,and pharmaceutical compositions
US4235886A (en) *	1979-10-31	1980-11-25	Merck & Co., Inc.	Cyclic hexapeptide somatostatin analogs
US4427661A (en) *	1982-07-30	1984-01-24	Merck & Co., Inc.	Fluorinated cyclic hexapeptide somatostatin analogs
DE3303345A1 (de) *	1983-02-02	1984-08-02	Hoechst Ag, 6230 Frankfurt	Cyclische peptide mit somatostatin-wirkung

1983
- 1983-06-06 US US06/501,321 patent/US4505897A/en not_active Expired - Lifetime
1984
- 1984-06-04 AT AT84106363T patent/ATE30326T1/de not_active IP Right Cessation
- 1984-06-04 DE DE8484106363T patent/DE3466879D1/de not_active Expired
- 1984-06-04 CA CA000455809A patent/CA1236451A/en not_active Expired
- 1984-06-04 EP EP84106363A patent/EP0127899B1/de not_active Expired
- 1984-06-05 AU AU30623/84A patent/AU596784B2/en not_active Expired
- 1984-06-05 EP EP84902476A patent/EP0145768A1/de not_active Withdrawn
- 1984-06-05 JP JP59502395A patent/JPS60501505A/ja active Pending
- 1984-06-05 WO PCT/US1984/000861 patent/WO1984004916A1/en not_active Ceased
- 1984-06-05 NZ NZ208376A patent/NZ208376A/xx unknown
- 1984-06-05 ZA ZA844222A patent/ZA844222B/xx unknown
- 1984-06-12 IL IL72082A patent/IL72082A/xx active IP Right Revival

Also Published As

Publication number	Publication date
EP0145768A1 (de)	1985-06-26
AU596784B2 (en)	1990-05-17
CA1236451A (en)	1988-05-10
ZA844222B (en)	1985-01-30
WO1984004916A1 (en)	1984-12-20
AU3062384A (en)	1985-01-04
EP0127899B1 (de)	1987-10-21
US4505897A (en)	1985-03-19
JPS60501505A (ja)	1985-09-12
NZ208376A (en)	1988-07-28
ATE30326T1 (de)	1987-11-15
EP0127899A1 (de)	1984-12-12
DE3466879D1 (en)	1987-11-26

Legal Events

Date	Code	Title
1998-11-26	KB	Patent renewed
1999-06-20	NE	Application for restoration - patent lapsed through non-payment of renewal fees (section 60, patents law, 5727-1967)
2002-07-25	KB	Patent renewed

Publication	Publication Date	Title
DE3466879D1 (en)	1987-11-26	Cyclic pentapeptides displaying somatostatin antagonism and method of treatment of mammals therewith
EP0294272A3 (en)	1989-04-05	Needleless injector, especially for dental use
DE3475622D1 (en)	1989-01-19	20-spiroxanes and analogues with open ring e, process for their preparation and pharmaceutical compositions
DE3775289D1 (de)	1992-01-30	Elastische einheit, vorrichtung zu ihrer herstellung, mit diesen einheiten versehene bekleidung und verfahren zur herstellung dieser bekleidung.
DE3369143D1 (en)	1987-02-19	Highly purified human antihemophilic factor and method for the preparation thereof
PH25772A (en)	1991-10-18	Insulin analogues, process for their preparation
DE3852440D1 (de)	1995-01-26	Supraleitendes Mischoxidmaterial und Methode zu dessen Herstellung.
DE3869542D1 (de)	1992-04-30	Lumineszentes material, verfahren zur herstellung desselben und dasselbe verwendende elektrolumineszente vorrichtung.
DE3862071D1 (de)	1991-04-25	Kathode fuer elektrolyse und verfahren zur herstellung derselben.
GB2192814B (en)	1991-01-16	Airblast fuel injector
ZA838277B (en)	1984-12-24	Porcine growth hormone produced by recombinant dna technology
EP0253190A3 (en)	1989-10-04	Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
ZA839358B (en)	1984-08-29	The cloning and expression of nucleotide sequences encoding bovine growth hormone
DE3484184D1 (de)	1991-04-04	Keramischer verbundkoerper und verfahren zu dessen herstellung.
DE3879536D1 (de)	1993-04-29	Supraleitender keramischer film und verfahren zu dessen herstellung.
IE840341L (en)	1985-08-14	Subcutaneous implant for promotion growth
EP0242512A3 (en)	1989-11-29	Composite materials, method for their production, and use
PT71966A (en)	1980-11-01	Process for preparing cyclic hexapeptide somatostatin compounds
CS202187A3 (en)	1992-03-18	Method for transporting synthetic rubber fragments
IL71702A (en)	1988-01-31	Polypeptide growth factors,their preparation,antibodies thereto and compositions containing them
FI900075A7 (fi)	1990-01-05	Kasvuhormoniin liittyvä peptidi
EP0264118A3 (en)	1988-12-14	Novel method for preparing proteins
IL86710A0 (en)	1988-11-30	Polypeptide receptor for interleukin-2,antibodies against this polypeptide and pharmaceutical compositions containing the same
DE3868875D1 (de)	1992-04-09	Apparat zur produktion von halbleitern.
PL269466A1 (en)	1988-12-22	Method for manufacturing pyretroids