ATE118220T1 - Kristallines menschliches proinsulin und verfahren zu dessen herstellung. - Google Patents

Kristallines menschliches proinsulin und verfahren zu dessen herstellung.

Info

Publication number: ATE118220T1
Authority: AT; Austria
Prior art keywords: production; human proinsulin; crystalline human; crystalline; proinsulin
Prior art date: 1987-04-23

Application number

AT88303573T

Other languages

English (en)

Inventor

Richard Lee Jackson

Eddie Herman Massey

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-23

Filing date

1988-04-20

Publication date

1995-02-15

1988-04-20 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE118220T1 publication Critical patent/ATE118220T1/de

Links

108010076181 Proinsulin Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT88303573T 1987-04-23 1988-04-20 Kristallines menschliches proinsulin und verfahren zu dessen herstellung. ATE118220T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/041,498 US4764592A (en)	1987-04-23	1987-04-23	Crystalline human proinsulin and process for its production

Publications (1)

Publication Number	Publication Date
ATE118220T1 true ATE118220T1 (de)	1995-02-15

Family

ID=21916831

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88303573T ATE118220T1 (de)	1987-04-23	1988-04-20	Kristallines menschliches proinsulin und verfahren zu dessen herstellung.

Country Status (21)

Country	Link
US (1)	US4764592A (de)
EP (1)	EP0288273B1 (de)
JP (1)	JP2602529B2 (de)
KR (1)	KR0126477B1 (de)
CN (1)	CN1030988C (de)
AR (1)	AR244242A1 (de)
AT (1)	ATE118220T1 (de)
AU (1)	AU609798B2 (de)
CA (1)	CA1339045C (de)
DE (1)	DE3852963T2 (de)
DK (1)	DK210188A (de)
ES (1)	ES2068826T3 (de)
GR (1)	GR3015662T3 (de)
HU (1)	HU202555B (de)
IE (1)	IE65952B1 (de)
IL (1)	IL86094A (de)
MX (1)	MX166069B (de)
NZ (1)	NZ224281A (de)
PH (1)	PH24261A (de)
PT (1)	PT87265B (de)
ZA (1)	ZA882714B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH23446A (en) *	1986-10-20	1989-08-07	Novo Industri As	Peptide preparations
DE58906966D1 (de) *	1988-06-23	1994-03-24	Hoechst Ag	Mini-Proinsulin, seine Herstellung und Verwendung.
US5130298A (en) *	1989-05-16	1992-07-14	Ethicon, Inc.	Stabilized compositions containing epidermal growth factor
DK168790D0 (de) *	1990-07-13	1990-07-13	Novo Nordisk As
US5504188A (en) *	1994-06-16	1996-04-02	Eli Lilly And Company	Preparation of stable zinc insulin analog crystals
US5631347A (en) *	1995-06-07	1997-05-20	Eli Lilly And Company	Reducing gelation of a fatty acid-acylated protein
RU2527893C2 (ru)	2004-07-19	2014-09-10	Биокон Лимитед	Инсулин-олигомерные конъюгаты, их препараты и применения
ES2371361T3 (es)	2005-12-28	2011-12-30	Novo Nordisk A/S	Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones.
RU2453332C2 (ru)	2007-10-16	2012-06-20	Байокон Лимитид	Твердая фармацевтическая композиция (варианты) и способ контроля концентрации глюкозы с ее помощью, способ получения твердой фармацевтической композиции (варианты), таблетка (варианты) и способ получения амфорных частиц
MX2012012943A (es) *	2010-05-10	2012-11-29	Novo Nordisk As	Proceso para preparacion de complejos de insulina-cinc.
WO2012104339A1 (en) *	2011-02-01	2012-08-09	Novo Nordisk A/S	Purification of insulin
CN102219851B (zh) *	2011-05-09	2012-05-30	甘李药业有限公司	甘精胰岛素结晶的制备方法
CN109957001B (zh) *	2017-12-26	2022-11-18	甘李药业股份有限公司	甘赖脯胰岛素结晶的制备方法
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
US12343383B2 (en)	2019-07-12	2025-07-01	Novo Nordisk A/S	High concentration insulin formulation
CN111304271A (zh) *	2020-02-28	2020-06-19	东莞市东阳光生物药研发有限公司	一种含脂肪酸侧链的胰岛素类似物的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE515508A (de) *
DE132863C (de) *	1901-07-11
US2143590A (en) *	1936-09-26	1939-01-10	Univ Alberta	Insulin preparation and process of producing crystals of insulin
US2174862A (en) *	1938-12-30	1939-10-03	Frederick Stearns & Company	Process of producing crystalline insulin
US2626228A (en) *	1945-05-17	1953-01-20	Novo Terapeutisk Labor As	Method of producing crystalline insulin
US2663666A (en) *	1949-03-31	1953-12-22	Organon	Process of preparing crystalline insulin from acid alcoholic extracts of pancreas glands
US2836542A (en) *	1952-02-13	1958-05-27	Novo Terapeutisk Labor As	Process of production of crystalline insulin
DK78069C (da) *	1952-06-23	1954-09-06	Novo Terapeutisk Labor As	Fremgangsmåde til fremstilling af krystallinsk insulin.
US3102077A (en) *	1953-08-19	1963-08-27	Christensen Henry Marinus	Preparation of insulin containing 2.75 to 8 percent zinc content
GB786635A (en) *	1953-08-19	1957-11-20	Roskilde Medical Company Ltd R	Method for the production of insulin with increased zinc content
US4430266A (en) *	1980-11-28	1984-02-07	Eli Lilly And Company	Process for producing an insulin precursor
US4654324A (en) *	1981-08-27	1987-03-31	Eli Lilly And Company	Human proinsulin pharmaceutical formulations
DE3326472A1 (de) *	1983-07-22	1985-02-14	Hoechst Ag, 6230 Frankfurt	Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3326473A1 (de) *	1983-07-22	1985-01-31	Hoechst Ag, 6230 Frankfurt	Pharmazeutisches mittel zur behandlung des diabetes mellitus
US4616078A (en) *	1985-04-08	1986-10-07	Eli Lilly And Company	Process for purifying proinsulin-like materials

1987
- 1987-04-23 US US07/041,498 patent/US4764592A/en not_active Expired - Fee Related
1988
- 1988-04-15 AR AR88310568A patent/AR244242A1/es active
- 1988-04-15 CA CA000564257A patent/CA1339045C/en not_active Expired - Fee Related
- 1988-04-17 IL IL86094A patent/IL86094A/xx not_active IP Right Cessation
- 1988-04-18 ZA ZA882714A patent/ZA882714B/xx unknown
- 1988-04-18 MX MX011154A patent/MX166069B/es unknown
- 1988-04-18 DK DK210188A patent/DK210188A/da not_active Application Discontinuation
- 1988-04-18 NZ NZ224281A patent/NZ224281A/xx unknown
- 1988-04-18 KR KR1019880004376A patent/KR0126477B1/ko not_active Expired - Fee Related
- 1988-04-18 PT PT87265A patent/PT87265B/pt not_active IP Right Cessation
- 1988-04-19 PH PH36813A patent/PH24261A/en unknown
- 1988-04-19 AU AU14747/88A patent/AU609798B2/en not_active Ceased
- 1988-04-20 CN CN88102311A patent/CN1030988C/zh not_active Expired - Fee Related
- 1988-04-20 HU HU882014A patent/HU202555B/hu not_active IP Right Cessation
- 1988-04-20 ES ES88303573T patent/ES2068826T3/es not_active Expired - Lifetime
- 1988-04-20 AT AT88303573T patent/ATE118220T1/de not_active IP Right Cessation
- 1988-04-20 DE DE3852963T patent/DE3852963T2/de not_active Expired - Fee Related
- 1988-04-20 EP EP88303573A patent/EP0288273B1/de not_active Expired - Lifetime
- 1988-04-20 IE IE118388A patent/IE65952B1/en not_active IP Right Cessation
- 1988-04-20 JP JP63099297A patent/JP2602529B2/ja not_active Expired - Lifetime
1995
- 1995-04-03 GR GR950400806T patent/GR3015662T3/el unknown

Also Published As

Publication number	Publication date
CN88102311A (zh)	1988-11-09
DE3852963T2 (de)	1995-06-29
AU609798B2 (en)	1991-05-09
CN1030988C (zh)	1996-02-14
KR880012642A (ko)	1988-11-28
DK210188D0 (da)	1988-04-18
KR0126477B1 (ko)	1997-12-19
IL86094A (en)	1993-06-10
ES2068826T3 (es)	1995-05-01
DE3852963D1 (de)	1995-03-23
JP2602529B2 (ja)	1997-04-23
CA1339045C (en)	1997-04-01
EP0288273B1 (de)	1995-02-08
HU202555B (en)	1991-03-28
DK210188A (da)	1989-01-03
HUT46705A (en)	1988-11-28
PH24261A (en)	1990-05-04
EP0288273A3 (en)	1990-08-08
ZA882714B (en)	1989-12-27
IE65952B1 (en)	1995-11-29
US4764592A (en)	1988-08-16
AR244242A1 (es)	1993-10-29
NZ224281A (en)	1990-06-26
MX166069B (es)	1992-12-17
IE881183L (en)	1988-10-23
IL86094A0 (en)	1988-09-30
EP0288273A2 (de)	1988-10-26
GR3015662T3 (en)	1995-07-31
JPS63280100A (ja)	1988-11-17
PT87265B (pt)	1992-08-31
PT87265A (pt)	1988-05-01
AU1474788A (en)	1988-11-10

Legal Events

Date	Code	Title	Description
1995-07-15	UEP	Publication of translation of european patent specification
2002-01-15	REN	Ceased due to non-payment of the annual fee

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