IL73892A - נגזרת פוליפפטיד בקצה ה-n של אינטרפרון- ז של בני אדם - Google Patents

נגזרת פוליפפטיד בקצה ה-n של אינטרפרון- ז של בני אדם

Info

Publication number: IL73892A
Authority: IL; Israel
Prior art keywords: ifn; dna; added; plasmid; ser
Prior art date: 1983-12-26

Application number

IL7389284A

Other languages

English (en)

Other versions

IL73892A0 (en

Original Assignee

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-12-26

Filing date

1984-12-21

Publication date

1995-06-29

1983-12-26 Priority claimed from JP58246456A external-priority patent/JPS60136600A/ja

1984-07-25 Priority claimed from JP15471384A external-priority patent/JPS6133196A/ja

1984-12-21 Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk

1985-03-31 Publication of IL73892A0 publication Critical patent/IL73892A0/xx

1995-06-29 Publication of IL73892A publication Critical patent/IL73892A/he

Links

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SIEBDTCABMZCLF-XGEHTFHBSA-N Ser-Val-Thr Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O SIEBDTCABMZCLF-XGEHTFHBSA-N 0.000 description 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
210000001744 T-lymphocyte Anatomy 0.000 description 1
241000252567 Thiara Species 0.000 description 1
JVTHIXKSVYEWNI-JRQIVUDYSA-N Thr-Asn-Tyr Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O JVTHIXKSVYEWNI-JRQIVUDYSA-N 0.000 description 1
BQBCIBCLXBKYHW-CSMHCCOUSA-N Thr-Leu Chemical compound CC(C)C[C@@H](C([O-])=O)NC(=O)[C@@H]([NH3+])[C@@H](C)O BQBCIBCLXBKYHW-CSMHCCOUSA-N 0.000 description 1
HUPLKEHTTQBXSC-YJRXYDGGSA-N Thr-Ser-Tyr Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 HUPLKEHTTQBXSC-YJRXYDGGSA-N 0.000 description 1
HJXOFWKCWLHYIJ-SZMVWBNQSA-N Trp-Lys-Glu Chemical compound [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(O)=O HJXOFWKCWLHYIJ-SZMVWBNQSA-N 0.000 description 1
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QZKVWWIUSQGWMY-IHRRRGAJSA-N Val-Ser-Phe Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 QZKVWWIUSQGWMY-IHRRRGAJSA-N 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
230000003213 activating effect Effects 0.000 description 1
239000013543 active substance Substances 0.000 description 1
229960000643 adenine Drugs 0.000 description 1
238000005273 aeration Methods 0.000 description 1
108010056243 alanylalanine Proteins 0.000 description 1
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229960000723 ampicillin Drugs 0.000 description 1
238000000137 annealing Methods 0.000 description 1
230000000259 anti-tumor effect Effects 0.000 description 1
230000002155 anti-virotic effect Effects 0.000 description 1
108010093581 aspartyl-proline Proteins 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
210000004899 c-terminal region Anatomy 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
235000011148 calcium chloride Nutrition 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
239000013611 chromosomal DNA Substances 0.000 description 1
238000010367 cloning Methods 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
235000018417 cysteine Nutrition 0.000 description 1
229940104302 cytosine Drugs 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
FFYPMLJYZAEMQB-UHFFFAOYSA-N diethyl pyrocarbonate Chemical compound CCOC(=O)OC(=O)OCC FFYPMLJYZAEMQB-UHFFFAOYSA-N 0.000 description 1
FSXRLASFHBWESK-UHFFFAOYSA-N dipeptide phenylalanyl-tyrosine Natural products C=1C=C(O)C=CC=1CC(C(O)=O)NC(=O)C(N)CC1=CC=CC=C1 FSXRLASFHBWESK-UHFFFAOYSA-N 0.000 description 1
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
235000019797 dipotassium phosphate Nutrition 0.000 description 1
229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000000284 extract Substances 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
210000002950 fibroblast Anatomy 0.000 description 1
101150045500 galK gene Proteins 0.000 description 1
108010050848 glycylleucine Proteins 0.000 description 1
230000000415 inactivating effect Effects 0.000 description 1
239000000411 inducer Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
229940047124 interferons Drugs 0.000 description 1
239000008101 lactose Substances 0.000 description 1
108010076756 leucyl-alanyl-phenylalanine Proteins 0.000 description 1
108010044056 leucyl-phenylalanine Proteins 0.000 description 1
125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
108010044348 lysyl-glutamyl-aspartic acid Proteins 0.000 description 1
210000002540 macrophage Anatomy 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
108700023046 methionyl-leucyl-phenylalanine Proteins 0.000 description 1
244000005700 microbiome Species 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
CJWXCNXHAIFFMH-AVZHFPDBSA-N n-[(2s,3r,4s,5s,6r)-2-[(2r,3r,4s,5r)-2-acetamido-4,5,6-trihydroxy-1-oxohexan-3-yl]oxy-3,5-dihydroxy-6-methyloxan-4-yl]acetamide Chemical compound C[C@H]1O[C@@H](O[C@@H]([C@@H](O)[C@H](O)CO)[C@@H](NC(C)=O)C=O)[C@H](O)[C@@H](NC(C)=O)[C@@H]1O CJWXCNXHAIFFMH-AVZHFPDBSA-N 0.000 description 1
OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 1
210000000822 natural killer cell Anatomy 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
108010012581 phenylalanylglutamate Proteins 0.000 description 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
235000002639 sodium chloride Nutrition 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
108010061238 threonyl-glycine Proteins 0.000 description 1
230000009466 transformation Effects 0.000 description 1
238000011426 transformation method Methods 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
108010073969 valyllysine Proteins 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/811—Interferon
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/142—Interferon
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/30—Signal or leader sequence

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

IL7389284A 1983-12-26 1984-12-21 נגזרת פוליפפטיד בקצה ה-n של אינטרפרון- ז של בני אדם IL73892A (he)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP58246456A JPS60136600A (ja)	1983-12-26	1983-12-26	新規ヒトインタ−フエロン−γポリペプチド誘導体
JP15471384A JPS6133196A (ja)	1984-07-25	1984-07-25	新規ヒトインタ−フエロン−γポリペプチド誘導体

Publications (2)

Publication Number	Publication Date
IL73892A0 IL73892A0 (en)	1985-03-31
IL73892A true IL73892A (he)	1995-06-29

Family

ID=26482924

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL7389284A IL73892A (he)	1983-12-26	1984-12-21	נגזרת פוליפפטיד בקצה ה-n של אינטרפרון- ז של בני אדם

Country Status (9)

Country	Link
US (1)	US4758656A (he)
EP (1)	EP0146944B1 (he)
AU (1)	AU580748B2 (he)
CA (1)	CA1303528C (he)
DE (2)	DE146944T1 (he)
DK (2)	DK168016B1 (he)
ES (1)	ES8606490A1 (he)
IL (1)	IL73892A (he)
NO (1)	NO174161C (he)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6936694B1 (en)	1982-05-06	2005-08-30	Intermune, Inc.	Manufacture and expression of large structural genes
JPS6124599A (ja) *	1984-07-11	1986-02-03	Kyowa Hakko Kogyo Co Ltd	新規ヒトインタ−フエロン−ｒポリペプチド誘導体
DE3536939A1 (de) *	1985-10-17	1987-04-23	Hoechst Ag	Biologisch aktive derivate des human-(gamma)-interferons, ihre herstellung und arzneimittel, die solche derivate enthalten
GB8619725D0 (en) *	1986-08-13	1986-09-24	Hoffmann La Roche	Homogenous interferon fragments
US6635715B1 (en)	1997-08-12	2003-10-21	Sudhin Datta	Thermoplastic polymer blends of isotactic polypropylene and alpha-olefin/propylene copolymers
US6921794B2 (en)	1997-08-12	2005-07-26	Exxonmobil Chemical Patents Inc.	Blends made from propylene ethylene polymers
US7232871B2 (en)	1997-08-12	2007-06-19	Exxonmobil Chemical Patents Inc.	Propylene ethylene polymers and production process
JP2002519497A (ja)	1998-07-01	2002-07-02	エクソンモービル・ケミカル・パテンツ・インク	結晶性プロピレンポリマーと結晶化可能プロピレンポリマーとを含んでなる弾性ブレンド
CA2390292A1 (en) *	1999-11-12	2001-05-25	Maxygen Holdings Ltd.	Interferon gamma conjugates
CN1309423C (zh)	1999-11-12	2007-04-11	马克西根控股公司	干扰素γ偶联物
US7038015B2 (en) *	2001-04-06	2006-05-02	Maxygen Holdings, Ltd.	Interferon gamma polypeptide variants
US6958388B2 (en)	2001-04-06	2005-10-25	Maxygen, Aps	Interferon gamma polypeptide variants
DE60238049D1 (de)	2001-04-12	2010-12-02	Exxonmobil Chem Patents Inc	Verfahren zur Polymerisation von Propylen und Ethylen in Lösung
ES2411007T3 (es)	2001-10-10	2013-07-04	Novo Nordisk A/S	Remodelación y glicoconjugación de péptidos
CA2491178A1 (en) *	2002-07-03	2004-01-15	Maxygen Holdings Ltd.	Full-length interferon gamma polypeptide variants

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58110548A (ja) *	1981-12-24	1983-07-01	Asahi Chem Ind Co Ltd	新規な生理活性ペプチド
IL68100A0 (en) *	1982-03-24	1983-06-15	Takeda Chemical Industries Ltd	Novel dna and use thereof
US6936694B1 (en) *	1982-05-06	2005-08-30	Intermune, Inc.	Manufacture and expression of large structural genes
US4681848A (en) *	1982-09-22	1987-07-21	Takeda Chemical Industries, Ltd.	Novel peptide and use thereof
IL69851A0 (en) *	1982-09-30	1983-12-30	Japan Found Cancer	Novel dna and recombinant plasmid containing the same
NZ208309A (en) *	1983-06-01	1988-04-29	Hoffmann La Roche	Recombinant leukocyte, fibroblast, or immune interferons (rifn-#a#, b or #g#) with one cys residue replaced
US4604284A (en) *	1983-09-20	1986-08-05	Hoffmann-La Roche Inc.	Homogeneous immune interferon fragment
JPH0788398B2 (ja) *	1983-10-17	1995-09-27	サントリー株式会社	新規生理活性ポリペプチドおよびその製造法
GB8334102D0 (en) *	1983-12-21	1984-02-01	Searle & Co	Interferons with cysteine pattern
US4855238A (en) *	1983-12-16	1989-08-08	Genentech, Inc.	Recombinant gamma interferons having enhanced stability and methods therefor
JPS60172999A (ja) *	1983-12-20	1985-09-06	Suntory Ltd	新規な塩基性ポリペプチドおよびその製造法

1984
- 1984-12-19 US US06/683,363 patent/US4758656A/en not_active Expired - Fee Related
- 1984-12-19 DK DK610884A patent/DK168016B1/da not_active IP Right Cessation
- 1984-12-20 NO NO845132A patent/NO174161C/no unknown
- 1984-12-21 DE DE198484116039T patent/DE146944T1/de active Pending
- 1984-12-21 EP EP84116039A patent/EP0146944B1/en not_active Expired - Lifetime
- 1984-12-21 DE DE84116039T patent/DE3486111T2/de not_active Expired - Fee Related
- 1984-12-21 IL IL7389284A patent/IL73892A/he not_active IP Right Cessation
- 1984-12-21 CA CA000470904A patent/CA1303528C/en not_active Expired - Lifetime
- 1984-12-24 AU AU37184/84A patent/AU580748B2/en not_active Ceased
- 1984-12-26 ES ES539068A patent/ES8606490A1/es not_active Expired
1992
- 1992-12-08 DK DK147292A patent/DK169347B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES8606490A1 (es)	1986-04-01
DK610884D0 (da)	1984-12-19
DK169347B1 (da)	1994-10-10
US4758656A (en)	1988-07-19
IL73892A0 (en)	1985-03-31
EP0146944A2 (en)	1985-07-03
AU3718484A (en)	1985-07-18
AU580748B2 (en)	1989-02-02
DE3486111T2 (de)	1993-10-07
NO174161B (no)	1993-12-13
EP0146944B1 (en)	1993-03-24
DK610884A (da)	1985-06-27
DE146944T1 (de)	1986-01-16
DK168016B1 (da)	1994-01-17
ES539068A0 (es)	1986-04-01
EP0146944A3 (en)	1987-03-25
CA1303528C (en)	1992-06-16
DE3486111D1 (de)	1993-04-29
NO845132L (no)	1985-06-27
DK147292A (da)	1992-12-08
NO174161C (no)	1994-03-23
DK147292D0 (da)	1992-12-08

Legal Events

Date	Code	Title	Description
1996-06-18	KB	Patent renewed
1999-12-22	RH	Patent void

Publication	Publication Date	Title
EP0170917B1 (en)	1991-05-29	Novel human interferon-gamma polypeptide derivative
Yelverton et al.	1981	Bacterial synthesis of a novel human leukocyte interferon
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