|
US4879236A
(en)
*
|
1984-05-16 |
1989-11-07 |
The Texas A&M University System |
Method for producing a recombinant baculovirus expression vector
|
|
JPS619288A
(ja)
*
|
1984-06-21 |
1986-01-16 |
Dai Ichi Seiyaku Co Ltd |
ペプチド類の製法
|
|
IL80529A0
(en)
*
|
1985-11-14 |
1987-02-27 |
Daiichi Seiyaku Co |
Method of producing peptides
|
|
IE60285B1
(en)
*
|
1985-12-18 |
1994-06-29 |
Microgenesys Inc |
Method for producing selected polypeptides in virally infected insect cells and polypeptides isolated therefrom
|
|
IL83003A
(en)
|
1986-07-01 |
1995-07-31 |
Genetics Inst |
Osteoinductive factors
|
|
US6150328A
(en)
|
1986-07-01 |
2000-11-21 |
Genetics Institute, Inc. |
BMP products
|
|
GR871029B
(en)
|
1986-07-14 |
1987-11-02 |
Genetics Inst |
Novel osteoinductive factors
|
|
NZ221702A
(en)
*
|
1986-09-08 |
1989-02-24 |
Bishop David H L |
Expression of human hepatitis b antigens in insects and cultured insect cells using recombinant baculoviruses
|
|
ES2008204A6
(es)
*
|
1986-09-09 |
1989-07-16 |
Genetics Inst |
Metodos para producir cuerpos de inclusion polihedrica de composicion mezclada (pib),para coinfectar insectos huespedes y para producir proteinas heterologas en insectos.
|
|
US5071748A
(en)
*
|
1986-09-09 |
1991-12-10 |
Genetics Institute, Inc. |
Mixed baculovirus compositions and uses thereof
|
|
US5041379A
(en)
*
|
1987-03-16 |
1991-08-20 |
American Biogenetic Science, Inc. |
Heliothis expression systems
|
|
US5024947A
(en)
*
|
1987-07-24 |
1991-06-18 |
Cetus Corporation |
Serum free media for the growth on insect cells and expression of products thereby
|
|
US5578468A
(en)
*
|
1987-08-10 |
1996-11-26 |
Duke University |
Site-specific RNA cleavage
|
|
US5443964A
(en)
*
|
1987-08-10 |
1995-08-22 |
Duke University |
Poxvirus insertion/expression vector
|
|
GB8810808D0
(en)
*
|
1988-05-06 |
1988-06-08 |
Wellcome Found |
Vectors
|
|
JP2511494B2
(ja)
*
|
1988-05-12 |
1996-06-26 |
善治 松浦 |
日本脳炎ウイルス表面抗原蛋白質の製造法
|
|
JPH0221955A
(ja)
*
|
1988-07-07 |
1990-01-24 |
Nippon Steel Corp |
流体噴射ノズル
|
|
SE8802939D0
(sv)
*
|
1988-08-19 |
1988-08-19 |
Kabigen Ab |
A method for the production and isolation of a fusion protein in eukaryotic cells
|
|
US5811523A
(en)
|
1988-11-10 |
1998-09-22 |
Trinchieri; Giorgio |
Antibodies to natural killer stimulatory factor
|
|
AU4647889A
(en)
*
|
1988-11-18 |
1990-06-12 |
Cetus Corporation |
Insect signal peptide mediated secretion of recombinant proteins
|
|
US5244805A
(en)
*
|
1989-05-17 |
1993-09-14 |
University Of Georgia Research Foundation, Inc. |
Baculovirus expression vectors
|
|
KR100259827B1
(ko)
|
1991-11-04 |
2000-06-15 |
브루스 엠. 에이센, 토마스 제이 데스로저 |
재조합 골형태 형성 단백질 헤테로다이머, 그 조성물 및 사용방법
|
|
ATE258984T1
(de)
|
1993-05-12 |
2004-02-15 |
Inst Genetics Llc |
Bmp-11 zusammensetzungen
|
|
US6291206B1
(en)
|
1993-09-17 |
2001-09-18 |
Genetics Institute, Inc. |
BMP receptor proteins
|
|
US6027919A
(en)
|
1993-12-07 |
2000-02-22 |
Genetics Institute, Inc. |
BMP-12 and BMP-13 proteins and DNA encoding them
|
|
EP0733109B9
(en)
|
1993-12-07 |
2006-07-05 |
Genetics Institute, LLC |
Bmp-12, bmp-13 and tendon-inducing compositions thereof
|
|
CA2179394A1
(en)
*
|
1993-12-23 |
1995-06-29 |
Kostas Iatrou |
Methods of expressing proteins in insect cells and methods of killing insects
|
|
US5629167A
(en)
|
1994-04-19 |
1997-05-13 |
Biocine S.P.A. |
Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay
|
|
US6544523B1
(en)
|
1996-11-13 |
2003-04-08 |
Chiron Corporation |
Mutant forms of Fas ligand and uses thereof
|
|
US6165748A
(en)
|
1997-07-11 |
2000-12-26 |
Genetics Institute, Inc. |
Frazzled nucleotide sequences and expression products
|
|
WO1999010372A1
(en)
|
1997-08-27 |
1999-03-04 |
Chiron Corporation |
Molecular mimetics of meningococcal b epitopes
|
|
CA2308606A1
(en)
|
1997-11-06 |
1999-05-20 |
Chiron S.P.A. |
Neisserial antigens
|
|
ATE446368T1
(de)
|
1998-01-14 |
2009-11-15 |
Novartis Vaccines & Diagnostic |
Antigene aus neisseria meningitidis
|
|
GB9808932D0
(en)
|
1998-04-27 |
1998-06-24 |
Chiron Spa |
Polyepitope carrier protein
|
|
EP2261345A3
(en)
|
1998-05-01 |
2012-01-11 |
Novartis Vaccines and Diagnostics, Inc. |
Neisseria meningitidis antigens and compositions
|
|
EP1121437B1
(en)
|
1998-10-15 |
2008-02-20 |
Novartis Vaccines and Diagnostics, Inc. |
Metastatic breast and colon cancer regulated genes
|
|
EP1961813B1
(en)
|
1998-12-16 |
2011-08-10 |
Novartis Vaccines and Diagnostics, Inc. |
Human cyclin-dependent kinase (hPNQALRE)
|
|
US6727224B1
(en)
|
1999-02-01 |
2004-04-27 |
Genetics Institute, Llc. |
Methods and compositions for healing and repair of articular cartilage
|
|
RU2245366C2
(ru)
|
1999-04-30 |
2005-01-27 |
Чирон С.Р.Л. |
Антиген neisseria, кодирующая его нуклеиновая кислота, их использование
|
|
GB9911683D0
(en)
|
1999-05-19 |
1999-07-21 |
Chiron Spa |
Antigenic peptides
|
|
GB9916529D0
(en)
|
1999-07-14 |
1999-09-15 |
Chiron Spa |
Antigenic peptides
|
|
EP1305412A2
(en)
|
1999-10-14 |
2003-05-02 |
Clontech Laboratories Inc. |
Anthozoa derived chromo/fluoroproteins and methods for using the same
|
|
WO2001028602A1
(en)
|
1999-10-15 |
2001-04-26 |
Genetics Institute, Inc. |
Formulations of hyaluronic acid for delivery of osteogenic proteins
|
|
PT2275552E
(pt)
|
1999-10-29 |
2015-12-07 |
Glaxosmithkline Biolog Sa |
Péptidos antigénicos de neisseria
|
|
AU2001229367A1
(en)
|
2000-01-10 |
2001-07-24 |
Chiron Corporation |
Genes differentially expressed in breast cancer
|
|
ES2588917T3
(es)
|
2000-01-17 |
2016-11-07 |
Glaxosmithkline Biologicals Sa |
Vacuna de VME suplementada contra meningococo
|
|
US6689599B1
(en)
|
2000-10-20 |
2004-02-10 |
Genetics Institute, Llc |
Aggrecanase molecules
|
|
MXPA03003690A
(es)
|
2000-10-27 |
2004-05-05 |
Chiron Spa |
Acidos nucleicos y proteinas de los grupos a y b de estreptococos.
|
|
TW200526779A
(en)
|
2001-02-08 |
2005-08-16 |
Wyeth Corp |
Modified and stabilized GDF propeptides and uses thereof
|
|
GB0107658D0
(en)
|
2001-03-27 |
2001-05-16 |
Chiron Spa |
Streptococcus pneumoniae
|
|
GB0107661D0
(en)
|
2001-03-27 |
2001-05-16 |
Chiron Spa |
Staphylococcus aureus
|
|
WO2002081639A2
(en)
|
2001-04-06 |
2002-10-17 |
Georgetown University |
Gene brcc2 and diagnostic and therapeutic uses thereof
|
|
AU2002305151A1
(en)
|
2001-04-06 |
2002-10-21 |
Georgetown University |
Gene scc-112 and diagnostic and therapeutic uses thereof
|
|
WO2002081642A2
(en)
|
2001-04-06 |
2002-10-17 |
Georgetown University |
Gene brcc-3 and diagnostic and therapeutic uses thereof
|
|
CA2449008A1
(en)
|
2001-06-01 |
2002-12-12 |
Wyeth |
Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
|
|
TWI267378B
(en)
|
2001-06-08 |
2006-12-01 |
Wyeth Corp |
Calcium phosphate delivery vehicles for osteoinductive proteins
|
|
AU2002319703A1
(en)
|
2001-07-27 |
2003-02-17 |
Wyeth |
Aggrecanase molecules
|
|
ES2312649T3
(es)
|
2001-12-12 |
2009-03-01 |
Novartis Vaccines And Diagnostics S.R.L. |
Inmunizacion frente a chlamydia trachomatis.
|
|
DE60233347D1
(de)
|
2001-12-19 |
2009-09-24 |
Univ Chicago |
Schnellreifende fluoreszierende proteine und verfahren zu deren anwendung
|
|
AU2003207795B2
(en)
|
2002-01-31 |
2009-01-08 |
Wyeth |
Aggrecanase molecules
|
|
CA2475329A1
(en)
|
2002-02-05 |
2003-08-14 |
Katy E. Georgiadis |
Truncated aggrecanase molecules
|
|
US7244565B2
(en)
|
2002-04-10 |
2007-07-17 |
Georgetown University |
Gene shinc-3 and diagnostic and therapeutic uses thereof
|
|
US7138512B2
(en)
|
2002-04-10 |
2006-11-21 |
Georgetown University |
Gene SHINC-2 and diagnostic and therapeutic uses thereof
|
|
WO2003099848A2
(en)
|
2002-05-24 |
2003-12-04 |
Restoragen Inc. |
Method for universal enzymatic production of bioactive peptides
|
|
AU2003243316A1
(en)
|
2002-05-24 |
2003-12-12 |
Nps Allelix Corp. |
Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
|
|
WO2004046177A2
(en)
|
2002-11-15 |
2004-06-03 |
Chiron Srl |
Unexpected surface proteins in neisseria meningitidis
|
|
GB0308198D0
(en)
|
2003-04-09 |
2003-05-14 |
Chiron Srl |
ADP-ribosylating bacterial toxin
|
|
KR20060133961A
(ko)
|
2003-09-12 |
2006-12-27 |
와이어쓰 |
골형성 단백질 전달용의 주사 가능한 인산칼슘 고형 로드및 페이스트
|
|
ME01366B
(me)
|
2003-11-21 |
2013-12-20 |
Nps Allelix Corp |
POSTUPAK ZA PROIZVODNJU PEPTIDA 2 NALIK NA GLUKAGON l NJIHOVIH ANALOGA
|
|
NZ548256A
(en)
|
2004-02-02 |
2010-02-26 |
Ambrx Inc |
Modified human four helical bundle polypeptides and their uses
|
|
WO2006069220A2
(en)
|
2004-12-22 |
2006-06-29 |
Ambrx, Inc. |
Modified human growth hormone
|
|
WO2005093064A1
(ja)
|
2004-03-29 |
2005-10-06 |
Galpharma Co., Ltd. |
新規ガレクチン9改変体タンパク質及びその用途
|
|
WO2005100387A1
(en)
|
2004-04-07 |
2005-10-27 |
The University Of Chicago |
Monomeric red fluorescent proteins
|
|
US7632924B2
(en)
|
2004-06-18 |
2009-12-15 |
Ambrx, Inc. |
Antigen-binding polypeptides and their uses
|
|
MX2007000728A
(es)
|
2004-07-21 |
2007-03-15 |
Ambrx Inc |
Polipeptidos biosinteticos que utilizan amino acidos no naturalmente codificados.
|
|
CA2927595C
(en)
|
2004-12-22 |
2023-01-31 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
NZ561681A
(en)
|
2005-03-21 |
2011-01-28 |
Virobay Inc |
Alpha ketoamide compounds as cysteine protease inhibitors
|
|
CA2607291A1
(en)
|
2005-05-12 |
2006-11-23 |
Steven D. Levin |
Compositions and methods for modulating immune responses
|
|
WO2007053732A2
(en)
|
2005-11-01 |
2007-05-10 |
Mayo Foundation For Medical Education And Research |
Promoter polymorphisms of the blys gene and use in diagnostic methods
|
|
WO2007059312A2
(en)
|
2005-11-16 |
2007-05-24 |
Ambrx, Inc. |
Methods and compositions comprising non-natural amino acids
|
|
WO2008020335A2
(en)
|
2006-06-09 |
2008-02-21 |
Novartis Ag |
Immunogenic compositions for streptococcus agalactiae
|
|
CN106008699A
(zh)
|
2006-09-08 |
2016-10-12 |
Ambrx公司 |
经修饰的人类血浆多肽或Fc骨架和其用途
|
|
US7985783B2
(en)
|
2006-09-21 |
2011-07-26 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
|
HRP20120522T1
(hr)
|
2007-03-30 |
2012-08-31 |
Ambrx |
Modificirani fgf-21 polipeptidi i njihova uporaba
|
|
ES2908934T3
(es)
|
2007-10-04 |
2022-05-04 |
Zymogenetics Inc |
ZB7H6 miembro de la familia B7 y composiciones y métodos relacionados
|
|
US8679749B2
(en)
|
2007-11-01 |
2014-03-25 |
The University Of Chicago |
Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation
|
|
NZ603812A
(en)
|
2007-11-20 |
2014-06-27 |
Ambrx Inc |
Modified insulin polypeptides and their uses
|
|
WO2009073511A2
(en)
|
2007-11-30 |
2009-06-11 |
Mayo Foundation For Medical Education And Research |
Polymorphisms of the blys gene and use in diagnostic methods
|
|
NZ602170A
(en)
|
2008-02-08 |
2014-03-28 |
Ambrx Inc |
Modified leptin polypeptides and their uses
|
|
PT2318029T
(pt)
|
2008-07-23 |
2018-01-10 |
Ambrx Inc |
Polipéptidos de g-csf bovino modificados e suas utilizações
|
|
MX2011003196A
(es)
|
2008-09-26 |
2011-04-27 |
Ambrx Inc |
Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.
|
|
DK2342223T3
(en)
|
2008-09-26 |
2017-07-24 |
Ambrx Inc |
Modified animal erythropoietin polypeptides and their uses
|
|
EP2292781A1
(en)
|
2009-08-17 |
2011-03-09 |
Genethon |
Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
|
|
EP2333074A1
(en)
|
2009-12-14 |
2011-06-15 |
Robert Steinfeld |
Substances and methods for the treatment of lysosmal storage diseases
|
|
EP2516455A4
(en)
|
2009-12-21 |
2013-05-22 |
Ambrx Inc |
MODIFIED SWINE SOMATOTROPIN POLYPEPTIDES AND THEIR USES
|
|
US20120283171A1
(en)
|
2009-12-21 |
2012-11-08 |
Ambrx, Inc. |
Modified bovine somatotropin polypeptides and their uses
|
|
PH12013500241A1
(en)
|
2010-08-17 |
2013-03-11 |
Ambrx Inc |
Modified relaxin polypeptides and their uses
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
TWI480288B
(zh)
|
2010-09-23 |
2015-04-11 |
Lilly Co Eli |
牛顆粒細胞群落刺激因子及其變體之調配物
|
|
DK2737071T3
(en)
|
2011-07-27 |
2017-05-08 |
Genethon |
IMPROVED BACULOVIRUS EXPRESSION SYSTEMS
|
|
AU2014318890B2
(en)
|
2013-09-12 |
2019-03-07 |
Biomarin Pharmaceutical Inc. |
Adeno-associated virus Factor VIII vectors
|
|
SMT202100388T1
(it)
|
2014-10-24 |
2021-09-14 |
Bristol Myers Squibb Co |
Polipeptidi fgf-21 modificati e loro usi
|
|
MA42934A
(fr)
|
2015-09-24 |
2018-08-01 |
Biomarin Pharm Inc |
Vecteurs de facteur viii à virus adéno-associé, particules virales associées et formulations thérapeutiques comprenant ceux-ci
|
|
BR112018009657A2
(pt)
|
2015-11-12 |
2018-11-13 |
Research Institute At Nationwide Children's Hospital |
métodos de tratamento de distrofia muscular
|
|
JP7418957B2
(ja)
|
2015-11-16 |
2024-01-22 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
タイチン系ミオパチー及び他のタイチノパチーの治療のための材料及び方法
|
|
BR112019001532A2
(pt)
|
2016-07-26 |
2019-09-10 |
Biomarin Pharm Inc |
proteínas de capsídeo de vírus adenoassociado inovadoras
|
|
US10266578B2
(en)
|
2017-02-08 |
2019-04-23 |
Bristol-Myers Squibb Company |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
|
WO2019067982A2
(en)
|
2017-09-29 |
2019-04-04 |
Massachusetts Eye And Ear Infirmary |
PRODUCTION OF ADENO-ASSOCIATED VIRUSES IN INSECT CELLS
|
|
CN119770682A
(zh)
|
2018-01-31 |
2025-04-08 |
国家儿童医院研究所 |
2c型肢带型肌营养不良的基因疗法
|
|
SG11202010830WA
(en)
|
2018-05-09 |
2020-11-27 |
Biomarin Pharm Inc |
Methods of treating phenylketonuria
|
|
TW202005978A
(zh)
|
2018-05-14 |
2020-02-01 |
美商拜奧馬林製藥公司 |
新穎肝靶向腺相關病毒載體
|
|
JP2021523198A
(ja)
|
2018-05-14 |
2021-09-02 |
ビオマリン プハルマセウトイカル インコーポレイテッド |
幼若対象におけるaavベクターの安定的発現
|
|
CN112543810A
(zh)
|
2018-06-29 |
2021-03-23 |
全国儿童医院研究所 |
治疗肢带型肌营养不良2a型的重组腺相关病毒产品和方法
|
|
AU2020229340A1
(en)
|
2019-02-26 |
2021-09-16 |
Research Institute At Nationwide Children's Hospital |
Adeno-associated virus vector delivery of B-sarcoglycan and the treatment of muscular dystrophy
|
|
TW202104592A
(zh)
|
2019-05-14 |
2021-02-01 |
美商拜奧馬林製藥公司 |
重複投予基因療法載體之方法
|
|
KR20220092489A
(ko)
|
2019-08-21 |
2022-07-01 |
더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 |
알파-사코글리칸의 아데노 관련 바이러스 벡터 전달 및 근위축증 치료
|
|
BR112022005392A2
(pt)
|
2019-09-27 |
2022-09-06 |
Biomarin Pharm Inc |
Caracterização de partículas virais de terapia genética que usa cromatografia por exclusão de tamanho e tecnologias de dispersão de luz multiangular
|
|
CN114829391A
(zh)
|
2019-11-14 |
2022-07-29 |
生物马林药物股份有限公司 |
用肝特异性基因疗法载体治疗遗传性血管性水肿
|
|
US20230075854A1
(en)
|
2020-02-10 |
2023-03-09 |
Biomarin Pharmaceutical Inc. |
Virus-free cell cultures
|
|
WO2021183895A1
(en)
|
2020-03-13 |
2021-09-16 |
Biomarin Pharmaceutical Inc. |
Treatment of fabry disease with aav gene therapy vectors
|
|
TW202144575A
(zh)
|
2020-04-03 |
2021-12-01 |
美商拜奧馬林製藥公司 |
使用aav及治療調配物之苯酮尿症治療
|
|
WO2021236908A2
(en)
|
2020-05-20 |
2021-11-25 |
Biomarin Pharmaceutical Inc. |
Use of regulatory proteins for the production of adeno-associated virus
|
|
WO2022094461A1
(en)
|
2020-11-02 |
2022-05-05 |
Biomarin Pharmaceutical Inc. |
Process for enriching adeno-associated virus
|
|
EP4408481A2
(en)
|
2021-10-01 |
2024-08-07 |
BioMarin Pharmaceutical Inc. |
Treatment of hereditary angioedema with aav gene therapy vectors and therapeutic formulations
|
|
US12285497B2
(en)
|
2021-10-15 |
2025-04-29 |
Research Institute At Nationwide Children's Hospital |
Self-complementary adeno-associated virus vector and its use in treatment of muscular dystrophy
|
|
UY40442A
(es)
|
2022-09-22 |
2024-02-15 |
Biomarin Pharm Inc |
Tratamiento de la miocardiopatía arritmogénica con vectores de genoterapia con aav
|
|
CA3267804A1
(en)
|
2022-09-22 |
2024-03-28 |
Dinaqor Ag |
TREATMENT OF CARDIOMYOPATHY USING AAV GENE THERAPY VECTORS
|
|
TW202444398A
(zh)
|
2023-01-09 |
2024-11-16 |
美商拜奧馬林製藥公司 |
表觀遺傳修飾劑改善aav基因療法之耐久性
|
|
WO2024238591A2
(en)
|
2023-05-15 |
2024-11-21 |
Biomarin Pharmaceutical Inc. |
Methods of treating anti-aav seropositive hemophilia patients
|
|
WO2025214477A1
(en)
|
2024-04-12 |
2025-10-16 |
Skyline Therapeutics (Shanghai) Co., Ltd. |
Treatment of genetic cardiomyopathies with aav gene therapy vectors
|