IL75574A0 - Benzofuran derivatives and pharmaceutical compositions containing them - Google Patents

Benzofuran derivatives and pharmaceutical compositions containing them

Info

Publication number: IL75574A0
Authority: IL; Israel
Prior art keywords: alkyl; independently; chem; compounds; useful
Prior art date: 1984-06-20

Application number

IL75574A

Other languages

English (en)

Original Assignee

Merck Frosst Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-06-20

Filing date

1985-06-19

Publication date

1985-10-31

1985-06-19 Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc

1985-10-31 Publication of IL75574A0 publication Critical patent/IL75574A0/xx

Links

150000001907 coumarones Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 5
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
206010027654 Allergic conditions Diseases 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
229940035676 analgesics Drugs 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000001120 cytoprotective effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
150000002617 leukotrienes Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
150000003536 tetrazoles Chemical class 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 abstract 1
229930192474 thiophene Natural products 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Furan Compounds (AREA)

IL75574A 1984-06-20 1985-06-19 Benzofuran derivatives and pharmaceutical compositions containing them IL75574A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US62237284A	1984-06-20	1984-06-20

Publications (1)

Publication Number	Publication Date
IL75574A0 true IL75574A0 (en)	1985-10-31

Family

ID=24493941

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL75574A IL75574A0 (en)	1984-06-20	1985-06-19	Benzofuran derivatives and pharmaceutical compositions containing them

Country Status (13)

Country	Link
EP (1)	EP0165810B1 (de)
JP (1)	JPS6117579A (de)
KR (1)	KR860000292A (de)
AT (1)	ATE45736T1 (de)
AU (1)	AU4377585A (de)
CA (1)	CA1281325C (de)
DE (1)	DE3572486D1 (de)
DK (1)	DK276985A (de)
ES (1)	ES8800190A1 (de)
GR (1)	GR851493B (de)
IL (1)	IL75574A0 (de)
PT (1)	PT80660B (de)
ZA (1)	ZA854652B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4863958A (en) *	1984-06-20	1989-09-05	Merck Frosst Canada, Inc.	Benzofuran derivatives useful as inhibitors of mammalian leukotriene biosynthesis
LU85544A1 (fr) *	1984-09-19	1986-04-03	Cird	Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique
GB2185741B (en) *	1986-01-27	1989-10-25	American Home Prod	Heterocyclic sulphonamides
US4714711A (en) *	1986-11-05	1987-12-22	Merck & Co., Inc.	6-hydroxy-2(2-hydroxy-4-methoxyphenyl)benzofuran derivatives to inhibit leukotriene biosynthesis
JPS63123547A (ja) *	1986-11-12	1988-05-27	Aisin Seiki Co Ltd	下降端設定ユニツトを有する自動カシメ装置
DE3777366D1 (de) *	1986-12-27	1992-04-16	Takeda Chemical Industries Ltd	2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung.
EP0295851A1 (de) *	1987-06-18	1988-12-21	Merck Frosst Canada Inc.	4,7-Diacyloxybenzofuran-Derivate
EP0301692A3 (de) *	1987-06-18	1989-03-15	Merck Frosst Canada Inc.	4,7-Benzofurandion-Derivate
IT1229482B (it) *	1988-08-01	1991-09-03	Foscama Biomed Chim Farma	Acidi (rs) 2 (2,3 diidro 5 idrossi 4,6,7 trimetilbenzofuranil) acetico e 2 (2,3 diidro 5 acilossi 4,6,7 trimetilbenzofuranil) acetici e loro esteri, utili come farmaci mucoregolatori ed antiischemici.
US4966907A (en) *	1988-08-12	1990-10-30	Merck & Co., Inc.	6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
WO1990003374A1 (en) *	1988-09-28	1990-04-05	The Upjohn Company	1,4-dihydrothionapthoquinone and heterocyclic congeners which inhibit lipoxygenase enzymes
US5093351A (en) *	1989-01-05	1992-03-03	Du Pont Merck Pharmaceutical Company	Substituted indole, benzofuran and benzothiophene derivatives as 5-lipoxygenase inhibitors
US5006549A (en) *	1989-05-24	1991-04-09	Merck & Co., Inc.	Novel 7-aroyl-4-hydroxy-3-methyl-benzofurans as dual inhibitors of cyclooxygenase and 5-lipoxygenase
IT1231341B (it) *	1989-08-18	1991-11-28	Foscama Biomed Chim Farma	2,3 diidro 5 ossi 4,6,7 trimetilbenzofurani 2 (rs) sostituiti, utili come farmaci antiossidanti con proprieta' mucoregolatrici e antiischemiche.
US5118707A (en) *	1990-10-31	1992-06-02	The Procter & Gamble Company	Compositions for regulating skin wrinkles comprising a benzofuran derivative
IE68675B1 (en) *	1990-11-01	1996-07-10	Takeda Chemical Industries Ltd	Aminocoumaran derivatives their production and use
JP3157882B2 (ja) *	1991-11-15	2001-04-16	帝国臓器製薬株式会社	新規なベンゾチオフエン誘導体
DE4139888A1 (de) *	1991-12-04	1993-06-09	Jagenberg Ag, 4000 Duesseldorf, De	Vorrichtung zum abbremsen von auf einem stapel abzulegenden boegen, insbesondere papier- oder kartonboegen
DE69418789T2 (de) *	1993-08-05	1999-12-02	Hoechst Marion Roussel, Inc.	2-(Piperidin-4-yl, Pyridin-4-yl und Tetrahydropyridin-4-yl)-benzofuran-7-carbamat Derivate, ihre Herstellung und Verwendung als Acetylcholinesterase Inhibitoren
EP0751126A4 (de)	1995-01-06	1998-05-13	Toray Industries	Benzokundensierte heterocyclen und deren verwendung
EP0988289A2 (de) *	1997-06-05	2000-03-29	Takeda Pharmaceutical Company Limited	Benzofurane und benzothiophene als unterdrücker der neurodegeneration
US6172106B1 (en)	1998-02-09	2001-01-09	R. Armour Forse	Sesamol inhibition of Δ-5-desaturase activity and uses therefor
US7709510B2 (en)	2001-02-20	2010-05-04	Chugai Seiyaku Kabushiki Kaisha	Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
JP4155351B2 (ja)	2001-02-20	2008-09-24	中外製薬株式会社	代謝調節剤として有用なマロニル−ＣｏＡ脱炭酸酵素阻害剤としてのアゾール
JP2005008631A (ja) *	2003-05-29	2005-01-13	New Industry Research Organization	ベンゾフラン化合物、およびそれを含有してなる医薬組成物
EP1627873A4 (de)	2003-05-29	2007-12-05	New Ind Res Organization	Benzofuranverbindung und medizinische zusammensetzung, die diese enthält
EP1653957B1 (de)	2003-08-01	2008-07-09	Chugai Seiyaku Kabushiki Kaisha	Piperidin-verbindungen als malonyl-coa decarboxylase-hemmer
EP2208495B1 (de)	2003-08-01	2011-12-14	Chugai Seiyaku Kabushiki Kaisha	Azol-Verbindungen auf Cyanoguanidin-Basis als Malonyl-Coa Decarboxylase-Hemmer
DE602004030017D1 (de)	2003-08-01	2010-12-23	Chugai Pharmaceutical Co Ltd	Heterocyclische verbindungen als nützliche malonyl-coa decarboxylase-hemmer
US7446201B2 (en)	2003-09-25	2008-11-04	Wyeth	Substituted heteroaryl benzofuran acids
US7351726B2 (en)	2003-09-25	2008-04-01	Wyeth	Substituted oxadiazolidinediones
MY148644A (en)	2005-07-18	2013-05-15	Orion Corp	New pharmaceutical compounds
WO2011022679A2 (en) *	2009-08-20	2011-02-24	University Of Tennessee Research Foundation, The	Benzofuran cannabinoid compounds and related methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3476760A (en) *	1967-03-06	1969-11-04	Smithkline Corp	Substituted piperidinoalkylthianaphthenes and benzofurans
CH540247A (de) *	1967-04-21	1973-09-28	Ciba Geigy Ag	Verfahren zur Herstellung von heterocyclischen, Asthylendoppelbindungen enthaltenden Verbindungen
US4354021A (en) *	1978-03-31	1982-10-12	The Upjohn Company	2-Decarboxy-2-tetrazolyl-6-alkoxy-PGI1 compounds
IT1154888B (it) *	1980-11-12	1987-01-21	Menarini Sas	Derivati del benzofurano 2-sostituiti e relativi metodi di preparazione
US4459420A (en) *	1982-05-17	1984-07-10	The Upjohn Company	Pyrogallol synthesis of anti-atherogenic furochromones
JPS59104374A (ja) *	1982-12-08	1984-06-16	Mitsui Petrochem Ind Ltd	ベンゾフラン誘導体の製造方法

1985
- 1985-06-14 CA CA000484076A patent/CA1281325C/en not_active Expired - Lifetime
- 1985-06-18 AU AU43775/85A patent/AU4377585A/en not_active Abandoned
- 1985-06-18 PT PT80660A patent/PT80660B/pt unknown
- 1985-06-19 AT AT85304382T patent/ATE45736T1/de not_active IP Right Cessation
- 1985-06-19 ES ES544349A patent/ES8800190A1/es not_active Expired
- 1985-06-19 EP EP85304382A patent/EP0165810B1/de not_active Expired
- 1985-06-19 GR GR851493A patent/GR851493B/el unknown
- 1985-06-19 IL IL75574A patent/IL75574A0/xx unknown
- 1985-06-19 DK DK276985A patent/DK276985A/da not_active Application Discontinuation
- 1985-06-19 DE DE8585304382T patent/DE3572486D1/de not_active Expired
- 1985-06-20 KR KR1019850004373A patent/KR860000292A/ko not_active Withdrawn
- 1985-06-20 JP JP60133155A patent/JPS6117579A/ja active Pending
- 1985-06-20 ZA ZA854652A patent/ZA854652B/xx unknown

Also Published As

Publication number	Publication date
PT80660B (en)	1987-05-04
ATE45736T1 (de)	1989-09-15
DE3572486D1 (en)	1989-09-28
EP0165810A2 (de)	1985-12-27
ZA854652B (en)	1986-04-30
EP0165810B1 (de)	1989-08-23
CA1281325C (en)	1991-03-12
AU4377585A (en)	1986-01-02
ES544349A0 (es)	1987-10-16
EP0165810A3 (en)	1986-06-25
KR860000292A (ko)	1986-01-27
DK276985A (da)	1985-12-21
JPS6117579A (ja)	1986-01-25
PT80660A (en)	1985-07-01
GR851493B (de)	1985-11-25
ES8800190A1 (es)	1987-10-16
DK276985D0 (da)	1985-06-19

Publication	Publication Date	Title
DE3572486D1 (en)	1989-09-28	Benzofuran and benzothiophene derivatives, their use in inhibiting mammalian leukotriene biosynthesis, and pharmaceutical compositions containing these derivatives
AU1663783A (en)	1984-01-19	Thieno(3,2-c)pyridine derivatives
NO823768L (no)	1983-05-13	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske forbindelser
HU902839D0 (en)	1991-03-28	Process for producing acriloyl-substituted pyrrole derivatives and pharmaceutical preparatives containing them
FI892497A0 (fi)	1989-05-23	Menetelmä terapeuttisesti aktiivisten bentsamidijohdannaisten valmistamiseksi
MY100665A (en)	1991-01-17	7-carboxymethoxy-furo-(3,4-c)-pyridine derivatives.
ES454656A1 (es)	1977-11-16	Procedimiento para preparar derivados de 4-pirimidona y 4- tiona.
IE780119L (en)	1978-07-20	IMIDAZO(1,2-a) QUINOLINE-2-CARBOXYLIC ACIDS
IL71639A0 (en)	1984-07-31	Imidazoline derivatives,processes for their preparation,pharmaceutical compositions containing them and their use as histamine h2-antagonists
ES2009209A6 (es)	1989-09-16	Procedimiento para la obtencion de dihidropiridinlactoles.
HUT51629A (en)	1990-05-28	Process for producing new, heterocyclically substituted 5,7-dihydro-pyrrolo(3,2-f)-benzoxazole-6-one derivatives as well as pharmaceutical preparations containing such compounds
ES8308565A1 (es)	1983-09-01	Procedimiento para la preparacion de compuestos de 1,4-benzodiazepina.
SE8703494L (sv)	1987-09-09	Mellanprodukter anvendbara vid framstellning av 2-tiofen-ettiksyraderivat
AU9021882A (en)	1983-05-12	I-furyl-3,4-dihydroisoquinolines
EP0054970A3 (en)	1983-03-23	Derivatives of 7-beta-(ketoximinoacylamido)-ceph-3-em-4-carboxylic acids, process for their preparation and their pharmaceutical compositions containing them
ES8302006A1 (es)	1983-01-01	Procedimiento para la preparacion de nuevas cefalosporinas .
JPS55104266A (en)	1980-08-09	Novel pyridone derivative
ZA872925B (en)	1987-11-25	Heterocyclic compounds
JPS52106895A (en)	1977-09-07	77nnacylaminooaaaryl orrthienylacetamido33heterocyclic thiomethyl* 33cephemm44carboxylic acids