IL75738A - Polypeptide Derivatives of M - Human Interferon - Google Patents

Polypeptide Derivatives of M - Human Interferon

Info

Publication number: IL75738A
Authority: IL; Israel
Prior art keywords: ifn; dna; cys; ser; plasmid
Prior art date: 1984-07-11

Application number

IL7573885A

Other languages

English (en)

Hebrew (he)

Other versions

IL75738A0 (en

Original Assignee

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-11

Filing date

1985-07-08

Publication date

1995-06-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15350817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL75738(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-07-08 Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk

1985-11-29 Publication of IL75738A0 publication Critical patent/IL75738A0/xx

1995-06-29 Publication of IL75738A publication Critical patent/IL75738A/en

Links

101000599940 Homo sapiens Interferon gamma Proteins 0.000 title abstract description 53
102000043557 human IFNG Human genes 0.000 title description 3
239000013612 plasmid Substances 0.000 claims description 83
229920001184 polypeptide Polymers 0.000 claims description 4
102000004196 processed proteins & peptides Human genes 0.000 claims description 4
108090000765 processed proteins & peptides Proteins 0.000 claims description 4
150000001413 amino acids Chemical class 0.000 abstract description 43
230000000694 effects Effects 0.000 abstract description 12
230000000840 anti-viral effect Effects 0.000 abstract description 2
239000002246 antineoplastic agent Substances 0.000 abstract 1
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108020004414 DNA Proteins 0.000 description 107
238000006243 chemical reaction Methods 0.000 description 73
239000012634 fragment Substances 0.000 description 55
108010074328 Interferon-gamma Proteins 0.000 description 53
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230000029087 digestion Effects 0.000 description 47
239000000243 solution Substances 0.000 description 45
238000000034 method Methods 0.000 description 44
235000001014 amino acid Nutrition 0.000 description 39
239000007853 buffer solution Substances 0.000 description 31
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241000588724 Escherichia coli Species 0.000 description 29
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TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 28
239000000203 mixture Substances 0.000 description 19
238000010276 construction Methods 0.000 description 18
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 17
239000011780 sodium chloride Substances 0.000 description 15
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229910001629 magnesium chloride Inorganic materials 0.000 description 14
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KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 8
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 7
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 7
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108010021757 Polynucleotide 5'-Hydroxyl-Kinase Proteins 0.000 description 5
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KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 4
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PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
239000004472 Lysine Substances 0.000 description 3
SOAYQFDWEIWPPR-IHRRRGAJSA-N Met-Ser-Tyr Chemical compound [H]N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O SOAYQFDWEIWPPR-IHRRRGAJSA-N 0.000 description 3
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108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 3
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238000007796 conventional method Methods 0.000 description 3
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239000008103 glucose Substances 0.000 description 3
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238000010257 thawing Methods 0.000 description 3
WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
108020004705 Codon Proteins 0.000 description 2
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239000007836 KH2PO4 Substances 0.000 description 2
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125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
108020004511 Recombinant DNA Proteins 0.000 description 2
241000700605 Viruses Species 0.000 description 2
239000002253 acid Substances 0.000 description 2
210000004102 animal cell Anatomy 0.000 description 2
229940041514 candida albicans extract Drugs 0.000 description 2
238000003776 cleavage reaction Methods 0.000 description 2
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
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238000002474 experimental method Methods 0.000 description 2
238000000605 extraction Methods 0.000 description 2
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 2
229910052943 magnesium sulfate Inorganic materials 0.000 description 2
244000005700 microbiome Species 0.000 description 2
229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
235000019796 monopotassium phosphate Nutrition 0.000 description 2
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 2
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NSHWGYPCYVZQOD-UHFFFAOYSA-N 2-(1h-indol-2-yl)prop-2-enoic acid Chemical compound C1=CC=C2NC(C(=C)C(=O)O)=CC2=C1 NSHWGYPCYVZQOD-UHFFFAOYSA-N 0.000 description 1
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FJVAQLJNTSUQPY-CIUDSAMLSA-N Ala-Ala-Lys Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CCCCN FJVAQLJNTSUQPY-CIUDSAMLSA-N 0.000 description 1
YYAVDNKUWLAFCV-ACZMJKKPSA-N Ala-Ser-Gln Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(O)=O YYAVDNKUWLAFCV-ACZMJKKPSA-N 0.000 description 1
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LMIWYCWRJVMAIQ-NHCYSSNCSA-N Asn-Val-Lys Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CC(=O)N)N LMIWYCWRJVMAIQ-NHCYSSNCSA-N 0.000 description 1
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125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma

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Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)
Plant Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

IL7573885A 1984-07-11 1985-07-08 Polypeptide Derivatives of M - Human Interferon IL75738A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP14395084A JPS6124599A (ja)	1984-07-11	1984-07-11	新規ヒトインタ−フエロン−ｒポリペプチド誘導体

Publications (2)

Publication Number	Publication Date
IL75738A0 IL75738A0 (en)	1985-11-29
IL75738A true IL75738A (en)	1995-06-29

Family

ID=15350817

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL7573885A IL75738A (en)	1984-07-11	1985-07-08	Polypeptide Derivatives of M - Human Interferon

Country Status (11)

Country	Link
US (1)	US4898931A (da)
EP (1)	EP0170917B1 (da)
JP (1)	JPS6124599A (da)
AT (1)	ATE63923T1 (da)
AU (1)	AU586822B2 (da)
CA (1)	CA1303529C (da)
DE (2)	DE3582973D1 (da)
DK (1)	DK164108C (da)
ES (1)	ES8609484A1 (da)
IL (1)	IL75738A (da)
NO (1)	NO175487C (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8334102D0 (en) *	1983-12-21	1984-02-01	Searle & Co	Interferons with cysteine pattern
CA1340265C (en) *	1985-01-18	1998-12-15	Kirston E. Koths	Oxidation resistant muteins
GB8619725D0 (en) *	1986-08-13	1986-09-24	Hoffmann La Roche	Homogenous interferon fragments
JP2653061B2 (ja) *	1986-12-27	1997-09-10	武田薬品工業株式会社	新規ポリペプチドおよびその製造法
AT393690B (de) *	1987-10-08	1991-11-25	Hoffmann La Roche	Homogene, rekombinante immun-interferonfragmente
DE3829180A1 (de) *	1988-08-29	1990-03-08	Boehringer Ingelheim Int	Neues arzneimittel zur vorbeugung und behandlung von durch primaere immundefekte verursachte krankheiten
DE4036856C1 (da) *	1990-11-19	1992-05-27	Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De
KR100475492B1 (ko) *	1995-01-26	2005-03-14	바이오겐 아이덱 엠에이 인코포레이티드	항종양제로서의 림프독소-α/β 복합체 및항-림프독소-β수용체 항체
DE19535853C2 (de) *	1995-09-18	1999-04-01	Fraunhofer Ges Forschung	Varianten des rekombinanten humanen Interferon-gamma, Verfahren zu ihrer Herstellung und ihre Verwendung
AU782635B2 (en) *	1999-11-12	2005-08-18	Maxygen Holdings Ltd.	Interferon gamma conjugates
CA2390292A1 (en)	1999-11-12	2001-05-25	Maxygen Holdings Ltd.	Interferon gamma conjugates
CN1309423C (zh)	1999-11-12	2007-04-11	马克西根控股公司	干扰素γ偶联物
US6958388B2 (en)	2001-04-06	2005-10-25	Maxygen, Aps	Interferon gamma polypeptide variants
US7038015B2 (en)	2001-04-06	2006-05-02	Maxygen Holdings, Ltd.	Interferon gamma polypeptide variants
CA2491178A1 (en)	2002-07-03	2004-01-15	Maxygen Holdings Ltd.	Full-length interferon gamma polypeptide variants
BRPI0507169A (pt) *	2004-02-02	2007-06-26	Ambrx Inc	polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos
AU2006255122B2 (en) *	2005-06-03	2010-10-21	Ambrx, Inc.	Improved human interferon molecules and their uses
EP1991679A2 (fr) *	2006-03-08	2008-11-19	Biomethodes	Variants de l'interferon- gamma humain (ifngamma)
FR2898359B1 (fr) *	2006-03-08	2011-07-15	Biomethodes	Variants ameliores de l'interferon-gamma humain (ifn gamma)
MX344166B (es)	2008-02-08	2016-12-07	Ambrx Inc	Leptina-polipeptidos modificados y sus usos.
WO2020028275A1 (en) *	2018-07-30	2020-02-06	The Board Of Trustees Of The Leland Stanford Junior University	Interferon-gamma biased agonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU561343B2 (en) *	1981-10-19	1987-05-07	Genentech Inc.	Human immune interferon by recombinant dna
JPS58110548A (ja) *	1981-12-24	1983-07-01	Asahi Chem Ind Co Ltd	新規な生理活性ペプチド
US6936694B1 (en) *	1982-05-06	2005-08-30	Intermune, Inc.	Manufacture and expression of large structural genes
JPH0787797B2 (ja) *	1982-05-20	1995-09-27	サントリー株式会社	ヒト・ガンマ・インタ−フエロン様ポリペプチドの製造法
US4681848A (en) *	1982-09-22	1987-07-21	Takeda Chemical Industries, Ltd.	Novel peptide and use thereof
IL69851A0 (en) *	1982-09-30	1983-12-30	Japan Found Cancer	Novel dna and recombinant plasmid containing the same
US4758656A (en) *	1983-12-26	1988-07-19	Kyowa Hakko Kogyo Co., Ltd.	Novel human interferon-gamma polypeptide derivative
AU582574B2 (en) *	1984-04-19	1989-04-06	Hoechst Aktiengesellschaft	The preparation of polypeptides having human gamma interferon activity
IL75302A0 (en) *	1984-06-06	1985-09-29	Takeda Chemical Industries Ltd	Novel polypeptide and production thereof

1984
- 1984-07-11 JP JP14395084A patent/JPS6124599A/ja active Pending
1985
- 1985-07-04 CA CA000486327A patent/CA1303529C/en not_active Expired - Lifetime
- 1985-07-08 IL IL7573885A patent/IL75738A/en not_active IP Right Cessation
- 1985-07-09 AT AT85108541T patent/ATE63923T1/de not_active IP Right Cessation
- 1985-07-09 DE DE8585108541T patent/DE3582973D1/de not_active Expired - Lifetime
- 1985-07-09 DE DE198585108541T patent/DE170917T1/de active Pending
- 1985-07-09 EP EP85108541A patent/EP0170917B1/en not_active Expired - Lifetime
- 1985-07-10 NO NO852776A patent/NO175487C/no unknown
- 1985-07-10 DK DK314485A patent/DK164108C/da not_active IP Right Cessation
- 1985-07-10 AU AU44749/85A patent/AU586822B2/en not_active Ceased
- 1985-07-10 ES ES545052A patent/ES8609484A1/es not_active Expired
- 1985-07-10 US US06/751,205 patent/US4898931A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NO175487C (no)	1994-10-19
US4898931A (en)	1990-02-06
DK314485A (da)	1986-01-12
ES8609484A1 (es)	1986-09-01
DK164108C (da)	1992-10-12
AU586822B2 (en)	1989-07-27
EP0170917B1 (en)	1991-05-29
JPS6124599A (ja)	1986-02-03
AU4474985A (en)	1986-01-16
EP0170917A1 (en)	1986-02-12
DK164108B (da)	1992-05-11
NO175487B (no)	1994-07-11
DE3582973D1 (de)	1991-07-04
IL75738A0 (en)	1985-11-29
ES545052A0 (es)	1986-09-01
ATE63923T1 (de)	1991-06-15
NO852776L (no)	1986-01-13
CA1303529C (en)	1992-06-16
DK314485D0 (da)	1985-07-10
DE170917T1 (de)	1986-09-04

Legal Events

Date	Code	Title	Description
1996-06-18	KB	Patent renewed
2000-07-16	RH	Patent void

Publication	Publication Date	Title
EP0170917B1 (en)	1991-05-29	Novel human interferon-gamma polypeptide derivative
US4530901A (en)	1985-07-23	Recombinant DNA molecules and their use in producing human interferon-like polypeptides
EP0077670B1 (en)	1989-06-28	Human immune interferon
Yelverton et al.	1981	Bacterial synthesis of a novel human leukocyte interferon
US4853332A (en)	1989-08-01	Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins
CA1341240C (en)	2001-06-05	Dna encoding human tumor necrosis factor and human tumor necrosis factor polypeptide
US5096705A (en)	1992-03-17	Human immune interferon
EP0152613A2 (en)	1985-08-28	Novel promoter
EP0146944B1 (en)	1993-03-24	Novel human interferon- polypeptide derivative
US5582824A (en)	1996-12-10	Recombinant DES-CYS-TYR-CYS human immune interferon
Valenzuela et al.	1985	Is sequence conservation in interferons due to selection for functional proteins?
EP0121157B1 (en)	1989-06-14	Novel human interferon-gamma polypeptide
EP0062971B1 (en)	1990-03-07	Genetically modified microorganisms
US4851512A (en)	1989-07-25	Novel human interleukin-2 polypeptide derivative
IL71232A (en)	1995-07-31	A recombinant plasmid encoding the human itferron-C polypeptide, the process for its preparation, and microorganisms containing it
EP0121569A1 (en)	1984-10-17	Novel vector
EP0174999B1 (en)	1991-04-17	Method for improving expression and method thereto
CA1300053C (en)	1992-05-05	Human interleukin-2 polypeptide derivative
Jiang et al.	1996	Translation initiation region plays an important role in the expression of human thrombopoietin in Escherichia coli
PH26492A (en)	1992-07-27	Recombinant human immune interferon