IL79210A - 7-oxabicycloheptane substituted diamide derivatives and their prostaglandin analogues,process for their preparation and pharmaceutical compositions containing the same - Google Patents

7-oxabicycloheptane substituted diamide derivatives and their prostaglandin analogues,process for their preparation and pharmaceutical compositions containing the same

Info

Publication number: IL79210A
Authority: IL; Israel
Prior art keywords: image; same; lower alkyl; preparation; pharmaceutical compositions
Prior art date: 1985-07-01

Application number

IL79210A

Other languages

English (en)

Other versions

IL79210A0 (en

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-01

Filing date

1986-06-24

Publication date

1991-03-10

1986-06-24 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1986-09-30 Publication of IL79210A0 publication Critical patent/IL79210A0/xx

1991-03-10 Publication of IL79210A publication Critical patent/IL79210A/xx

Links

DYWAPFDKPAHSED-UHFFFAOYSA-N 2-cycloheptyloxepane Chemical group C1CCCCCC1C1OCCCCC1 DYWAPFDKPAHSED-UHFFFAOYSA-N 0.000 title abstract 2
229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 title 1
150000001470 diamides Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
-1 amide prostaglandin Chemical class 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
208000007536 Thrombosis Diseases 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000005127 aryl alkoxy alkyl group Chemical group 0.000 abstract 1
125000001691 aryl alkyl amino group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
125000005128 aryl amino alkyl group Chemical group 0.000 abstract 1
125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229940125692 cardiovascular agent Drugs 0.000 abstract 1
239000002327 cardiovascular agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL79210A 1985-07-01 1986-06-24 7-oxabicycloheptane substituted diamide derivatives and their prostaglandin analogues,process for their preparation and pharmaceutical compositions containing the same IL79210A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US75094885A	1985-07-01	1985-07-01
US06/853,788 US4663336A (en)	1985-07-01	1986-04-18	7-oxabicycloheptane substituted diamide and its congener prostaglandin analogs useful in the treatment of thrombotic disease

Publications (2)

Publication Number	Publication Date
IL79210A0 IL79210A0 (en)	1986-09-30
IL79210A true IL79210A (en)	1991-03-10

Family

ID=27115346

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL79210A IL79210A (en)	1985-07-01	1986-06-24	7-oxabicycloheptane substituted diamide derivatives and their prostaglandin analogues,process for their preparation and pharmaceutical compositions containing the same

Country Status (20)

Country	Link
US (1)	US4663336A (fr)
EP (1)	EP0207684B1 (fr)
JP (1)	JPH07103125B2 (fr)
KR (1)	KR910004721B1 (fr)
CN (1)	CN1009645B (fr)
AT (1)	ATE114312T1 (fr)
AU (1)	AU603058B2 (fr)
CA (1)	CA1284643C (fr)
DE (1)	DE3650144T2 (fr)
DK (1)	DK162528C (fr)
ES (10)	ES8801626A1 (fr)
FI (1)	FI93218C (fr)
GR (1)	GR861711B (fr)
HU (1)	HU196779B (fr)
IE (1)	IE65827B1 (fr)
IL (1)	IL79210A (fr)
NO (1)	NO168038C (fr)
NZ (1)	NZ216544A (fr)
PH (1)	PH22413A (fr)
PT (1)	PT82875B (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1278577C (fr) *	1985-11-18	1991-01-02	Tatsuo Tsuri	Derives bicycliques de sulfonamides
US4958036A (en) *	1986-06-04	1990-09-18	E. R. Squibb & Sons, Inc.	Enantiomerically selective synthesis of certain N-substituted-2-(carbamyl 7-oxabicyclo[2.2.1]heptane-3-carboxylic acids
US4743697A (en) *	1986-06-04	1988-05-10	E. R. Squibb & Sons, Inc.	Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists and novel intermediates procuced therein
US4749715A (en) *	1987-03-02	1988-06-07	E. R. Squibb & Sons, Inc.	7-oxabicycloheptane substituted amino prostaglandin analogs
US4931460A (en) *	1987-09-17	1990-06-05	E. R. Squibb & Sons, Inc.	Post-ischemic myocardial dysfunction using thromboxane A2 antagonists
US5066480A (en) *	1988-04-11	1991-11-19	E. R. Squibb & Sons, Inc.	Method of preventing or reducing adverse reactions to protamine using a thromboxane a2 receptor antagonist
USH1139H (en)	1988-07-21	1993-02-02	E. R. Squibb & Sons, Inc.	Combination of a calcium channel blocker and thromboxane A2 receptor antagonist or synthetase inhibitor and method for treating ischemia employing such combination
US4925873A (en) *	1988-09-01	1990-05-15	E. R. Squibb & Sons, Inc.	Method of treating skin injuries using thromboxane A2 receptor antagonists
US4839384A (en) *	1988-10-07	1989-06-13	E. R. Squibb & Sons, Inc.	Method of inhibiting onset of or treating migraine headache using a thromboxane A2 receptor antagonist
US4965279A (en) *	1988-11-18	1990-10-23	E. R. Squibb & Sons, Inc.	Cyclopropyl aza prostaglandin analogs
US5100889A (en) *	1989-04-03	1992-03-31	E. R. Squibb & Sons, Inc.	7-oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5153327A (en) *	1988-12-23	1992-10-06	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
CA2006086A1 (fr) *	1989-01-17	1990-07-17	A. K. Gunnar Aberg	Methode de prevention ou de traitment de l'atherosclerose par un inhibiteur des recepteurs de la thromboxane a
CA2007896A1 (fr) *	1989-02-06	1990-08-06	A.K. Gunnar Aberg	Methode de traitement de l'hypertension a l'aide d'un inhibiteur des recepteurs de thromboxane az et nouvelles combinaisons
CA2012852A1 (fr) *	1989-05-01	1990-11-01	Miguel A. Ondetti	Methode d'inhibition des spasmes des vaisseaux et de l'aggregation des plaquettes resultant d'une angioplastie a l'aide d'antagonistes des recepteurs de la thromboxane a
US4977174A (en) *	1989-06-12	1990-12-11	E. R. Squibb & Sons, Inc.	7-oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US4975279A (en) *	1989-10-10	1990-12-04	E. R. Squibb & Sons, Inc.	Method of improving post-ischemic myocardial function using a thromboxane A2 antagonist in combination with a thrombolytic agent and combination
US5141865A (en) *	1989-11-17	1992-08-25	E. R. Squibb & Sons, Inc.	Monoclonal antibodies which bind thromboxane A2 receptor antagonists and diagnostic methods based thereon
US4978762A (en) *	1990-02-26	1990-12-18	E. R. Squibb & Sons, Inc.	Process for preparing [1S-[1α,2α)Z),3α,4α]]-7-[3-[[[[[1-oxoheptyl]-amino]acetyl]amino]methyl]-7-oxabicyclo-[2,2,1]hept-2-yl]-5-heptenoic acid
US5081266A (en) *	1990-02-26	1992-01-14	E. R. Squibb & Sons, Inc.	Process for preparing [1S-[1α,2α(Z),3α,4α]]-7-[3-[[[[(1-oxoheptyl)-amino]acetyl]amino]methyl]-7-oxabicyclo-[2.2.1]hept-2-yl]-5-heptenoic acid
JP2984077B2 (ja) *	1990-04-19	1999-11-29	塩野義製薬株式会社	スルホニルアミノ置換ビシクロ環系ヒドロキサム酸誘導体
DE69109953T2 (de) *	1990-07-27	1995-09-21	Zeneca Ltd	Alfa-fluorocarbonsäurederivate als Zwischenprodukte zur Herstellung von Fungiziden.
US5290799A (en) *	1990-09-19	1994-03-01	E. R. Squibb & Sons, Inc.	7-oxabicycloheptyl substituted heterocyclic thioamide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5266710A (en) *	1990-12-18	1993-11-30	Patel Ramesh N	(Exo,exo)-7-oxabicyclo[2.2.1]heptane-2,3-dimethanol; monoacyl ester and diacyl ester
US5084387A (en) *	1990-12-18	1992-01-28	E. R. Squibb & Sons, Inc.	Microbiological hydrolysis for the preparation of (exo,exo)-7-oxabicyclo(2.2.1) heptane-2,3, monoacyl ester dimethanol
US5245055A (en) *	1990-12-18	1993-09-14	E. R. Squibb & Sons, Inc.	Process for preparing a cis oxabicyclo olefinic acid and ester from an oxabicyclo pyranol
US5084581A (en) *	1990-12-18	1992-01-28	E. R. Squibb & Sons, Inc.	Process for preparing (3R-(3aα,4β,7ββ,7aα))-octahydro-4,7 epoxyisobenzofuranol from associated aldehydes
CA2055572A1 (fr) *	1990-12-18	1992-06-19	David Kronenthal	Procedes et intermediaires lies aux antagonistes du recepteur de la thromboxane
US5126370A (en) *	1990-12-24	1992-06-30	E. R. Squibb & Sons, Inc.	Anti-thrombotic heterocyclic amido prostaglandin analogs
US5135939A (en) *	1991-01-28	1992-08-04	E. R. Squibb & Sons, Inc.	Heterocyclic ketone prostaglandin analogs
US5158967A (en) *	1991-06-12	1992-10-27	E. R. Squibb & Sons, Inc.	7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US7842727B2 (en)	2001-03-27	2010-11-30	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
US8026280B2 (en) *	2001-03-27	2011-09-27	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
US7312247B2 (en) *	2001-03-27	2007-12-25	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
US7314953B2 (en) *	2001-03-27	2008-01-01	Errant Gene Therapeutics, Llc	Treatment of lung cells with histone deacetylase inhibitors
WO2003009815A2 (fr)	2001-07-25	2003-02-06	Biomarin Pharmaceutical Inc.	Compositions et procedes de modulation du transport a travers la barriere hematho-encephalique
AU2003243272A1 (en) *	2002-05-22	2003-12-12	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
EP1817020A4 (fr) *	2004-11-08	2012-11-21	Errant Gene Therapeutics Inc	Inhibiteurs d'histone deacetylase
SI1889198T1 (sl)	2005-04-28	2015-02-27	Proteus Digital Health, Inc.	Farma-informacijski sistem
EP2063905B1 (fr)	2006-09-18	2014-07-30	Raptor Pharmaceutical Inc	Traitement des troubles hépatiques par l'administration de conjugués de protéine associée au récepteur (rap)
DK2398500T3 (da)	2009-02-20	2019-05-13	2 Bbb Medicines B V	Glutathion-baseret lægemiddelafgivelsessystem
SG175896A1 (en)	2009-05-06	2011-12-29	Lab Skin Care Inc	Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates
US12161632B2 (en)	2014-05-16	2024-12-10	Cumberland Pharmaceuticals Inc.	Compositions and methods of treating cardiac fibrosis with ifetroban
CN111728970A (zh)	2014-05-16	2020-10-02	坎伯兰医药品股份有限公司	用伊非曲班治疗心脏纤维化的组合物和方法
EP3316882A4 (fr)	2015-06-30	2019-02-20	Cumberland Pharmaceuticals Inc.	Antagonistes du récepteur du thromboxane dans la mrea/l'asthme
CN115624549A (zh)	2016-05-11	2023-01-20	坎伯兰医药品股份有限公司	用血栓烷-a2受体拮抗剂治疗肌营养不良的组合物和方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4143054A (en) *	1977-11-04	1979-03-06	E. R. Squibb & Sons, Inc.	7-oxabicycloheptane- and 7-oxabicycloheptene compounds
US4187236A (en) *	1977-11-04	1980-02-05	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane compounds
US4254044A (en) *	1977-11-04	1981-03-03	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
US4220594A (en) *	1977-11-04	1980-09-02	E. R. Squibb & Sons, Inc.	Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol
JPH025739B2 (fr) *	1979-01-05	1990-02-05	Nat Res Dev
US4228180A (en) *	1979-11-01	1980-10-14	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs
ZA814307B (en) *	1980-07-01	1983-02-23	Nat Res Dev	Prostaglandins
US4628061A (en) *	1981-12-23	1986-12-09	National Research Development Corporation	Prostaglandins
KR840003462A (ko)	1982-05-14	1984-09-08	데이빗 핸더슨	복합성분의 가소물질투여 및 혼합총
US4416896A (en) *	1982-05-17	1983-11-22	E. R. Squibb & Sons, Inc.	7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease
US4456615A (en)	1982-10-25	1984-06-26	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4456617A (en) *	1983-01-12	1984-06-26	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4533673A (en) *	1984-01-26	1985-08-06	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane substituted enaminone prostaglandin analogs and their use in treatment of thrombolytic disease
US4536514A (en) *	1984-04-06	1985-08-20	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombolytic disease
US4654356A (en) *	1985-08-01	1987-03-31	E. R. Squibb & Sons, Inc.	7-oxabicycloheptane substituted diacid diamide prostaglandin analogs

1986
- 1986-04-18 US US06/853,788 patent/US4663336A/en not_active Expired - Fee Related
- 1986-06-13 AU AU58715/86A patent/AU603058B2/en not_active Ceased
- 1986-06-16 NZ NZ216544A patent/NZ216544A/xx unknown
- 1986-06-17 EP EP86304675A patent/EP0207684B1/fr not_active Expired - Lifetime
- 1986-06-17 DE DE3650144T patent/DE3650144T2/de not_active Expired - Fee Related
- 1986-06-17 AT AT86304675T patent/ATE114312T1/de not_active IP Right Cessation
- 1986-06-18 PH PH33901A patent/PH22413A/en unknown
- 1986-06-24 IL IL79210A patent/IL79210A/xx not_active IP Right Cessation
- 1986-06-24 ES ES556530A patent/ES8801626A1/es not_active Expired
- 1986-06-30 IE IE174986A patent/IE65827B1/en not_active IP Right Cessation
- 1986-06-30 PT PT82875A patent/PT82875B/pt not_active IP Right Cessation
- 1986-06-30 NO NO862635A patent/NO168038C/no unknown
- 1986-06-30 DK DK310686A patent/DK162528C/da not_active IP Right Cessation
- 1986-06-30 CN CN86105664A patent/CN1009645B/zh not_active Expired
- 1986-06-30 KR KR1019860005253A patent/KR910004721B1/ko not_active Expired
- 1986-06-30 HU HU862725A patent/HU196779B/hu not_active IP Right Cessation
- 1986-07-01 JP JP61155905A patent/JPH07103125B2/ja not_active Expired - Lifetime
- 1986-07-01 GR GR861711A patent/GR861711B/el unknown
- 1986-07-01 FI FI862797A patent/FI93218C/fi not_active IP Right Cessation
- 1986-07-02 CA CA000512924A patent/CA1284643C/fr not_active Expired - Lifetime
1987
- 1987-09-23 ES ES557747A patent/ES8802017A1/es not_active Expired
- 1987-09-23 ES ES557754A patent/ES8800896A1/es not_active Expired
- 1987-09-23 ES ES557746A patent/ES8802016A1/es not_active Expired
- 1987-09-23 ES ES557752A patent/ES8802019A1/es not_active Expired
- 1987-09-23 ES ES557750A patent/ES8801899A1/es not_active Expired
- 1987-09-23 ES ES557749A patent/ES8900229A1/es not_active Expired
- 1987-09-23 ES ES557748A patent/ES8801898A1/es not_active Expired
- 1987-09-23 ES ES557751A patent/ES8802018A1/es not_active Expired
- 1987-09-23 ES ES557753A patent/ES8802020A1/es not_active Expired

Also Published As

Publication number	Publication date
ES8801899A1 (es)	1988-03-01
DE3650144D1 (de)	1995-01-05
PT82875A (en)	1986-07-01
FI862797A0 (fi)	1986-07-01
AU603058B2 (en)	1990-11-08
NO168038C (no)	1992-01-08
ES8801626A1 (es)	1988-02-16
NO862635L (no)	1987-01-02
CN86105664A (zh)	1987-02-18
ES8802017A1 (es)	1988-03-16
ES557751A0 (es)	1988-03-16
EP0207684A2 (fr)	1987-01-07
US4663336A (en)	1987-05-05
HUT45041A (en)	1988-05-30
ES557754A0 (es)	1987-12-01
HU196779B (en)	1989-01-30
CA1284643C (fr)	1991-06-04
FI862797A7 (fi)	1987-01-02
ES556530A0 (es)	1988-02-16
ES8900229A1 (es)	1989-04-01
DK162528C (da)	1992-03-30
FI93218C (fi)	1995-03-10
IE861749L (en)	1987-01-01
ES8802018A1 (es)	1988-03-16
ES8802016A1 (es)	1988-03-16
ES8800896A1 (es)	1987-12-01
ES557750A0 (es)	1988-03-01
KR910004721B1 (ko)	1991-07-10
IL79210A0 (en)	1986-09-30
ES557746A0 (es)	1988-03-16
PT82875B (pt)	1988-04-21
DK310686A (da)	1987-01-02
ES557747A0 (es)	1988-03-16
PH22413A (en)	1988-08-26
ATE114312T1 (de)	1994-12-15
IE65827B1 (en)	1995-11-15
ES557748A0 (es)	1988-03-01
KR870001229A (ko)	1987-03-12
JPS6263589A (ja)	1987-03-20
CN1009645B (zh)	1990-09-19
ES557749A0 (es)	1989-04-01
AU5871586A (en)	1987-01-08
NZ216544A (en)	1990-02-26
FI93218B (fi)	1994-11-30
JPH07103125B2 (ja)	1995-11-08
EP0207684B1 (fr)	1994-11-23
GR861711B (en)	1986-11-03
DK162528B (da)	1991-11-11
ES557752A0 (es)	1988-03-16
ES557753A0 (es)	1988-03-16
DE3650144T2 (de)	1995-04-06
NO168038B (no)	1991-09-30
ES8801898A1 (es)	1988-03-01
ES8802020A1 (es)	1988-03-16
EP0207684A3 (en)	1987-04-29
DK310686D0 (da)	1986-06-30
ES8802019A1 (es)	1988-03-16
NO862635D0 (no)	1986-06-30

Legal Events

Date	Code	Title	Description
1996-10-16	KB	Patent renewed
2001-06-14	RH	Patent void

Publication	Publication Date	Title
IL79210A (en)	1991-03-10	7-oxabicycloheptane substituted diamide derivatives and their prostaglandin analogues,process for their preparation and pharmaceutical compositions containing the same
ATE46696T1 (de)	1989-10-15	1- und 1,1-disubstituierte, 6-substituierte, 2carbamimidoyl-1-carbadethiapen-2-em-3carbons\|uren, verfahren zur herstellung und diese enthaltende antibiotische zusammensetzung.
EP0193148A3 (fr)	1988-04-20	2-(Acyl contenant un alcoxy)hydrazides de l'acide 8-chlorodibenzo[B,F][1,4]oxazazépine-10(11H)carboxylique
GR3007389T3 (fr)	1993-07-30
ES2001341A6 (es)	1988-05-16	Un procedimiento de producir un derivado de acido guanidinometilbenzoico.
DE3363550D1 (en)	1986-06-19	New nitro aliphatic compounds, process for preparation thereof and use thereof
DE3868013D1 (de)	1992-03-05	Thiazolderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
GR3023444T3 (en)	1997-08-29	Nitrogen containing bicyclic derivatives, method for their preparation and pharmaceutical compositions containing them
IL69210A0 (en)	1983-11-30	Cephalosporin derivatives,their process of preparation and pharmaceutical compositions containing them
DE3063105D1 (en)	1983-06-16	Clavulanic acid derivatives, process for their preparation and pharmaceutical compositions containing them