NO168038C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 7-oksabicykloheptan-substituerte diamider og deres kongenere prostaglandinanaloger. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive 7-oksabicykloheptan-substituerte diamider og deres kongenere prostaglandinanaloger.

Info

Publication number
NO168038C
NO168038C NO862635A NO862635A NO168038C NO 168038 C NO168038 C NO 168038C NO 862635 A NO862635 A NO 862635A NO 862635 A NO862635 A NO 862635A NO 168038 C NO168038 C NO 168038C
Authority
NO
Norway
Prior art keywords
image
prostaglandin analogs
ocsabicycloheptan
congene
diamids
Prior art date
Application number
NO862635A
Other languages
English (en)
Norwegian (no)
Other versions
NO862635D0 (no
NO168038B (no
NO862635L (no
Inventor
Joyce Ann Reid
Masami Nakane
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of NO862635D0 publication Critical patent/NO862635D0/no
Publication of NO862635L publication Critical patent/NO862635L/no
Publication of NO168038B publication Critical patent/NO168038B/no
Publication of NO168038C publication Critical patent/NO168038C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO862635A 1985-07-01 1986-06-30 Analogifremgangsmaate for fremstilling av terapeutisk aktive 7-oksabicykloheptan-substituerte diamider og deres kongenere prostaglandinanaloger. NO168038C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75094885A 1985-07-01 1985-07-01
US06/853,788 US4663336A (en) 1985-07-01 1986-04-18 7-oxabicycloheptane substituted diamide and its congener prostaglandin analogs useful in the treatment of thrombotic disease

Publications (4)

Publication Number Publication Date
NO862635D0 NO862635D0 (no) 1986-06-30
NO862635L NO862635L (no) 1987-01-02
NO168038B NO168038B (no) 1991-09-30
NO168038C true NO168038C (no) 1992-01-08

Family

ID=27115346

Family Applications (1)

Application Number Title Priority Date Filing Date
NO862635A NO168038C (no) 1985-07-01 1986-06-30 Analogifremgangsmaate for fremstilling av terapeutisk aktive 7-oksabicykloheptan-substituerte diamider og deres kongenere prostaglandinanaloger.

Country Status (20)

Country Link
US (1) US4663336A (fr)
EP (1) EP0207684B1 (fr)
JP (1) JPH07103125B2 (fr)
KR (1) KR910004721B1 (fr)
CN (1) CN1009645B (fr)
AT (1) ATE114312T1 (fr)
AU (1) AU603058B2 (fr)
CA (1) CA1284643C (fr)
DE (1) DE3650144T2 (fr)
DK (1) DK162528C (fr)
ES (10) ES8801626A1 (fr)
FI (1) FI93218C (fr)
GR (1) GR861711B (fr)
HU (1) HU196779B (fr)
IE (1) IE65827B1 (fr)
IL (1) IL79210A (fr)
NO (1) NO168038C (fr)
NZ (1) NZ216544A (fr)
PH (1) PH22413A (fr)
PT (1) PT82875B (fr)

Families Citing this family (47)

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NZ218115A (en) * 1985-11-18 1990-02-26 Shionogi & Co Bicyclic sulphonamides and pharmaceutical compositions
US4743697A (en) * 1986-06-04 1988-05-10 E. R. Squibb & Sons, Inc. Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists and novel intermediates procuced therein
US4958036A (en) * 1986-06-04 1990-09-18 E. R. Squibb & Sons, Inc. Enantiomerically selective synthesis of certain N-substituted-2-(carbamyl 7-oxabicyclo[2.2.1]heptane-3-carboxylic acids
US4749715A (en) * 1987-03-02 1988-06-07 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amino prostaglandin analogs
US4931460A (en) * 1987-09-17 1990-06-05 E. R. Squibb & Sons, Inc. Post-ischemic myocardial dysfunction using thromboxane A2 antagonists
US5066480A (en) * 1988-04-11 1991-11-19 E. R. Squibb & Sons, Inc. Method of preventing or reducing adverse reactions to protamine using a thromboxane a2 receptor antagonist
USH1139H (en) 1988-07-21 1993-02-02 E. R. Squibb & Sons, Inc. Combination of a calcium channel blocker and thromboxane A2 receptor antagonist or synthetase inhibitor and method for treating ischemia employing such combination
US4925873A (en) * 1988-09-01 1990-05-15 E. R. Squibb & Sons, Inc. Method of treating skin injuries using thromboxane A2 receptor antagonists
US4839384A (en) * 1988-10-07 1989-06-13 E. R. Squibb & Sons, Inc. Method of inhibiting onset of or treating migraine headache using a thromboxane A2 receptor antagonist
US4965279A (en) * 1988-11-18 1990-10-23 E. R. Squibb & Sons, Inc. Cyclopropyl aza prostaglandin analogs
US5100889A (en) * 1989-04-03 1992-03-31 E. R. Squibb & Sons, Inc. 7-oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5153327A (en) * 1988-12-23 1992-10-06 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
CA2006086A1 (fr) * 1989-01-17 1990-07-17 A. K. Gunnar Aberg Methode de prevention ou de traitment de l'atherosclerose par un inhibiteur des recepteurs de la thromboxane a
CA2007896A1 (fr) * 1989-02-06 1990-08-06 A.K. Gunnar Aberg Methode de traitement de l'hypertension a l'aide d'un inhibiteur des recepteurs de thromboxane az et nouvelles combinaisons
CA2012852A1 (fr) * 1989-05-01 1990-11-01 Miguel A. Ondetti Methode d'inhibition des spasmes des vaisseaux et de l'aggregation des plaquettes resultant d'une angioplastie a l'aide d'antagonistes des recepteurs de la thromboxane a
US4977174A (en) * 1989-06-12 1990-12-11 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US4975279A (en) * 1989-10-10 1990-12-04 E. R. Squibb & Sons, Inc. Method of improving post-ischemic myocardial function using a thromboxane A2 antagonist in combination with a thrombolytic agent and combination
US5141865A (en) * 1989-11-17 1992-08-25 E. R. Squibb & Sons, Inc. Monoclonal antibodies which bind thromboxane A2 receptor antagonists and diagnostic methods based thereon
US4978762A (en) * 1990-02-26 1990-12-18 E. R. Squibb & Sons, Inc. Process for preparing [1S-[1α,2α)Z),3α,4α]]-7-[3-[[[[[1-oxoheptyl]-amino]acetyl]amino]methyl]-7-oxabicyclo-[2,2,1]hept-2-yl]-5-heptenoic acid
US5081266A (en) * 1990-02-26 1992-01-14 E. R. Squibb & Sons, Inc. Process for preparing [1S-[1α,2α(Z),3α,4α]]-7-[3-[[[[(1-oxoheptyl)-amino]acetyl]amino]methyl]-7-oxabicyclo-[2.2.1]hept-2-yl]-5-heptenoic acid
JP2984077B2 (ja) * 1990-04-19 1999-11-29 塩野義製薬株式会社 スルホニルアミノ置換ビシクロ環系ヒドロキサム酸誘導体
EP0468681B1 (fr) * 1990-07-27 1995-05-24 Zeneca Limited Dérivés d'acides alpha-fluorocarboxyliques comme intermédiares pour la préparation de fongicides
US5290799A (en) * 1990-09-19 1994-03-01 E. R. Squibb & Sons, Inc. 7-oxabicycloheptyl substituted heterocyclic thioamide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5245055A (en) * 1990-12-18 1993-09-14 E. R. Squibb & Sons, Inc. Process for preparing a cis oxabicyclo olefinic acid and ester from an oxabicyclo pyranol
CA2055572A1 (fr) * 1990-12-18 1992-06-19 David Kronenthal Procedes et intermediaires lies aux antagonistes du recepteur de la thromboxane
US5266710A (en) * 1990-12-18 1993-11-30 Patel Ramesh N (Exo,exo)-7-oxabicyclo[2.2.1]heptane-2,3-dimethanol; monoacyl ester and diacyl ester
US5084387A (en) * 1990-12-18 1992-01-28 E. R. Squibb & Sons, Inc. Microbiological hydrolysis for the preparation of (exo,exo)-7-oxabicyclo(2.2.1) heptane-2,3, monoacyl ester dimethanol
US5084581A (en) * 1990-12-18 1992-01-28 E. R. Squibb & Sons, Inc. Process for preparing (3R-(3aα,4β,7ββ,7aα))-octahydro-4,7 epoxyisobenzofuranol from associated aldehydes
US5126370A (en) * 1990-12-24 1992-06-30 E. R. Squibb & Sons, Inc. Anti-thrombotic heterocyclic amido prostaglandin analogs
US5135939A (en) * 1991-01-28 1992-08-04 E. R. Squibb & Sons, Inc. Heterocyclic ketone prostaglandin analogs
US5158967A (en) * 1991-06-12 1992-10-27 E. R. Squibb & Sons, Inc. 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US8026280B2 (en) * 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7842727B2 (en) 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2003099272A1 (fr) * 2002-05-22 2003-12-04 Errant Gene Therapeutics, Llc Inhibiteurs d'histone desacetylase bases sur des composes alpha-ceto-epoxydes
JP2006508986A (ja) * 2002-11-20 2006-03-16 エルラント ゲネ セラペウチクス エルエルシー ヒストンデアセチラーゼ阻害剤による肺細胞の治療方法
EP1817020A4 (fr) * 2004-11-08 2012-11-21 Errant Gene Therapeutics Inc Inhibiteurs d'histone deacetylase
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
EP2398500B1 (fr) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Sustème d'administration de médicament à base de glutathionne
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US12161632B2 (en) 2014-05-16 2024-12-10 Cumberland Pharmaceuticals Inc. Compositions and methods of treating cardiac fibrosis with ifetroban
US9693998B2 (en) 2014-05-16 2017-07-04 Cumberland Pharmaceuticals, Inc. Compositions and methods of treating cardiac fibrosis with ifetroban
AU2016285566A1 (en) 2015-06-30 2017-12-14 Cumberland Pharmaceuticals, Inc. Thromboxane receptor antagonists in AERD/asthma
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US4254044A (en) * 1977-11-04 1981-03-03 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
US4187236A (en) * 1977-11-04 1980-02-05 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane compounds
US4143054A (en) * 1977-11-04 1979-03-06 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane- and 7-oxabicycloheptene compounds
US4220594A (en) * 1977-11-04 1980-09-02 E. R. Squibb & Sons, Inc. Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol
EP0045118B1 (fr) * 1979-01-05 1984-04-04 National Research Development Corporation Intermédiaires pour la synthèse de bicyclo (2,2,1) heptanes et bicyclo (2,2,1) hept-2Z-ènes
US4228180A (en) * 1979-11-01 1980-10-14 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs
ZA814307B (en) * 1980-07-01 1983-02-23 Nat Res Dev Prostaglandins
DE3280020D1 (en) * 1981-12-23 1989-12-21 Nat Res Dev Prostaglandins
KR840003462A (ko) 1982-05-14 1984-09-08 데이빗 핸더슨 복합성분의 가소물질투여 및 혼합총
US4416896A (en) * 1982-05-17 1983-11-22 E. R. Squibb & Sons, Inc. 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease
US4456615A (en) 1982-10-25 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4456617A (en) * 1983-01-12 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4533673A (en) * 1984-01-26 1985-08-06 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted enaminone prostaglandin analogs and their use in treatment of thrombolytic disease
US4536514A (en) * 1984-04-06 1985-08-20 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombolytic disease
US4654356A (en) * 1985-08-01 1987-03-31 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted diacid diamide prostaglandin analogs

Also Published As

Publication number Publication date
JPH07103125B2 (ja) 1995-11-08
ES8802018A1 (es) 1988-03-16
DK310686A (da) 1987-01-02
ES557747A0 (es) 1988-03-16
ES8802020A1 (es) 1988-03-16
ES557748A0 (es) 1988-03-01
ES557750A0 (es) 1988-03-01
JPS6263589A (ja) 1987-03-20
ATE114312T1 (de) 1994-12-15
CN86105664A (zh) 1987-02-18
ES557752A0 (es) 1988-03-16
AU5871586A (en) 1987-01-08
NO862635D0 (no) 1986-06-30
DK162528B (da) 1991-11-11
ES557746A0 (es) 1988-03-16
KR870001229A (ko) 1987-03-12
KR910004721B1 (ko) 1991-07-10
HUT45041A (en) 1988-05-30
FI862797A0 (fi) 1986-07-01
DK162528C (da) 1992-03-30
FI93218C (fi) 1995-03-10
NO168038B (no) 1991-09-30
IE65827B1 (en) 1995-11-15
EP0207684B1 (fr) 1994-11-23
CN1009645B (zh) 1990-09-19
PT82875B (pt) 1988-04-21
EP0207684A2 (fr) 1987-01-07
ES8801899A1 (es) 1988-03-01
PH22413A (en) 1988-08-26
IL79210A (en) 1991-03-10
ES557751A0 (es) 1988-03-16
ES8802017A1 (es) 1988-03-16
ES8802016A1 (es) 1988-03-16
IE861749L (en) 1987-01-01
ES8801626A1 (es) 1988-02-16
ES8801898A1 (es) 1988-03-01
ES556530A0 (es) 1988-02-16
ES8800896A1 (es) 1987-12-01
ES557754A0 (es) 1987-12-01
HU196779B (en) 1989-01-30
ES8802019A1 (es) 1988-03-16
AU603058B2 (en) 1990-11-08
ES557753A0 (es) 1988-03-16
PT82875A (en) 1986-07-01
CA1284643C (fr) 1991-06-04
FI93218B (fi) 1994-11-30
GR861711B (en) 1986-11-03
DK310686D0 (da) 1986-06-30
DE3650144D1 (de) 1995-01-05
ES557749A0 (es) 1989-04-01
DE3650144T2 (de) 1995-04-06
EP0207684A3 (en) 1987-04-29
ES8900229A1 (es) 1989-04-01
NZ216544A (en) 1990-02-26
FI862797A7 (fi) 1987-01-02
NO862635L (no) 1987-01-02
US4663336A (en) 1987-05-05
IL79210A0 (en) 1986-09-30

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