IL80467A - ((((3-pyridinyl)methylen)amino)oxy)alkanoic acids and esters thereof,their preparation and pharmaceutical compositions containing them - Google Patents
((((3-pyridinyl)methylen)amino)oxy)alkanoic acids and esters thereof,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL80467A IL80467A IL80467A IL8046786A IL80467A IL 80467 A IL80467 A IL 80467A IL 80467 A IL80467 A IL 80467A IL 8046786 A IL8046786 A IL 8046786A IL 80467 A IL80467 A IL 80467A
- Authority
- IL
- Israel
- Prior art keywords
- sub
- pyridinyl
- pharmaceutical compositions
- methylen
- oxy
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 title abstract 2
- -1 (3-pyridinyl)methylen Chemical class 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79499985A | 1985-11-04 | 1985-11-04 | |
| US06/888,670 US4746671A (en) | 1985-11-04 | 1986-07-23 | Pharmaceutical use of [[[(3-pyridinyl)methylen]amino]oxy]alkanoic acids and esters |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL80467A0 IL80467A0 (en) | 1987-01-30 |
| IL80467A true IL80467A (en) | 1990-11-05 |
Family
ID=27121572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL80467A IL80467A (en) | 1985-11-04 | 1986-10-31 | ((((3-pyridinyl)methylen)amino)oxy)alkanoic acids and esters thereof,their preparation and pharmaceutical compositions containing them |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4746671A (da) |
| EP (1) | EP0221601B1 (da) |
| JP (1) | JPH0670014B2 (da) |
| AT (1) | ATE86613T1 (da) |
| AU (1) | AU587873B2 (da) |
| CA (2) | CA1298580C (da) |
| CS (1) | CS382391A3 (da) |
| CY (1) | CY1864A (da) |
| DE (1) | DE3687945T2 (da) |
| DK (2) | DK164159C (da) |
| ES (1) | ES2002015A6 (da) |
| FI (1) | FI85372C (da) |
| GR (1) | GR862634B (da) |
| HK (1) | HK114595A (da) |
| IE (1) | IE59775B1 (da) |
| IL (1) | IL80467A (da) |
| LV (1) | LV5768B4 (da) |
| NO (1) | NO170974C (da) |
| NZ (1) | NZ218121A (da) |
| PT (1) | PT83667B (da) |
| SG (1) | SG119194G (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8820578D0 (en) * | 1988-08-31 | 1988-09-28 | Glaxo Group Ltd | Chemical compositions |
| JP2765876B2 (ja) * | 1988-10-24 | 1998-06-18 | 科研製薬株式会社 | ピリジルケトオキシムエーテル誘導体 |
| FR2722193B1 (fr) * | 1994-07-08 | 1996-10-04 | Sanofi Sa | Derives n-oxydes de 1-(7-chloro-4-quinoleinyl)pyrazole-3-carboxamides substitues, procede pour leur preparation et les compositions pharmaceitiques les contenant |
| AU5397496A (en) * | 1995-03-28 | 1996-10-16 | Janssen Pharmaceutica N.V. | Low dose ridogrel formulations and their use for the treatme nt of inflammatory bowel diseases |
| GB9620709D0 (en) * | 1996-10-04 | 1996-11-20 | Danbiosyst Uk | Colonic delivery of weak acid drugs |
| JP2011517313A (ja) | 2007-12-11 | 2011-06-02 | ビアメト ファーマシューティカルズ，インク． | 金属結合部分を標的化部分と組み合わせて使用する金属酵素阻害剤 |
| EA027433B1 (ru) * | 2012-10-08 | 2017-07-31 | Дафот Энтерпраизес Лимитед | Производное оксима бензоилпиридина, обладающее противосудорожной активностью |
| CN121005380B (zh) * | 2025-10-23 | 2026-01-06 | 浙江锦华新材料股份有限公司 | 一种基于高纯丁酮肟与电子级酸合成电子级羟胺盐的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4003734A (en) * | 1974-01-22 | 1977-01-18 | The Dow Chemical Company | Substituted pyridinyloxy(thio)phenyl-acetamides, -ureas and urea derivatives and herbicidal compositions and methods containing said compounds |
| DE2415063A1 (de) * | 1974-03-28 | 1975-10-16 | Bayer Ag | Pyridylalkylamidine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| CH616406A5 (en) * | 1975-06-27 | 1980-03-31 | Siegfried Ag | Process for the preparation of novel oxime derivatives |
| US4092419A (en) * | 1976-06-15 | 1978-05-30 | Merck & Co., Inc. | Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use |
| US4297359A (en) * | 1978-07-25 | 1981-10-27 | Acf Chemiefarma Nv | Anti-ulcer compositions containing certain pyridyl oxime ethers |
| NL8000869A (nl) * | 1979-02-16 | 1980-08-19 | Eisai Co Ltd | Cyanoguanidine-derivaten en werkwijze voor de bereiding daarvan. |
| US4518602A (en) * | 1982-10-07 | 1985-05-21 | Takeda Chemical Industries, Ltd. | Vinyl carboxylic acid derivatives, their production and use as inhibitors of thromboxane synthetase |
| GB8311003D0 (en) * | 1983-04-22 | 1983-05-25 | Shell Int Research | Aniline compounds |
| JPS6078966A (ja) * | 1983-10-04 | 1985-05-04 | Nippon Tokushu Noyaku Seizo Kk | トリクロルアクリロイルオキシム誘導体，その製法及び農業用殺菌剤 |
| IT1175720B (it) * | 1984-09-13 | 1987-07-15 | Baldacci Lab Spa | Composti derivati dell'acido beta-ossimino-propionico ad attivita' terapeutica,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
-
1986
- 1986-07-23 US US06/888,670 patent/US4746671A/en not_active Expired - Lifetime
- 1986-09-29 ES ES8602279A patent/ES2002015A6/es not_active Expired
- 1986-10-06 CA CA000519851A patent/CA1298580C/en not_active Expired - Fee Related
- 1986-10-22 AT AT86201836T patent/ATE86613T1/de not_active IP Right Cessation
- 1986-10-22 EP EP86201836A patent/EP0221601B1/en not_active Expired - Lifetime
- 1986-10-22 DE DE8686201836T patent/DE3687945T2/de not_active Expired - Lifetime
- 1986-10-30 GR GR862634A patent/GR862634B/el unknown
- 1986-10-30 NZ NZ218121A patent/NZ218121A/xx unknown
- 1986-10-31 IL IL80467A patent/IL80467A/xx not_active IP Right Cessation
- 1986-11-03 PT PT83667A patent/PT83667B/pt unknown
- 1986-11-03 DK DK524686A patent/DK164159C/da not_active IP Right Cessation
- 1986-11-03 AU AU64825/86A patent/AU587873B2/en not_active Expired
- 1986-11-03 NO NO864379A patent/NO170974C/no not_active IP Right Cessation
- 1986-11-03 IE IE288886A patent/IE59775B1/en not_active IP Right Cessation
- 1986-11-03 FI FI864461A patent/FI85372C/fi not_active IP Right Cessation
-
1990
- 1990-07-17 JP JP2187317A patent/JPH0670014B2/ja not_active Expired - Fee Related
-
1991
- 1991-04-30 CA CA000616060A patent/CA1319151C/en not_active Expired - Fee Related
- 1991-06-14 DK DK115491A patent/DK169517B1/da not_active IP Right Cessation
- 1991-12-16 CS CS913823A patent/CS382391A3/cs unknown
-
1994
- 1994-08-20 SG SG119194A patent/SG119194G/en unknown
-
1995
- 1995-07-13 HK HK114595A patent/HK114595A/en not_active IP Right Cessation
-
1996
- 1996-04-05 CY CY186496A patent/CY1864A/xx unknown
- 1996-06-18 LV LV960188A patent/LV5768B4/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |