IL81317A - 1,2,4,5,6,7-hexahydro-4-benzazecine-3,8-dione derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

1,2,4,5,6,7-hexahydro-4-benzazecine-3,8-dione derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number: IL81317A
Authority: IL; Israel
Prior art keywords: benzazecine; chloro; hexahydro; preparation; pharmaceutical compositions
Prior art date: 1986-01-23

Application number

IL81317A

Other languages

English (en)

Other versions

IL81317A0 (en

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-01-23

Filing date

1987-01-20

Publication date

1991-06-30

1987-01-20 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1987-08-31 Publication of IL81317A0 publication Critical patent/IL81317A0/xx

1991-06-30 Publication of IL81317A publication Critical patent/IL81317A/xx

Links

ULBJIFAUAZIJLH-UHFFFAOYSA-N 1,2,4,5,6,7-hexahydro-4-benzazecine-3,8-dione Chemical class C1CC(NCCCC(C2=C1C=CC=C2)=O)=O ULBJIFAUAZIJLH-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
-1 chloro benzoyl Chemical group 0.000 abstract 3
WZJYKHNJTSNBHV-UHFFFAOYSA-N benzo[h]quinoline Chemical compound C1=CN=C2C3=CC=CC=C3C=CC2=C1 WZJYKHNJTSNBHV-UHFFFAOYSA-N 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
LOLJNNQHTPVJJR-UHFFFAOYSA-N 1-benzazecine Chemical compound N1=CC=CC=CC=CC2=CC=CC=C21 LOLJNNQHTPVJJR-UHFFFAOYSA-N 0.000 abstract 1
NWJFECNBGMVGDV-UHFFFAOYSA-N 4-acetyl-9-chloro-2,5,6,7-tetrahydro-1h-4-benzazecine-3,8-dione Chemical compound C1CC(=O)N(C(=O)C)CCCC(=O)C2=C(Cl)C=CC=C21 NWJFECNBGMVGDV-UHFFFAOYSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D227/00—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00
- C07D227/02—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D227/06—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D227/08—Oxygen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Steroid Compounds (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

IL81317A 1986-01-23 1987-01-20 1,2,4,5,6,7-hexahydro-4-benzazecine-3,8-dione derivatives,their preparation and pharmaceutical compositions containing them IL81317A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH26686		1986-01-23

Publications (2)

Publication Number	Publication Date
IL81317A0 IL81317A0 (en)	1987-08-31
IL81317A true IL81317A (en)	1991-06-30

Family

ID=4183090

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL81317A IL81317A (en)	1986-01-23	1987-01-20	1,2,4,5,6,7-hexahydro-4-benzazecine-3,8-dione derivatives,their preparation and pharmaceutical compositions containing them

Country Status (30)

Country	Link
US (4)	US4732979A (cs)
EP (1)	EP0230967B1 (cs)
JP (1)	JPS62169770A (cs)
KR (1)	KR910000659B1 (cs)
CN (1)	CN1013111B (cs)
AT (1)	ATE68790T1 (cs)
AU (1)	AU590042B2 (cs)
CS (1)	CS258147B2 (cs)
DD (1)	DD264431A5 (cs)
DE (1)	DE3773950D1 (cs)
DK (1)	DK35887A (cs)
FI (1)	FI82931C (cs)
GB (1)	GB2185744B (cs)
HU (1)	HU197883B (cs)
IE (1)	IE870167L (cs)
IL (1)	IL81317A (cs)
IS (1)	IS3190A7 (cs)
MC (1)	MC1795A1 (cs)
MT (1)	MTP996B (cs)
MW (1)	MW187A1 (cs)
NO (1)	NO167385C (cs)
NZ (1)	NZ218987A (cs)
OA (1)	OA08469A (cs)
PH (1)	PH22879A (cs)
PL (1)	PL263796A1 (cs)
PT (1)	PT84181B (cs)
TN (1)	TNSN87006A1 (cs)
YU (1)	YU7087A (cs)
ZA (1)	ZA87407B (cs)
ZW (1)	ZW1087A1 (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL81317A (en) *	1986-01-23	1991-06-30	Hoffmann La Roche	1,2,4,5,6,7-hexahydro-4-benzazecine-3,8-dione derivatives,their preparation and pharmaceutical compositions containing them
IN167395B (cs) *	1987-07-21	1990-10-20	Hoffmann La Roche
US5239075A (en) *	1991-08-21	1993-08-24	Eli Lilly And Company	Process for the preparation of benzo (f) quinolinones
ES2169026T3 (es) *	1991-08-21	2002-07-01	Lilly Co Eli	Benzo(f)quinolinonas como inhibidores de 5-alfa-reductasa.
US5250539A (en) *	1991-08-21	1993-10-05	Eli Lilly And Company	Hexahydrobenzo[f]quinolinones
ES2125884T3 (es) *	1991-08-21	1999-03-16	Lilly Co Eli	Hexahidrobenzo(f)quinolinonas como inhibidores de la 5-alfa-reductasa.
WO1994022444A1 (en) *	1993-03-29	1994-10-13	Smithkline Beecham Corporation	Tricyclic compounds for inhibiting platelet aggregation
GB9317314D0 (en) *	1993-08-20	1993-10-06	Smithkline Beecham Corp	Compounds
DE69515321T2 (de) *	1994-09-20	2000-08-24	The Regents Of The University Of California, Oakland	Brefeldin a und analoge zur verbesserung synaptischer übertragungen
US20050067341A1 (en) *	2003-09-25	2005-03-31	Green Dennis H.	Continuous production membrane water treatment plant and method for operating same
US7094331B2 (en) *	2003-11-05	2006-08-22	Marathon Ashland Petroleum Llc	Viscosity modification of heavy hydrocarbons using dihydric alcohols
US20090263439A1 (en) *	2008-04-18	2009-10-22	The Procter & Gamble Company	Antimicrobial Preservative Free Wipe
CN106117028B (zh) *	2016-06-14	2019-01-01	浙江永太药业有限公司	一种制备卤代-3,4-二氢-1h-2-萘酮的工艺方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE442586A (cs) *	1940-07-31
JPS5129710B2 (cs) *	1972-09-09	1976-08-27
US4341786A (en) *	1981-03-02	1982-07-27	Smithkline Corporation	Pharmaceutical compositions and method of producing central alpha1 agonist activity utilizing octahydrobenzo[f]quinoline compounds
US4521423A (en) *	1983-10-31	1985-06-04	Ayerst, Mckenna & Harrison, Ltd.	7,8,9,10-Tetrahydrobenzo[h]quinolin-9-amine derivatives and compositions and methods for treating depression employing them
IL81317A (en) *	1986-01-23	1991-06-30	Hoffmann La Roche	1,2,4,5,6,7-hexahydro-4-benzazecine-3,8-dione derivatives,their preparation and pharmaceutical compositions containing them

1987
- 1987-01-20 IL IL81317A patent/IL81317A/xx unknown
- 1987-01-20 AT AT87100733T patent/ATE68790T1/de not_active IP Right Cessation
- 1987-01-20 CS CS87418A patent/CS258147B2/cs unknown
- 1987-01-20 DE DE8787100733T patent/DE3773950D1/de not_active Expired - Lifetime
- 1987-01-20 FI FI870220A patent/FI82931C/fi not_active IP Right Cessation
- 1987-01-20 PH PH34744A patent/PH22879A/en unknown
- 1987-01-20 EP EP87100733A patent/EP0230967B1/de not_active Expired - Lifetime
- 1987-01-20 ZA ZA87407A patent/ZA87407B/xx unknown
- 1987-01-20 YU YU00070/87A patent/YU7087A/xx unknown
- 1987-01-20 MW MW1/87A patent/MW187A1/xx unknown
- 1987-01-20 NZ NZ218987A patent/NZ218987A/en unknown
- 1987-01-21 ZW ZW10/87A patent/ZW1087A1/xx unknown
- 1987-01-21 DD DD87299380A patent/DD264431A5/de unknown
- 1987-01-21 US US07/005,712 patent/US4732979A/en not_active Expired - Fee Related
- 1987-01-21 HU HU87163A patent/HU197883B/hu not_active IP Right Cessation
- 1987-01-22 IE IE870167A patent/IE870167L/xx unknown
- 1987-01-22 AU AU67911/87A patent/AU590042B2/en not_active Ceased
- 1987-01-22 PT PT84181A patent/PT84181B/pt not_active IP Right Cessation
- 1987-01-22 DK DK035887A patent/DK35887A/da not_active Application Discontinuation
- 1987-01-22 IS IS3190A patent/IS3190A7/is unknown
- 1987-01-22 CN CN87100312A patent/CN1013111B/zh not_active Expired
- 1987-01-22 TN TNTNSN87006A patent/TNSN87006A1/fr unknown
- 1987-01-22 MC MC871868A patent/MC1795A1/fr unknown
- 1987-01-22 MT MT996A patent/MTP996B/xx unknown
- 1987-01-22 NO NO870280A patent/NO167385C/no unknown
- 1987-01-22 JP JP62011477A patent/JPS62169770A/ja active Pending
- 1987-01-22 GB GB8701416A patent/GB2185744B/en not_active Expired
- 1987-01-23 KR KR1019870000533A patent/KR910000659B1/ko not_active Expired
- 1987-01-23 PL PL1987263796A patent/PL263796A1/xx unknown
- 1987-01-23 OA OA59052A patent/OA08469A/xx unknown
- 1987-11-18 US US07/121,987 patent/US4749791A/en not_active Expired - Fee Related
1988
- 1988-02-11 US US07/154,760 patent/US4876340A/en not_active Expired - Fee Related
1989
- 1989-08-17 US US07/395,380 patent/US4957911A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT84181A (pt)	1987-02-01
ATE68790T1 (de)	1991-11-15
NO870280D0 (no)	1987-01-22
CS41887A2 (en)	1987-11-12
IS3190A7 (is)	1987-07-24
FI82931C (fi)	1991-05-10
DK35887D0 (da)	1987-01-22
DK35887A (da)	1987-07-24
NO167385C (no)	1991-10-30
US4732979A (en)	1988-03-22
PT84181B (pt)	1989-09-14
JPS62169770A (ja)	1987-07-25
CN87100312A (zh)	1987-09-09
MC1795A1 (fr)	1987-10-22
GB8701416D0 (en)	1987-02-25
EP0230967A2 (de)	1987-08-05
GB2185744A (en)	1987-07-29
NO870280L (no)	1987-07-24
IE870167L (en)	1987-07-23
PH22879A (en)	1989-01-19
US4749791A (en)	1988-06-07
NO167385B (no)	1991-07-22
KR910000659B1 (ko)	1991-01-31
MTP996B (en)	1987-08-21
PL263796A1 (en)	1988-10-27
YU7087A (en)	1988-06-30
EP0230967B1 (de)	1991-10-23
US4957911A (en)	1990-09-18
OA08469A (fr)	1988-07-29
MW187A1 (en)	1987-10-14
AU6791187A (en)	1987-07-30
KR870007132A (ko)	1987-08-17
ZA87407B (en)	1987-09-30
CN1013111B (zh)	1991-07-10
DE3773950D1 (de)	1991-11-28
EP0230967A3 (en)	1988-08-31
CS258147B2 (en)	1988-07-15
TNSN87006A1 (fr)	1990-01-01
HUT44519A (en)	1988-03-28
IL81317A0 (en)	1987-08-31
FI870220A0 (fi)	1987-01-20
GB2185744B (en)	1989-12-06
US4876340A (en)	1989-10-24
HU197883B (en)	1989-06-28
ZW1087A1 (en)	1987-08-12
DD264431A5 (de)	1989-02-01
FI870220A7 (fi)	1987-07-24
FI82931B (fi)	1991-01-31
AU590042B2 (en)	1989-10-26
NZ218987A (en)	1990-04-26

Publication	Publication Date	Title
AU590042B2 (en)	1989-10-26	Benzazecine Derivatives
GB2126226B (en)	1985-09-18	Pyridine derivatives
NZ216172A (en)	1989-08-29	Nucleosides and pharmaceutical compositions
MY103801A (en)	1993-09-30	Dideoxydidehydrocarbocyclic nucleosides
DE3887014D1 (de)	1994-02-24	Nukleoside, ihre Herstellung und pharmazeutische Zusammenstellungen.
NO179834C (no)	1996-12-27	Substituerte cykloheksanderivater og anvendelse av forbindelsene for fremstilling av legemidler
IL84359A0 (en)	1988-04-29	Substituted cephalosporin sulfones,their preparation and pharmaceutical compositions containing them
IL85945A0 (en)	1988-09-30	Pharmaceutical compositions containing 2'-fluoronucleosides and derivatives thereof,certain such novel compounds and their preparation
DK192988A (da)	1988-10-10	Dihydropyridinamider, deres fremstilling og anvendelse
IL87799A0 (en)	1989-03-31	Saccharide derivatives,their preparation and pharmaceutical compositions containing them
SE8304062L (sv)	1984-04-06	Nya diklorerade derivat av 16alfa-metyl-pregnanserien, framstellning derav, anvendning derav som lekemedel och kompositioner innehallande dem
NO911798D0 (no)	1991-05-08	3'-deamino-4'-deoksy-4'-amino-8-fluorantracykliner og deres fremstilling.
NZ224812A (en)	1991-06-25	Derivatives of 2',3'-dideoxycytidine and pharmaceutical compositions
IL87104A0 (en)	1988-12-30	Pest-combating compositions comprising derivatives of 2,3-diaminomaleonitrile,certain such new derivatives and their preparation
OA09021A (fr)	1991-03-31	Nouveaux dérivés de l'octahydro indeno-furane, leur préparation et compositions thérapeutiques en contenant.
IL85508A (en)	1991-11-21	2-substituted-4-(2-benzyl-aminophenyl)-1,4,5,7-tetra-hydro-5-oxofuro(3,4,-b)-pyridine-3-carboxylic acid derivatives and pharmaceutical compositions containing them