IL81609A - 2-(Picolylthio) thienoimidazole derivatives and analogs, a process for their preparation, pharmaceutical compositions containing them and their use as inhibitors of gastric acid secretion - Google Patents

2-(Picolylthio) thienoimidazole derivatives and analogs, a process for their preparation, pharmaceutical compositions containing them and their use as inhibitors of gastric acid secretion

Info

Publication number
IL81609A
IL81609A IL8160987A IL8160987A IL81609A IL 81609 A IL81609 A IL 81609A IL 8160987 A IL8160987 A IL 8160987A IL 8160987 A IL8160987 A IL 8160987A IL 81609 A IL81609 A IL 81609A
Authority
IL
Israel
Prior art keywords
ome
compound
formula
oet
och2cf3
Prior art date
Application number
IL8160987A
Other languages
English (en)
Other versions
IL81609A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19863605395 external-priority patent/DE3605395A1/de
Priority claimed from DE19863623683 external-priority patent/DE3623683A1/de
Priority claimed from DE19873700436 external-priority patent/DE3700436A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL81609A0 publication Critical patent/IL81609A0/xx
Publication of IL81609A publication Critical patent/IL81609A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL8160987A 1986-02-20 1987-02-18 2-(Picolylthio) thienoimidazole derivatives and analogs, a process for their preparation, pharmaceutical compositions containing them and their use as inhibitors of gastric acid secretion IL81609A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19863605395 DE3605395A1 (de) 1986-02-20 1986-02-20 Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
DE19863623683 DE3623683A1 (de) 1986-07-12 1986-07-12 Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
DE19873700436 DE3700436A1 (de) 1987-01-09 1987-01-09 Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer

Publications (2)

Publication Number Publication Date
IL81609A0 IL81609A0 (en) 1987-09-16
IL81609A true IL81609A (en) 1994-10-21

Family

ID=27194035

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8160987A IL81609A (en) 1986-02-20 1987-02-18 2-(Picolylthio) thienoimidazole derivatives and analogs, a process for their preparation, pharmaceutical compositions containing them and their use as inhibitors of gastric acid secretion

Country Status (22)

Country Link
US (1) US4845118A (fr)
EP (1) EP0234485B1 (fr)
JP (1) JPH0633275B2 (fr)
KR (2) KR950001025B1 (fr)
CN (1) CN1021911C (fr)
AR (1) AR246739A1 (fr)
AU (1) AU590390B2 (fr)
CA (1) CA1337197C (fr)
DE (1) DE3777855D1 (fr)
DK (1) DK85087A (fr)
EG (1) EG18128A (fr)
ES (1) ES2032394T3 (fr)
FI (1) FI870672A7 (fr)
GR (1) GR3004765T3 (fr)
HU (1) HU197330B (fr)
IE (1) IE60572B1 (fr)
IL (1) IL81609A (fr)
MA (1) MA20880A1 (fr)
NO (1) NO170155C (fr)
NZ (1) NZ219320A (fr)
PT (1) PT84319B (fr)
TN (1) TNSN87024A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI861772L (fi) * 1985-05-07 1986-11-08 Chemie Linz Ag Nya tieno(2,3-d)imidazolderivat och foerfarande for deras framstaellning.
CA1256109A (fr) * 1986-09-10 1989-06-20 Franz Rovenszky Methode de preparation de derives de 4,5-dihydro- oxazoles
US4912101A (en) * 1987-03-13 1990-03-27 Fujirebio Kabushiki Kaisha 4-aminomethyl-pyridyl-2-oxy derivatives having anti-ulcer activity
DE3723327A1 (de) * 1987-07-15 1989-02-02 Hoechst Ag Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer, magenschutzmittel sowie als medikament gegen intestinale entzuendungen
AU622866B2 (en) * 1987-07-21 1992-04-30 Hoechst Aktiengesellschaft Substituted thienoimidazole derivatives, processes for their preparation, pharmaceutical formulations containing them and their use as gastric acid secretion inhibitors
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
DE3827276A1 (de) * 1987-08-15 1989-03-23 Hoechst Ag Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
EP0321385B1 (fr) * 1987-11-13 1994-08-17 Hoechst Aktiengesellschaft Dérivés substitués du thiénoimidazol, procédés pour leur préparation, compositions pharmaceutiques les contenant et leur application comme inhibiteurs de la sécrétion du suc gastrique
FI885878A7 (fi) * 1987-12-22 1989-06-23 Hoechst Ag Substituoituja tienoimidatsolijohdannaisia, menetelmä niiden valmistamiseksi, niitä sisältäviä farmaseuttisia koostumuksia sekä näiden käyttö mahahapon erityksen inhibiittoreina
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
YU86001A (sh) 1999-06-07 2004-07-15 Altana Pharma Ag. Novi preparat i oblik, u kojem se daje lek, koji sadrži aktivno jedinjenje labilno prema kiselini
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
JP4634144B2 (ja) * 2002-08-01 2011-02-16 ニコックス エスエー ニトロソ化プロトンポンプ阻害剤、組成物および使用方法
EP2112920B1 (fr) 2003-06-26 2018-07-25 Intellipharmaceutics Corp. Capsules contenant un inhibiteur de la pompe a protons comprenant des unites secondaires differemment structurees permettant une liberation retardee de l'ingredient actif
ATE531361T1 (de) * 2004-05-07 2011-11-15 Nycomed Gmbh Neue pharmazeutische dosierform und herstellungsverfahren
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
WO2007112581A1 (fr) 2006-04-03 2007-10-11 Isa Odidi Dispositif d'administration à libération commandée comprenant un enrobage organosol
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
WO2008057802A2 (fr) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprenant des agents d'inhibition de la pompe à protons labiles d'acide, au moins un autre agent pharmaceutiquement actif et leurs procédés d'utilisation
US20080194307A1 (en) * 2007-02-13 2008-08-14 Jeff Sanger Sports-based game of chance
CA2716367C (fr) 2008-02-20 2015-05-26 The Curators Of The University Of Missouri Composition comprenant une combinaison d'omeprazole et de lansoprazole, et un agent tampon, et ses methodes d'utilisation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3132167A1 (de) 1981-08-14 1983-03-03 Hoechst Ag, 6000 Frankfurt "5(6)-phenylsulfonyloxy-benzimidazolderivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung gegen leberegel"
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4472409A (en) 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
GB8417171D0 (en) * 1984-07-05 1984-08-08 Beecham Group Plc Compounds
AU568441B2 (en) 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
FI861772L (fi) * 1985-05-07 1986-11-08 Chemie Linz Ag Nya tieno(2,3-d)imidazolderivat och foerfarande for deras framstaellning.
WO1987005296A1 (fr) * 1986-03-07 1987-09-11 Pfizer Inc. 2-[(2-pyridyl)methylsulfinyl]thienoimidazoles et composes apparentes utilises en tant qu'agents de traitement ou de prevention des ulceres

Also Published As

Publication number Publication date
EG18128A (en) 1992-08-30
AU6906687A (en) 1987-08-27
FI870672A0 (fi) 1987-02-18
MA20880A1 (fr) 1987-10-01
TNSN87024A1 (fr) 1990-01-01
EP0234485B1 (fr) 1992-04-01
HUT44255A (en) 1988-02-29
CA1337197C (fr) 1995-10-03
AR246739A1 (es) 1994-09-30
CN1021911C (zh) 1993-08-25
NO870666L (no) 1987-08-21
ES2032394T3 (es) 1993-02-16
US4845118A (en) 1989-07-04
KR950001025B1 (ko) 1995-02-07
KR890009937A (ko) 1989-08-05
DK85087D0 (da) 1987-02-19
NO170155C (no) 1992-09-16
DK85087A (da) 1987-08-21
PT84319B (pt) 1989-09-14
NZ219320A (en) 1990-06-26
AU590390B2 (en) 1989-11-02
NO870666D0 (no) 1987-02-19
PT84319A (de) 1987-03-01
JPS62198683A (ja) 1987-09-02
IL81609A0 (en) 1987-09-16
IE60572B1 (en) 1994-07-27
KR870007934A (ko) 1987-09-23
EP0234485A1 (fr) 1987-09-02
FI870672A7 (fi) 1987-08-21
GR3004765T3 (fr) 1993-04-28
IE870421L (en) 1987-08-20
NO170155B (no) 1992-06-09
HU197330B (en) 1989-03-28
DE3777855D1 (de) 1992-05-07
CN87100719A (zh) 1987-09-09
JPH0633275B2 (ja) 1994-05-02

Similar Documents

Publication Publication Date Title
IL81609A (en) 2-(Picolylthio) thienoimidazole derivatives and analogs, a process for their preparation, pharmaceutical compositions containing them and their use as inhibitors of gastric acid secretion
US4256748A (en) Imidazo[2,1-b]quinazolin-2(3H)-ones and pharmaceutical compositions for treatment and prophylaxis of cardiac insufficiency and cardiac failure
KR920004936B1 (ko) 벤즈이미다졸 유도체의 제조방법.
RU2129549C1 (ru) Производные пиримидина и способы их получения
AU593278B2 (en) Pharmaceutically active 2-thiomethyl-substituted-1,4- dihydropyridines
HU191301B (en) Process for preparing 1-/hydroxy-methyl/-1,6,7,11b-tetrahydro-2h,4h-/1,3/-oxazino- or -thiazino/4,3-a/isoquinoline -derivatives
US4766133A (en) (Bezimidazol-2-yl)-pyridinium compounds
IE71688B1 (en) Tricyclic quinoline antineoplastic agents
CA1262731A (fr) Procede de preparation de derives de thieno (2,3-d)-imidazole et sels d'addition acide desdits derives acceptables en pharmacologie
NZ225346A (en) Benzimidazole derivatives and pharmaceutical compositions
SU1362402A3 (ru) Способ получени производных имидазола или их солей с кислотами
KR940005020B1 (ko) 톨루이딘 유도체의 제조방법
AU618540B2 (en) Substituted thienoimidazole derivatives, a process for the preparation thereof, pharmaceutical compositions containing them, and the use thereof as inhibitors of gastric acid secretion, as gastroprotectives and as medicaments for intestinal inflammations
EP0329126B1 (fr) Composés hétérocycliques et agents antiulcéreux
EP0354788A1 (fr) Dérivés d'imidazole
FI80458B (fi) Foerfarande foer framstaellning av . terapeutiskt anvaendbara tiazolo/3,2-a/bensimidazoler och 2,3-dihydroanaloger daerav.
FI89602B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara substituerade tienoimidazolderivat
EP0412529A1 (fr) Dérivés d'imidazole, procédé de leur préparation et agents anti-ulcère les contenant
FI60712B (fi) Foerfarande foer framstaellning av 6-(m-(6-halogennikotinoylamino)fenyl)- eller 6-(m-(6-halogenisonikotinoylamino)fenyl)-2,3,5,6-tetrahydroimidazo-(2,1-b)tiazol anvaendbar som maskmedel
US4721718A (en) 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers
KR0156327B1 (ko) 벤즈 또는 피리도이미다졸 유도체
PH26407A (en) Substituted pyridylmethyl mercapto sulfinyl-or-sulfonyl thienoimidazole derivatives pharmaceutical compositions containing them and their use as inhibitors of gastric acid secretion
FI78290C (fi) 3-(pyridyloxi)pyrrolidin- och 3-(pyridyloxi)-azedinderivat, som aer anvaendbara som mellanprodukter.
SU920056A1 (ru) Способ получени R,S-2,3,5,6-тетрагидро-6-фенилимидазо /2.1-в/-тиазола
US4427589A (en) Pyrimido[4,5-d][2]benzazepines

Legal Events

Date Code Title Description
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees