IL81924A - Quinazolinone derivatives,their preparation and antitumor pharmaceutical compositions containing them - Google Patents

Quinazolinone derivatives,their preparation and antitumor pharmaceutical compositions containing them

Info

Publication number
IL81924A
IL81924A IL81924A IL8192487A IL81924A IL 81924 A IL81924 A IL 81924A IL 81924 A IL81924 A IL 81924A IL 8192487 A IL8192487 A IL 8192487A IL 81924 A IL81924 A IL 81924A
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
quinazolinone derivatives
antitumor pharmaceutical
Prior art date
Application number
IL81924A
Other languages
English (en)
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Plc filed Critical Ici Plc
Publication of IL81924A publication Critical patent/IL81924A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL81924A 1986-03-27 1987-03-18 Quinazolinone derivatives,their preparation and antitumor pharmaceutical compositions containing them IL81924A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868607683A GB8607683D0 (en) 1986-03-27 1986-03-27 Anti-tumor agents

Publications (1)

Publication Number Publication Date
IL81924A true IL81924A (en) 1991-07-18

Family

ID=10595358

Family Applications (1)

Application Number Title Priority Date Filing Date
IL81924A IL81924A (en) 1986-03-27 1987-03-18 Quinazolinone derivatives,their preparation and antitumor pharmaceutical compositions containing them

Country Status (22)

Country Link
US (2) US4992550A (fr)
EP (1) EP0239362B1 (fr)
JP (1) JPH0657699B2 (fr)
AR (1) AR244213A1 (fr)
AT (1) ATE70057T1 (fr)
AU (1) AU592628B2 (fr)
CA (1) CA1285943C (fr)
DE (1) DE3774909D1 (fr)
DK (1) DK166621B1 (fr)
ES (1) ES2038170T3 (fr)
FI (1) FI89912C (fr)
GB (2) GB8607683D0 (fr)
GR (1) GR3003282T3 (fr)
HK (1) HK8594A (fr)
HU (1) HU197317B (fr)
IE (1) IE60302B1 (fr)
IL (1) IL81924A (fr)
LU (1) LU88797I2 (fr)
NL (1) NL970024I2 (fr)
NO (2) NO173545C (fr)
PT (1) PT84571B (fr)
ZA (1) ZA871998B (fr)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8513754D0 (en) * 1985-05-31 1985-07-03 Jones T R Anti-cancer quinazoline derivatives
GB8625019D0 (en) * 1986-10-18 1986-11-19 Wellcome Found Compounds
GB8707053D0 (en) * 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
US4857530A (en) * 1987-11-03 1989-08-15 Warner-Lambert Company Substituted quinazolinones as anticancer agents
GB8727737D0 (en) * 1987-11-26 1987-12-31 Ici Plc Antitumour agents
US5019577A (en) * 1988-04-15 1991-05-28 Burroughs Welcome Co. Novel compounds and use
US4940713A (en) * 1988-04-15 1990-07-10 Burroughs Wellcome Co. Substituted glutamic acids
GB8809978D0 (en) * 1988-04-27 1988-06-02 Ici Plc Anti-tumour agents
EP0365763A1 (fr) * 1988-09-30 1990-05-02 Agouron Pharmaceuticals, Inc. Composés cycliques antiproléfératifs
US5252573A (en) * 1988-12-15 1993-10-12 Imperial Chemical Industries Plc Anti-tumor agents
GB8829296D0 (en) * 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
US5286726A (en) * 1990-04-12 1994-02-15 The Regents Of The University Of Michigan Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
IL98167A0 (en) * 1990-05-30 1992-06-21 Ici Plc Anti-tumour quinazoline derivatives,processes for their preparation and pharmaceutical compositions comprising them
GB9013615D0 (en) 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
US5290780A (en) * 1991-01-30 1994-03-01 American Cyanamid Co. Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
GB9105771D0 (en) * 1991-03-19 1991-05-01 Cancer Res Inst Royal Anti-cancer compounds
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
ATE147386T1 (de) * 1991-08-12 1997-01-15 Takeda Chemical Industries Ltd Kondensierte pyrimidinderivate, ihre herstellung und ihre verwendung als antitumormittel
US5145854A (en) * 1991-11-27 1992-09-08 Nair Madhavan G 1-formyl-5,8,10-trideazafolates
GB9205320D0 (en) * 1992-03-11 1992-04-22 Ici Plc Anti-tumour compounds
GB9205907D0 (en) * 1992-03-18 1992-04-29 Cancer Res Inst Royal Anti-cancer compounds
ES2049659B1 (es) * 1992-10-08 1994-10-16 Ici Plc Una composicion farmaceutica a base de derivados de quinazolina con actividad anti-cancerigena.
GB9223352D0 (en) * 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
GB9323290D0 (en) 1992-12-10 1994-01-05 Zeneca Ltd Quinazoline derivatives
US7910624B1 (en) 1995-03-03 2011-03-22 The Trustees Of Boston University Compositions for the treatment of blood disorders
WO1995011699A1 (fr) * 1993-10-29 1995-05-04 The Trustees Of Boston University Compositions physiologiquement stables d'acide butyrique, de sels et de derives d'acide butyrique, utilisees comme agents antineoplasiques
US6011000A (en) * 1995-03-03 2000-01-04 Perrine; Susan P. Compositions for the treatment of blood disorders
DE69616993T2 (de) * 1995-03-14 2002-07-04 Novartis Ag, Basel Trisubstituierte phenyl derivate
GB9508565D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
US5593999A (en) * 1995-06-07 1997-01-14 Nair; Madhavan G. Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT)
EP1024134A4 (fr) * 1997-10-09 2003-05-14 Ono Pharmaceutical Co Derives d'acide aminobutanoique
US5912251A (en) * 1998-01-17 1999-06-15 Nair; Madhavan G. Metabolically inert anti-inflammatory and anti-tumor antifolates
AU774861B2 (en) * 1998-02-11 2004-07-08 Douglas V Faller Compositions and methods for the treatment of cystic fibrosis
GB9904275D0 (en) 1999-02-24 1999-04-21 Cancer Res Campaign Tech Anti-cancer compounds
US7671200B2 (en) * 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US6143776A (en) * 2000-02-02 2000-11-07 Sunesis Pharmaceuticals, Inc. Tosylproline analogs as thymidylate synthase inhibitors
AU2002345792A1 (en) 2001-06-21 2003-01-08 Pfizer Inc. Thienopyridine and thienopyrimidine anticancer agents
EP1420809B1 (fr) 2001-08-31 2011-09-28 BTG International Limited Utilisation de derives de cyclopenta[g]quinazoline pour le traitement du cancer
KR100983962B1 (ko) 2001-08-31 2010-09-27 비티지 인터내셔널 리미티드 항암제로서 사용되는 시클로펜타[ｇ]퀴나졸린 화합물
AU2002346471A1 (en) * 2001-11-20 2003-06-10 Cytokinetics, Inc. Process for the racemization of chiral quinazolinones
WO2003070701A2 (fr) * 2002-02-15 2003-08-28 Cytokinetics, Inc. Syntheses de quinazolinones
SG2013013339A (en) 2002-03-13 2014-12-30 Array Biopharma Inc N3 alkylated benzimidazole derivatives as mek inhibitors
US7214800B2 (en) * 2002-05-09 2007-05-08 Cytokinetics, Inc. Compounds, compositions, and methods
CA2485148A1 (fr) * 2002-05-09 2003-11-20 Cytokinetics, Inc. Composes, compositions et procedes
EP1513820A4 (fr) * 2002-05-23 2006-09-13 Cytokinetics Inc Composes, compositions et procedes
WO2003106426A1 (fr) * 2002-06-14 2003-12-24 Cytokinetics, Inc. Composes, compositions et procedes
AU2003256805A1 (en) * 2002-07-23 2004-02-09 Cytokinetics, Inc. Compounds compositions and methods
US20040048853A1 (en) * 2002-08-21 2004-03-11 Gustave Bergnes Compounds, compositions, and methods
PA8580301A1 (es) 2002-08-28 2005-05-24 Pfizer Prod Inc Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos
WO2004034972A2 (fr) * 2002-09-30 2004-04-29 Cytokinetics, Inc. Composes, compositions, et procedes
OA13309A (en) 2002-12-20 2007-04-13 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth.
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
JP2007510652A (ja) * 2003-11-03 2007-04-26 サイトキネティクス・インコーポレーテッド ピリミジン−４−オン化合物、組成物、および方法
EP1680420A4 (fr) * 2003-11-07 2008-09-24 Cytokinetics Inc Composes, compositions et methodes
CA2546353A1 (fr) 2003-11-19 2005-06-09 Array Biopharma Inc. Inhibiteurs bicycliques de mek, et leurs procedes d'utilisation
EP1692112A4 (fr) * 2003-12-08 2008-09-24 Cytokinetics Inc Composes, compositions, et methodes associees
MXPA06013805A (es) 2004-05-27 2007-02-02 Pfizer Prod Inc Derivados de pirrolopirimidina de utilidad en el tratamiento contra el cancer.
EP1791544A4 (fr) 2004-09-08 2007-09-12 Chelsea Therapeutics Inc Derives de la quinazoline comme antifoliques metaboliquement inertes
US7429667B2 (en) 2005-01-20 2008-09-30 Ardea Biosciences, Inc. Phenylamino isothiazole carboxamidines as MEK inhibitors
CA2763671A1 (fr) 2005-04-26 2006-11-02 Pfizer Inc. Anticorps de la p-cadherine
SG177981A1 (en) 2005-05-18 2012-02-28 Array Biopharma Inc 4-(phenylamino)-6-oxo-1, 6-dihydropyridazine-3-carboxamide derivatives as mek inhibitors for the treatment of hyperproliferative diseases
US8101799B2 (en) 2005-07-21 2012-01-24 Ardea Biosciences Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
CA2621371C (fr) 2005-09-07 2018-05-15 Amgen Fremont Inc. Anticorps monoclonaux humains de kinase-1 du type de recepteur d'activine
US7842836B2 (en) 2006-04-11 2010-11-30 Ardea Biosciences N-aryl-N'alkyl sulfamides as MEK inhibitors
MX2008013097A (es) 2006-04-18 2008-10-27 Ardea Biosciences Inc Piridona sulfonamidas y piridona sulfamidas como inhibidores de metiletilcetona.
EA200802058A1 (ru) 2006-05-09 2009-06-30 Пфайзер Продактс Инк. Производные циклоалкиламинокислот и их фармацевтические композиции
BRPI0806632A2 (pt) 2007-01-19 2011-09-06 Chelsea Therapeutics Inc composto, composição farmacêutica, método para o tratamento de uma condição selecionada a partir do grupo constituìdo de proliferação celular anormal, inflamação, asma e artrite
WO2010105112A1 (fr) * 2009-03-11 2010-09-16 Hemaquest Pharmaceuticals, Inc. Détection d'acides gras à chaîne courte dans des échantillons biologiques
CN106478496A (zh) 2009-03-27 2017-03-08 阿迪生物科学公司 作为mek抑制剂的二氢吡啶磺酰胺和二氢吡啶硫酰胺
LT2445502T (lt) 2009-06-25 2017-09-25 Alkermes Pharma Ireland Limited Heterocikliniai junginiai, skirti neurologinių ir fiziologinių susirgimų gydymui
CA2772194A1 (fr) 2009-09-01 2011-03-10 Pfizer Inc. Derives de benzimidazole
US20110086869A1 (en) 2009-09-24 2011-04-14 The Trustees Of Boston University Methods for treating viral disorders
AU2010315152A1 (en) 2009-11-06 2012-06-14 Chelsea Therapeutics, Inc. Enzyme inhibiting compounds
WO2011068403A2 (fr) 2009-12-02 2011-06-09 Ultimorphix Technologies B.V. Nouveaux sels de n-(3-éthynylphénylamino)-6,7-bis(2-méthoxyéthoxy)-4-quinazolinamine
WO2011072086A1 (fr) 2009-12-08 2011-06-16 Hemaquest Pharmaceuticals, Inc. Procédés et régimes à faible dose pour traiter des troubles des globules rouges
WO2011084846A1 (fr) * 2010-01-07 2011-07-14 Alkermes, Inc. Promédicaments contenant des sels d'ammonium quaternaire
EP2534153B2 (fr) 2010-02-12 2024-05-22 Pfizer Inc. Sels et polymorphes de la 8-fluoro-2-{4-[(méthylamino}méthyl]phényl}-1,3,4,5-tétrahydro-6h-azépino[5,4,3-cd]indol-6-one
US20110245154A1 (en) 2010-03-11 2011-10-06 Hemaquest Pharmaceuticals, Inc. Methods and Compositions for Treating Viral or Virally-Induced Conditions
AU2011270701B2 (en) 2010-06-24 2015-05-14 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
CN103228141B (zh) 2010-09-03 2016-04-20 拜耳知识产权有限责任公司 取代的稠合的嘧啶酮和二氢嘧啶酮
JP5802756B2 (ja) 2010-10-20 2015-11-04 ファイザー・インク スムーズンド受容体モジュレーターとしてのピリジン−２−誘導体
WO2012078708A1 (fr) 2010-12-07 2012-06-14 Chelsea Therapeutics, Inc. Combinaison comprenant du méthotrexate et un composé d'antifolate
GB201103578D0 (en) 2011-03-02 2011-04-13 Sabrepharm Ltd Dipyridinium derivatives
BR112013023847B1 (pt) 2011-03-18 2021-02-23 Alkermes Pharma Ireland Limited composições farmacêuticas compreendendo ésteres de sorbitano e uso das mesmas
KR20140059246A (ko) 2011-09-22 2014-05-15 화이자 인코포레이티드 피롤로피리미딘 및 퓨린 유도체
CN102424679B (zh) * 2011-11-15 2014-07-30 扬子江药业集团有限公司 一种雷替曲塞的制备方法
AU2013235523B9 (en) 2012-03-19 2018-01-04 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising glycerol esters
AU2013235526B2 (en) 2012-03-19 2017-11-30 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising benzyl alcohol
CA2867121C (fr) 2012-03-19 2021-05-25 Alkermes Pharma Ireland Limited Compositions pharmaceutiques comprenant des esters d'acides gras
JP6654042B2 (ja) 2012-09-19 2020-02-26 アルカームス ファーマ アイルランド リミテッド 貯蔵安定性が改善された医薬組成物
ES2775579T3 (es) 2013-10-04 2020-07-27 Aptose Biosciences Inc Composiciones para el tratamiento del cáncer
UA115388C2 (uk) 2013-11-21 2017-10-25 Пфайзер Інк. 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань
CN106132415A (zh) 2014-03-20 2016-11-16 奥克梅斯制药爱尔兰有限公司 具有增加的注射速度的阿立哌唑制剂
WO2015155624A1 (fr) 2014-04-10 2015-10-15 Pfizer Inc. Dérivés de dihydropyrrolopyrimidine
EP3556757A1 (fr) 2014-04-30 2019-10-23 Pfizer Inc Dérivés de dihétérocycle liés à cycloalkyle
WO2016001789A1 (fr) 2014-06-30 2016-01-07 Pfizer Inc. Dérivés de pyrimidine en tant qu'inhibiteurs de pi3k destinés à être utilisés dans le traitement du cancer
ES2718175T3 (es) 2014-12-02 2019-06-28 Lilly Co Eli Compuestos de 1-oxo-1,2-dihidroisoquinolin-7-il-(tiofen-2-il-5-sustituido)-sulfonamida, formulaciones que contienen esos compuestos, y su uso como inhibidores de AICARFT en el tratamiento de cánceres
ES2746839T3 (es) 2014-12-18 2020-03-09 Pfizer Derivados de pirimidina y triazina y su uso como inhibidores de AXL
CN104447724B (zh) * 2014-12-31 2017-11-10 四川峨嵋山药业有限公司 一种雷替曲塞的精制方法
JP2018519327A (ja) 2015-06-29 2018-07-19 ベラステム・インコーポレーテッドＶｅｒａｓｔｅｍ，Ｉｎｃ． 治療用組成物、組合せ物および使用の方法
WO2017009751A1 (fr) 2015-07-15 2017-01-19 Pfizer Inc. Dérivés de pyrimidine
GB2543550A (en) 2015-10-21 2017-04-26 Hox Therapeutics Ltd Peptides
HUE052893T2 (hu) 2016-01-13 2021-05-28 Acerta Pharma Bv Antifolát és BTK-gátló terápiás kombinációi
GB2567093A (en) 2016-07-15 2019-04-03 Viracta Therapeutics Inc Histone deacetylase inhibitors for use in immunotherapy
CN106957312B (zh) * 2016-12-29 2019-11-01 南京正大天晴制药有限公司 雷替曲塞水合物晶型及其制备方法
CN106957311B (zh) * 2016-12-29 2020-03-31 南京正大天晴制药有限公司 雷替曲塞的溶剂化物及其制备方法
EP3761983A1 (fr) 2018-03-05 2021-01-13 Alkermes Pharma Ireland Limited Stratégie de dosage d'aripiprazole
CN109734698B (zh) * 2019-01-25 2020-07-17 宏冠生物药业有限公司 一种雷替曲塞关键中间体的合成工艺
CA3142142A1 (fr) 2019-05-31 2020-12-03 Viracta Subsidiary, Inc. Methodes de traitement de cancers associes a un virus avec des inhibiteurs d'histone desacetylase
KR102823056B1 (ko) 2019-06-18 2025-06-23 화이자 인코포레이티드 벤즈이속사졸 설폰아마이드 유도체
US12545669B2 (en) 2019-06-19 2026-02-10 Pfizer Inc. Cycloalkyl and heterocycloalkyl benzisoxazole sulfonamide derivatives
CN117327060A (zh) * 2023-09-27 2024-01-02 无锡紫杉药业股份有限公司 一种雷替曲塞中间态杂质的制备方法
CN119060033A (zh) * 2024-08-27 2024-12-03 无锡紫杉药业股份有限公司 一种雷替曲塞降解杂质及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1021196A (en) * 1964-02-20 1966-03-02 Parke Davis & Co Novel amino acids and means for producing the same
DE3069468D1 (en) * 1979-12-19 1984-11-22 Nat Res Dev Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
GB8513754D0 (en) * 1985-05-31 1985-07-03 Jones T R Anti-cancer quinazoline derivatives

Also Published As

Publication number Publication date
NO1998020I1 (no) 1998-09-28
DK166621B1 (da) 1993-06-21
JPH01125373A (ja) 1989-05-17
NL970024I2 (nl) 1997-10-01
LU88797I2 (fr) 1996-11-05
FI871139A0 (fi) 1987-03-16
AU592628B2 (en) 1990-01-18
EP0239362B1 (fr) 1991-12-04
ZA871998B (en) 1987-11-25
DK155087A (da) 1987-09-28
ATE70057T1 (de) 1991-12-15
CA1285943C (fr) 1991-07-09
NO871266L (no) 1987-09-28
ES2038170T3 (es) 1993-07-16
NL970024I1 (nl) 1997-09-01
DK155087D0 (da) 1987-03-26
PT84571B (pt) 1989-11-30
FI871139A7 (fi) 1987-09-28
HK8594A (en) 1994-02-04
FI89912B (fi) 1993-08-31
NO173545C (no) 1993-12-29
PT84571A (en) 1987-04-01
NO173545B (no) 1993-09-20
EP0239362A2 (fr) 1987-09-30
HUT43835A (en) 1987-12-28
HU197317B (en) 1989-03-28
IE870699L (en) 1987-09-27
GR3003282T3 (en) 1993-02-17
GB2188319B (en) 1989-12-13
EP0239362A3 (en) 1989-07-05
US4992550A (en) 1991-02-12
DE3774909D1 (de) 1992-01-16
IE60302B1 (en) 1994-06-29
GB8607683D0 (en) 1986-04-30
US5081124A (en) 1992-01-14
GB8706948D0 (en) 1987-04-29
NO871266D0 (no) 1987-03-26
JPH0657699B2 (ja) 1994-08-03
AR244213A1 (es) 1993-10-29
GB2188319A (en) 1987-09-30
AU7047287A (en) 1987-10-01
FI89912C (fi) 1993-12-10

Similar Documents

Publication Publication Date Title
IL81924A (en) Quinazolinone derivatives,their preparation and antitumor pharmaceutical compositions containing them
IL82246A0 (en) Quinoline derivatives,their preparation and pharmaceutical compositions containing them
NZ222411A (en) Isoflavan derivatives, their preparation, and pharmaceutical compositions
IL89205A (en) Chloroaniline derivatives, their preparation and pharmaceutical compositions containing them
IL78605A0 (en) Xanthine derivatives,their preparation and pharmaceutical compositions containing them
IL92558A0 (en) Pharmaceutical compositions comprising pyrimidine derivatives,certain novel such derivatives and their preparation
IL80296A (en) Phenylpyridone derivatives,their preparation and pharmaceutical compositions containing them
IL75147A0 (en) Pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
GR3002636T3 (en) Pyrimidine derivatives, their preparation and medicaments containing these derivatives
IL80032A (en) Anti-tumor phenyl-aminocarbonylsulfonamides,their preparation and pharmaceutical compositions containing them
IL83093A (en) Nitrofuran derivatives,their preparation and pharmaceutical compositions containing them
IL83432A (en) N-phenylcarboxamide derivatives,their preparation and pharmaceutical compositions containing them
IL81707A0 (en) Heteroaromatic derivatives,their preparation and pharmaceutical compositions containing them
IL84765A0 (en) Pyridazodiazepine derivatives,their manufacture and pharmaceutical compositions containing them
IL84098A0 (en) Tetrahydroquinoline derivatives,their preparation and pharmaceutical compositions containing them
IL79402A (en) Poly-4-aminopyrrole-2-carboxamido derivatives,their preparation and pharmaceutical compositions containing them
IL84554A0 (en) Imidazole derivatives,their preparation and pharmaceutical compositions containing them
IL84128A (en) 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them
IL83049A0 (en) 4-pyridone derivatives,their manufacture and pharmaceutical compositions containing them
IL84636A0 (en) Lactam derivatives,their preparation and pharmaceutical compositions containing them
IL83753A (en) Sulphonamidoethyl derivatives,their preparation and pharmaceutical compositions containing them
IL83452A0 (en) Pyrimidine derivatives,their manufacture and pharmaceutical compositions containing them
IL84728A0 (en) Triazine derivatives,their manufacture and pharmaceutical compositions containing them
IL92634A0 (en) Adenosine derivatives,their preparation and pharmaceutical compositions containing them
IL85738A0 (en) Nucleoside derivatives,their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
PEL Intention of commissioner to extend period of protection
EXTG Extension of patent term granted
KB Patent renewed
EXTN Extension order renewed
EXTN Extension order renewed
EXP Patent expired