IL82812A0 - Cyclic azepin-2-ones and antihypertensive agents containing them - Google Patents

Cyclic azepin-2-ones and antihypertensive agents containing them

Info

Publication number
IL82812A0
IL82812A0 IL82812A IL8281287A IL82812A0 IL 82812 A0 IL82812 A0 IL 82812A0 IL 82812 A IL82812 A IL 82812A IL 8281287 A IL8281287 A IL 8281287A IL 82812 A0 IL82812 A0 IL 82812A0
Authority
IL
Israel
Prior art keywords
azepin
ones
cyclic
agents containing
antihypertensive agents
Prior art date
Application number
IL82812A
Other languages
English (en)
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL82812A0 publication Critical patent/IL82812A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
IL82812A 1986-06-13 1987-06-09 Cyclic azepin-2-ones and antihypertensive agents containing them IL82812A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87393986A 1986-06-13 1986-06-13

Publications (1)

Publication Number Publication Date
IL82812A0 true IL82812A0 (en) 1987-12-20

Family

ID=25362652

Family Applications (1)

Application Number Title Priority Date Filing Date
IL82812A IL82812A0 (en) 1986-06-13 1987-06-09 Cyclic azepin-2-ones and antihypertensive agents containing them

Country Status (11)

Country Link
EP (1) EP0249224A3 (fr)
JP (1) JPS62298592A (fr)
KR (1) KR880000400A (fr)
CN (1) CN87104167A (fr)
AU (1) AU7402387A (fr)
DK (1) DK300287A (fr)
FI (1) FI872612L (fr)
IL (1) IL82812A0 (fr)
NO (1) NO872462L (fr)
PT (1) PT85071A (fr)
ZA (1) ZA874106B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2053340C (fr) * 1990-10-18 2002-04-02 Timothy P. Burkholder Derives de mercaptoacetylamide utiles comme inhibiteurs de l'encephalinase et de l'ace
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
AU657793B2 (en) * 1991-09-27 1995-03-23 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
ZA927211B (en) * 1991-09-27 1993-03-24 Merrell Dow Pharma Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE.
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2078758C (fr) * 1991-09-27 2003-12-09 Alan M. Warshawsky Derives de substitution en 2 d'indane-2-mercaptoacetylamide, utiles comme inhibiteurs de l'enkephalinase et de l'enzyme de conversion de l'angiotensine
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
DE69317764T2 (de) * 1992-02-14 1998-07-30 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
DK0640086T3 (da) * 1992-05-15 1999-12-06 Merrell Pharma Inc Mercaptoacetylamido-pyridazo[1,2-a][1,2]diazepin-derivateranvendelige som enkephalinase- og ACE-inhibitorer
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
PT669936E (pt) * 1992-10-30 2001-04-30 Merrell Pharma Inc Derivados de lactama biciclica de mercaptoacetilamida uteis como inibidores de encefalinase e de ace
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
CA2183314C (fr) * 1994-02-14 1999-08-31 Gary A. Flynn Nouveaux derives bisulfure d'idane-2-mercaptoacetylamides substitues en position 2, utiles comme inhibiteurs de l'encephalinase et de l'enzyme de conversion de l'angiotensine (ace)
JPH09508906A (ja) * 1994-02-14 1997-09-09 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド１，３，４，５−テトラヒドロベンゾ［ｃ］アゼピン−３−オンジスルフィド誘導体類
CA2183313C (fr) * 1994-02-14 2001-01-02 Gary A. Flynn Nouveaux derives de bisulfure d'indane-2-mercaptoacetylamide utiles en tant qu'inhibiteurs de l'encephalinase
WO1995021839A1 (fr) * 1994-02-14 1995-08-17 Merrell Pharmaceuticals Inc. Nouveaux derives bisulfure de mercaptoacetylamides utiles comme inhibiteurs de l'enkephalinase et de l'enzyme de conversion de l'angiotensine (ace)
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
FI963784A0 (fi) * 1994-03-24 1996-09-23 Merrell Pharma Inc Hypokolesteroleemisiä, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamididisulfidijohdannaisia
NZ282568A (en) * 1994-03-24 1997-07-27 Merrell Pharma Inc Use of condensed aminoacetylmercaptobenzazepines in treating elevated cholesterol levels, atherosclerosis, and hypotriglyceridemia
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3586445T2 (de) * 1984-06-26 1993-01-14 Merck & Co Inc Kondensierte benzo-laktam-verbindungen und deren pharmazeutische zusammensetzungen.
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents

Also Published As

Publication number Publication date
DK300287A (da) 1987-12-14
DK300287D0 (da) 1987-06-12
FI872612A0 (fi) 1987-06-11
KR880000400A (ko) 1988-03-25
NO872462D0 (no) 1987-06-12
FI872612A7 (fi) 1987-12-14
JPS62298592A (ja) 1987-12-25
PT85071A (en) 1987-07-01
CN87104167A (zh) 1988-01-20
EP0249224A2 (fr) 1987-12-16
ZA874106B (en) 1987-12-08
NO872462L (no) 1987-12-14
EP0249224A3 (fr) 1989-01-25
AU7402387A (en) 1987-12-17
FI872612L (fi) 1987-12-14

Similar Documents

Publication Publication Date Title
NZ222373A (en) Antihypertensive agents and pharmaceutical compositions containing nor-statine and cyclostatine
PH24830A (en) Indolize compounds and compositions containing them
IL82221A0 (en) Phenyl-piperazines and pharmaceutical compositions containing them
EP0249223A3 (en) Novel antihypertensive agent
ZA874106B (en) Novel antihypertensive agent
IL82146A0 (en) Liposomes based on phosphatidyl-inositolmannosides and pharmaceutical compositions containing them
PH24904A (en) N-substituted-arylalkyl and arylalkylene aminoheterocyclics as antisectory agents
ZA874097B (en) Certain 4-oxo-3-benzoylvalerolactones and thiolactones
EP0255801A3 (en) Anilinotriazines and their use
GB2190918B (en) Polyanhydride-siloxanes and polyimide-siloxanes obtained therefrom
JPS6416766A (en) Substituted quinoxalinediones and quinolinediones
DE3760806D1 (en) Monohalogenotrifluorooxetane and its preparation
ZA865426B (en) Antihypertensive agents
EP0273571A3 (en) Separating-agents composition and method using same
GB2194235B (en) Dichlorotrifluoromethyltoluenes and preparation thereof
GB8712044D0 (en) Circuitry
GB8618196D0 (en) Antihypertensive agents
GB8601382D0 (en) Dihydropyridine antiischaemic & antihypertensive agents
EP0233740A3 (en) Aerocavin and aerocyanidin - antibiotics
GB2191482B (en) Substituted pyrimidoindoles and diazepinoindoles
PT84738A (en) Oxyalkylcellulose containing gel-preparation
GR861916B (en) Antihypertensive agents
GB8706202D0 (en) Carrying case
GR871082B (en) Compounds and processes
CS358086A1 (en) Zpusob pripravy aromatickych n glycidylaminu