IL83819A - Acetic acid ester of haloperidol and pharmaceutical compositions thereof - Google Patents

Acetic acid ester of haloperidol and pharmaceutical compositions thereof

Info

Publication number: IL83819A
Authority: IL; Israel
Prior art keywords: haloperidol; pharmaceutical compositions; acetic acid; acid ester; compounds
Prior art date: 1986-09-11

Application number

IL83819A

Other languages

English (en)

Other versions

IL83819A0 (en

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-09-11

Filing date

1987-09-08

Publication date

1992-02-16

1987-09-08 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

1988-02-29 Publication of IL83819A0 publication Critical patent/IL83819A0/xx

1992-02-16 Publication of IL83819A publication Critical patent/IL83819A/xx

Links

LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 title abstract 6
229960003878 haloperidol Drugs 0.000 title abstract 3
150000002168 ethanoic acid esters Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
239000003921 oil Substances 0.000 abstract 1
235000019198 oils Nutrition 0.000 abstract 1
XAMUDJHXFNRLCY-UHFFFAOYSA-N phenthoate Chemical compound CCOC(=O)C(SP(=S)(OC)OC)C1=CC=CC=C1 XAMUDJHXFNRLCY-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
235000011803 sesame oil Nutrition 0.000 abstract 1
239000008159 sesame oil Substances 0.000 abstract 1
235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
239000008158 vegetable oil Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Medicinal Preparation (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Saccharide Compounds (AREA)
Cephalosporin Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IL83819A 1986-09-11 1987-09-08 Acetic acid ester of haloperidol and pharmaceutical compositions thereof IL83819A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB868621892A GB8621892D0 (en)	1986-09-11	1986-09-11	Organic compound

Publications (2)

Publication Number	Publication Date
IL83819A0 IL83819A0 (en)	1988-02-29
IL83819A true IL83819A (en)	1992-02-16

Family

ID=10604021

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL83819A IL83819A (en)	1986-09-11	1987-09-08	Acetic acid ester of haloperidol and pharmaceutical compositions thereof

Country Status (16)

Country	Link
US (1)	US4855307A (da)
EP (1)	EP0260070B1 (da)
JP (1)	JPS6377857A (da)
AT (1)	ATE92917T1 (da)
AU (1)	AU591334B2 (da)
DE (1)	DE3786966T2 (da)
DK (1)	DK166320C (da)
ES (1)	ES2058120T3 (da)
FI (1)	FI88155C (da)
GB (1)	GB8621892D0 (da)
IE (1)	IE60902B1 (da)
IL (1)	IL83819A (da)
NO (1)	NO169893C (da)
NZ (1)	NZ221711A (da)
PT (1)	PT85678B (da)
ZA (1)	ZA876819B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3742580C1 (de) *	1987-12-16	1989-05-11	Schaper & Bruemmer Gmbh	Verwendung des alpha,alpha-Diphenyl-alpha-(3-carboxy-propionyloxy)-essigsaeure-4-(N-methylpiperidyl)-esters zur Behandlung hypertoner Funktionszustaende im Bereich der Harnblase
US5776963A (en)	1989-05-19	1998-07-07	Hoechst Marion Roussel, Inc.	3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
DK238190D0 (da) *	1990-10-03	1990-10-03	Lundbeck & Co As H	Depotderivater
ES2278729T3 (es) *	2000-03-06	2007-08-16	Acadia Pharmaceuticals Inc.	Compuestos azaciclicos para usar en el tratamiento de enfermedades relacionadas con la serotonina.
EP1787984B1 (en) *	2000-03-06	2016-10-19	Acadia Pharmaceuticals Inc.	Azacyclic compounds for use in the treatment of serotonin related diseases
MXPA04006280A (es)	2001-12-28	2004-09-27	Acadia Pharm Inc	Compuestos espiroazaciclicos como moduladores de receptor de monoamina.
EP1562937A2 (en)	2002-06-24	2005-08-17	Acadia Pharmaceuticals Inc.	N-substituted piperidine derivatives as serotonin receptor agents
US7538222B2 (en)	2002-06-24	2009-05-26	Acadia Pharmaceuticals, Inc.	N-substituted piperidine derivatives as serotonin receptor agents
US7253186B2 (en)	2002-06-24	2007-08-07	Carl-Magnus Andersson	N-substituted piperidine derivatives as serotonin receptor agents
DK2009000T3 (da)	2003-01-16	2011-09-05	Acadia Pharm Inc	Selektive serotonin 2A/2C-receptor invers-agonister som terapeutika for neurodegenerative sygdomme
US7820695B2 (en)	2004-05-21	2010-10-26	Acadia Pharmaceuticals, Inc.	Selective serotonin receptor inverse agonists as therapeutics for disease
US20050261278A1 (en)	2004-05-21	2005-11-24	Weiner David M	Selective serotonin receptor inverse agonists as therapeutics for disease
US7790899B2 (en)	2004-09-27	2010-09-07	Acadia Pharmaceuticals, Inc.	Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
CA2580129A1 (en)	2004-09-27	2006-04-06	Acadia Pharmaceuticals Inc.	Salts of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and their preparation
CA2681506C (en)	2007-03-19	2016-05-24	Perry Peters	Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics
ES2890492T3 (es)	2015-07-20	2022-01-20	Acadia Pharm Inc	Métodos para preparar N-(4-fluorobencil)-N-(1-metilpiperidin-4-il)-N'-(4-(2-metilpropiloxi)fenilmetil)carbamida y su sal de tartrato y forma polimórfica C
US10953000B2 (en)	2016-03-25	2021-03-23	Acadia Pharmaceuticals Inc.	Combination of pimavanserin and cytochrome P450 modulators
WO2017165635A1 (en)	2016-03-25	2017-09-28	Acadia Pharmaceuticals Inc.	Combination of pimavanserin and cytochrome p450 modulators
EP3558311A1 (en)	2016-12-20	2019-10-30	Acadia Pharmaceuticals Inc.	Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
EP3615028A1 (en)	2017-04-28	2020-03-04	Acadia Pharmaceuticals Inc.	Pimavanserin for treating impulse control disorder
EP3675827A1 (en)	2017-08-30	2020-07-08	Acadia Pharmaceuticals Inc.	Formulations of pimavanserin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB895309A (en) *	1959-11-18	1962-05-02	Res Lab Dr C Janssen Nv	Pyrrolidine and piperidine derivatives
US3408356A (en) *	1965-08-31	1968-10-29	Squibb & Sons Inc	Long chain esters of 4'-fluoro-4-[4-hydroxy-4-(alpha, alpha, alpha-trifluorotolyl)piperi-dino]butyrophenone and the like
DE1695194A1 (de) *	1966-07-11	1971-03-18	Hoffmann La Roche	Verfahren zur Herstellung von Piperidinderivaten
US4070473A (en) *	1973-01-26	1978-01-24	Ab Ferrosan	Piperidino-butyrophenones
JPS568318A (en) *	1979-06-28	1981-01-28	Janssen Pharmaceutica Nv	Non oral long acting composition of haloperidol and bromperidol derivative

1986
- 1986-09-11 GB GB868621892A patent/GB8621892D0/en active Pending
1987
- 1987-09-03 EP EP87307799A patent/EP0260070B1/en not_active Expired - Lifetime
- 1987-09-03 ES ES87307799T patent/ES2058120T3/es not_active Expired - Lifetime
- 1987-09-03 DE DE87307799T patent/DE3786966T2/de not_active Expired - Lifetime
- 1987-09-03 IE IE236687A patent/IE60902B1/en not_active IP Right Cessation
- 1987-09-03 AT AT87307799T patent/ATE92917T1/de not_active IP Right Cessation
- 1987-09-04 US US07/093,404 patent/US4855307A/en not_active Expired - Lifetime
- 1987-09-08 IL IL83819A patent/IL83819A/xx not_active IP Right Cessation
- 1987-09-08 NZ NZ221711A patent/NZ221711A/xx unknown
- 1987-09-10 FI FI873924A patent/FI88155C/fi not_active IP Right Cessation
- 1987-09-10 NO NO873785A patent/NO169893C/no unknown
- 1987-09-10 PT PT85678A patent/PT85678B/pt not_active IP Right Cessation
- 1987-09-10 AU AU78232/87A patent/AU591334B2/en not_active Ceased
- 1987-09-11 JP JP62226744A patent/JPS6377857A/ja active Pending
- 1987-09-11 DK DK479587A patent/DK166320C/da not_active IP Right Cessation
- 1987-09-11 ZA ZA876819A patent/ZA876819B/xx unknown

Also Published As

Publication number	Publication date
DK166320B (da)	1993-04-05
NO873785D0 (no)	1987-09-10
PT85678A (en)	1987-10-01
IE872366L (en)	1988-03-11
DE3786966T2 (de)	1994-03-17
DK166320C (da)	1993-08-23
FI873924A0 (fi)	1987-09-10
NO169893B (no)	1992-05-11
NZ221711A (en)	1989-11-28
DE3786966D1 (de)	1993-09-16
JPS6377857A (ja)	1988-04-08
IL83819A0 (en)	1988-02-29
ES2058120T3 (es)	1994-11-01
NO873785L (no)	1988-03-14
GB8621892D0 (en)	1986-10-15
FI873924L (fi)	1988-03-12
ZA876819B (en)	1988-06-29
US4855307A (en)	1989-08-08
FI88155B (fi)	1992-12-31
AU7823287A (en)	1988-03-17
DK479587A (da)	1988-03-12
FI88155C (fi)	1993-04-13
EP0260070A1 (en)	1988-03-16
IE60902B1 (en)	1994-08-24
DK479587D0 (da)	1987-09-11
ATE92917T1 (de)	1993-08-15
AU591334B2 (en)	1989-11-30
EP0260070B1 (en)	1993-08-11
NO169893C (no)	1992-08-19
PT85678B (pt)	1990-05-31

Legal Events

Date	Code	Title	Description
1998-09-24	RH	Patent void

Publication	Publication Date	Title
IL83819A0 (en)	1988-02-29	Acetic acid ester of haloperidol and pharmaceutical compositions thereof
FI945703A0 (fi)	1994-12-02	3,4,4-trisybstituoitujen piperidinyyli-N-alkyylikarboksylaattien ja välituotteiden valmistus
DK34289A (da)	1989-07-27	Madlavnings/salatolie
PT91553A (pt)	1990-03-08	Processo de preparacao de uma composicao contendo morfina
IL67623A0 (en)	1983-05-15	1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it
FI850449A0 (fi)	1985-02-04	Foerfarande foer framstaellning av (-) -trans-4-(4-fluorfenyl)-3-(4-metoxifenoxi)-metylpiperidin eller farmaceutiskt godtagbara syraadditionssalter daerav.
HUT52374A (en)	1990-07-28	Process for producing pharmaceutical compositions
DE69022162D1 (de)	1995-10-12	Polyester-Mischung, ihre Herstellung und Verwendung.
ATE78693T1 (de)	1992-08-15	Ein dideoxynukleosid enthaltendes arzneimittel.
NO891260D0 (no)	1989-03-22	Fremgangsmaate for fremstilling av 4-aryl-4-piperidin (eller pyrrolidin eller hexahydroazepin) carbinoler.
EP0191724A3 (de)	1986-12-03	1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DK149888C (da)	1987-05-04	Analogifremgangsmaade til fremstilling af 1-(1,3,4-oxadiazolyl-2-phenoxy)-3-(4-phenylpiperazinyl)-propan-2-oler eller fysiologisk acceptable syreadditionssalte heraf
AU566077B2 (en)	1987-10-08	2,6-bis-fluoromethyl-dihydropyridine-3, 5-dicarboxylic
DE69007738D1 (de)	1994-05-05	Haarbehandlungsmittel.
ATE80388T1 (de)	1992-09-15	Verfahren zur herstellung von 5-gliedrigen, stickstoffhaltigen heteroaromaten.
ATE113598T1 (de)	1994-11-15	Substituierte vinylcephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
IE792328L (en)	1980-06-08	Derivatives of dihydropyrrole and tetrahydropyridine.
DE3762854D1 (de)	1990-06-28	Pharmazeutische zusammensetzungen mit inhalt von 5-phenyl-1,3-dioxoalkenylverbindungen.
SE8505801D0 (sv)	1985-12-09	1,4-dihydropyridin-derivate, ihre herstellung und sie enthaltende pharmazeutische zubereitungen
DE3854557D1 (de)	1995-11-09	Stickstoffhaltige ester von carboxylgruppenhaltigen copolymerisaten.
DE59204444D1 (de)	1996-01-04	Verfahren zur herstellung von epoxygruppen aufweisenden organosiliciumverbindungen.
DE3784851D1 (de)	1993-04-22	Verfahren zur herstellung von 4-amino-1,2,4-(4h)-triazol-derivaten.
ATE111732T1 (de)	1994-10-15	Verwendung von 1,4-dihydropyridinen zur herstellung eines arzneimittels, zur behandlung von neuropathien, die durch diabetes mellitus verursacht sind.
NZ194192A (en)	1982-11-23	Long-acting injectable composition containing sulfadimethoxine or sulfamethazine
ATE7893T1 (de)	1984-06-15	10b-carboxy-aminoborane, verfahren zur herstellung derselben sowie ihre verwendung als arzneimittel zur neutroneneinfangtherapie.