IL84705A - Medicinal products containing atrial peptine and blocking of adrenergic A1 or ganglion and disease treatment methods - Google Patents

Medicinal products containing atrial peptine and blocking of adrenergic A1 or ganglion and disease treatment methods

Info

Publication number: IL84705A
Authority: IL; Israel
Prior art keywords: atriopeptin; renal; blocking agent; group; adrenergic
Prior art date: 1986-12-04

Application number

IL8470587A

Other languages

English (en)

Hebrew (he)

Original Assignee

New York Medical College

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-04

Filing date

1987-12-03

Publication date

1994-01-25

1987-12-03 Application filed by New York Medical College filed Critical New York Medical College

1994-01-25 Publication of IL84705A publication Critical patent/IL84705A/en

Links

NSQLIUXCMFBZME-MPVJKSABSA-N carperitide Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 NSQLIUXCMFBZME-MPVJKSABSA-N 0.000 title claims description 100
101800001288 Atrial natriuretic factor Proteins 0.000 title claims description 99
102000002723 Atrial Natriuretic Factor Human genes 0.000 title claims description 98
229950008486 carperitide Drugs 0.000 title claims description 59
239000000674 adrenergic antagonist Substances 0.000 title claims description 49
238000000034 method Methods 0.000 title claims description 36
239000003457 ganglion blocking agent Substances 0.000 title claims description 33
239000000825 pharmaceutical preparation Substances 0.000 title claims description 33
229940127557 pharmaceutical product Drugs 0.000 title claims description 33
201000010099 disease Diseases 0.000 title description 10
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 10
230000000694 effects Effects 0.000 claims description 63
108010034646 atrial natriuretic factor prohormone (103-126) Proteins 0.000 claims description 45
RKZZUZKLXUMHFK-FELCLXEWSA-N atriopeptin 24 Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1N(CCC1)C(=O)CN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)=O)[C@@H](C)CC)[C@@H](C)CC)C1=CC=CC=C1 RKZZUZKLXUMHFK-FELCLXEWSA-N 0.000 claims description 45
229940124550 renal vasodilator Drugs 0.000 claims description 43
150000001875 compounds Chemical class 0.000 claims description 18
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239000002981 blocking agent Substances 0.000 claims description 14
208000024172 Cardiovascular disease Diseases 0.000 claims description 12
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239000003071 vasodilator agent Substances 0.000 claims description 11
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IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 claims description 10
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LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims description 8
XULIXFLCVXWHRF-UHFFFAOYSA-N 1,2,2,6,6-pentamethylpiperidine Chemical compound CN1C(C)(C)CCCC1(C)C XULIXFLCVXWHRF-UHFFFAOYSA-N 0.000 claims description 4
108010034703 atrial natriuretic factor prohormone (103-125) Proteins 0.000 claims description 4
XXPVSJGWOXCVLF-VSJANKAZSA-N atriopeptin ii Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1N(CCC1)C(=O)CN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)=O)[C@@H](C)CC)[C@@H](C)CC)C1=CC=CC=C1 XXPVSJGWOXCVLF-VSJANKAZSA-N 0.000 claims description 4
229960004779 azapetine Drugs 0.000 claims description 4
NYGHGTMKALXFIA-UHFFFAOYSA-N azapetine Chemical compound C1N(CC=C)CC2=CC=CC=C2C2=CC=CC=C21 NYGHGTMKALXFIA-UHFFFAOYSA-N 0.000 claims description 4
BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical class C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 claims description 4
DXXUGBPKQDTBQW-UHFFFAOYSA-L chlorisondamine Chemical compound [Cl-].[Cl-].ClC1=C(Cl)C(Cl)=C(Cl)C2=C1C[N+](CC[N+](C)(C)C)(C)C2 DXXUGBPKQDTBQW-UHFFFAOYSA-L 0.000 claims description 4
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ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 claims description 4
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IMYZQPCYWPFTAG-IQJOONFLSA-N mecamylamine Chemical compound C1C[C@@H]2C(C)(C)[C@@](NC)(C)[C@H]1C2 IMYZQPCYWPFTAG-IQJOONFLSA-N 0.000 claims description 4
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HSMKTIKKPMTUQH-WBPXWQEISA-L pentolinium tartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C([O-])=O.OC(=O)[C@H](O)[C@@H](O)C([O-])=O.C1CCC[N+]1(C)CCCCC[N+]1(C)CCCC1 HSMKTIKKPMTUQH-WBPXWQEISA-L 0.000 claims description 4
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JIVZKJJQOZQXQB-UHFFFAOYSA-N tolazoline Chemical compound C=1C=CC=CC=1CC1=NCCN1 JIVZKJJQOZQXQB-UHFFFAOYSA-N 0.000 claims description 4
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YNZXWQJZEDLQEG-UHFFFAOYSA-N trimazosin Chemical compound N1=C2C(OC)=C(OC)C(OC)=CC2=C(N)N=C1N1CCN(C(=O)OCC(C)(C)O)CC1 YNZXWQJZEDLQEG-UHFFFAOYSA-N 0.000 claims description 4
CHQOEHPMXSHGCL-UHFFFAOYSA-N trimethaphan Chemical compound C12C[S+]3CCCC3C2N(CC=2C=CC=CC=2)C(=O)N1CC1=CC=CC=C1 CHQOEHPMXSHGCL-UHFFFAOYSA-N 0.000 claims description 4
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GPUGLFZXYGTLBI-UHFFFAOYSA-N trimethidinium Chemical compound C1[N+](C)(CCC[N+](C)(C)C)CC2(C)CCC1C2(C)C GPUGLFZXYGTLBI-UHFFFAOYSA-N 0.000 claims description 4
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QZVCTJOXCFMACW-UHFFFAOYSA-N Phenoxybenzamine Chemical compound C=1C=CC=CC=1CN(CCCl)C(C)COC1=CC=CC=C1 QZVCTJOXCFMACW-UHFFFAOYSA-N 0.000 claims description 3
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PYIHTIJNCRKDBV-UHFFFAOYSA-L trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;dichloride Chemical compound [Cl-].[Cl-].C[N+](C)(C)CCCCCC[N+](C)(C)C PYIHTIJNCRKDBV-UHFFFAOYSA-L 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2242—Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Heart & Thoracic Surgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL8470587A 1986-12-04 1987-12-03 Medicinal products containing atrial peptine and blocking of adrenergic A1 or ganglion and disease treatment methods IL84705A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/937,903 US4749686A (en)	1986-12-04	1986-12-04	Combinations of renal vasodilators and α1 -adrenergic or ganglionic blocking agents and methods for treating diseases
CA000553949A CA1322717C (en)	1986-12-04	1987-12-09	Combination of renal vasodilators and alpha 1-adrenergic or ganglionic blocking agents and methods for treating diseases

Publications (1)

Publication Number	Publication Date
IL84705A true IL84705A (en)	1994-01-25

Family

ID=25671625

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL8470587A IL84705A (en)	1986-12-04	1987-12-03	Medicinal products containing atrial peptine and blocking of adrenergic A1 or ganglion and disease treatment methods

Country Status (7)

Country	Link
US (1)	US4749686A (de)
EP (1)	EP0333769A4 (de)
JP (1)	JPH02501479A (de)
AU (1)	AU1085988A (de)
CA (1)	CA1322717C (de)
IL (1)	IL84705A (de)
WO (1)	WO1988004179A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5087564A (en) *	1985-06-20	1992-02-11	Monsanto Company	Release of recombinant peptides from polypeptides using V8 endopeptidase
US6121276A (en) *	1994-04-22	2000-09-19	Pentech Pharmaceuticals, Inc.	Apomorphine-containing dosage forms for ameliorating male erectile dysfunction
US5994363A (en) *	1998-08-24	1999-11-30	Pentech Pharmaceuticals, Inc.	Amelioration of apomorphine adverse effects
US6734215B2 (en) *	1998-12-16	2004-05-11	University Of South Florida	Exo-S-mecamylamine formulation and use in treatment
PT1634498E (pt) *	1998-12-16	2008-10-28	Univ South Florida	Formulação de exo-s-mecamilamina
US7045534B2 (en) *	2002-02-12	2006-05-16	The Board Of Trustees Of The Leland Stanford Junior University	Methods of reducing angiogenesis
AU2006331790A1 (en) *	2005-12-19	2007-07-05	Comentis, Inc.	Topical mecamylamine formulations for ocular administration and uses therof
WO2010080183A1 (en)	2009-01-08	2010-07-15	The Trustees Of Columbia University In The City Of New York	Potent non-urea inhibitors of soluble epoxide hydrolase

1986
- 1986-12-04 US US06/937,903 patent/US4749686A/en not_active Expired - Lifetime
1987
- 1987-12-02 WO PCT/US1987/003172 patent/WO1988004179A1/en not_active Ceased
- 1987-12-02 EP EP19880900508 patent/EP0333769A4/de not_active Ceased
- 1987-12-02 AU AU10859/88A patent/AU1085988A/en not_active Abandoned
- 1987-12-02 JP JP63501069A patent/JPH02501479A/ja active Pending
- 1987-12-03 IL IL8470587A patent/IL84705A/en not_active IP Right Cessation
- 1987-12-09 CA CA000553949A patent/CA1322717C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1988004179A1 (en)	1988-06-16
CA1322717C (en)	1993-10-05
JPH02501479A (ja)	1990-05-24
AU1085988A (en)	1988-06-30
EP0333769A1 (de)	1989-09-27
US4749686A (en)	1988-06-07
EP0333769A4 (de)	1990-06-27

Legal Events

Date	Code	Title	Description
1998-12-06	RH	Patent void

Publication	Publication Date	Title
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Yaksh	1981	Spinal opiate analgesia: characteristics and principles of action
Koyama et al.	1989	Plasma endothelin levels in patients with uraemia
RU2166958C2 (ru)	2001-05-20	Лечение сахарного диабета типа ii агонистами амилина
Murphy et al.	1987	Augmentation of renal blood flow and sodium excretion in hypertensive patients during blood pressure reduction by intravenous administration of the dopamine1 agonist fenoldopam.
Lightman et al.	1980	Evidence for dopamine as an inhibitor of vasoprotein release in man
JPH06504286A (ja)	1994-05-19	人ｉｇｆ−ｉの利用方法
Van Loon et al.	1971	Effect of intraventricular administration of adrenergic drugs on the adrenal venous 17-hydroxycorticosteroid response to surgical stress in the dog
EP1610800A2 (de)	2006-01-04	Verfahren und zusammensetzungen zur erhöhung der anaeroben arbeitskapazität in geweben
Oldroyd et al.	1992	Beta endorphin release in patients after spontaneous and provoked acute myocardial ischaemia.
US4749686A (en)	1988-06-07	Combinations of renal vasodilators and α1 -adrenergic or ganglionic blocking agents and methods for treating diseases
JPH08245385A (ja)	1996-09-24	高血圧症およびうっ血性心不全の治療
HOFFBRAND et al.	1973	Regional blood flow changes during norepinephrine, tyramine and methoxamine infusions in the unanesthetized rhesus monkey
Tarjan et al.	1988	Atrial natriuretic peptide inhibits water and sodium intake in rabbits
AU738269B2 (en)	2001-09-13	Pharmaceutical composition for treatment of heart disease based on cardiac hypertrophy
Tsuda et al.	1986	Neurotransmitter release, vascular responsiveness and their suppression by Ca-antagonist in perfused mesenteric vasculature of DOCA-salt hypertensive rats
WO1997032898A1 (en)	1997-09-12	Anti-inflammatory crf analogs, their compositions and use
WO1997032898A9 (en)	1997-10-30	Anti-inflammatory crf analogs, their compositions and use
Higashi et al.	2002	Renal endothelial dysfunction and hypertension
Matsuguchi et al.	1982	Central mechanisms in DOC-salt hypertensive rats
EP0928191A1 (de)	1999-07-14	S-alkylisothiouronium-derivate enthaltende pharmazeutische zusammensetzungen
Ziegler et al.	1986	The effect of propranolol on catecholamine clearance
Clementi et al.	1986	Captopril modifies the hemodynamic and neuroendocrine responses to sodium nitroprusside in hypertensive patients.
Horiuchi et al.	1989	Do D-1 dopamine receptors mediate dopamine-induced pancreatic exocrine secretion in anesthetized dogs?
EP0256402A2 (de)	1988-02-24	Pharmazeutische Zubereitung