IL84928A - Preparations and methods for synthesis and encaplase testing - Google Patents

Preparations and methods for synthesis and encaplase testing

Info

Publication number
IL84928A
IL84928A IL8492887A IL8492887A IL84928A IL 84928 A IL84928 A IL 84928A IL 8492887 A IL8492887 A IL 8492887A IL 8492887 A IL8492887 A IL 8492887A IL 84928 A IL84928 A IL 84928A
Authority
IL
Israel
Prior art keywords
enkephalinase
gly
dna
sequence
dansyl
Prior art date
Application number
IL8492887A
Other languages
English (en)
Hebrew (he)
Other versions
IL84928A0 (en
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL84928A0 publication Critical patent/IL84928A0/xx
Publication of IL84928A publication Critical patent/IL84928A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6494—Neprilysin (3.4.24.11), i.e. enkephalinase or neutral-endopeptidase 24.11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24011—Neprilysin (3.4.24.11), i.e. enkephalinase or neutral endopeptidase 24.11
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL8492887A 1986-12-24 1987-12-23 Preparations and methods for synthesis and encaplase testing IL84928A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94656686A 1986-12-24 1986-12-24
US07/002,478 US4960700A (en) 1986-12-24 1987-01-12 Compositions and methods for the synthesis and assay of a mammalian enkephalinase

Publications (2)

Publication Number Publication Date
IL84928A0 IL84928A0 (en) 1988-06-30
IL84928A true IL84928A (en) 1994-02-27

Family

ID=26670440

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8492887A IL84928A (en) 1986-12-24 1987-12-23 Preparations and methods for synthesis and encaplase testing

Country Status (11)

Country Link
US (2) US4960700A (fr)
EP (2) EP0272928B1 (fr)
JP (1) JP2685468B2 (fr)
AT (1) ATE119936T1 (fr)
AU (1) AU623845B2 (fr)
DE (1) DE3751169T2 (fr)
DK (1) DK684087A (fr)
ES (1) ES2072251T3 (fr)
IE (1) IE66333B1 (fr)
IL (1) IL84928A (fr)
NZ (1) NZ223028A (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272929B1 (fr) * 1986-12-24 1996-03-20 Genentech, Inc. Encéphalinase pour application théraupeutique
IL88535A0 (en) * 1987-12-04 1989-06-30 Dana Farber Cancer Inst Inc Common acute lymphoblastic leukemia antigen
US6372438B1 (en) * 1988-02-02 2002-04-16 The Regents Of The University Of California Human platelet-derived growth factor receptors
US5486599A (en) * 1989-03-29 1996-01-23 The Board Of Trustees Of The Leland Stanford Junior University Construction and use of synthetic constructs encoding syndecan
US5541083A (en) * 1989-10-24 1996-07-30 The Regents Of The University Of California Method for producing secretable glycosyltransferases and other golgi processing enzymes
FR2664287A1 (fr) * 1990-07-03 1992-01-10 Inst Nat Sante Rech Med Nouveau polypeptide presentant une activite enzymatique, et gene codant pour ce polypeptide.
FI102072B (fi) * 1990-09-14 1998-10-15 Aventis Pharma Gmbh 2-dansyylietoksiklooriformiaattihydrokloridin käyttö hydroksiryhmän su ojaamiseen oligonukleotidisynteesissä, näin suojattuja välituotteita, menetelmiä niiden valmistamiseksi ja menetelmä oligonukleotidien synte tisoimiseksi
DE69232779T2 (de) * 1991-03-15 2003-01-30 Applied Research Systems Ars Holding N.V., Curacao Menschlicher Rezeptor für das Follikel-stimulierendes Hormon.
US6048975A (en) * 1991-09-12 2000-04-11 Hoechst Aktiengesellschaft Process for the chemical synthesis of oligonucleotides
AU5457294A (en) * 1992-10-29 1994-05-24 Board Of Regents, The University Of Texas System Adenovirus-mediated ldl receptor gene transfer and targeting
WO1994012209A1 (fr) * 1992-12-02 1994-06-09 Dana-Farber Cancer Institute, Inc. Regulation de la croissance cellulaire maligne par l'antigene commun de la leucemie lymphoblastique aigue
CA2158727A1 (fr) * 1993-03-23 1994-09-29 Hiroshi Hara Substances de croissance d'hepatocytes parenchymateux
JP4043535B2 (ja) * 1994-06-21 2008-02-06 サントリー株式会社 ペプチド基質並びにこれを用いるプロテイナーゼａ活性およびビールの泡安定性の測定方法
GB9525403D0 (en) * 1995-12-13 1996-02-14 Univ Sunderland Method for monitoring enzymes
GB9815163D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds
FR2777291B1 (fr) * 1998-04-08 2000-07-07 Inst Nat Sante Rech Med Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie
EP1069188A1 (fr) * 1999-07-15 2001-01-17 Sanofi-Synthelabo Métallopeptidases membranaires de type neprolysin
DE60040089D1 (de) * 1999-11-19 2008-10-09 Solvay Pharm Bv Menschliches homolog aus der familie der metalloproteasen
US20020120409A1 (en) * 2000-05-19 2002-08-29 Affymetrix, Inc. Methods for gene expression analysis
WO2002100353A2 (fr) * 2001-06-11 2002-12-19 Medarex, Inc. Composes pour promedicaments actives cd10
US20060029590A1 (en) * 2004-06-10 2006-02-09 Christopher Thanos Administration of neutral endopeptidase to treat inflammatory bowel disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760025A (en) * 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US5262178A (en) * 1987-01-12 1993-11-16 Genentech, Inc. Therapeutic use of enkephalinase

Also Published As

Publication number Publication date
IE66333B1 (en) 1995-12-27
IL84928A0 (en) 1988-06-30
DE3751169D1 (de) 1995-04-20
IE873535L (en) 1988-06-24
JPH01104178A (ja) 1989-04-21
EP0272928A2 (fr) 1988-06-29
DK684087A (da) 1988-10-03
US5780025A (en) 1998-07-14
ATE119936T1 (de) 1995-04-15
DE3751169T2 (de) 1995-10-26
DK684087D0 (da) 1987-12-23
JP2685468B2 (ja) 1997-12-03
ES2072251T3 (es) 1995-07-16
EP0272928A3 (en) 1990-04-04
US4960700A (en) 1990-10-02
AU8305887A (en) 1988-06-30
EP0272928B1 (fr) 1995-03-15
EP0596355A1 (fr) 1994-05-11
AU623845B2 (en) 1992-05-28
NZ223028A (en) 1990-09-26

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Legal Events

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