DK684087A - Fremgangsmaade til fremstilling af enkephalinase og dna-isolater, rekombinante udtrykkelsesvektorer og transformerede celler til anvendelse ved fremgangsmaaden samt fremgangsmaade til proevning af enkephalinase-aktivitet og farmaceutiske praeparater til behandling af sygdomme formidlet af endogene peptider - Google Patents
Fremgangsmaade til fremstilling af enkephalinase og dna-isolater, rekombinante udtrykkelsesvektorer og transformerede celler til anvendelse ved fremgangsmaaden samt fremgangsmaade til proevning af enkephalinase-aktivitet og farmaceutiske praeparater til behandling af sygdomme formidlet af endogene peptiderInfo
- Publication number
- DK684087A DK684087A DK684087A DK684087A DK684087A DK 684087 A DK684087 A DK 684087A DK 684087 A DK684087 A DK 684087A DK 684087 A DK684087 A DK 684087A DK 684087 A DK684087 A DK 684087A
- Authority
- DK
- Denmark
- Prior art keywords
- enkephalinase
- activity
- testing
- preparation
- pharmaceutical compositions
- Prior art date
Links
- 102000003729 Neprilysin Human genes 0.000 title abstract 4
- 108090000028 Neprilysin Proteins 0.000 title abstract 4
- 230000000694 effects Effects 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 3
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000013604 expression vector Substances 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000003259 recombinant expression Methods 0.000 title 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C12N9/6494—Neprilysin (3.4.24.11), i.e. enkephalinase or neutral-endopeptidase 24.11
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24011—Neprilysin (3.4.24.11), i.e. enkephalinase or neutral endopeptidase 24.11
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96486—Metalloendopeptidases (3.4.24)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94656686A | 1986-12-24 | 1986-12-24 | |
| US07/002,478 US4960700A (en) | 1986-12-24 | 1987-01-12 | Compositions and methods for the synthesis and assay of a mammalian enkephalinase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK684087D0 DK684087D0 (da) | 1987-12-23 |
| DK684087A true DK684087A (da) | 1988-10-03 |
Family
ID=26670440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK684087A DK684087A (da) | 1986-12-24 | 1987-12-23 | Fremgangsmaade til fremstilling af enkephalinase og dna-isolater, rekombinante udtrykkelsesvektorer og transformerede celler til anvendelse ved fremgangsmaaden samt fremgangsmaade til proevning af enkephalinase-aktivitet og farmaceutiske praeparater til behandling af sygdomme formidlet af endogene peptider |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US4960700A (da) |
| EP (2) | EP0272928B1 (da) |
| JP (1) | JP2685468B2 (da) |
| AT (1) | ATE119936T1 (da) |
| AU (1) | AU623845B2 (da) |
| DE (1) | DE3751169T2 (da) |
| DK (1) | DK684087A (da) |
| ES (1) | ES2072251T3 (da) |
| IE (1) | IE66333B1 (da) |
| IL (1) | IL84928A (da) |
| NZ (1) | NZ223028A (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0272929B1 (en) * | 1986-12-24 | 1996-03-20 | Genentech, Inc. | Enkephalinase for therapeutic use |
| IL88535A0 (en) * | 1987-12-04 | 1989-06-30 | Dana Farber Cancer Inst Inc | Common acute lymphoblastic leukemia antigen |
| US6372438B1 (en) * | 1988-02-02 | 2002-04-16 | The Regents Of The University Of California | Human platelet-derived growth factor receptors |
| US5486599A (en) * | 1989-03-29 | 1996-01-23 | The Board Of Trustees Of The Leland Stanford Junior University | Construction and use of synthetic constructs encoding syndecan |
| US5541083A (en) * | 1989-10-24 | 1996-07-30 | The Regents Of The University Of California | Method for producing secretable glycosyltransferases and other golgi processing enzymes |
| FR2664287A1 (fr) * | 1990-07-03 | 1992-01-10 | Inst Nat Sante Rech Med | Nouveau polypeptide presentant une activite enzymatique, et gene codant pour ce polypeptide. |
| HUT63432A (en) * | 1990-09-14 | 1993-08-30 | Hoechst Ag | Process for cemically producing oliginucletides |
| AU671417B2 (en) * | 1991-03-15 | 1996-08-29 | Merck Serono Sa | Human follicle stimulating hormone receptor |
| US6048975A (en) * | 1991-09-12 | 2000-04-11 | Hoechst Aktiengesellschaft | Process for the chemical synthesis of oligonucleotides |
| AU5457294A (en) * | 1992-10-29 | 1994-05-24 | Board Of Regents, The University Of Texas System | Adenovirus-mediated ldl receptor gene transfer and targeting |
| WO1994012209A1 (en) * | 1992-12-02 | 1994-06-09 | Dana-Farber Cancer Institute, Inc. | Malignant cell growth regulation by common acute lymphoblastic leukemia antigen |
| CA2158727A1 (en) * | 1993-03-23 | 1994-09-29 | Hiroshi Hara | Parenchymal hepatocyte growth substances |
| JP4043535B2 (ja) * | 1994-06-21 | 2008-02-06 | サントリー株式会社 | ペプチド基質並びにこれを用いるプロテイナーゼａ活性およびビールの泡安定性の測定方法 |
| GB9525403D0 (en) * | 1995-12-13 | 1996-02-14 | Univ Sunderland | Method for monitoring enzymes |
| GB9815163D0 (en) * | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds |
| FR2777291B1 (fr) * | 1998-04-08 | 2000-07-07 | Inst Nat Sante Rech Med | Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie |
| EP1069188A1 (en) * | 1999-07-15 | 2001-01-17 | Sanofi-Synthelabo | Three neprilysin-like membrane metallopeptidases |
| ES2310527T3 (es) * | 1999-11-19 | 2009-01-16 | Solvay Pharmaceuticals B.V. | Enzimas humanas de la familia de las metaloproteasas. |
| US20020120409A1 (en) * | 2000-05-19 | 2002-08-29 | Affymetrix, Inc. | Methods for gene expression analysis |
| US6897034B2 (en) * | 2001-06-11 | 2005-05-24 | Medarex, Inc. | CD10-activated prodrug compounds |
| WO2005123119A2 (en) * | 2004-06-10 | 2005-12-29 | Catalyst Biosciences, Inc. | Administration of neutral endopeptidase to treat inflammatory bowel disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4760025A (en) * | 1984-05-29 | 1988-07-26 | Genencor, Inc. | Modified enzymes and methods for making same |
| US5262178A (en) * | 1987-01-12 | 1993-11-16 | Genentech, Inc. | Therapeutic use of enkephalinase |
-
1987
- 1987-01-12 US US07/002,478 patent/US4960700A/en not_active Expired - Lifetime
- 1987-12-21 NZ NZ223028A patent/NZ223028A/xx unknown
- 1987-12-23 ES ES87311365T patent/ES2072251T3/es not_active Expired - Lifetime
- 1987-12-23 IE IE353587A patent/IE66333B1/en not_active IP Right Cessation
- 1987-12-23 EP EP87311365A patent/EP0272928B1/en not_active Expired - Lifetime
- 1987-12-23 DE DE3751169T patent/DE3751169T2/de not_active Expired - Fee Related
- 1987-12-23 IL IL8492887A patent/IL84928A/en not_active IP Right Cessation
- 1987-12-23 EP EP93117230A patent/EP0596355A1/en not_active Withdrawn
- 1987-12-23 DK DK684087A patent/DK684087A/da not_active Application Discontinuation
- 1987-12-23 AT AT87311365T patent/ATE119936T1/de not_active IP Right Cessation
- 1987-12-24 JP JP62336782A patent/JP2685468B2/ja not_active Expired - Lifetime
- 1987-12-24 AU AU83058/87A patent/AU623845B2/en not_active Ceased
-
1993
- 1993-10-12 US US08/134,481 patent/US5780025A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IE66333B1 (en) | 1995-12-27 |
| IL84928A (en) | 1994-02-27 |
| EP0272928A2 (en) | 1988-06-29 |
| NZ223028A (en) | 1990-09-26 |
| JPH01104178A (ja) | 1989-04-21 |
| ES2072251T3 (es) | 1995-07-16 |
| EP0272928A3 (en) | 1990-04-04 |
| US4960700A (en) | 1990-10-02 |
| US5780025A (en) | 1998-07-14 |
| AU623845B2 (en) | 1992-05-28 |
| DE3751169D1 (de) | 1995-04-20 |
| DE3751169T2 (de) | 1995-10-26 |
| EP0272928B1 (en) | 1995-03-15 |
| JP2685468B2 (ja) | 1997-12-03 |
| DK684087D0 (da) | 1987-12-23 |
| IE873535L (en) | 1988-06-24 |
| ATE119936T1 (de) | 1995-04-15 |
| AU8305887A (en) | 1988-06-30 |
| IL84928A0 (en) | 1988-06-30 |
| EP0596355A1 (en) | 1994-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |