IL85696A - Substituted quinazolines, their preparation and pharmaceutical compositions comprising them - Google Patents

Substituted quinazolines, their preparation and pharmaceutical compositions comprising them

Info

Publication number: IL85696A
Authority: IL; Israel
Prior art keywords: alkyl; hydrogen; alkoxy; alkylthio; preparation
Prior art date: 1987-03-25

Application number

IL85696A

Other languages

English (en)

Original Assignee

Ici Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-25

Filing date

1988-03-10

Publication date

1993-05-13

1988-03-10 Application filed by Ici Plc filed Critical Ici Plc

1993-05-13 Publication of IL85696A publication Critical patent/IL85696A/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
150000003246 quinazolines Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000004414 alkyl thio group Chemical group 0.000 abstract 3
125000000547 substituted alkyl group Chemical group 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000005110 aryl thio group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000004957 naphthylene group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL85696A 1987-03-25 1988-03-10 Substituted quinazolines, their preparation and pharmaceutical compositions comprising them IL85696A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878707053A GB8707053D0 (en)	1987-03-25	1987-03-25	Anti-tumour agents

Publications (1)

Publication Number	Publication Date
IL85696A true IL85696A (en)	1993-05-13

Family

ID=10614570

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL85696A IL85696A (en)	1987-03-25	1988-03-10	Substituted quinazolines, their preparation and pharmaceutical compositions comprising them

Country Status (17)

Country	Link
US (1)	US4981856A (da)
EP (1)	EP0284338B1 (da)
JP (1)	JP2577036B2 (da)
AT (1)	ATE98956T1 (da)
AU (1)	AU600105B2 (da)
CA (1)	CA1301756C (da)
DE (1)	DE3886435T2 (da)
DK (1)	DK167013B1 (da)
ES (1)	ES2061641T3 (da)
FI (1)	FI881340A7 (da)
GB (2)	GB8707053D0 (da)
GR (1)	GR3010208T3 (da)
IL (1)	IL85696A (da)
NO (1)	NO881300L (da)
NZ (1)	NZ224010A (da)
PT (1)	PT87074B (da)
ZA (1)	ZA881885B (da)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8727737D0 (en) *	1987-11-26	1987-12-31	Ici Plc	Antitumour agents
GB8809978D0 (en) *	1988-04-27	1988-06-02	Ici Plc	Anti-tumour agents
EP0365763A1 (en) *	1988-09-30	1990-05-02	Agouron Pharmaceuticals, Inc.	Antiproliferative cyclic compounds
US5252573A (en) *	1988-12-15	1993-10-12	Imperial Chemical Industries Plc	Anti-tumor agents
GB8829296D0 (en) *	1988-12-15	1989-01-25	Ici Plc	Anti-tumour compounds
US5160727A (en) *	1990-02-13	1992-11-03	Warner-Lambert Company	Tumor cell sensitization method using quinazolinedione derivatives
AU640016B2 (en) *	1990-05-30	1993-08-12	Imperial Chemical Industries Plc	Hydroquinazoline derivatives
GB9013615D0 (en) *	1990-06-19	1990-08-08	Wellcome Found	Pharmaceutical compounds
GB9105771D0 (en) *	1991-03-19	1991-05-01	Cancer Res Inst Royal	Anti-cancer compounds
US5145854A (en) *	1991-11-27	1992-09-08	Nair Madhavan G	1-formyl-5,8,10-trideazafolates
GB9205320D0 (en) *	1992-03-11	1992-04-22	Ici Plc	Anti-tumour compounds
GB9205907D0 (en) *	1992-03-18	1992-04-29	Cancer Res Inst Royal	Anti-cancer compounds
US5430148A (en) *	1992-03-31	1995-07-04	Agouron Pharmaceuticals, Inc.	Antiproliferative quinazolines
GB9223352D0 (en) *	1992-11-06	1992-12-23	Ici Plc	Tricyclic compounds
DE4421884A1 (de)	1994-06-23	1996-01-04	Hoechst Ag	Verfahren zur Herstellung von Hydroxycarbonsäureaniliden
DE4427837A1 (de)	1994-08-05	1996-02-08	Hoechst Ag	Verfahren zur Herstellung von O-Acylglykolsäureaniliden
DE19504225A1 (de)	1995-02-09	1996-08-14	Hoechst Ag	Verfahren zur Herstellung von O-Acyloxycarbonsäureaniliden
US5739330A (en) *	1996-02-05	1998-04-14	Hoechst Celanese Corporation	Process for preparing quinazolones
GB9904275D0 (en)	1999-02-24	1999-04-21	Cancer Res Campaign Tech	Anti-cancer compounds
US7230000B1 (en)	1999-10-27	2007-06-12	Cytokinetics, Incorporated	Methods and compositions utilizing quinazolinones
US6545004B1 (en)	1999-10-27	2003-04-08	Cytokinetics, Inc.	Methods and compositions utilizing quinazolinones
AU2002346471A1 (en) *	2001-11-20	2003-06-10	Cytokinetics, Inc.	Process for the racemization of chiral quinazolinones
WO2003054155A2 (en)	2001-12-19	2003-07-03	Bristol-Myers Squibb Company	Pichia pastoris formate dehydrogenase and uses therefor
US7009049B2 (en) *	2002-02-15	2006-03-07	Cytokinetics, Inc.	Syntheses of quinazolinones
AU2003270015A1 (en)	2002-05-09	2003-12-02	Cytokinetics, Inc.	Compounds, compositions, and methods
US7166595B2 (en) *	2002-05-09	2007-01-23	Cytokinetics, Inc.	Compounds, methods and compositions
WO2003103575A2 (en) *	2002-05-23	2003-12-18	Cytokinetics, Inc.	Compounds, compositions, and methods
CA2489367A1 (en) *	2002-06-14	2003-12-24	Cytokinetics, Inc.	Compounds, compositions, and methods
WO2004009036A2 (en) *	2002-07-23	2004-01-29	Cytokinetics, Inc.	Compounds compositions and methods
EP1539180A4 (en) *	2002-08-21	2006-08-30	Cytokinetics Inc	COMPOUNDS, COMPOSITIONS AND METHODS
WO2004034972A2 (en) *	2002-09-30	2004-04-29	Cytokinetics, Inc.	Compounds, compositions, and methods
GB0317631D0 (en) *	2003-07-28	2003-08-27	Btg Int Ltd	Synthetic method
JP2007510652A (ja) *	2003-11-03	2007-04-26	サイトキネティクス・インコーポレーテッド	ピリミジン−４−オン化合物、組成物、および方法
WO2005046588A2 (en) *	2003-11-07	2005-05-26	Cytokinetics, Inc.	Compounds, compositions, and methods
EP1692112A4 (en) *	2003-12-08	2008-09-24	Cytokinetics Inc	COMPOUNDS, COMPOSITIONS, AND METHODS
CN101801937A (zh) *	2007-06-22	2010-08-11	艾科尔公司	喹唑啉酮化合物及其使用方法
US8940742B2 (en)	2012-04-10	2015-01-27	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
EP3964507A1 (en)	2013-10-04	2022-03-09	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
WO2015051241A1 (en)	2013-10-04	2015-04-09	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
CN106456628A (zh)	2014-03-19	2017-02-22	无限药品股份有限公司	用于治疗PI3K‑γ介导的障碍的杂环化合物
WO2016054491A1 (en)	2014-10-03	2016-04-07	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
CN114230571B (zh)	2015-09-14	2025-07-08	无限药品股份有限公司	异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
WO2017161116A1 (en)	2016-03-17	2017-09-21	Infinity Pharmaceuticals, Inc.	Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
US10919914B2 (en)	2016-06-08	2021-02-16	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0031237B1 (en) *	1979-12-19	1984-10-17	National Research Development Corporation	Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
GB8513754D0 (en) *	1985-05-31	1985-07-03	Jones T R	Anti-cancer quinazoline derivatives
GB8607683D0 (en) *	1986-03-27	1986-04-30	Ici Plc	Anti-tumor agents

1987
- 1987-03-25 GB GB878707053A patent/GB8707053D0/en active Pending
1988
- 1988-03-10 IL IL85696A patent/IL85696A/xx not_active IP Right Cessation
- 1988-03-14 GB GB8805982A patent/GB2202847B/en not_active Expired - Lifetime
- 1988-03-16 ZA ZA881885A patent/ZA881885B/xx unknown
- 1988-03-18 AU AU13279/88A patent/AU600105B2/en not_active Ceased
- 1988-03-21 FI FI881340A patent/FI881340A7/fi not_active IP Right Cessation
- 1988-03-22 AT AT88302486T patent/ATE98956T1/de not_active IP Right Cessation
- 1988-03-22 DE DE88302486T patent/DE3886435T2/de not_active Expired - Fee Related
- 1988-03-22 ES ES88302486T patent/ES2061641T3/es not_active Expired - Lifetime
- 1988-03-22 EP EP88302486A patent/EP0284338B1/en not_active Expired - Lifetime
- 1988-03-24 PT PT87074A patent/PT87074B/pt active IP Right Grant
- 1988-03-24 NO NO881300A patent/NO881300L/no unknown
- 1988-03-24 CA CA000562300A patent/CA1301756C/en not_active Expired - Lifetime
- 1988-03-24 NZ NZ224010A patent/NZ224010A/en unknown
- 1988-03-25 DK DK168488A patent/DK167013B1/da not_active IP Right Cessation
- 1988-03-25 JP JP63069943A patent/JP2577036B2/ja not_active Expired - Fee Related
1990
- 1990-04-12 US US07/508,528 patent/US4981856A/en not_active Expired - Lifetime
1993
- 1993-12-23 GR GR920402608T patent/GR3010208T3/el unknown

Also Published As

Publication number	Publication date
FI881340A7 (fi)	1988-09-26
JP2577036B2 (ja)	1997-01-29
NO881300D0 (no)	1988-03-24
DE3886435D1 (de)	1994-02-03
EP0284338B1 (en)	1993-12-22
GB8707053D0 (en)	1987-04-29
NZ224010A (en)	1990-12-21
NO881300L (no)	1988-09-26
FI881340A0 (fi)	1988-03-21
ATE98956T1 (de)	1994-01-15
CA1301756C (en)	1992-05-26
PT87074A (pt)	1988-04-01
JPS63255270A (ja)	1988-10-21
DK168488A (da)	1988-09-26
GB2202847B (en)	1990-06-06
EP0284338A2 (en)	1988-09-28
EP0284338A3 (en)	1989-05-17
AU1327988A (en)	1988-09-29
ES2061641T3 (es)	1994-12-16
GR3010208T3 (da)	1994-03-31
US4981856A (en)	1991-01-01
ZA881885B (en)	1988-09-26
GB8805982D0 (en)	1988-04-13
DK167013B1 (da)	1993-08-16
DK168488D0 (da)	1988-03-25
AU600105B2 (en)	1990-08-02
GB2202847A (en)	1988-10-05
DE3886435T2 (de)	1994-04-14
PT87074B (pt)	1992-07-31

Legal Events

Date	Code	Title	Description
1999-03-12	RH	Patent void

Publication	Publication Date	Title
GB2202847B (en)	1990-06-06	Anti-tumour agents
IE870699L (en)	1987-09-27	Quinazoline derivatives
TW223635B (da)	1994-05-11
SG47986A1 (en)	1998-04-17	A pharmaceutical solution
EP0680988A3 (en)	1996-05-22	Carbamic acid ester derivatives and coating compositions containing them.
IL100289A0 (en)	1992-09-06	N-iodopropargyloxycarbonyl amino acid esters and derivatives,their preparation and their use as antimicrobial agents
ES8402581A1 (es)	1984-02-01	Un procedimiento para preparar derivados de imidazol y triazol.
GB8617780D0 (en)	1986-08-28	Fungicides
AU555944B2 (en)	1986-10-16	Phosphorus derivatives of carbamimidothioic esters
DE3573775D1 (en)	1989-11-23	Diphenyl ether herbicides
IL80821A0 (en)	1987-03-31	Herbicidal compositions containing halophenylalkyl biurets,certain such novel compounds and their preparation