IL85746A - Preparations comprising t-lymphocyte cells treated with 8-methoxypsoralen or cell membranes separated therefrom for preventing or treating autoimmune diseases - Google Patents
Preparations comprising t-lymphocyte cells treated with 8-methoxypsoralen or cell membranes separated therefrom for preventing or treating autoimmune diseasesInfo
- Publication number
- IL85746A IL85746A IL8574688A IL8574688A IL85746A IL 85746 A IL85746 A IL 85746A IL 8574688 A IL8574688 A IL 8574688A IL 8574688 A IL8574688 A IL 8574688A IL 85746 A IL85746 A IL 85746A
- Authority
- IL
- Israel
- Prior art keywords
- cells
- lymphocyte cells
- treated
- autoimmune disease
- preparation
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title claims abstract description 44
- 208000023275 Autoimmune disease Diseases 0.000 title claims abstract description 26
- BUNGCZLFHHXKBX-UHFFFAOYSA-N 8-methoxypsoralen Natural products C1=CC(=O)OC2=C1C=C1CCOC1=C2OC BUNGCZLFHHXKBX-UHFFFAOYSA-N 0.000 title claims abstract description 19
- QXKHYNVANLEOEG-UHFFFAOYSA-N Methoxsalen Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OC QXKHYNVANLEOEG-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 229960004469 methoxsalen Drugs 0.000 title claims abstract description 19
- SQBBOVROCFXYBN-UHFFFAOYSA-N methoxypsoralen Natural products C1=C2OC(=O)C(OC)=CC2=CC2=C1OC=C2 SQBBOVROCFXYBN-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 210000000170 cell membrane Anatomy 0.000 title claims description 7
- 210000004027 cell Anatomy 0.000 claims abstract description 33
- 239000012528 membrane Substances 0.000 claims abstract description 28
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 10
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 claims abstract description 10
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 3
- 238000004132 cross linking Methods 0.000 claims description 6
- 230000002186 photoactivation Effects 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 4
- 239000003226 mitogen Substances 0.000 claims description 4
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims description 3
- 206010012601 diabetes mellitus Diseases 0.000 claims description 3
- 201000006417 multiple sclerosis Diseases 0.000 claims description 3
- 206010028417 myasthenia gravis Diseases 0.000 claims description 3
- 206010043778 thyroiditis Diseases 0.000 claims description 3
- 206010022941 Iridocyclitis Diseases 0.000 claims description 2
- 201000004612 anterior uveitis Diseases 0.000 claims description 2
- 239000008188 pellet Substances 0.000 claims description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000003855 cell nucleus Anatomy 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 238000005199 ultracentrifugation Methods 0.000 claims 1
- 238000011534 incubation Methods 0.000 abstract description 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 241000700159 Rattus Species 0.000 description 17
- 201000002491 encephalomyelitis Diseases 0.000 description 8
- 238000011282 treatment Methods 0.000 description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 238000002255 vaccination Methods 0.000 description 5
- 229960005486 vaccine Drugs 0.000 description 5
- 208000009386 Experimental Arthritis Diseases 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 201000004681 Psoriasis Diseases 0.000 description 3
- 238000007912 intraperitoneal administration Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- 206010033799 Paralysis Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 206010003246 arthritis Diseases 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000005281 excited state Effects 0.000 description 2
- 238000011694 lewis rat Methods 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 description 1
- 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 102000047918 Myelin Basic Human genes 0.000 description 1
- 101710107068 Myelin basic protein Proteins 0.000 description 1
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 1
- 230000037338 UVA radiation Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002502 anti-myelin effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 229940030156 cell vaccine Drugs 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 208000012997 experimental autoimmune encephalomyelitis Diseases 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000001459 mortal effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000012134 supernatant fraction Substances 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL8574688A IL85746A (en) | 1988-03-15 | 1988-03-15 | Preparations comprising t-lymphocyte cells treated with 8-methoxypsoralen or cell membranes separated therefrom for preventing or treating autoimmune diseases |
| US07/323,705 US5114721A (en) | 1988-03-15 | 1989-03-15 | Preparation of t-cell and t-cell membrane for use in prevention and treatment of autoimmune diseases |
| EP89420092A EP0333606B1 (de) | 1988-03-15 | 1989-03-15 | Herstellung von T-Zellen und T-Zellmembranen, verwendbar zur Verhütung und Behandlung von Autoimmunkrankheiten |
| AT89420092T ATE106740T1 (de) | 1988-03-15 | 1989-03-15 | Herstellung von t-zellen und t-zellmembranen, verwendbar zur verhütung und behandlung von autoimmunkrankheiten. |
| DE68915834T DE68915834T2 (de) | 1988-03-15 | 1989-03-15 | Herstellung von T-Zellen und T-Zellmembranen, verwendbar zur Verhütung und Behandlung von Autoimmunkrankheiten. |
| CA000593746A CA1328601C (en) | 1988-03-15 | 1989-03-15 | Preparation of t-cell and t-cell membrane for use in autoimmune diseases |
| JP1064919A JPH029822A (ja) | 1988-03-15 | 1989-03-15 | 自己免疫疾患の予防と治療とに用いるｔ―細胞とｔ―細胞膜との調製 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL8574688A IL85746A (en) | 1988-03-15 | 1988-03-15 | Preparations comprising t-lymphocyte cells treated with 8-methoxypsoralen or cell membranes separated therefrom for preventing or treating autoimmune diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL85746A0 IL85746A0 (en) | 1988-08-31 |
| IL85746A true IL85746A (en) | 1994-05-30 |
Family
ID=11058666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL8574688A IL85746A (en) | 1988-03-15 | 1988-03-15 | Preparations comprising t-lymphocyte cells treated with 8-methoxypsoralen or cell membranes separated therefrom for preventing or treating autoimmune diseases |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5114721A (de) |
| EP (1) | EP0333606B1 (de) |
| JP (1) | JPH029822A (de) |
| AT (1) | ATE106740T1 (de) |
| CA (1) | CA1328601C (de) |
| DE (1) | DE68915834T2 (de) |
| IL (1) | IL85746A (de) |
Families Citing this family (127)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0615758B1 (de) * | 1988-05-24 | 1999-09-22 | Yeda Research And Development Co. Ltd. | Antitumor Impfstoff |
| IL89431A0 (en) * | 1989-02-27 | 1989-09-10 | Yeda Res & Dev | Pharmaceutical compositions for the treatment of autoimmune diseases |
| US5780034A (en) * | 1989-03-14 | 1998-07-14 | Yeda Research And Development Co. Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus using heat shock protein determinents |
| US5114844A (en) * | 1989-03-14 | 1992-05-19 | Yeda Research And Development Co., Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
| US5578303A (en) * | 1989-03-14 | 1996-11-26 | Yeda Research And Development Co. Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
| US5612035A (en) * | 1989-03-21 | 1997-03-18 | The Immune Response Corporation | Vaccination against diseases resulting from pathogenic responses by specific T cell populations |
| US5614192A (en) * | 1989-07-19 | 1997-03-25 | Connective Therapeutics, Inc. | T cell receptor peptides as therapeutics for immune-related disease |
| IL99589A0 (en) * | 1990-10-03 | 1992-08-18 | Yeda Res & Dev | T cell vaccination for prevention and treatment of allergy or graft rejection |
| US5719064A (en) * | 1992-08-31 | 1998-02-17 | Oklahoma Medical Research Foundation | Peptide diagnostics and therapeutics for spondyloarthropathies |
| US5651993A (en) * | 1992-11-18 | 1997-07-29 | Yale University | Specific immune system modulation |
| US5354774A (en) * | 1992-12-24 | 1994-10-11 | Yale University | Inhibition of smooth muscle cell proliferation by 8-methoxypsoralen photoactivated by visible light |
| US5462733A (en) * | 1993-02-04 | 1995-10-31 | Yale University | Immune system modulation using psoralens activated with visible light |
| US5674487A (en) * | 1994-09-28 | 1997-10-07 | Univ Jefferson | Method for treating autoimmune diseases |
| US5723503A (en) * | 1994-09-28 | 1998-03-03 | Thomas Jefferson University | Biological treatment for rheumatoid arthritis |
| US6033661A (en) * | 1995-06-07 | 2000-03-07 | Thomas Jefferson University | Composition and method for allogenetic mononuclear cell immunotherapy |
| US5843462A (en) | 1995-11-30 | 1998-12-01 | Regents Of The University Of Minnesota | Diphtheria toxin epitopes |
| JP2000508628A (ja) * | 1996-03-22 | 2000-07-11 | エール・ユニバーシティ | 対象体内で免疫応答を誘導する方法 |
| DE19740357A1 (de) * | 1997-09-13 | 1999-03-18 | Martin Wilhelm | Phosphoryliertes Zuckermolekül |
| EP1037663A2 (de) | 1997-12-16 | 2000-09-27 | Regents Of The University Of Minnesota | Verfahren zur behandlung unerwünschter immunantworten |
| US20020072493A1 (en) * | 1998-05-19 | 2002-06-13 | Yeda Research And Development Co. Ltd. | Activated T cells, nervous system-specific antigens and their uses |
| IL140888A0 (en) * | 2001-01-14 | 2002-02-10 | Yeda Res & Dev | Pharmaceutical compositions comprising peptides for immune neuroprotection |
| US7109031B2 (en) * | 1999-04-20 | 2006-09-19 | Yale University | Methods for inducing the differentiation of monocytes into functional dendritic cells and immunotherapeutic compositions including such dendritic cells |
| US20050084966A1 (en) * | 1999-04-20 | 2005-04-21 | Edelson Richard L. | Methods for inducing the differentiation of blood monocytes into functional dendritic cells |
| EP1176986B1 (de) | 1999-04-20 | 2018-07-04 | Yale University | Differenzierung von monozyten in funktionale dentritische zellen |
| US20080241815A1 (en) * | 1999-04-20 | 2008-10-02 | Edelson Richard L | Methods for Inducing the Differentiation of Blood Monocytes into Functional Dendritic Cells |
| US20050158856A1 (en) * | 1999-04-20 | 2005-07-21 | Edelson Richard L. | Methods for producing functional antigen presenting dendritic cells using biodegradable microparticles for delivery of antigenic materials |
| AU2001259142C1 (en) * | 2000-04-25 | 2006-11-23 | Biogen Idec Inc. | Intrathecal administration of rituximab for treatment of central nervous system lymphomas |
| JP2004512262A (ja) | 2000-06-20 | 2004-04-22 | アイデック ファーマスーティカルズ コーポレイション | 非放射性抗ｃｄ２０抗体／放射標識抗ｃｄ２２抗体の組合せ |
| KR20080087184A (ko) | 2001-01-31 | 2008-09-30 | 바이오겐 아이덱 인크. | 종양질환 치료를 위한 ｃｄ23 길항제의 용도 |
| US20020159996A1 (en) | 2001-01-31 | 2002-10-31 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
| TWI335821B (en) | 2002-12-16 | 2011-01-11 | Genentech Inc | Immunoglobulin variants and uses thereof |
| EP1613350B1 (de) | 2003-04-09 | 2009-03-18 | Genentech, Inc. | Behandlung von autoimmunkrankheit bei einem patienten mit unzureichendem ansprechen auf einen tnf-alpha-hemmer |
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| AU2005247303A1 (en) * | 2004-04-16 | 2005-12-08 | Genentech, Inc. | Treatment of polychondritis and mononeuritis multiplex with anti-CD20 antibodies |
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| US20060134111A1 (en) * | 2004-12-17 | 2006-06-22 | Genentech, Inc. | Antiangiogenesis therapy of autoimmune disease in patients who have failed prior therapy |
| HUE025945T2 (en) | 2005-02-15 | 2016-07-28 | Univ Duke | Anti-CD19 antibodies and their applications in oncology |
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| ZA200707490B (en) | 2005-03-10 | 2008-12-31 | Genentech Inc | Methods and compositions for modulatiing vascular integrity |
| EP1885755A4 (de) | 2005-05-05 | 2009-07-29 | Univ Duke | Cd19-antikörper-therapie für autoimmunerkrankungen |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| EP1999148B8 (de) | 2006-03-06 | 2014-03-05 | Medlmmune, LLC | Humanisierte anti-cd22-antikörper und ihre verwendung für die behandlung von krebs, transplantationen und autoimmunerkrankungen |
| AU2008247382B2 (en) | 2007-05-07 | 2014-06-05 | Medimmune, Llc | Anti-ICOS antibodies and their use in treatment of oncology, transplantation and autoimmune disease |
| EP2200611A4 (de) | 2007-09-14 | 2010-09-22 | Biogen Idec Inc | Zusammensetzungen und verfahren zur behandlung von progressiver multifokaler leukoenzephalopathie (pml) |
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| KR101361905B1 (ko) | 2008-05-16 | 2014-02-21 | 제넨테크, 인크. | 베타7 인테그린 길항제를 이용한 위장관 염증 장애의 치료를 평가하기 위한 바이오마커의 용도 |
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| JP5933975B2 (ja) | 2008-11-12 | 2016-06-15 | メディミューン，エルエルシー | 抗体製剤 |
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| CA2756244A1 (en) | 2009-04-02 | 2010-10-07 | Roche Glycart Ag | Multispecific antibodies comprising full length antibodies and single chain fab fragments |
| NZ597531A (en) | 2009-07-31 | 2014-05-30 | Genentech Inc | Inhibition of tumor metastasis using bv8- or g-csf-antagonists |
| EP2478013B1 (de) | 2009-09-16 | 2018-10-24 | F.Hoffmann-La Roche Ag | Coiled-coil- und/oder tether-haltige proteinkomplexe und verwendungen davon |
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|---|---|---|---|---|
| US4612007A (en) * | 1981-06-16 | 1986-09-16 | Edelson Richard Leslie | Method and system for externally treating the blood |
| US4684521A (en) * | 1982-12-08 | 1987-08-04 | Frederic A. Bourke, Jr. | Method and system for externally treating the blood |
| IL69686A (en) * | 1983-09-11 | 1988-03-31 | Yeda Res & Dev | Compositions containing cell membrane proteins and process for their preparation |
| CA1320907C (en) * | 1986-09-23 | 1993-08-03 | Irun Robert Cohen | Cell membrane proteins, compositions containing them and procedure for their preparation |
| US4999375A (en) * | 1989-04-11 | 1991-03-12 | Hoffmann-La Roche Inc. | Psoralen reagent compositions for extracorporeal treatment of blood |
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1988
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- 1989-03-15 AT AT89420092T patent/ATE106740T1/de not_active IP Right Cessation
- 1989-03-15 DE DE68915834T patent/DE68915834T2/de not_active Expired - Fee Related
- 1989-03-15 US US07/323,705 patent/US5114721A/en not_active Expired - Fee Related
- 1989-03-15 EP EP89420092A patent/EP0333606B1/de not_active Expired - Lifetime
- 1989-03-15 JP JP1064919A patent/JPH029822A/ja active Pending
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| JPH029822A (ja) | 1990-01-12 |
| ATE106740T1 (de) | 1994-06-15 |
| IL85746A0 (en) | 1988-08-31 |
| DE68915834T2 (de) | 1994-11-24 |
| CA1328601C (en) | 1994-04-19 |
| US5114721A (en) | 1992-05-19 |
| EP0333606A2 (de) | 1989-09-20 |
| DE68915834D1 (de) | 1994-07-14 |
| EP0333606B1 (de) | 1994-06-08 |
| EP0333606A3 (en) | 1990-05-30 |
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