IL86736A - Process for the preparation of indolinones and some intermediates thereof - Google Patents

Process for the preparation of indolinones and some intermediates thereof

Info

Publication number: IL86736A
Authority: IL; Israel
Prior art keywords: indolinones; intermediates; preparation; chem; equivalents
Prior art date: 1987-06-19

Application number

IL86736A

Other languages

English (en)

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-19

Filing date

1988-06-14

Publication date

1992-03-29

1988-06-14 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1992-03-29 Publication of IL86736A publication Critical patent/IL86736A/xx

Links

JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 abstract 2
229910021578 Iron(III) chloride Inorganic materials 0.000 abstract 1
-1 acetyl halide Chemical class 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000002829 reductive effect Effects 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/08—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms
- C07C205/09—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/85—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to a chemical modification

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Polyesters Or Polycarbonates (AREA)
Heat Sensitive Colour Forming Recording (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Glass Compositions (AREA)
Iron Core Of Rotating Electric Machines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)

IL86736A 1987-06-19 1988-06-14 Process for the preparation of indolinones and some intermediates thereof IL86736A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878714371A GB8714371D0 (en)	1987-06-19	1987-06-19	Process

Publications (1)

Publication Number	Publication Date
IL86736A true IL86736A (en)	1992-03-29

Family

ID=10619198

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL86736A IL86736A (en)	1987-06-19	1988-06-14	Process for the preparation of indolinones and some intermediates thereof

Country Status (25)

Country	Link
US (1)	US4997954A (de)
EP (1)	EP0300614B1 (de)
JP (1)	JPH07596B2 (de)
KR (1)	KR0143088B1 (de)
CN (1)	CN1019296B (de)
AT (1)	ATE93521T1 (de)
AU (1)	AU600582B2 (de)
CA (1)	CA1326035C (de)
CY (1)	CY1951A (de)
DE (1)	DE3883456T2 (de)
DK (1)	DK169965B1 (de)
EG (1)	EG18412A (de)
ES (1)	ES2058285T3 (de)
FI (1)	FI89264C (de)
GB (1)	GB8714371D0 (de)
HK (1)	HK1003226A1 (de)
HU (4)	HUT55360A (de)
IE (1)	IE62830B1 (de)
IL (1)	IL86736A (de)
MY (1)	MY103583A (de)
NO (1)	NO172577C (de)
NZ (1)	NZ225072A (de)
PH (1)	PH24608A (de)
PT (1)	PT87770B (de)
ZA (1)	ZA884334B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9008605D0 (en) *	1990-04-17	1990-06-13	Smith Kline French Lab	Process
MX9304801A (es) *	1992-08-06	1997-06-28	Warner Lambert Co	2-toindoles (selenoidoles) disulfuros (seleniduros) relacinados, los cuales inhiben a las proteinas tirosina cinasas y los cuales tienen propiedades anti-tumorales.
US5278162A (en) *	1992-09-18	1994-01-11	The Du Pont Merck Pharmaceutical Company	3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man
GB9300309D0 (en) *	1993-01-08	1993-03-03	Smithkline Beecham Plc	Process
US6218421B1 (en) *	1999-07-01	2001-04-17	Smithkline Beecham P.L.C.	Method of promoting smoking cessation
AR030557A1 (es)	2000-04-14	2003-08-27	Jagotec Ag	Una tableta en multicapa de liberacion controlada y metodo de tratamiento
WO2002048104A1 (en) *	2000-12-14	2002-06-20	Nissan Chemical Industries, Ltd.	Method for producing indole derivative
WO2005074387A2 (en) *	2003-12-30	2005-08-18	Sun Pharmaceutical Industries Limited	Novel crystal forms of 4-[2-di-n-propylamino)ethyl]-2 (3h)- indolone hydrochloride
US7378439B2 (en) *	2004-01-20	2008-05-27	Usv, Ltd.	Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride
WO2005105741A1 (en) *	2004-02-11	2005-11-10	Sun Pharmaceutical Industries Limited	Substantially pure 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone hydrochloride
EP1568689A1 (de) *	2004-02-19	2005-08-31	Helm AG	Verfahren zur Herstellung der 2-oxoindol-Derivat, Ropinirole
WO2005080333A1 (en) *	2004-02-19	2005-09-01	Torrent Pharmaceuticals Ltd	Process for purification of ropinirole
CA2563063C (en) *	2004-04-27	2014-06-03	Wyeth	Purification of progesterone receptor modulators
BRPI0709184A2 (pt)	2006-03-29	2011-06-28	Alembic Ltd	processo para a purificação de cloridrato de ropinirol
US20070254941A1 (en) *	2006-04-21	2007-11-01	Glenmark Pharmaceuticals Limited	Subtantially pure ropinirole hydrochloride, polymorphic form of ropinirole and process for their preparation
CN100457732C (zh) *	2006-05-25	2009-02-04	药源药物化学（上海）有限公司	罗匹尼罗的制备方法
US20110195117A1 (en) *	2008-09-01	2011-08-11	Lupin Limited	Controlled release compositions of ropinirole
EP2438917B1 (de) *	2009-05-21	2014-09-03	Hisamitsu Pharmaceutical Co., Inc.	Transdermales präparat
US10961194B2 (en)	2017-06-16	2021-03-30	Zhejiang Huahai Licheng Pharmaceutical Co., Ltd.	Method for purifying ropinirole hydrochloride

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4588740A (en) *	1982-12-07	1986-05-13	Smithkline Beckman Corporation	Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones
US4452808A (en) *	1982-12-07	1984-06-05	Smithkline Beckman Corporation	4-Aminoalkyl-2(3H)-indolones
US4761485A (en) *	1987-03-11	1988-08-02	Pfizer Inc.	Synthetic method for indol-2(3H)-ones

1987
- 1987-06-19 GB GB878714371A patent/GB8714371D0/en active Pending
1988
- 1988-06-13 NO NO882588A patent/NO172577C/no not_active IP Right Cessation
- 1988-06-13 CA CA000569292A patent/CA1326035C/en not_active Expired - Lifetime
- 1988-06-13 PH PH37063A patent/PH24608A/en unknown
- 1988-06-14 IL IL86736A patent/IL86736A/xx not_active IP Right Cessation
- 1988-06-15 US US07/207,351 patent/US4997954A/en not_active Expired - Lifetime
- 1988-06-16 EP EP88305510A patent/EP0300614B1/de not_active Expired - Lifetime
- 1988-06-16 ES ES88305510T patent/ES2058285T3/es not_active Expired - Lifetime
- 1988-06-16 CN CN88103732A patent/CN1019296B/zh not_active Expired
- 1988-06-16 AT AT88305510T patent/ATE93521T1/de not_active IP Right Cessation
- 1988-06-16 DE DE88305510T patent/DE3883456T2/de not_active Expired - Lifetime
- 1988-06-17 ZA ZA884334A patent/ZA884334B/xx unknown
- 1988-06-17 NZ NZ225072A patent/NZ225072A/xx unknown
- 1988-06-17 KR KR1019880007283A patent/KR0143088B1/ko not_active Expired - Lifetime
- 1988-06-17 DK DK334788A patent/DK169965B1/da not_active IP Right Cessation
- 1988-06-17 JP JP63151067A patent/JPH07596B2/ja not_active Expired - Lifetime
- 1988-06-17 MY MYPI88000674A patent/MY103583A/en unknown
- 1988-06-17 HU HU906948A patent/HUT55360A/hu unknown
- 1988-06-17 IE IE183788A patent/IE62830B1/en not_active IP Right Cessation
- 1988-06-17 HU HU883123A patent/HU202200B/hu unknown
- 1988-06-17 FI FI882919A patent/FI89264C/fi active IP Right Grant
- 1988-06-17 HU HU893988A patent/HU203723B/hu not_active IP Right Cessation
- 1988-06-17 AU AU18119/88A patent/AU600582B2/en not_active Expired
- 1988-06-17 PT PT87770A patent/PT87770B/pt not_active IP Right Cessation
- 1988-06-17 HU HU911599A patent/HU205339B/hu not_active IP Right Cessation
- 1988-06-19 EG EG342/88A patent/EG18412A/xx active
1997
- 1997-05-16 CY CY195197A patent/CY1951A/xx unknown
1998
- 1998-03-19 HK HK98102343A patent/HK1003226A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
GB8714371D0 (en)	1987-07-22
DE3883456D1 (de)	1993-09-30
ES2058285T3 (es)	1994-11-01
ZA884334B (en)	1990-04-25
MY103583A (en)	1993-08-28
DK334788A (da)	1988-12-20
FI882919A0 (fi)	1988-06-17
DK169965B1 (da)	1995-04-18
ATE93521T1 (de)	1993-09-15
CN1019296B (zh)	1992-12-02
NO882588D0 (no)	1988-06-13
FI882919L (fi)	1988-12-20
EG18412A (en)	1992-12-30
NO882588L (no)	1988-12-20
KR890000421A (ko)	1989-03-14
JPS6419065A (en)	1989-01-23
AU600582B2 (en)	1990-08-16
FI89264B (fi)	1993-05-31
HUT52043A (en)	1990-06-28
HU202200B (en)	1991-02-28
HUT55360A (en)	1991-05-28
PT87770B (pt)	1992-10-30
AU1811988A (en)	1988-12-22
HU205339B (en)	1992-04-28
CN1030076A (zh)	1989-01-04
NO172577C (no)	1993-08-11
IE881837L (en)	1988-12-19
NO172577B (no)	1993-05-03
JPH07596B2 (ja)	1995-01-11
HUT48583A (en)	1989-06-28
PT87770A (pt)	1989-05-31
CA1326035C (en)	1994-01-11
PH24608A (en)	1990-08-17
FI89264C (fi)	1993-09-10
HU911599D0 (en)	1991-11-28
HU203723B (en)	1991-09-30
EP0300614B1 (de)	1993-08-25
DE3883456T2 (de)	1994-03-17
NZ225072A (en)	1990-05-28
DK334788D0 (da)	1988-06-17
HK1003226A1 (en)	1998-10-16
CY1951A (en)	1997-05-16
EP0300614A1 (de)	1989-01-25
KR0143088B1 (ko)	1998-07-15
US4997954A (en)	1991-03-05
IE62830B1 (en)	1995-03-08

Legal Events

Date	Code	Title
1998-12-27	KB	Patent renewed
2002-07-25	KB	Patent renewed
2008-12-29	EXP	Patent expired

Publication	Publication Date	Title
NZ225072A (en)	1990-05-28	Preparation of substituted indolinone derivatives and intermediates therefor
ES2188661T3 (es)	2003-07-01	Preparacion de un derivado de camptothecin por ciclacion intramolecular.
CA1262357A (en)	1989-10-17	N-HYDROXYL PROTECTIVE GROUPS AND METHOD FOR THE PREPARATION OF 3-ACYLAMINO-1-HYDROXY-2-AZETIDINONES
EP0638575A3 (de)	1995-05-24	Verfahren zur Herstellung von Diorganodialkoxysilanen.
CA1273957C (de)	1990-09-11
PT85850A (en)	1987-11-01	Process for preparing 7-((meta-substituted) phenylglycine)-1-carba-1-dethiacephalosporins
FI873443A7 (fi)	1987-08-07	Norfloxacinmellanprodukt.
HUT34478A (en)	1985-03-28	Process for producing hexahydro-pyrrolo/2.1-a/isoquinoline derivatives and pharmaceutical compositions containing them
PT100272A (pt)	1993-08-31	Novo complexo de platina(ii) e processo para a sua preparacao
PL244610A1 (en)	1985-07-16	Process for preparing novel derivatives of benzazepine
ZA924888B (en)	1993-04-28	Process for the synthesis of enantiomers of 3-aminochroman compounds
DE3465737D1 (en)	1987-10-08	Process for the preparation of 4-quinolinones
DE3462035D1 (en)	1987-02-19	Process for the preparation of 4-quinolinones
HUT41776A (en)	1987-05-28	Process for producing ergolinyl- thiourea derivatives