IL87332A - Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology, process, expression vector and recombinant host therefor and pharmaceutical compositions containing them - Google Patents

Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology, process, expression vector and recombinant host therefor and pharmaceutical compositions containing them

Info

Publication number: IL87332A
Authority: IL; Israel
Prior art keywords: variants; dna technology; trypsin inhibitor; pharmaceutical compositions; expression vector
Prior art date: 1987-08-07

Application number

IL87332A

Other languages

English (en)

Other versions

IL87332A0 (en

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-07

Filing date

1988-08-04

Publication date

1993-01-14

1988-08-04 Application filed by Bayer Ag filed Critical Bayer Ag

1989-01-31 Publication of IL87332A0 publication Critical patent/IL87332A0/xx

1993-01-14 Publication of IL87332A publication Critical patent/IL87332A/xx

Links

108010039627 Aprotinin Proteins 0.000 title abstract 2
108020004511 Recombinant DNA Proteins 0.000 title abstract 2
239000013604 expression vector Substances 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
150000001413 amino acids Chemical class 0.000 abstract 2
241000283690 Bos taurus Species 0.000 abstract 1
229940122618 Trypsin inhibitor Drugs 0.000 abstract 1
101710162629 Trypsin inhibitor Proteins 0.000 abstract 1
229960004405 aprotinin Drugs 0.000 abstract 1
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
239000002753 trypsin inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL87332A 1987-08-07 1988-08-04 Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology, process, expression vector and recombinant host therefor and pharmaceutical compositions containing them IL87332A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8718777A GB2208511A (en)	1987-08-07	1987-08-07	Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology

Publications (2)

Publication Number	Publication Date
IL87332A0 IL87332A0 (en)	1989-01-31
IL87332A true IL87332A (en)	1993-01-14

Family

ID=10621986

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL87332A IL87332A (en)	1987-08-07	1988-08-04	Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology, process, expression vector and recombinant host therefor and pharmaceutical compositions containing them

Country Status (11)

Country	Link
US (2)	US5118668A (ja)
EP (1)	EP0307592B1 (ja)
JP (1)	JP2894354B2 (ja)
KR (1)	KR890003802A (ja)
AT (1)	ATE173478T1 (ja)
AU (1)	AU604953B2 (ja)
DE (1)	DE3856265D1 (ja)
ES (1)	ES2124685T3 (ja)
GB (1)	GB2208511A (ja)
IL (1)	IL87332A (ja)
ZA (1)	ZA885764B (ja)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
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US5223482A (en) *	1986-11-17	1993-06-29	Scios Nova Inc.	Recombinant Alzheimer's protease inhibitory amyloid protein and method of use
GB2208511A (en) *	1987-08-07	1989-04-05	Bayer Ag	Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
US5591603A (en) *	1987-08-28	1997-01-07	Novo Nordisk A/S	Process for preparing aprotinin and aprotinin analogs in yeast cells
DK225488D0 (da) *	1988-04-26	1988-04-26	Novo Industri As	Polypeptid
US5223409A (en)	1988-09-02	1993-06-29	Protein Engineering Corp.	Directed evolution of novel binding proteins
US20060134087A1 (en) *	1988-09-02	2006-06-22	Dyax Corp.	ITI-D1 Kunitz domain mutants as hNE inhibitors
WO1992015605A2 (en) *	1991-03-01	1992-09-17	Protein Engineering Corporation	Inhibitors of human neutrophil elastase and human cathepsin g
US7078383B2 (en) *	1988-09-02	2006-07-18	Dyax Corp.	ITI-D1 Kunitz domain mutants as HNE inhibitors
US5866413A (en) *	1989-03-06	1999-02-02	Board Of Regents Of The University Of Texas System	Pai-1 mutants
DK0462207T3 (da) *	1989-03-06	2001-06-18	Univ Texas	t-Pa mutanter resistente mod deres respektive inhibitorer
US7413537B2 (en)	1989-09-01	2008-08-19	Dyax Corp.	Directed evolution of disulfide-bonded micro-proteins
DE3930522A1 (de) *	1989-09-13	1991-03-21	Bayer Ag	Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
US5231010A (en) *	1989-09-13	1993-07-27	Bayer Aktiengesellschaft	Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
DE69233769D1 (de)	1991-03-01	2009-09-24	Dyax Corp	Chimäres Protein mit Mikroprotein mit zwei oder mehr Disulfidbindungen und Ausgestaltungen davon
US20030223977A1 (en) *	1991-03-01	2003-12-04	Ley Arthur Charles	Kunitz domain mutants as cathepsin G inhibitors
JPH07509229A (ja) *	1992-07-13	1995-10-12	コルバス・インターナショナル、インコーポレイテッド	ウシ膵トリプシン阻害因子から誘導される因子Ｘａの阻害因子
JPH08504568A (ja) *	1992-09-25	1996-05-21	コルバス・インターナショナル、インコーポレイテッド	ウシ膵トリプシン阻害因子から誘導される因子ＶＩＩａ−組織因子複合体の阻害因子
US5650394A (en) *	1993-11-04	1997-07-22	Adeza Biomedical	Use of urinastatin-like compounds to prevent premature delivery
US6057287A (en)	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
ATE529444T1 (de) *	1994-01-11	2011-11-15	Dyax Corp	Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
DE4417353A1 (de) *	1994-05-18	1996-01-25	Bayer Ag	Verfahren zur Herstellung von rekombinantem Aprotinin und rekombinanten Aprotinin Varianten mit der natürlichen N-terminlaen Sequenz
US5786328A (en) *	1995-06-05	1998-07-28	Genentech, Inc.	Use of kunitz type plasma kallikrein inhibitors
US5780265A (en) *	1995-06-05	1998-07-14	Genentech, Inc.	Kunitz type plasma kallikrein inhibitors
DE19629982A1 (de) *	1996-07-25	1998-01-29	Bayer Ag	Aprotinin-Varianten mit verbesserten Eigenschaften
DE19725014A1 (de) *	1997-06-13	1998-12-17	Bayer Ag	Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
KR20040004562A (ko) *	2001-03-27	2004-01-13	어웨어, 인크.	수신기 투과성 ｑ-모드
US7153829B2 (en) *	2002-06-07	2006-12-26	Dyax Corp.	Kallikrein-inhibitor therapies
DK2311432T3 (en) *	2002-06-07	2015-02-02	Dyax Corp	Modified Kunitz domain polypeptides and their use in reducing ischemia or the onset of a systemic inflammatory response associated with a surgical procedure
TR201900937T4 (tr) *	2002-08-28	2019-02-21	Dyax Corp	Organların ve dokuların muhafaza edilmesine yönelik yöntem.
CN1747747B (zh) *	2003-01-06	2012-09-05	安吉奥开米公司	作为穿过血脑屏障的载体的抑酶肽及类似物
JP2007524348A (ja) *	2003-01-07	2007-08-30	ダイアックス、コープ	クニッツドメインライブラリー
US6989369B2 (en) *	2003-02-07	2006-01-24	Dyax Corp.	Kunitz domain peptides
US7235530B2 (en) *	2004-09-27	2007-06-26	Dyax Corporation	Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US20060218667A1 (en) *	2004-10-12	2006-09-28	Vojdani Fakhrieh S	Plant-produced recombinant aprotinin and aprotinin variants
DE602005005284T2 (de) *	2004-11-15	2009-04-16	Roche Diagnostics Gmbh	Prion-Assays mit hoher Durchlaufleistung
CN101160403B (zh) *	2005-02-18	2014-08-13	安吉奥开米公司	转运化合物穿过血脑屏障的分子
US20090016959A1 (en) *	2005-02-18	2009-01-15	Richard Beliveau	Delivery of antibodies to the central nervous system
US20060247442A1 (en) *	2005-04-29	2006-11-02	Wyeth	Process for preparing isatins with control of side-product formation
JP5436856B2 (ja) *	2005-07-15	2014-03-05	アンジオケムインコーポレーティッド	薬学的複合体における担体としてのアプロチニンポリペプチドの使用
EP2001500A4 (en) *	2006-03-10	2010-07-28	Dyax Corp	FORMULATIONS FOR ECALLANTIDE
EP2069377A4 (en)	2006-09-27	2009-11-11	Univ California	METHOD AND COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES AND SKIN FUNCTIONAL DISORDERS
WO2008110301A1 (de) *	2007-03-13	2008-09-18	Bayer Schering Pharma Aktiengesellschaft	Aprotinin-varianten mit verbesserten eigenschaften
EP2789628A3 (en)	2007-05-29	2015-03-04	Angiochem Inc.	Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US9365634B2 (en) *	2007-05-29	2016-06-14	Angiochem Inc.	Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
DE102007056231A1 (de)	2007-09-08	2009-03-12	Bayer Healthcare Ag	Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
US8071555B2 (en) *	2007-10-29	2011-12-06	Helix Biomedix Inc.	Protective skin care peptides
RU2518240C2 (ru)	2008-04-18	2014-06-10	Ангиочем Инк.	Композиция, на основе гидрофобных агентов и способ ее получения(варианты)
US8921314B2 (en)	2008-10-15	2014-12-30	Angiochem, Inc.	Conjugates of GLP-1 agonists and uses thereof
RU2531591C2 (ru)	2008-10-15	2014-10-20	Ангиокем Инк.	Конъюгаты этопозида и доксорубицина для доставки лекарственных средств
MX2011005963A (es) *	2008-12-05	2011-09-01	Angiochem Inc	Conjugados de neurotensina o analogos de neurotensina y sus usos.
CN102300987A (zh)	2008-12-17	2011-12-28	安吉奥开米公司	膜型-1基质金属蛋白抑制剂及其用途
US8637454B2 (en) *	2009-01-06	2014-01-28	Dyax Corp.	Treatment of mucositis with kallikrein inhibitors
AU2010239069B2 (en)	2009-04-20	2015-05-14	Angiochem Inc	Treatment of ovarian cancer using an anticancer agent conjugated to an Angiopep-2 analog
MX2012000016A (es)	2009-07-02	2012-03-26	Angiochem Inc	Conjugados de peptidos multimericos y sus usos.
ES2688093T3 (es) *	2010-01-06	2018-10-30	Dyax Corp.	Proteínas de unión a calicreína plasmática
WO2011153642A1 (en) *	2010-06-10	2011-12-15	Angiochem Inc.	Leptin and leptin analog conjugates and fusion proteins and uses thereof
IL269565B2 (en)	2011-01-06	2024-06-01	Dyax Corp	Plasma kallikrein binding proteins
EP3122782A4 (en)	2014-03-27	2017-09-13	Dyax Corp.	Compositions and methods for treatment of diabetic macular edema
US10980892B2 (en)	2015-06-15	2021-04-20	Angiochem Inc.	Methods for the treatment of leptomeningeal carcinomatosis
BR112018011622A2 (pt)	2015-12-11	2018-11-27	Dyax Corp	método para tratar ataque de angioedema hereditário (hae) ou reduzir a taxa de ataque de hae
CN111295196A (zh)	2017-08-31	2020-06-16	加利福尼亚大学董事会	控制皮肤酶活性的分子细菌疗法
CA3167336A1 (en)	2020-01-13	2021-07-22	Takeda Pharmaceutical Company Limited	Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU560584B2 (en) *	1983-07-28	1987-04-09	Bayer Aktiengesellschaft	Homologues of aprotinin
JPH0616716B2 (ja) *	1986-10-14	1994-03-09	塩野義製薬株式会社	酵母におけるヒトｐｓｔｉの製造法
SE8604600L (sv) *	1986-10-29	1988-04-30	Nixflu Ab	Anordning for att kontrollera kontokort
GB2199582A (en) *	1987-01-07	1988-07-13	Bayer Ag	Analogues of pancreatic secretory trypsin inhibitor
US5032573A (en) *	1987-03-23	1991-07-16	Bayer Aktiengesellschaft	Homologs of aprotinin produced from a recombinant host, process, expression vector and recombinant host therefor and pharmaceutical use thereof
DE3724570A1 (de) *	1987-06-27	1989-01-05	Bayer Ag	Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
GB2208511A (en) *	1987-08-07	1989-04-05	Bayer Ag	Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
US5591603A (en) *	1987-08-28	1997-01-07	Novo Nordisk A/S	Process for preparing aprotinin and aprotinin analogs in yeast cells
DK225488D0 (da) *	1988-04-26	1988-04-26	Novo Industri As	Polypeptid
DE3930522A1 (de) *	1989-09-13	1991-03-21	Bayer Ag	Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben

1987
- 1987-08-07 GB GB8718777A patent/GB2208511A/en not_active Withdrawn
1988
- 1988-07-20 US US07/221,835 patent/US5118668A/en not_active Expired - Fee Related
- 1988-07-27 AT AT88112130T patent/ATE173478T1/de not_active IP Right Cessation
- 1988-07-27 EP EP88112130A patent/EP0307592B1/de not_active Expired - Lifetime
- 1988-07-27 ES ES88112130T patent/ES2124685T3/es not_active Expired - Lifetime
- 1988-07-27 DE DE3856265T patent/DE3856265D1/de not_active Expired - Fee Related
- 1988-08-04 IL IL87332A patent/IL87332A/xx not_active IP Right Cessation
- 1988-08-05 ZA ZA885764A patent/ZA885764B/xx unknown
- 1988-08-06 KR KR1019880010059A patent/KR890003802A/ko not_active Ceased
- 1988-08-06 JP JP63195323A patent/JP2894354B2/ja not_active Expired - Fee Related
- 1988-08-08 AU AU20588/88A patent/AU604953B2/en not_active Ceased
1995
- 1995-01-09 US US08/369,987 patent/US5770568A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPH02480A (ja)	1990-01-05
ES2124685T3 (es)	1999-02-16
ZA885764B (en)	1989-04-26
KR890003802A (ko)	1989-04-18
US5770568A (en)	1998-06-23
ATE173478T1 (de)	1998-12-15
GB2208511A (en)	1989-04-05
JP2894354B2 (ja)	1999-05-24
US5118668A (en)	1992-06-02
AU2058888A (en)	1989-04-20
AU604953B2 (en)	1991-01-03
DE3856265D1 (de)	1998-12-24
EP0307592A3 (de)	1990-06-06
IL87332A0 (en)	1989-01-31
EP0307592A2 (de)	1989-03-22
GB8718777D0 (en)	1987-09-16
EP0307592B1 (de)	1998-11-18

Legal Events

Date	Code	Title
1998-12-27	KB	Patent renewed
2002-09-12	KB	Patent renewed
2007-07-24	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL87332A0 (en)	1989-01-31	Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology,process,expression vector and recombinant host therefor and pharmaceutical compositions containing them
IL85020A0 (en)	1988-06-30	Pancreatic secretory trypsin inhibitor and variants thereof,process expression vector and recombinant host therefor and pharmaceutical compositions containing it
PT81837A (en)	1986-02-01	Process for preparing oligopeptides and intermediates therefor
PT85977A (en)	1987-11-01	Process for the preparation of human apolipoprotein ai and their variant forms by recombinant dna methods
DE69233245D1 (de)	2003-12-11	Verfahren zur Herstellung von Peptiden
AU9026691A (en)	1992-06-11	New human recombinant gamma interferon
NZ335633A (en)	2000-10-27	Production of recombinant H. pylori polypeptides for treatment and diagnosis of H. pylori related diseases
HUT75831A (en)	1997-05-28	Non-splicing variants of gp350/220
WO1999002708A8 (en)	1999-04-01	Fusion proteins comprising sequences derived from bovine if1 atpase inhibitor protein
ZA894181B (en)	1990-02-28	Amblyommin,a new active substance for anticoagulant therapy
EP0490383A3 (en)	1993-06-30	Peptides of the hiv-gag protein, their preparation and use
ATE112290T1 (de)	1994-10-15	Peptiden von retinblastoma gen produkten und antikoerper dagegen.
EP0723016A3 (en)	1997-08-20	Leukocyte activation factor
EP0290029A3 (en)	1990-07-18	(19-alanine) calcitonin