IL87582A - Immunoproximi catalysts and the process for their preparation - Google Patents

Immunoproximi catalysts and the process for their preparation

Info

Publication number: IL87582A
Authority: IL; Israel
Prior art keywords: group; hapten; catalytic; substituent; converting
Prior art date: 1987-09-02

Application number

IL8758288A

Other languages

English (en)

Hebrew (he)

Other versions

IL87582A0 (en

Original Assignee

Igen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-02

Filing date

1988-08-28

Publication date

1995-08-31

1988-08-28 Application filed by Igen Inc filed Critical Igen Inc

1989-01-31 Publication of IL87582A0 publication Critical patent/IL87582A0/xx

1995-08-31 Publication of IL87582A publication Critical patent/IL87582A/en

Links

239000003054 catalyst Substances 0.000 title claims abstract description 43
238000000034 method Methods 0.000 title claims abstract description 36
230000008569 process Effects 0.000 title claims abstract description 36
238000004519 manufacturing process Methods 0.000 title claims description 8
238000006243 chemical reaction Methods 0.000 claims abstract description 63
230000003197 catalytic effect Effects 0.000 claims description 70
239000000376 reactant Substances 0.000 claims description 44
125000001424 substituent group Chemical group 0.000 claims description 21
230000027455 binding Effects 0.000 claims description 19
125000005647 linker group Chemical group 0.000 claims description 13
230000028993 immune response Effects 0.000 claims description 10
238000006460 hydrolysis reaction Methods 0.000 claims description 9
230000007062 hydrolysis Effects 0.000 claims description 8
238000006555 catalytic reaction Methods 0.000 claims description 7
230000007704 transition Effects 0.000 claims description 7
241000282326 Felis catus Species 0.000 claims description 5
229910052799 carbon Inorganic materials 0.000 claims description 5
150000001413 amino acids Chemical class 0.000 claims description 4
125000003636 chemical group Chemical group 0.000 claims description 4
230000004048 modification Effects 0.000 claims description 4
238000012986 modification Methods 0.000 claims description 4
229910052757 nitrogen Inorganic materials 0.000 claims description 4
239000002253 acid Substances 0.000 claims description 3
150000001408 amides Chemical group 0.000 claims description 3
238000004132 cross linking Methods 0.000 claims description 3
150000002148 esters Chemical group 0.000 claims description 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
239000003814 drug Substances 0.000 claims description 2
229940079593 drug Drugs 0.000 claims description 2
229910052739 hydrogen Inorganic materials 0.000 claims description 2
239000001257 hydrogen Substances 0.000 claims description 2
230000004936 stimulating effect Effects 0.000 claims description 2
235000000346 sugar Nutrition 0.000 claims description 2
229910052717 sulfur Inorganic materials 0.000 claims description 2
DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 3
150000007513 acids Chemical class 0.000 claims 1
229910052782 aluminium Inorganic materials 0.000 claims 1
229910052802 copper Inorganic materials 0.000 claims 1
150000004676 glycans Chemical class 0.000 claims 1
229910052745 lead Inorganic materials 0.000 claims 1
239000012011 nucleophilic catalyst Substances 0.000 claims 1
230000033116 oxidation-reduction process Effects 0.000 claims 1
229910052763 palladium Inorganic materials 0.000 claims 1
229920001282 polysaccharide Polymers 0.000 claims 1
239000005017 polysaccharide Substances 0.000 claims 1
230000007065 protein hydrolysis Effects 0.000 claims 1
150000008163 sugars Chemical class 0.000 claims 1
229910052719 titanium Inorganic materials 0.000 claims 1
108090000790 Enzymes Proteins 0.000 description 7
102000004190 Enzymes Human genes 0.000 description 7
102000004169 proteins and genes Human genes 0.000 description 7
108090000623 proteins and genes Proteins 0.000 description 7
238000003786 synthesis reaction Methods 0.000 description 5
238000003776 cleavage reaction Methods 0.000 description 4
150000001875 compounds Chemical class 0.000 description 4
239000002184 metal Substances 0.000 description 4
229910052751 metal Inorganic materials 0.000 description 4
230000007017 scission Effects 0.000 description 4
239000000758 substrate Substances 0.000 description 4
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
108010078791 Carrier Proteins Proteins 0.000 description 3
102000014914 Carrier Proteins Human genes 0.000 description 3
241001465754 Metazoa Species 0.000 description 3
239000000427 antigen Substances 0.000 description 3
230000000890 antigenic effect Effects 0.000 description 3
108091007433 antigens Proteins 0.000 description 3
102000036639 antigens Human genes 0.000 description 3
238000002649 immunization Methods 0.000 description 3
230000003053 immunization Effects 0.000 description 3
125000006239 protecting group Chemical group 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
239000004971 Cross linker Substances 0.000 description 2
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
239000012039 electrophile Substances 0.000 description 2
230000003301 hydrolyzing effect Effects 0.000 description 2
239000012038 nucleophile Substances 0.000 description 2
229910052760 oxygen Inorganic materials 0.000 description 2
238000000734 protein sequencing Methods 0.000 description 2
241000894007 species Species 0.000 description 2
238000006467 substitution reaction Methods 0.000 description 2
108010032595 Antibody Binding Sites Proteins 0.000 description 1
229910014033 C-OH Inorganic materials 0.000 description 1
229910014570 C—OH Inorganic materials 0.000 description 1
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
230000004075 alteration Effects 0.000 description 1
230000005875 antibody response Effects 0.000 description 1
238000011319 anticancer therapy Methods 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 1
229920001222 biopolymer Polymers 0.000 description 1
CVXBEEMKQHEXEN-UHFFFAOYSA-N carbaryl Chemical compound C1=CC=C2C(OC(=O)NC)=CC=CC2=C1 CVXBEEMKQHEXEN-UHFFFAOYSA-N 0.000 description 1
229960005286 carbaryl Drugs 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
235000013351 cheese Nutrition 0.000 description 1
150000001840 cholesterol esters Chemical class 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
150000004696 coordination complex Chemical class 0.000 description 1
230000000593 degrading effect Effects 0.000 description 1
238000009795 derivation Methods 0.000 description 1
239000003599 detergent Substances 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
238000010931 ester hydrolysis Methods 0.000 description 1
235000013305 food Nutrition 0.000 description 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
239000000203 mixture Substances 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
230000000269 nucleophilic effect Effects 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
DVDUMIQZEUTAGK-UHFFFAOYSA-N p-nitrophenyl butyrate Chemical compound CCCC(=O)OC1=CC=C([N+]([O-])=O)C=C1 DVDUMIQZEUTAGK-UHFFFAOYSA-N 0.000 description 1
150000004713 phosphodiesters Chemical class 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000012545 processing Methods 0.000 description 1
238000006479 redox reaction Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
229920002477 rna polymer Polymers 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
238000002741 site-directed mutagenesis Methods 0.000 description 1
150000003384 small molecules Chemical class 0.000 description 1
125000006850 spacer group Chemical group 0.000 description 1
230000009870 specific binding Effects 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
238000011282 treatment Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Mycology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

IL8758288A 1987-09-02 1988-08-28 Immunoproximi catalysts and the process for their preparation IL87582A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9223087A	1987-09-02	1987-09-02

Publications (2)

Publication Number	Publication Date
IL87582A0 IL87582A0 (en)	1989-01-31
IL87582A true IL87582A (en)	1995-08-31

Family

ID=22232277

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL8758288A IL87582A (en)	1987-09-02	1988-08-28	Immunoproximi catalysts and the process for their preparation

Country Status (14)

Country	Link
US (1)	US5460960A (de)
EP (1)	EP0305870B1 (de)
JP (1)	JPH01163131A (de)
KR (1)	KR970003055B1 (de)
CN (1)	CN1056647C (de)
AT (1)	ATE104341T1 (de)
AU (1)	AU2425788A (de)
CA (1)	CA1340534C (de)
DE (1)	DE3889041T2 (de)
ES (1)	ES2051804T3 (de)
GB (1)	GB2209340B (de)
IL (1)	IL87582A (de)
WO (1)	WO1989001784A1 (de)
ZA (1)	ZA886483B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA893284B (en) *	1988-05-04	1990-03-28	Igen Inc	Peptide analogs and their use as haptens to elicit catalytic antibodies
US5215889A (en) *	1988-11-18	1993-06-01	The Regents Of The University Of California	Catalytic and reactive polypeptides and methods for their preparation and use
US5162218A (en) *	1988-11-18	1992-11-10	The Regents Of The University Of California	Conjugated polypeptides and methods for their preparation
DK547589D0 (da) *	1989-11-02	1989-11-02	Novo Nordisk As	Fremgangsmaade til fremstilling af organiske forbindelser
CA2116652A1 (en) *	1991-10-04	1993-04-15	Claus Ehrhardt	Tetraphenylporphyn derivatives
GB9510830D0 (en) *	1995-05-27	1995-07-19	Zeneca Ltd	Proteins
AU2003259064A1 (en)	2002-07-25	2004-02-16	Boston Scientific Limited	Medical device for navigation through anatomy and method of making same
US7001369B2 (en)	2003-03-27	2006-02-21	Scimed Life Systems, Inc.	Medical device
US7850623B2 (en)	2005-10-27	2010-12-14	Boston Scientific Scimed, Inc.	Elongate medical device with continuous reinforcement member

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4196265A (en) *	1977-06-15	1980-04-01	The Wistar Institute	Method of producing antibodies
US4492751A (en) *	1978-04-10	1985-01-08	Miles Laboratories, Inc.	Heterogenous specific binding assay employing an enzyme substrate as label
US4376110A (en) *	1980-08-04	1983-03-08	Hybritech, Incorporated	Immunometric assays using monoclonal antibodies
US4493890A (en) *	1981-03-23	1985-01-15	Miles Laboratories, Inc.	Activated apoglucose oxidase and its use in specific binding assays
US4888281A (en) *	1983-11-29	1989-12-19	Igen, Inc.	Method of catalyzing chemical reactions
US5030717A (en) *	1986-09-17	1991-07-09	Scripps Clinic And Research Foundation	Antibodies which catalyze hydrolysis of ester bonds
US4659567A (en) *	1984-09-07	1987-04-21	Scripps Clinic & Research Foundation	Molecules with antibody combining sites that bind to hydrolytic transition states
US4792446A (en) *	1986-06-23	1988-12-20	Igen, Inc.	Production of antibody catalysts
US4963355A (en) *	1986-06-23	1990-10-16	Igen, Inc.	Production of antibody catalysts
US4900674A (en) *	1987-05-28	1990-02-13	Scripps Clinic And Research Foundation	Antibody combining sites that exhibit amide or ester synthase activity

1988
- 1988-08-24 ES ES88113744T patent/ES2051804T3/es not_active Expired - Lifetime
- 1988-08-24 AU AU24257/88A patent/AU2425788A/en not_active Abandoned
- 1988-08-24 AT AT88113744T patent/ATE104341T1/de not_active IP Right Cessation
- 1988-08-24 EP EP88113744A patent/EP0305870B1/de not_active Expired - Lifetime
- 1988-08-24 DE DE3889041T patent/DE3889041T2/de not_active Expired - Lifetime
- 1988-08-24 WO PCT/US1988/002900 patent/WO1989001784A1/en not_active Ceased
- 1988-08-25 GB GB8820172A patent/GB2209340B/en not_active Expired - Lifetime
- 1988-08-28 IL IL8758288A patent/IL87582A/en not_active IP Right Cessation
- 1988-08-31 ZA ZA886483A patent/ZA886483B/xx unknown
- 1988-09-01 JP JP63219587A patent/JPH01163131A/ja active Pending
- 1988-09-01 CN CN88107059A patent/CN1056647C/zh not_active Expired - Fee Related
- 1988-12-22 CA CA000576478A patent/CA1340534C/en not_active Expired - Fee Related
1989
- 1989-05-02 KR KR89700789A patent/KR970003055B1/ko not_active Expired - Fee Related
1994
- 1994-01-27 US US08/187,810 patent/US5460960A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0305870A2 (de)	1989-03-08
AU2425788A (en)	1989-03-31
ZA886483B (en)	1990-04-25
KR970003055B1 (en)	1997-03-14
KR890701131A (ko)	1989-12-19
GB2209340A (en)	1989-05-10
ATE104341T1 (de)	1994-04-15
WO1989001784A1 (en)	1989-03-09
JPH01163131A (ja)	1989-06-27
DE3889041T2 (de)	1994-10-27
CA1340534C (en)	1999-05-11
ES2051804T3 (es)	1994-07-01
EP0305870A3 (en)	1990-04-25
IL87582A0 (en)	1989-01-31
CN1056647C (zh)	2000-09-20
GB2209340B (en)	1992-06-24
EP0305870B1 (de)	1994-04-13
US5460960A (en)	1995-10-24
DE3889041D1 (de)	1994-05-19
GB8820172D0 (en)	1988-09-28
CN1034021A (zh)	1989-07-19

Legal Events

Date	Code	Title
1996-03-31	KB	Patent renewed
1999-01-26	KB	Patent renewed
2002-11-10	KB	Patent renewed
2006-10-30	KB	Patent renewed
2009-02-11	EXP	Patent expired
2010-04-14	EXP	Patent expired

Publication	Publication Date	Title
EP0251093B1 (de)	1994-08-17	Herstellung von Antikörperkatalysatoren
US4792446A (en)	1988-12-20	Production of antibody catalysts
Miles et al.	1989	The β subunit of Tryptophan synthase: clarification of the roles of histidine 86, lysine 87, arginine 148, cysteine 170, and cysteine 230
Durfor et al.	1988	Antibody catalysis in reverse micelles
Shokat et al.	1990	Catalytic antibodies
Brocklehurst et al.	1974	[66] Covalent chromatography by thiol-disulfide interchange
AU646290B2 (en)	1994-02-17	Antibody-mediated cofactor-driven reactions
EP1009759B1 (de)	2008-05-28	Kohlenhydrat-vernetzte glykoproteinkristalle
IL87582A (en)	1995-08-31	Immunoproximi catalysts and the process for their preparation
CN111620927A (zh)	2020-09-04	一种抗体药物偶联物中间体的一锅法制备工艺
KR0185967B1 (ko)	1999-05-01	치료용 약물의 부위 특이적 생체내 활성작용
EP0172577B1 (de)	1990-05-16	Superoxid-Dismutase, ihre Herstellung und dieselbe enthaltende pharmazeutische Zusammensetzungen
JP3266276B2 (ja)	2002-03-18	二重特異性抗体断片の簡易化した製造
KR100270981B1 (ko)	2000-11-01	폴리펩티드 항원 바닥상태에 대해 도출된 모노클로날 항체 및 항체 성분
JPS6255079A (ja)	1987-03-10	修飾ウリカ−ゼ
Lerner et al.	1999	Thiazolium-dependent catalytic antibodies produced using a covalent modification strategy
den Heeten et al.	2010	Synthesis of hybrid transition-metalloproteins via thiol-selective covalent anchoring of Rh-phosphine and Ru-phenanthroline complexes
JPS5839514B2 (ja)	1983-08-30	グリコエンザイムの固定
US5302707A (en)	1994-04-12	5-fluorouridine nucleoside phosphate compounds
AU729928B2 (en)	2001-02-15	Immobilized esterases from crude extract and their use
CN1063484C (zh)	2001-03-21	化学突变具有底物结合部位的单克隆抗体制备含硒抗体酶
Mozhaev et al.	1981	The influence of effectors on the refolding (reactivation) of immobilized trypsin
JPH04154794A (ja)	1992-05-27	アンチセンスオリゴデオキシリボヌクレオチドおよびそれを有効成分とするｈｉｖ活性阻害剤
CN121378394A (zh)	2026-01-23	一种抗体偶联药物中间体set0575及其制备方法和应用
FR2710068A1 (fr)	1995-03-24	Dérivés de nucléosides, procédés de fabrication de ces dérivés de nucléosides et anticorps polyclonaux et monoclonaux spécifiques de ces dérivés.