IL87780A - 3-substituted 4-alkyl-4,5-dihydro-5-oxo-imidazo(1,5-a)thieno(2,3-d)-and(3,2-e)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

3-substituted 4-alkyl-4,5-dihydro-5-oxo-imidazo(1,5-a)thieno(2,3-d)-and(3,2-e)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number: IL87780A
Authority: IL; Israel
Prior art keywords: alkyl; thieno; imidazo; dihydro; oxo
Prior art date: 1987-10-06

Application number

IL87780A

Other languages

English (en)

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-06

Filing date

1988-09-16

Publication date

1992-02-16

1988-09-16 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1992-02-16 Publication of IL87780A publication Critical patent/IL87780A/xx

Links

238000002360 preparation method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
150000003230 pyrimidines Chemical class 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
229940125681 anticonvulsant agent Drugs 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
229940005530 anxiolytics Drugs 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
210000004556 brain Anatomy 0.000 abstract 1
230000003920 cognitive function Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
239000003326 hypnotic agent Substances 0.000 abstract 1
230000000147 hypnotic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

IL87780A 1987-10-06 1988-09-16 3-substituted 4-alkyl-4,5-dihydro-5-oxo-imidazo(1,5-a)thieno(2,3-d)-and(3,2-e)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them IL87780A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK522187A DK522187D0 (da)	1987-10-06	1987-10-06	Imidozothienopyrimidiner, deres fremstilling og anvendelse

Publications (1)

Publication Number	Publication Date
IL87780A true IL87780A (en)	1992-02-16

Family

ID=8140567

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL87780A IL87780A (en)	1987-10-06	1988-09-16	3-substituted 4-alkyl-4,5-dihydro-5-oxo-imidazo(1,5-a)thieno(2,3-d)-and(3,2-e)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them

Country Status (18)

Country	Link
US (1)	US4866065A (de)
EP (1)	EP0311321B1 (de)
JP (1)	JP2662426B2 (de)
KR (1)	KR0130978B1 (de)
AT (1)	ATE100107T1 (de)
AU (1)	AU611718B2 (de)
CA (1)	CA1323365C (de)
DE (1)	DE3887064T2 (de)
DK (1)	DK522187D0 (de)
ES (1)	ES2061675T3 (de)
FI (1)	FI91759C (de)
IE (1)	IE64931B1 (de)
IL (1)	IL87780A (de)
NO (1)	NO168646C (de)
NZ (1)	NZ226461A (de)
PH (1)	PH25297A (de)
PT (1)	PT88673B (de)
ZA (1)	ZA887313B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5185446A (en) *	1990-09-04	1993-02-09	Neurogen Corporation	Certain cycloalkyl imidazopyrimidines; a new class of gaba brainreceptor ligands
FR2872165B1 (fr) *	2004-06-24	2006-09-22	Sod Conseils Rech Applic	Nouveaux derives de pyrimido-benzimidazole
CA2644996A1 (en) *	2006-03-02	2007-09-13	Cv Therapeutics, Inc.	A2a adenosine receptor antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2411274A1 (de) *	1974-03-06	1975-09-18	Schering Ag	Neue 2-nitrothieno eckige klammer auf 2,3-d eckige klammer zu pyrimidinon-derivate und verfahren zu ihrer herstellung
ZW11781A1 (en) *	1980-06-27	1982-01-20	Hoffmann La Roche	Pyrimidine derivatives
GB8432073D0 (en) *	1984-12-19	1985-01-30	Roussel Lab Ltd	Chemical compounds
AU587802B2 (en) *	1985-03-08	1989-08-31	Ferrosan A/S	Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
US4622321A (en) *	1985-05-17	1986-11-11	As Ferrosan	Oxadiazolylimidazobenzodiazepine, compositions, and method
US4771051A (en) *	1985-05-17	1988-09-13	A/S Ferrosan	3-substituted-4,5-dihydro-5-oxo imidazoquinazolines, their preparation, and their use in treating benzodiazepin receptor-related ailments
EP0226282B1 (de) *	1985-10-17	1989-07-05	A/S Ferrosan	Heterocyclische Verbindungen und ihre Herstellung und Verwendung

1987
- 1987-10-06 DK DK522187A patent/DK522187D0/da not_active Application Discontinuation
1988
- 1988-09-15 IE IE279488A patent/IE64931B1/en not_active IP Right Cessation
- 1988-09-16 IL IL87780A patent/IL87780A/xx not_active IP Right Cessation
- 1988-09-29 ZA ZA887313A patent/ZA887313B/xx unknown
- 1988-10-03 ES ES88309153T patent/ES2061675T3/es not_active Expired - Lifetime
- 1988-10-03 AT AT88309153T patent/ATE100107T1/de not_active IP Right Cessation
- 1988-10-03 DE DE88309153T patent/DE3887064T2/de not_active Expired - Fee Related
- 1988-10-03 EP EP88309153A patent/EP0311321B1/de not_active Expired - Lifetime
- 1988-10-03 AU AU23341/88A patent/AU611718B2/en not_active Ceased
- 1988-10-04 KR KR1019880012905A patent/KR0130978B1/ko not_active Expired - Fee Related
- 1988-10-04 PT PT88673A patent/PT88673B/pt not_active IP Right Cessation
- 1988-10-04 NZ NZ226461A patent/NZ226461A/xx unknown
- 1988-10-05 CA CA000579431A patent/CA1323365C/en not_active Expired - Fee Related
- 1988-10-05 NO NO884431A patent/NO168646C/no unknown
- 1988-10-06 US US07/254,421 patent/US4866065A/en not_active Expired - Fee Related
- 1988-10-06 PH PH8837645A patent/PH25297A/en unknown
- 1988-10-06 FI FI884595A patent/FI91759C/fi not_active IP Right Cessation
- 1988-10-06 JP JP63251001A patent/JP2662426B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU611718B2 (en)	1991-06-20
EP0311321A2 (de)	1989-04-12
US4866065A (en)	1989-09-12
EP0311321A3 (en)	1990-08-01
KR0130978B1 (ko)	1998-04-16
ZA887313B (en)	1989-06-28
CA1323365C (en)	1993-10-19
FI884595A0 (fi)	1988-10-06
NO884431L (no)	1989-04-07
FI884595A7 (fi)	1989-04-07
IE64931B1 (en)	1995-09-20
NO168646C (no)	1992-03-18
NZ226461A (en)	1990-05-28
EP0311321B1 (de)	1994-01-12
PH25297A (en)	1991-04-30
DE3887064T2 (de)	1994-05-05
JPH01121291A (ja)	1989-05-12
JP2662426B2 (ja)	1997-10-15
NO884431D0 (no)	1988-10-05
DE3887064D1 (de)	1994-02-24
AU2334188A (en)	1989-04-06
IE882794L (en)	1989-04-06
PT88673B (pt)	1992-12-31
DK522187D0 (da)	1987-10-06
FI91759C (fi)	1994-08-10
NO168646B (no)	1991-12-09
KR890006653A (ko)	1989-06-15
ES2061675T3 (es)	1994-12-16
ATE100107T1 (de)	1994-01-15
FI91759B (fi)	1994-04-29

Legal Events

Date	Code	Title	Description
1999-09-22	RH	Patent void

Publication	Publication Date	Title
BG103417A (en)	2000-06-30	Condensed pyrimidine bicyclic derivatives
IL88313A (en)	1993-06-10	Derivatives of 3-substituted- 5-isopropylimidazo (1,5-a) quinoxalin-4(5h)-one and the isosteric pyridine analog, their preparation and pharmaceutical compositions containing them
PH24165A (en)	1990-03-22	A process for the preparation of heterocyclic fused derivatives of imidazoles
NZ229499A (en)	1991-04-26	Imidazo(1,5-a)quinoxaline derivatives and pharmaceutical compositions
AU586043B2 (en)	1989-06-29	Imidazo``1,5-a``quinazoline derivatives, their preparation and use.
IL82117A (en)	1992-03-29	Substituted 4h-imidazo(1,5-a)benzodiazepin-6-one derivatives,their preparation and pharmaceutical compositions containing them
IL99305A (en)	1997-02-18	4-substituted dihydropyrido [4,3-d]pyrimidines their preparation and analgesic and topical antiinflammatory compositions containing them for the treatment of skin disorders
AU567163B2 (en)	1987-11-12	B-carbolin-3-carboxylic acid derivatives
NZ226461A (en)	1990-05-28	S-oxo-imidazo-(1,5-a)-thienopyrimidine derivatives; pharmaceutical compositions and processes for preparation
NZ236156A (en)	1993-01-27	Substituted imidazo(1,5-a)quinoxaline derivatives; pharmaceutical compositions, methods of preparation and treatment
DK555688A (da)	1989-04-07	Heterocykliske forbindelser, deres fremstilling og anvendelse