IL88107A - Aminomethyloxo- oxazolidinyl ethenylbenzene derivatives, their preparation and antibacterial compositions containing them - Google Patents

Aminomethyloxo- oxazolidinyl ethenylbenzene derivatives, their preparation and antibacterial compositions containing them

Info

Publication number: IL88107A
Authority: IL; Israel
Prior art keywords: ethenylbenzene; derivatives; aminomethyloxo; oxazolidinyl; preparation
Prior art date: 1987-10-21

Application number

IL88107A

Other languages

English (en)

Other versions

IL88107A0 (en

Original Assignee

Du Pont Merck Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-21

Filing date

1988-10-20

Publication date

1993-02-21

1988-10-20 Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma

1989-06-30 Publication of IL88107A0 publication Critical patent/IL88107A0/xx

1993-02-21 Publication of IL88107A publication Critical patent/IL88107A/xx

Links

JDUVGUNRPRUDMH-UHFFFAOYSA-N NCC=1C(=C(C=CC=1)C=C=O)C1OCCN1 Chemical class NCC=1C(=C(C=CC=1)C=C=O)C1OCCN1 JDUVGUNRPRUDMH-UHFFFAOYSA-N 0.000 title abstract 2
230000000844 anti-bacterial effect Effects 0.000 title abstract 2
239000000203 mixture Substances 0.000 title 1
SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical compound NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 abstract 1
150000003869 acetamides Chemical class 0.000 abstract 1
229940047583 cetamide Drugs 0.000 abstract 1
150000002825 nitriles Chemical class 0.000 abstract 1
150000002828 nitro derivatives Chemical class 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003462 sulfoxides Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

IL88107A 1987-10-21 1988-10-20 Aminomethyloxo- oxazolidinyl ethenylbenzene derivatives, their preparation and antibacterial compositions containing them IL88107A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11083787A	1987-10-21	1987-10-21

Publications (2)

Publication Number	Publication Date
IL88107A0 IL88107A0 (en)	1989-06-30
IL88107A true IL88107A (en)	1993-02-21

Family

ID=22335197

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL88107A IL88107A (en)	1987-10-21	1988-10-20	Aminomethyloxo- oxazolidinyl ethenylbenzene derivatives, their preparation and antibacterial compositions containing them

Country Status (18)

Country	Link
EP (1)	EP0316594B1 (da)
JP (1)	JPH01135777A (da)
KR (1)	KR890006603A (da)
AT (1)	ATE95176T1 (da)
AU (1)	AU617697B2 (da)
CA (1)	CA1317594C (da)
DE (1)	DE3884563T2 (da)
DK (1)	DK584188A (da)
ES (1)	ES2059467T3 (da)
FI (1)	FI884849A7 (da)
HU (1)	HU201915B (da)
IL (1)	IL88107A (da)
MY (1)	MY103433A (da)
NO (1)	NO884676L (da)
NZ (1)	NZ226631A (da)
PT (1)	PT88811B (da)
RU (1)	RU1801109C (da)
ZA (1)	ZA887853B (da)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5032605A (en) *	1987-10-09	1991-07-16	Du Pont Merck Pharmaceutical Company	Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
US5036093A (en) *	1987-10-09	1991-07-30	Du Pont Merck Pharmaceutical	Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
US4948801A (en) *	1988-07-29	1990-08-14	E. I. Du Pont De Nemours And Company	Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5225565A (en) *	1988-09-15	1993-07-06	The Upjohn Company	Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
US5231188A (en) *	1989-11-17	1993-07-27	The Upjohn Company	Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
AU667198B2 (en) *	1991-11-01	1996-03-14	Pharmacia & Upjohn Company	Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
SK283420B6 (sk) *	1992-05-08	2003-07-01	Pharmacia & Upjohn Company	Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
JP3558088B2 (ja) *	1992-12-08	2004-08-25	ファルマシア・アンド・アップジョン・カンパニー	トロポン−置換のフェニルオキサゾリジノン抗菌剤
TW299332B (da) *	1992-12-08	1997-03-01	Upjohn Co
US5688792A (en) *	1994-08-16	1997-11-18	Pharmacia & Upjohn Company	Substituted oxazine and thiazine oxazolidinone antimicrobials
JP3698724B2 (ja) *	1993-11-22	2005-09-21	ファルマシア・アンド・アップジョン・カンパニー	置換−ヒドロキシアセチルピペラジンフェニルオキサゾリジノンのエステル
DK0788498T3 (da) *	1994-10-26	2001-11-05	Upjohn Co	Phenyloxazolidinoner med antimikrobiel virkning
BR9509673A (pt) *	1994-11-15	1997-09-30	Upjohn Co	Compostos e uso dos mesmos
CA2208603A1 (en) *	1995-02-03	1996-08-08	The Upjohn Company	Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials
AU702752B2 (en) *	1995-05-11	1999-03-04	Pharmacia & Upjohn Company	Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones
US5883093A (en) *	1995-09-12	1999-03-16	Pharmacia & Upjohn Company	Phenyloxazolidinone antimicrobials
GB9702213D0 (en)	1996-02-24	1997-03-26	Zeneca Ltd	Chemical compounds
GB9609919D0 (en)	1996-05-11	1996-07-17	Zeneca Ltd	Chemical compounds
JP4214537B2 (ja)	1996-08-12	2009-01-28	セルジーンコーポレーション	新規な免疫治療薬とこの薬物を使用してサイトカインレベルを抵減する方法
GB9717804D0 (en)	1997-08-22	1997-10-29	Zeneca Ltd	Chemical compounds
GB9717807D0 (en)	1997-08-22	1997-10-29	Zeneca Ltd	Chemical compounds
US5998406A (en) *	1997-11-12	1999-12-07	Pharmacia & Upjohn Company	Oxazolidinone derivatives and pharmaceutical compositions
GB9725244D0 (en)	1997-11-29	1998-01-28	Zeneca Ltd	Chemical compounds
US6562844B2 (en)	1998-01-23	2003-05-13	Pharmacia & Upjohn Company	Oxazolidinone combinatorial libraries, compositions and methods of preparation
WO1999037630A1 (en) *	1998-01-23	1999-07-29	Versicor, Inc.	Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en)	1998-01-23	2006-02-21	Pharmacia & Upjohn Company	Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6441005B1 (en)	1999-07-28	2002-08-27	Pharmacia & Upjohn Company	Oxazolidinone compounds and compositions, and methods of using the same
DE19962924A1 (de)	1999-12-24	2001-07-05	Bayer Ag	Substituierte Oxazolidinone und ihre Verwendung
WO2002018354A1 (en) *	2000-08-31	2002-03-07	Abbott Laboratories	Oxazolidinones and their use as antibacterial agents
WO2002020515A1 (en) *	2000-09-08	2002-03-14	Abbott Laboratories	Oxazolidinone antibacterial agents
DE10129725A1 (de)	2001-06-20	2003-01-02	Bayer Ag	Kombinationstherapie substituierter Oxazolidinone
US7125568B2 (en)	2001-08-23	2006-10-24	Sung Michael T	Lipophilic drug compositions
DE10300111A1 (de)	2003-01-07	2004-07-15	Bayer Healthcare Ag	Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
BRPI0408005A (pt)	2003-03-05	2006-02-14	Celgene Corp	composto, composição farmacêutica, métodos para inibir angiogênese, atividade de pde4 em uma célula e proliferação de célula de cáncer, para inibir ou reduzir polimerização de tubulina ou estabilidade de tubulina em uma célula, para tratar ou melhorar um distúrbio inflamatório, um cáncer e um distúrbio do sistema nervoso central e para visar, bloquear ou destruir a função de vasculatura de tumor e o endotélio de vasos de tumor
US7470723B2 (en)	2003-03-05	2008-12-30	Celgene Corporation	Diphenylethylene compounds and uses thereof
DE10355461A1 (de)	2003-11-27	2005-06-23	Bayer Healthcare Ag	Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
EP1794139A2 (en)	2004-09-03	2007-06-13	Celgene Corporation	Substituted heterocyclic compounds and uses thereof
EP1685841A1 (en)	2005-01-31	2006-08-02	Bayer Health Care Aktiengesellschaft	Prevention and treatment of thromboembolic disorders
DE102005045518A1 (de)	2005-09-23	2007-03-29	Bayer Healthcare Ag	2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
PT1934208E (pt)	2005-10-04	2011-06-01	Bayer Schering Pharma Ag	Nova forma polimorfa de 5-cloro-n-({(5s)-2-oxo-3-[4-(3- oxo-4-morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2- tiofenocarboxamida
DE102005047561A1 (de)	2005-10-04	2007-04-05	Bayer Healthcare Ag	Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
CN101965353B (zh)	2008-03-26	2014-12-17	丹诺医药(苏州）有限公司	共价连接到取代苯基噁唑烷酮的双环硝基咪唑类
EP3498273A1 (en) *	2017-12-14	2019-06-19	Universität Wien	Pharmaceutical composition for modulating the response of a gaba-a receptor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1222708A (en) *	1968-10-22	1971-02-17	Delalande Sa	Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation
FR2500450A1 (fr) *	1981-02-25	1982-08-27	Delalande Sa	Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
ES8506659A1 (es) *	1983-06-07	1985-08-01	Du Pont	Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
US4705799A (en) *	1983-06-07	1987-11-10	E. I. Du Pont De Nemours And Company	Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
CA1260948A (en) *	1984-12-05	1989-09-26	E. I. Du Pont De Nemours And Company	Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents

1988
- 1988-10-18 ES ES88117304T patent/ES2059467T3/es not_active Expired - Lifetime
- 1988-10-18 CA CA000580498A patent/CA1317594C/en not_active Expired - Fee Related
- 1988-10-18 AT AT88117304T patent/ATE95176T1/de active
- 1988-10-18 DE DE88117304T patent/DE3884563T2/de not_active Expired - Fee Related
- 1988-10-18 EP EP88117304A patent/EP0316594B1/en not_active Expired - Lifetime
- 1988-10-19 MY MYPI88001186A patent/MY103433A/en unknown
- 1988-10-19 AU AU24043/88A patent/AU617697B2/en not_active Ceased
- 1988-10-19 NZ NZ226631A patent/NZ226631A/xx unknown
- 1988-10-20 IL IL88107A patent/IL88107A/xx not_active IP Right Cessation
- 1988-10-20 KR KR1019880013655A patent/KR890006603A/ko not_active Ceased
- 1988-10-20 ZA ZA887853A patent/ZA887853B/xx unknown
- 1988-10-20 NO NO88884676A patent/NO884676L/no unknown
- 1988-10-20 PT PT88811A patent/PT88811B/pt not_active IP Right Cessation
- 1988-10-20 RU SU884356676A patent/RU1801109C/ru active
- 1988-10-20 JP JP63263043A patent/JPH01135777A/ja active Pending
- 1988-10-20 FI FI884849A patent/FI884849A7/fi not_active Application Discontinuation
- 1988-10-20 DK DK584188A patent/DK584188A/da not_active Application Discontinuation
- 1988-10-20 HU HU885417A patent/HU201915B/hu not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA887853B (en)	1990-06-27
MY103433A (en)	1993-06-30
NO884676D0 (no)	1988-10-20
RU1801109C (ru)	1993-03-07
IL88107A0 (en)	1989-06-30
EP0316594B1 (en)	1993-09-29
FI884849A0 (fi)	1988-10-20
DE3884563D1 (de)	1993-11-04
PT88811B (pt)	1993-04-30
AU2404388A (en)	1989-04-27
HUT52075A (en)	1990-06-28
JPH01135777A (ja)	1989-05-29
ATE95176T1 (de)	1993-10-15
DK584188A (da)	1989-04-22
KR890006603A (ko)	1989-06-14
NO884676L (no)	1989-04-24
ES2059467T3 (es)	1994-11-16
EP0316594A1 (en)	1989-05-24
FI884849A7 (fi)	1989-04-22
DK584188D0 (da)	1988-10-20
CA1317594C (en)	1993-05-11
NZ226631A (en)	1991-01-29
HU201915B (en)	1991-01-28
DE3884563T2 (de)	1994-02-17
AU617697B2 (en)	1991-12-05

Legal Events

Date	Code	Title	Description
1999-04-11	KB	Patent renewed
2003-07-06	RH1	Patent not in force

Publication	Publication Date	Title
IL88107A0 (en)	1989-06-30	Aminomethyloxooxazolidinyl ethenyl-benzene derivatives,their preparation and antibacterial composition containing them
IL88047A (en)	1992-11-15	Aminomethyl oxooxazolidinyl aroylbenzene derivatives,their preparation and pharmaceutical compositions containing them
PT81610A (en)	1986-01-01	Process for the preparation of aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents and of pharmaceutical compositions containing the same
IE892438L (en)	1990-01-29	Aminomethyloxooxazolidinyl Arylbenzene derivatives useful¹as Antibacterial agents
CA2009735A1 (en)	1990-08-13	Insecticidally active nitro compounds
AU2066088A (en)	1989-02-16	Safening herbicidal compounds with 5-heterocyclic-substituted oxazolidine dihaloacetamides
MY103618A (en)	1993-08-28	Aminomethyl oxooxazolidinyl cycloalkylbenzene deravatives useful as antibacterial agents
IT1212143B (it)	1989-11-08	Composizione ad attivita'tricogena.
IL59737A (en)	1984-03-30	1,2,3-thiadiazole-5-carboxylic acid amide derivatives,process for the preparation thereof and compositions having herbicidal growthregulating,defoliating and fungicidal action containing the same
IL56513A (en)	1983-02-23	3-(n-(acyloxyacetyl)-n-(substituted phenyl))-aminotetrahydro-2-furanone derivatives,their production and microbicidal compositions containing them
GB8714005D0 (en)	1987-07-22	Organic compounds
IL58327A0 (en)	1979-12-30	Herbicidal composition comprising trifluralin together with another active compound
ZW13890A1 (en)	1991-10-02	Novel compounds
NZ195310A (en)	1983-04-12	N-(2,6-dialkylphenyl)-n-2(but-3-ynyl)-n-2(5-halo(or nitro or alkoxy)-furancarboxamides) fungicidal compositions
AU7005887A (en)	1987-09-24	Synergistic herbicidal compositions and method of use