BRPI0408005A - composto, composição farmacêutica, métodos para inibir angiogênese, atividade de pde4 em uma célula e proliferação de célula de cáncer, para inibir ou reduzir polimerização de tubulina ou estabilidade de tubulina em uma célula, para tratar ou melhorar um distúrbio inflamatório, um cáncer e um distúrbio do sistema nervoso central e para visar, bloquear ou destruir a função de vasculatura de tumor e o endotélio de vasos de tumor - Google Patents

composto, composição farmacêutica, métodos para inibir angiogênese, atividade de pde4 em uma célula e proliferação de célula de cáncer, para inibir ou reduzir polimerização de tubulina ou estabilidade de tubulina em uma célula, para tratar ou melhorar um distúrbio inflamatório, um cáncer e um distúrbio do sistema nervoso central e para visar, bloquear ou destruir a função de vasculatura de tumor e o endotélio de vasos de tumor

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Publication number
BRPI0408005A
BRPI0408005A BRPI0408005-0A BRPI0408005A BRPI0408005A BR PI0408005 A BRPI0408005 A BR PI0408005A BR PI0408005 A BRPI0408005 A BR PI0408005A BR PI0408005 A BRPI0408005 A BR PI0408005A
Authority
BR
Brazil
Prior art keywords
cell
cancer
inhibiting
methods
compound
Prior art date
Application number
BRPI0408005-0A
Other languages
English (en)
Inventor
George W Muller
Faribourz Payvandi
Ling H Zhang
Michael J Robarge
Roger Chen
Hon-Wah Man
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of BRPI0408005A publication Critical patent/BRPI0408005A/pt

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    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/60—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
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Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODOS PARA INIBIR ANGIOGêNESE, ATIVIDADE DE PDE4 EM UMA CéLULA E PROLIFERAçãO DE CéLULA DE CáNCER, PARA INIBIR OU REDUZIR POLIMERIZAçãO DE TUBULINA OU ESTABILIDADE DE TUBULINA EM UMA CéLULA, PARA TRATAR OU MELHORAR UM DISTúRBIO INFLAMATóRIO, UM CáNCER E UM DISTúRBIO DO SISTEMA NERVOSO CENTRAL E PARA VISAR, BLOQUEAR OU DESTRUIR A FUNçãO DE VASCULATURA DE TUMOR E O ENDOTéLIO DE VASOS DE TUMOR". A presente invenção trata de compostos de difeniletileno. E<39>composições compreendendo um composto de difeniletileno. A presente invenção se refere também a métodos para prevenção de várias doenças e distúrbios por administração a um paciente em necessidade dos mesmos de um ou mais compostos de difeniletileno. Em particular, a invenção se refere a métodos para prevenção ou tratamento de câncer ou um distúrbio inflamatório por administração a um paciente em necessidade dos mesmos de um ou mais compostos de difeniletileno. A presente invenção se refere também a artigos de manufatura a kits compreendendo um ou mais compostos de difeniletileno.
BRPI0408005-0A 2003-03-05 2004-03-05 composto, composição farmacêutica, métodos para inibir angiogênese, atividade de pde4 em uma célula e proliferação de célula de cáncer, para inibir ou reduzir polimerização de tubulina ou estabilidade de tubulina em uma célula, para tratar ou melhorar um distúrbio inflamatório, um cáncer e um distúrbio do sistema nervoso central e para visar, bloquear ou destruir a função de vasculatura de tumor e o endotélio de vasos de tumor BRPI0408005A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45246003P 2003-03-05 2003-03-05
PCT/US2004/006781 WO2004078144A2 (en) 2003-03-05 2004-03-05 Diphenylethylene compounds and uses thereof

Publications (1)

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BRPI0408005A true BRPI0408005A (pt) 2006-02-14

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BRPI0408005-0A BRPI0408005A (pt) 2003-03-05 2004-03-05 composto, composição farmacêutica, métodos para inibir angiogênese, atividade de pde4 em uma célula e proliferação de célula de cáncer, para inibir ou reduzir polimerização de tubulina ou estabilidade de tubulina em uma célula, para tratar ou melhorar um distúrbio inflamatório, um cáncer e um distúrbio do sistema nervoso central e para visar, bloquear ou destruir a função de vasculatura de tumor e o endotélio de vasos de tumor

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US (2) US7312241B2 (pt)
EP (1) EP1603864A4 (pt)
JP (1) JP2006519874A (pt)
KR (1) KR20050117533A (pt)
CN (2) CN101053558A (pt)
AU (1) AU2004218364A1 (pt)
BR (1) BRPI0408005A (pt)
CA (1) CA2517886A1 (pt)
MX (1) MXPA05009434A (pt)
NZ (1) NZ542407A (pt)
WO (1) WO2004078144A2 (pt)
ZA (1) ZA200507321B (pt)

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DE60137273D1 (de) 2000-10-20 2009-02-12 Eisai R&D Man Co Ltd Verfahren zur Herstellung von 4-Phenoxy chinolin Derivaten
US20100129363A1 (en) * 2002-05-17 2010-05-27 Zeldis Jerome B Methods and compositions using pde4 inhibitors for the treatment and management of cancers
IL165258A0 (en) * 2002-05-17 2005-12-18 Celgene Corp Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases
MXPA05003889A (es) * 2002-10-15 2005-06-22 Celgene Corp Farmacos inhibidores de citosina selectiva para tratar sindrome mielodisplastico.
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