IL89140A - 4-oxo-4h-pyrido(1,2-a) pyrimidine-3-carboxamides and 3-acetamides, pharmaceutical compositions containing them and process for preparing same - Google Patents

4-oxo-4h-pyrido(1,2-a) pyrimidine-3-carboxamides and 3-acetamides, pharmaceutical compositions containing them and process for preparing same

Info

Publication number: IL89140A
Authority: IL; Israel
Prior art keywords: carbon atoms; pyrido; pyrimidine; oxo; group
Prior art date: 1988-02-03

Application number

IL89140A

Other languages

English (en)

Other versions

IL89140A0 (en

Original Assignee

Chinoin Gyogyszer Es Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-02-03

Filing date

1989-02-01

Publication date

1993-01-14

1989-02-01 Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet

1989-09-10 Publication of IL89140A0 publication Critical patent/IL89140A0/xx

1993-01-14 Publication of IL89140A publication Critical patent/IL89140A/xx

Links

JKOKNGJSLCNFKR-UHFFFAOYSA-N 4-oxopyrido[1,2-a]pyrimidine-3-carboxamide Chemical class C1=CC=CN2C(=O)C(C(=O)N)=CN=C21 JKOKNGJSLCNFKR-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
YGHFAYBPBVHKHY-UHFFFAOYSA-N 4-oxopyrido[1,2-a]pyrimidine-3-carboxylic acid Chemical class C1=CC=CN2C(=O)C(C(=O)O)=CN=C21 YGHFAYBPBVHKHY-UHFFFAOYSA-N 0.000 abstract 1
125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000002178 gastroprotective effect Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IL89140A 1988-02-03 1989-02-01 4-oxo-4h-pyrido(1,2-a) pyrimidine-3-carboxamides and 3-acetamides, pharmaceutical compositions containing them and process for preparing same IL89140A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU88501A HU201551B (en)	1988-02-03	1988-02-03	Process for producing 4-oxo-4h-pyrido(1,2-a)pyrimidine-3-carboxylic acid amide derivatives and pharmaceutical compositions comprising same

Publications (2)

Publication Number	Publication Date
IL89140A0 IL89140A0 (en)	1989-09-10
IL89140A true IL89140A (en)	1993-01-14

Family

ID=10949869

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL89140A IL89140A (en)	1988-02-03	1989-02-01	4-oxo-4h-pyrido(1,2-a) pyrimidine-3-carboxamides and 3-acetamides, pharmaceutical compositions containing them and process for preparing same

Country Status (18)

Country	Link
US (1)	US5158951A (cs)
EP (1)	EP0326981B1 (cs)
JP (1)	JPH01265090A (cs)
CN (1)	CN1027263C (cs)
AT (1)	ATE113948T1 (cs)
AU (1)	AU611526B2 (cs)
CZ (1)	CZ72689A3 (cs)
DD (1)	DD283392A5 (cs)
DE (1)	DE58908613D1 (cs)
DK (1)	DK48389A (cs)
ES (1)	ES2063771T3 (cs)
FI (1)	FI91257C (cs)
HU (1)	HU201551B (cs)
IL (1)	IL89140A (cs)
NO (1)	NO170281C (cs)
NZ (1)	NZ227822A (cs)
RU (2)	RU1820909C (cs)
YU (1)	YU47205B (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5580872A (en) *	1990-05-02	1996-12-03	Abbott Laboratories	Quinolizinone type compounds
SE9700661D0 (sv) *	1997-02-25	1997-02-25	Astra Ab	New compounds
KR101574332B1 (ko) *	2008-06-17	2015-12-08	재단법인 한국파스퇴르연구소	항감염성 화합물
CA2891523A1 (en) *	2012-11-19	2014-05-22	Jiangsu Hansoh Pharmaceutical Co., Ltd.	Pyrrole sulfonamide derivative, preparation method for same, and medical application thereof
CN104447491B (zh) *	2014-11-19	2017-06-23	连云港恒运医药有限公司	含吡咯环质子泵抑制剂的半富马酸盐及其中间体和医药用途
WO2017040879A1 (en) *	2015-09-04	2017-03-09	Lysosomal Therapeutics Inc.	Thiazolo(3,2-a) pyrimidinone and other heterobicyclic pyrimidinone compounds for use in medical therapy
AU2022407717A1 (en) *	2021-12-07	2024-06-20	Inca Renewable Technologies Inc.	Balsa-like wood alternative products and methods for preparing same
WO2024196695A2 (en) *	2023-03-17	2024-09-26	Curadh Mtr	Compounds and constructs useful for targeting fibroblast activation protein

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1670480C2 (de) *	1966-11-02	1983-06-01	Chinoin Gyógyszer és Vegyészeti Termékek Gyára R.T., 1045 Budapest	Pyrido[1,2-a]pyrimidinderivate, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende pharmazeutische Präparate
US4209622A (en) *	1973-03-30	1980-06-24	Chinoin Gygyszer es Vegyeszeti Termekek Gyara Rt.	3-(Ethoxycarbonyl-methyl)-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine
HU168014B (cs) *	1973-03-30	1976-02-28
HU173438B (hu) *	1975-11-27	1979-05-28	Chinoin Gyogyszer Es Vegyeszet	Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom
US4495189A (en) *	1975-11-27	1985-01-22	Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T.	Condensed pyrimidines
HU180439B (en) *	1977-12-29	1983-03-28	Chinoin Gyogyszer Es Vegyeszet	Process for producing 9-amino-pyrido-square bracket-1,2-a-square bracket closed-pyrimidine derivatives
US4192944A (en) *	1978-04-03	1980-03-11	Bristol-Myers Company	Optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-4-yl)carboxamides and their use as antiallergy agents
US4666912A (en) *	1984-11-12	1987-05-19	Chinoin Gyogyszer Es Vegyeszeti Termeker Gyara Rt	Treating process

1988
- 1988-02-03 HU HU88501A patent/HU201551B/hu not_active IP Right Cessation
1989
- 1989-01-30 AT AT89101523T patent/ATE113948T1/de not_active IP Right Cessation
- 1989-01-30 EP EP89101523A patent/EP0326981B1/de not_active Expired - Lifetime
- 1989-01-30 ES ES89101523T patent/ES2063771T3/es not_active Expired - Lifetime
- 1989-01-30 DE DE58908613T patent/DE58908613D1/de not_active Expired - Fee Related
- 1989-02-01 NZ NZ227822A patent/NZ227822A/xx unknown
- 1989-02-01 DD DD89325395A patent/DD283392A5/de not_active IP Right Cessation
- 1989-02-01 FI FI890478A patent/FI91257C/fi not_active IP Right Cessation
- 1989-02-01 IL IL89140A patent/IL89140A/xx not_active IP Right Cessation
- 1989-02-02 DK DK048389A patent/DK48389A/da not_active Application Discontinuation
- 1989-02-02 NO NO890431A patent/NO170281C/no unknown
- 1989-02-02 RU SU894613485A patent/RU1820909C/ru active
- 1989-02-02 CZ CS89726A patent/CZ72689A3/cs unknown
- 1989-02-03 YU YU26089A patent/YU47205B/sh unknown
- 1989-02-03 AU AU29594/89A patent/AU611526B2/en not_active Ceased
- 1989-02-03 CN CN89102006A patent/CN1027263C/zh not_active Expired - Fee Related
- 1989-02-03 JP JP1025587A patent/JPH01265090A/ja active Pending
- 1989-02-06 US US07/307,665 patent/US5158951A/en not_active Expired - Fee Related
1993
- 1993-04-28 RU RU9393004774A patent/RU2051917C1/ru active

Also Published As

Publication number	Publication date
CN1036762A (zh)	1989-11-01
HU201551B (en)	1990-11-28
FI890478A7 (fi)	1989-08-04
RU2051917C1 (ru)	1996-01-10
DK48389D0 (da)	1989-02-02
NO170281C (no)	1992-09-30
FI91257B (fi)	1994-02-28
CN1027263C (zh)	1995-01-04
NZ227822A (en)	1990-08-28
ES2063771T3 (es)	1995-01-16
RU1820909C (ru)	1993-06-07
NO890431L (no)	1989-08-04
NO170281B (no)	1992-06-22
EP0326981A3 (de)	1991-03-13
AU2959489A (en)	1989-08-03
ATE113948T1 (de)	1994-11-15
JPH01265090A (ja)	1989-10-23
US5158951A (en)	1992-10-27
DE58908613D1 (de)	1994-12-15
DD283392A5 (de)	1990-10-10
FI890478A0 (fi)	1989-02-01
HUT49608A (en)	1989-10-30
YU47205B (sh)	1995-01-31
AU611526B2 (en)	1991-06-13
NO890431D0 (no)	1989-02-02
CZ72689A3 (en)	1997-08-13
DK48389A (da)	1989-08-04
IL89140A0 (en)	1989-09-10
FI91257C (fi)	1994-06-10
EP0326981A2 (de)	1989-08-09
EP0326981B1 (de)	1994-11-09
YU26089A (en)	1990-06-30

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Legal Events

Date	Code	Title	Description
2000-01-31	RH	Patent void