IL89703A - Polynucleotide encoding human acetylcholinesterase, vectors comprising said polynucleotide, cells transformed by said vectors, enzyme produced by said transformed cell, and uses thereof - Google Patents

Polynucleotide encoding human acetylcholinesterase, vectors comprising said polynucleotide, cells transformed by said vectors, enzyme produced by said transformed cell, and uses thereof

Info

Publication number
IL89703A
IL89703A IL8970389A IL8970389A IL89703A IL 89703 A IL89703 A IL 89703A IL 8970389 A IL8970389 A IL 8970389A IL 8970389 A IL8970389 A IL 8970389A IL 89703 A IL89703 A IL 89703A
Authority
IL
Israel
Prior art keywords
dna
ache
human
acetylcholinesterase
polynucleotide molecule
Prior art date
Application number
IL8970389A
Other languages
English (en)
Other versions
IL89703A0 (en
Inventor
Hermona Soreq
Haim Zakut
Original Assignee
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co filed Critical Yissum Res Dev Co
Priority to IL8970389A priority Critical patent/IL89703A/en
Publication of IL89703A0 publication Critical patent/IL89703A0/xx
Priority to JP1338048A priority patent/JPH03195496A/ja
Priority to CA002006744A priority patent/CA2006744A1/en
Priority to DE69020018T priority patent/DE69020018T2/de
Priority to AT90105274T priority patent/ATE123814T1/de
Priority to EP90105274A priority patent/EP0388906B1/de
Priority to CA002012720A priority patent/CA2012720A1/en
Priority to US08/111,314 priority patent/US5595903A/en
Publication of IL89703A publication Critical patent/IL89703A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL8970389A 1989-03-21 1989-03-21 Polynucleotide encoding human acetylcholinesterase, vectors comprising said polynucleotide, cells transformed by said vectors, enzyme produced by said transformed cell, and uses thereof IL89703A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IL8970389A IL89703A (en) 1989-03-21 1989-03-21 Polynucleotide encoding human acetylcholinesterase, vectors comprising said polynucleotide, cells transformed by said vectors, enzyme produced by said transformed cell, and uses thereof
JP1338048A JPH03195496A (ja) 1989-03-21 1989-12-26 成長因子
CA002006744A CA2006744A1 (en) 1989-03-21 1989-12-27 Nucleid acids and polypeptides encoded thereby
DE69020018T DE69020018T2 (de) 1989-03-21 1990-03-20 Gentechnologische menschliche Cholinesterasen.
AT90105274T ATE123814T1 (de) 1989-03-21 1990-03-20 Gentechnologische menschliche cholinesterasen.
EP90105274A EP0388906B1 (de) 1989-03-21 1990-03-20 Gentechnologische menschliche Cholinesterasen
CA002012720A CA2012720A1 (en) 1989-03-21 1990-03-21 Genetically engineered human cholinesterases
US08/111,314 US5595903A (en) 1989-03-21 1993-08-02 Genetically engineered human acetylcholinesterase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL8970389A IL89703A (en) 1989-03-21 1989-03-21 Polynucleotide encoding human acetylcholinesterase, vectors comprising said polynucleotide, cells transformed by said vectors, enzyme produced by said transformed cell, and uses thereof

Publications (2)

Publication Number Publication Date
IL89703A0 IL89703A0 (en) 1989-09-28
IL89703A true IL89703A (en) 2001-10-31

Family

ID=11059811

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8970389A IL89703A (en) 1989-03-21 1989-03-21 Polynucleotide encoding human acetylcholinesterase, vectors comprising said polynucleotide, cells transformed by said vectors, enzyme produced by said transformed cell, and uses thereof

Country Status (7)

Country Link
US (1) US5595903A (de)
EP (1) EP0388906B1 (de)
JP (1) JPH03195496A (de)
AT (1) ATE123814T1 (de)
CA (1) CA2012720A1 (de)
DE (1) DE69020018T2 (de)
IL (1) IL89703A (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5248604A (en) * 1991-07-22 1993-09-28 Bio-Technology General Corp. Enzymatically active recombinant human acetylcholinesterase and hosts and vectors for expression thereof
US6025183A (en) * 1994-02-28 2000-02-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Transgenic animal assay system for anti-cholinesterase substances
US6326139B1 (en) * 1996-01-11 2001-12-04 Yissum Research Development Company Of Hebrew University Of Jerusalem Method of screening for genetic predisposition to anticholinesterase therapy
US6441388B1 (en) 1998-10-13 2002-08-27 Rio Grande Medical Technologies, Inc. Methods and apparatus for spectroscopic calibration model transfer
US6157041A (en) * 1998-10-13 2000-12-05 Rio Grande Medical Technologies, Inc. Methods and apparatus for tailoring spectroscopic calibration models
US7098037B2 (en) 1998-10-13 2006-08-29 Inlight Solutions, Inc. Accommodating subject and instrument variations in spectroscopic determinations
US6770799B2 (en) * 2000-03-17 2004-08-03 Thompson Boyce Plant Res Expression of recombinant human acetylcholinesterase in transgenic plants
IL161354A0 (en) * 2004-04-13 2004-09-27 Yissum Res Dev Co NOVEL AChE VARIANTS
WO2007040568A2 (en) 2004-12-01 2007-04-12 Arizona Board Of Regents, Acting For And On Behalf Of Arizona State Univeristy Production and use of human butyrylcholinesterase
US20090220587A1 (en) * 2005-02-01 2009-09-03 United State Army Liposomal drug delivery constructs targeted by lipid-conjugated peptide ligands
US7741431B2 (en) * 2005-02-01 2010-06-22 The United States Of America As Represented By The Secretary Of The Army Liposomes containing novel targeting and/or fusogenic peptides, preparations containing them and therapeutic use thereof
WO2009139905A2 (en) * 2008-05-16 2009-11-19 Nektar Therapeutics Conjugates of a cholinesterase moiety and a polymer
CA2784861A1 (en) 2009-12-21 2011-07-14 Pharmathene, Inc. Recombinant butyrylcholinesterases and truncates thereof
US20130071394A1 (en) 2011-09-16 2013-03-21 John K. Troyer Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and methods of use
PL240561B1 (pl) 2017-10-09 2022-05-02 Gdanski Univ Medyczny Wektory DNA zdolne do transformacji i integracji z chromosomem Leishmania tarentolae zawierające gen kodujący butyrylocholinoesterazę BChE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA84232B (en) * 1983-01-21 1984-11-28 Bio Response Inc Isolation and culture of mammalian cells secreting acetylcholinesterase and recovering of acetylcholinesterase therefrom
IL75553A (en) * 1985-06-18 1993-07-08 Yeda Res & Dev Dna sequence coding for a cholinesterase-like peptide, peptides produced by cells containing said dna and antibodies thereto
US5248604A (en) * 1991-07-22 1993-09-28 Bio-Technology General Corp. Enzymatically active recombinant human acetylcholinesterase and hosts and vectors for expression thereof

Also Published As

Publication number Publication date
EP0388906A2 (de) 1990-09-26
IL89703A0 (en) 1989-09-28
DE69020018T2 (de) 1995-10-26
US5595903A (en) 1997-01-21
ATE123814T1 (de) 1995-06-15
EP0388906A3 (de) 1991-04-17
DE69020018D1 (de) 1995-07-20
JPH03195496A (ja) 1991-08-27
CA2012720A1 (en) 1990-09-21
EP0388906B1 (de) 1995-06-14

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Legal Events

Date Code Title Description
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees