IL89871A - The use of 2-oxindole-1-carboxamides converted in position 3 for the manufacture of pharmaceutical preparations for the treatment of interleukin-related diseases - Google Patents

The use of 2-oxindole-1-carboxamides converted in position 3 for the manufacture of pharmaceutical preparations for the treatment of interleukin-related diseases

Info

Publication number: IL89871A
Authority: IL; Israel
Prior art keywords: compound; pharmaceutically; acceptable base; base salt; thienyl
Prior art date: 1988-04-13

Application number

IL8987189A

Other languages

English (en)

Hebrew (he)

Other versions

IL89871A0 (en

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-13

Filing date

1989-04-06

Publication date

1994-11-11

1989-04-06 Application filed by Pfizer filed Critical Pfizer

1989-12-15 Publication of IL89871A0 publication Critical patent/IL89871A0/xx

1994-11-11 Publication of IL89871A publication Critical patent/IL89871A/en

Links

102000000589 Interleukin-1 Human genes 0.000 title claims abstract description 38
108010002352 Interleukin-1 Proteins 0.000 title claims abstract description 38
239000008194 pharmaceutical composition Substances 0.000 title claims description 10
-1 3-substituted-2-oxindole-1-carboxamides Chemical class 0.000 title abstract description 14
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract description 10
238000004519 manufacturing process Methods 0.000 title description 4
201000010099 disease Diseases 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims abstract description 45
150000003839 salts Chemical class 0.000 claims abstract description 35
241000124008 Mammalia Species 0.000 claims abstract description 15
230000001404 mediated effect Effects 0.000 claims abstract description 14
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims abstract description 12
125000001544 thienyl group Chemical group 0.000 claims abstract description 12
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208000026278 immune system disease Diseases 0.000 claims abstract description 10
208000030159 metabolic disease Diseases 0.000 claims abstract description 10
230000015572 biosynthetic process Effects 0.000 claims abstract description 9
210000000988 bone and bone Anatomy 0.000 claims abstract description 8
230000002401 inhibitory effect Effects 0.000 claims abstract description 5
239000012453 solvate Substances 0.000 claims description 10
238000002360 preparation method Methods 0.000 claims description 9
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 5
238000007911 parenteral administration Methods 0.000 claims description 5
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238000000338 in vitro Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
229960000905 indomethacin Drugs 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
239000008101 lactose Substances 0.000 description 1
150000002617 leukotrienes Chemical class 0.000 description 1
229920006008 lipopolysaccharide Polymers 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
230000007102 metabolic function Effects 0.000 description 1
229910052987 metal hydride Inorganic materials 0.000 description 1
150000004681 metal hydrides Chemical class 0.000 description 1
229910000000 metal hydroxide Inorganic materials 0.000 description 1
150000004692 metal hydroxides Chemical class 0.000 description 1
239000011707 mineral Substances 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
230000008506 pathogenesis Effects 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
239000003961 penetration enhancing agent Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
108010086652 phytohemagglutinin-P Proteins 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229910052573 porcelain Inorganic materials 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
BDAWXSQJJCIFIK-UHFFFAOYSA-N potassium methoxide Chemical compound [K+].[O-]C BDAWXSQJJCIFIK-UHFFFAOYSA-N 0.000 description 1
235000008476 powdered milk Nutrition 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000001525 receptor binding assay Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
230000004043 responsiveness Effects 0.000 description 1
229910052895 riebeckite Inorganic materials 0.000 description 1
150000003335 secondary amines Chemical class 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
229940054269 sodium pyruvate Drugs 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
241000894007 species Species 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
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239000000126 substance Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
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239000000829 suppository Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
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235000012222 talc Nutrition 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
208000008732 thymoma Diseases 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
238000012546 transfer Methods 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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238000001262 western blot Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Indole Compounds (AREA)

IL8987189A 1988-04-13 1989-04-06 The use of 2-oxindole-1-carboxamides converted in position 3 for the manufacture of pharmaceutical preparations for the treatment of interleukin-related diseases IL89871A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/181,131 US4861794A (en)	1988-04-13	1988-04-13	3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis

Publications (2)

Publication Number	Publication Date
IL89871A0 IL89871A0 (en)	1989-12-15
IL89871A true IL89871A (en)	1994-11-11

Family

ID=22663029

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL8987189A IL89871A (en)	1988-04-13	1989-04-06	The use of 2-oxindole-1-carboxamides converted in position 3 for the manufacture of pharmaceutical preparations for the treatment of interleukin-related diseases

Country Status (17)

Country	Link
US (1)	US4861794A (da)
EP (1)	EP0337627B1 (da)
JP (1)	JPH01305028A (da)
KR (1)	KR920002327B1 (da)
AT (1)	ATE89724T1 (da)
AU (1)	AU601325B2 (da)
CA (1)	CA1324761C (da)
DE (1)	DE68906706T2 (da)
DK (1)	DK174389A (da)
HU (1)	HU203970B (da)
IE (1)	IE63458B1 (da)
IL (1)	IL89871A (da)
MY (1)	MY103871A (da)
NZ (1)	NZ228711A (da)
PH (1)	PH25884A (da)
PT (1)	PT90248B (da)
ZA (1)	ZA892623B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5300655A (en) *	1989-04-18	1994-04-05	Pfizer Inc.	2-carboxy-thiophene derivatives
US5047554A (en) *	1989-04-18	1991-09-10	Pfizer Inc.	3-substituted-2-oxindole derivatives
IL95880A (en) *	1989-10-13	1995-12-31	Pfizer	Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis
US5006547A (en) *	1990-03-19	1991-04-09	Pfizer Inc.	Tenidap as an inhibitor of the release of elastase by neutrophils
US5008283A (en) *	1990-03-19	1991-04-16	Pfizer Inc.	Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
US5064851A (en) *	1990-07-24	1991-11-12	Pfizer Inc.	3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
DE69221794T2 (de) *	1991-01-21	1998-03-19	Shionogi Seiyaku Kk	3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga
US5122534A (en) *	1991-02-08	1992-06-16	Pfizer Inc.	Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides
WO1992016226A1 (en) *	1991-03-19	1992-10-01	Smithkline Beecham Corporation	Il-1 inhibitors
DE4111305C2 (de) *	1991-04-08	1994-12-01	Mack Chem Pharm	Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält
US5298522A (en) *	1993-01-22	1994-03-29	Pfizer Inc.	6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
US5545656A (en) *	1995-04-05	1996-08-13	Pfizer Inc.	2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4556672A (en) *	1984-03-19	1985-12-03	Pfizer Inc.	3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4569942A (en) *	1984-05-04	1986-02-11	Pfizer Inc.	N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
US4678802A (en) *	1985-07-09	1987-07-07	Pfizer Inc.	1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
GB8517958D0 (en) *	1985-07-16	1985-08-21	Cellena Cell Eng Ag	Compositions containing melatonin/homologues
WO1987004618A1 (en) *	1986-01-30	1987-08-13	University Of Utah	Treatment of bone loss
US4677132A (en) *	1986-03-12	1987-06-30	American Home Products Corporation	Inhibition of bone resorption by etodolac
UA25898A1 (uk) *	1987-02-02	1999-02-26	Пфайзер Інк.	Спосіб одержаhhя кристалічhої hатрієвої солі 5-хлор-3-(2-теhоїл)-2-оксііhдол-1-карбоксаміду

1988
- 1988-04-13 US US07/181,131 patent/US4861794A/en not_active Expired - Lifetime
1989
- 1989-03-28 DE DE8989303049T patent/DE68906706T2/de not_active Expired - Fee Related
- 1989-03-28 AT AT89303049T patent/ATE89724T1/de not_active IP Right Cessation
- 1989-03-28 EP EP89303049A patent/EP0337627B1/en not_active Expired - Lifetime
- 1989-03-31 PH PH38414A patent/PH25884A/en unknown
- 1989-04-06 IL IL8987189A patent/IL89871A/en not_active IP Right Cessation
- 1989-04-08 MY MYPI89000447A patent/MY103871A/en unknown
- 1989-04-11 PT PT90248A patent/PT90248B/pt not_active IP Right Cessation
- 1989-04-11 ZA ZA892623A patent/ZA892623B/xx unknown
- 1989-04-11 CA CA000596295A patent/CA1324761C/en not_active Expired - Fee Related
- 1989-04-11 JP JP1091706A patent/JPH01305028A/ja active Pending
- 1989-04-12 IE IE117289A patent/IE63458B1/en not_active IP Right Cessation
- 1989-04-12 NZ NZ228711A patent/NZ228711A/en unknown
- 1989-04-12 KR KR1019890004821A patent/KR920002327B1/ko not_active Expired
- 1989-04-12 AU AU32711/89A patent/AU601325B2/en not_active Ceased
- 1989-04-12 DK DK174389A patent/DK174389A/da not_active Application Discontinuation
- 1989-04-12 HU HU891755A patent/HU203970B/hu not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA1324761C (en)	1993-11-30
PT90248B (pt)	1994-11-30
NZ228711A (en)	1997-02-24
AU601325B2 (en)	1990-09-06
ZA892623B (en)	1990-11-28
DK174389D0 (da)	1989-04-12
PT90248A (pt)	1989-11-10
EP0337627B1 (en)	1993-05-26
AU3271189A (en)	1989-10-19
US4861794A (en)	1989-08-29
HU203970B (en)	1991-11-28
JPH01305028A (ja)	1989-12-08
EP0337627A2 (en)	1989-10-18
MY103871A (en)	1993-09-30
DE68906706D1 (de)	1993-07-01
DE68906706T2 (de)	1993-09-16
EP0337627A3 (en)	1991-01-02
IE891172L (en)	1989-10-13
HUT52377A (en)	1990-07-28
IE63458B1 (en)	1995-04-19
KR920002327B1 (ko)	1992-03-21
PH25884A (en)	1991-12-02
IL89871A0 (en)	1989-12-15
ATE89724T1 (de)	1993-06-15
KR890015739A (ko)	1989-11-25
DK174389A (da)	1989-10-16

Legal Events

Date	Code	Title	Description
1999-10-28	KB	Patent renewed
2004-01-04	RH1	Patent not in force

Publication	Publication Date	Title
HU203670B (en)	1991-09-30	Process for producing pharmaceutical composition containing basically modificated insuline derivatives and zinc-ions for treating diabetes mellitus
US4861794A (en)	1989-08-29	3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
OA12413A (en)	2004-09-30	Combination of GABA agonists and aldose reductase inhibitors.
RU2303452C2 (ru)	2007-07-27	Применение ингибиторов сох-2 для предупреждения иммунодефицита
Otterness et al.	1988	The pharmacologic regulation of interleukin-1 production: the role of prostaglandins
US4853409A (en)	1989-08-01	3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
AU700932B2 (en)	1999-01-14	Pharmaceutical agents for the treatment of Alzheimer's disease
Landoni et al.	1996	Effects of flunixin, tolfenamic acid, R (−) and S (+) ketoprofen on the response of equine synoviocytes to lipopolysaccharide stimulation
US5635478A (en)	1997-06-03	Use of calcitonin gene-related peptide to regulate immune response
Evans et al.	1996	Nitric oxide in arthritis
KR930010581B1 (ko)	1993-10-30	콜라게나제의 활성화를 저해하기 위한 테니댑(Tenidap)의 용도
EP0425109B1 (en)	1994-08-03	3-Substituted-2-oxindole derivatives as inhibitors of interleukin-1 biosynthesis
EP0373827B1 (en)	1993-10-27	Derivatives of 5-hydroxy and 5-methoxy 2-amino-pyrimidines as inhibitors of interleukin-1 production
CA2286341A1 (en)	1998-11-12	Mtp inhibitors and fat soluble vitamin therapeutic combinations to lower serum lipid levels
WO1992003130A1 (en)	1992-03-05	Use of aryl hydroxyurea compounds for the treatment of atherosclerosis
US5071852A (en)	1991-12-10	Derivatives of 5-hydroxy and 5-methoxy 2-amino-pyrimidines as inhibitors of interleukin-1 production
NZ235638A (en)	1997-02-24	The use of indole derivatives for treating interleukin-1 related disorders
JPH1067653A (ja)	1998-03-10	関節疾患治療剤