IL90942A - Pharmaceutical preparations for topical use containing histories of tetrahydronphthalene and indane - Google Patents

Pharmaceutical preparations for topical use containing histories of tetrahydronphthalene and indane

Info

Publication number: IL90942A
Authority: IL; Israel
Prior art keywords: formula; compound; skin; composition; topical
Prior art date: 1988-07-14

Application number

IL9094289A

Other languages

English (en)

Hebrew (he)

Other versions

IL90942A0 (en

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-14

Filing date

1989-07-12

Publication date

1994-06-24

1989-07-12 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1990-02-09 Publication of IL90942A0 publication Critical patent/IL90942A0/xx

1994-06-24 Publication of IL90942A publication Critical patent/IL90942A/en

Links

125000003392 indanyl group Chemical class C1(CCC2=CC=CC=C12)* 0.000 title description 2
CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 title description 2
239000012049 topical pharmaceutical composition Substances 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 48
230000008832 photodamage Effects 0.000 claims abstract description 10
206010063493 Premature ageing Diseases 0.000 claims abstract description 4
208000032038 Premature aging Diseases 0.000 claims abstract description 4
239000000203 mixture Substances 0.000 claims description 32
230000000699 topical effect Effects 0.000 claims description 19
239000006071 cream Substances 0.000 claims description 9
239000008194 pharmaceutical composition Substances 0.000 claims description 6
239000004480 active ingredient Substances 0.000 claims description 5
239000000499 gel Substances 0.000 claims description 5
239000000516 sunscreening agent Substances 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 3
239000008177 pharmaceutical agent Substances 0.000 claims description 3
239000002674 ointment Substances 0.000 claims description 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
230000000475 sunscreen effect Effects 0.000 claims description 2
KZDCMKVLEYCGQX-UDPGNSCCSA-N 2-(diethylamino)ethyl 4-aminobenzoate;(2s,5r,6r)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;hydrate Chemical compound O.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 KZDCMKVLEYCGQX-UDPGNSCCSA-N 0.000 claims 2
208000017520 skin disease Diseases 0.000 claims 2
239000000825 pharmaceutical preparation Substances 0.000 claims 1
IHKKALGZNCSLTA-UHFFFAOYSA-N s-[4-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]phenyl] n,n-dimethylcarbamothioate Chemical compound C1=CC(SC(=O)N(C)C)=CC=C1C=C(C)C1=CC=C2C(C)(C)CCC(C)(C)C2=C1 IHKKALGZNCSLTA-UHFFFAOYSA-N 0.000 claims 1
125000000217 alkyl group Chemical group 0.000 abstract description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000035475 disorder Diseases 0.000 abstract 2
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
239000003860 topical agent Substances 0.000 abstract 1
210000003491 skin Anatomy 0.000 description 35
102000016942 Elastin Human genes 0.000 description 9
108010014258 Elastin Proteins 0.000 description 9
230000000694 effects Effects 0.000 description 9
229920002549 elastin Polymers 0.000 description 9
235000019282 butylated hydroxyanisole Nutrition 0.000 description 8
230000006378 damage Effects 0.000 description 8
241001465754 Metazoa Species 0.000 description 7
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 6
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 6
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
230000037303 wrinkles Effects 0.000 description 6
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
241000699670 Mus sp. Species 0.000 description 4
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
239000002537 cosmetic Substances 0.000 description 4
VEVRNHHLCPGNDU-MUGJNUQGSA-O desmosine Chemical compound OC(=O)[C@@H](N)CCCC[N+]1=CC(CC[C@H](N)C(O)=O)=C(CCC[C@H](N)C(O)=O)C(CC[C@H](N)C(O)=O)=C1 VEVRNHHLCPGNDU-MUGJNUQGSA-O 0.000 description 4
230000002500 effect on skin Effects 0.000 description 4
229940075529 glyceryl stearate Drugs 0.000 description 4
230000036561 sun exposure Effects 0.000 description 4
239000004255 Butylated hydroxyanisole Substances 0.000 description 3
229940126062 Compound A Drugs 0.000 description 3
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 3
NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
229940043253 butylated hydroxyanisole Drugs 0.000 description 3
CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 3
229960000541 cetyl alcohol Drugs 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
-1 conditioners Substances 0.000 description 3
SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 3
239000012153 distilled water Substances 0.000 description 3
238000002844 melting Methods 0.000 description 3
230000008018 melting Effects 0.000 description 3
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 3
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 3
229960002216 methylparaben Drugs 0.000 description 3
239000000546 pharmaceutical excipient Substances 0.000 description 3
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 3
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 3
229960003415 propylparaben Drugs 0.000 description 3
239000000600 sorbitol Substances 0.000 description 3
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 3
RGHHSNMVTDWUBI-UHFFFAOYSA-N 4-hydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C=C1 RGHHSNMVTDWUBI-UHFFFAOYSA-N 0.000 description 2
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
206010068388 Actinic elastosis Diseases 0.000 description 2
239000004322 Butylated hydroxytoluene Substances 0.000 description 2
NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
241000699666 Mus <mouse, genus> Species 0.000 description 2
RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 2
230000001133 acceleration Effects 0.000 description 2
239000000654 additive Substances 0.000 description 2
235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
229940095259 butylated hydroxytoluene Drugs 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
239000003086 colorant Substances 0.000 description 2
210000004207 dermis Anatomy 0.000 description 2
ZXSBDSGRQIWJPM-UHFFFAOYSA-N dimethylcarbamothioic s-acid Chemical compound CN(C)C(S)=O ZXSBDSGRQIWJPM-UHFFFAOYSA-N 0.000 description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 2
239000007788 liquid Substances 0.000 description 2
238000000034 method Methods 0.000 description 2
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
239000003921 oil Substances 0.000 description 2
229940100460 peg-100 stearate Drugs 0.000 description 2
239000002304 perfume Substances 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000002562 thickening agent Substances 0.000 description 2
210000001519 tissue Anatomy 0.000 description 2
238000011200 topical administration Methods 0.000 description 2
LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
229910002016 Aerosil® 200 Inorganic materials 0.000 description 1
241001440269 Cutina Species 0.000 description 1
101100326757 Drosophila melanogaster Capr gene Proteins 0.000 description 1
206010015150 Erythema Diseases 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
239000004258 Ethoxyquin Substances 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
241000282412 Homo Species 0.000 description 1
QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
NPPQSCRMBWNHMW-UHFFFAOYSA-N Meprobamate Chemical compound NC(=O)OCC(C)(CCC)COC(N)=O NPPQSCRMBWNHMW-UHFFFAOYSA-N 0.000 description 1
239000004909 Moisturizer Substances 0.000 description 1
241000282320 Panthera leo Species 0.000 description 1
229920002516 Poloxamer 331 Polymers 0.000 description 1
229920001214 Polysorbate 60 Polymers 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
229930182558 Sterol Natural products 0.000 description 1
238000000692 Student's t-test Methods 0.000 description 1
101150052863 THY1 gene Proteins 0.000 description 1
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 1
GNVMUORYQLCPJZ-UHFFFAOYSA-M Thiocarbamate Chemical compound NC([S-])=O GNVMUORYQLCPJZ-UHFFFAOYSA-M 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
238000005903 acid hydrolysis reaction Methods 0.000 description 1
239000011149 active material Substances 0.000 description 1
SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
230000003712 anti-aging effect Effects 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
235000010385 ascorbyl palmitate Nutrition 0.000 description 1
239000003212 astringent agent Substances 0.000 description 1
239000003899 bactericide agent Substances 0.000 description 1
229960001631 carbomer Drugs 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000012050 conventional carrier Substances 0.000 description 1
239000012043 crude product Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
239000002978 dental impression material Substances 0.000 description 1
239000003599 detergent Substances 0.000 description 1
238000011161 development Methods 0.000 description 1
230000018109 developmental process Effects 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
238000002845 discoloration Methods 0.000 description 1
231100000673 dose–response relationship Toxicity 0.000 description 1
210000004177 elastic tissue Anatomy 0.000 description 1
238000010828 elution Methods 0.000 description 1
239000003974 emollient agent Substances 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
239000003623 enhancer Substances 0.000 description 1
210000002615 epidermis Anatomy 0.000 description 1
231100000321 erythema Toxicity 0.000 description 1
235000019285 ethoxyquin Nutrition 0.000 description 1
229940093500 ethoxyquin Drugs 0.000 description 1
DECIPOUIJURFOJ-UHFFFAOYSA-N ethoxyquin Chemical compound N1C(C)(C)C=C(C)C2=CC(OCC)=CC=C21 DECIPOUIJURFOJ-UHFFFAOYSA-N 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000000835 fiber Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical class COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 1
239000003906 humectant Substances 0.000 description 1
206010020718 hyperplasia Diseases 0.000 description 1
230000002390 hyperplastic effect Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
208000014674 injury Diseases 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000006210 lotion Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
230000001333 moisturizer Effects 0.000 description 1
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
230000035515 penetration Effects 0.000 description 1
229960005323 phenoxyethanol Drugs 0.000 description 1
238000001126 phototherapy Methods 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
235000010388 propyl gallate Nutrition 0.000 description 1
239000000473 propyl gallate Substances 0.000 description 1
229940075579 propyl gallate Drugs 0.000 description 1
230000005855 radiation Effects 0.000 description 1
238000003127 radioimmunoassay Methods 0.000 description 1
238000010992 reflux Methods 0.000 description 1
229930002330 retinoic acid Natural products 0.000 description 1
230000037390 scarring Effects 0.000 description 1
239000002453 shampoo Substances 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
239000000344 soap Substances 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000000243 solution Substances 0.000 description 1
229950011392 sorbitan stearate Drugs 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
150000003432 sterols Chemical class 0.000 description 1
235000003702 sterols Nutrition 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
235000010384 tocopherol Nutrition 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
229960001295 tocopherol Drugs 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
229960001727 tretinoin Drugs 0.000 description 1
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Birds (AREA)
Gerontology & Geriatric Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Cosmetics (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

IL9094289A 1988-07-14 1989-07-12 Pharmaceutical preparations for topical use containing histories of tetrahydronphthalene and indane IL90942A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US21955088A	1988-07-14	1988-07-14

Publications (2)

Publication Number	Publication Date
IL90942A0 IL90942A0 (en)	1990-02-09
IL90942A true IL90942A (en)	1994-06-24

Family

ID=22819722

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9094289A IL90942A (en)	1988-07-14	1989-07-12	Pharmaceutical preparations for topical use containing histories of tetrahydronphthalene and indane

Country Status (15)

Country	Link
EP (1)	EP0358880B1 (ja)
JP (1)	JPH0688965B2 (ja)
KR (1)	KR900001648A (ja)
AT (1)	ATE100311T1 (ja)
AU (1)	AU630613B2 (ja)
CA (1)	CA1331196C (ja)
DE (1)	DE68912472T2 (ja)
DK (1)	DK348389A (ja)
ES (1)	ES2061815T3 (ja)
HU (1)	HU203969B (ja)
IE (1)	IE63116B1 (ja)
IL (1)	IL90942A (ja)
NZ (1)	NZ229917A (ja)
PH (1)	PH25980A (ja)
ZA (1)	ZA894879B (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH686285A5 (fr) *	1992-08-06	1996-02-29	Beiersdorf Ag	Preparation cosmetique ou pharmaceutique servant a retarder le vieillissement de la peau humaine.
DE4228455A1 (de) *	1992-08-26	1994-09-15	Beiersdorf Ag	Kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an Thiolen und/oder Thiolderivaten
JP5665276B2 (ja)	2008-02-27	2015-02-04	花王株式会社	皮膚老化予防又は改善剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1162200A (en) *	1981-02-13	1984-02-14	Michael Klaus	Process for the manufacture of indanyl (or tetrahydronaphthyl)propenyl phenyl derivatives

1989
- 1989-06-27 ZA ZA894879A patent/ZA894879B/xx unknown
- 1989-07-12 HU HU893535A patent/HU203969B/hu not_active IP Right Cessation
- 1989-07-12 NZ NZ229917A patent/NZ229917A/xx unknown
- 1989-07-12 IL IL9094289A patent/IL90942A/en not_active IP Right Cessation
- 1989-07-13 IE IE227189A patent/IE63116B1/en not_active IP Right Cessation
- 1989-07-13 AU AU38094/89A patent/AU630613B2/en not_active Ceased
- 1989-07-13 JP JP1179193A patent/JPH0688965B2/ja not_active Expired - Lifetime
- 1989-07-13 AT AT89112859T patent/ATE100311T1/de not_active IP Right Cessation
- 1989-07-13 DE DE68912472T patent/DE68912472T2/de not_active Expired - Fee Related
- 1989-07-13 PH PH38939A patent/PH25980A/en unknown
- 1989-07-13 ES ES89112859T patent/ES2061815T3/es not_active Expired - Lifetime
- 1989-07-13 EP EP89112859A patent/EP0358880B1/en not_active Expired - Lifetime
- 1989-07-13 CA CA000605537A patent/CA1331196C/en not_active Expired - Fee Related
- 1989-07-13 DK DK348389A patent/DK348389A/da not_active Application Discontinuation
- 1989-07-14 KR KR1019890010022A patent/KR900001648A/ko not_active Ceased

Also Published As

Publication number	Publication date
DE68912472D1 (de)	1994-03-03
EP0358880B1 (en)	1994-01-19
IL90942A0 (en)	1990-02-09
IE892271L (en)	1990-01-14
CA1331196C (en)	1994-08-02
NZ229917A (en)	1992-09-25
PH25980A (en)	1992-01-13
EP0358880A2 (en)	1990-03-21
IE63116B1 (en)	1995-03-22
DK348389D0 (da)	1989-07-13
AU630613B2 (en)	1992-11-05
HU203969B (en)	1991-11-28
EP0358880A3 (en)	1990-11-28
AU3809489A (en)	1990-01-18
JPH0688965B2 (ja)	1994-11-09
DK348389A (da)	1990-01-15
HUT50628A (en)	1990-03-28
ZA894879B (en)	1991-03-27
DE68912472T2 (de)	1994-05-19
JPH0272157A (ja)	1990-03-12
ATE100311T1 (de)	1994-02-15
KR900001648A (ko)	1990-02-27
ES2061815T3 (es)	1994-12-16

Legal Events

Date	Code	Title	Description
1996-05-14	RH	Patent void

Publication	Publication Date	Title
AU610632B2 (en)	1991-05-23	Improvements in or relating to methods of treating damaged skin
AU666949B2 (en)	1996-02-29	Compositions containing retinoic acids and tocopherol
US5885595A (en)	1999-03-23	Cosmetic composition with a retinol fatty acid ester
EP2285342B9 (en)	2014-11-26	Compositions for lightening skin color
US5690948A (en)	1997-11-25	Antisebum and antioxidant compositions containing guguliped and alcoholic fraction thereof
US5728732A (en)	1998-03-17	Skin treatment with salicylic acid esters and retinoids
JPH09510723A (ja)	1997-10-28	皮膚の処置用組成物類
US5804574A (en)	1998-09-08	Vitamin D3 analogs useful for reversing the photodamage in sun-exposed skin
JP3667937B2 (ja)	2005-07-06	メリナミドおよびレチノイドを含有するスキンケア組成物
US5075333A (en)	1991-12-24	Tetrahydronaphthalene and indane compounds useful for reversing the photo-damage in sun-exposed skin
US5811414A (en)	1998-09-22	Vitamin D3 analogs useful for reversing the photodamage in sun-exposed skin
US6372795B1 (en)	2002-04-16	Cosmetic compositions containing substituted amide derivatives
AU630613B2 (en)	1992-11-05	A method of using thiocarbamoyl retinoid analogues and pharmaceutical compositions containing them
AU721625B2 (en)	2000-07-13	Method for reducing skin oils and grease
US5061733A (en)	1991-10-29	Tetrahydronaphthalene and indane compounds useful for reversing the photodamage in sun-exposed skin
US5770626A (en)	1998-06-23	Tetrahydronaphtalene and indane compounds useful for reversing the photodamage in sun-exposed skin
US6432427B1 (en)	2002-08-13	Cosmetic compositions containing substituted sulfonamide derivatives
WO2007090553A2 (en)	2007-08-16	Compounds useful as agonists of a2a adenosine receptors, cosmetic compositions with a2a agonists and a method for using the same