IL90983A - Enzyme electrodes and improvements in the maufacture thereof - Google Patents
Enzyme electrodes and improvements in the maufacture thereofInfo
- Publication number
- IL90983A IL90983A IL9098389A IL9098389A IL90983A IL 90983 A IL90983 A IL 90983A IL 9098389 A IL9098389 A IL 9098389A IL 9098389 A IL9098389 A IL 9098389A IL 90983 A IL90983 A IL 90983A
- Authority
- IL
- Israel
- Prior art keywords
- enzyme
- finely divided
- group metal
- oxide
- platinum group
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title claims description 130
- 108090000790 Enzymes Proteins 0.000 title claims description 130
- 229940088598 enzyme Drugs 0.000 claims description 129
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 112
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 87
- 229910052799 carbon Inorganic materials 0.000 claims description 55
- 239000002245 particle Substances 0.000 claims description 48
- 229910052751 metal Inorganic materials 0.000 claims description 44
- 239000002184 metal Substances 0.000 claims description 44
- 239000011230 binding agent Substances 0.000 claims description 39
- 238000000034 method Methods 0.000 claims description 38
- 229910002804 graphite Inorganic materials 0.000 claims description 36
- 239000010439 graphite Substances 0.000 claims description 36
- 239000000758 substrate Substances 0.000 claims description 35
- 239000010410 layer Substances 0.000 claims description 31
- 239000000725 suspension Substances 0.000 claims description 24
- 108010015776 Glucose oxidase Proteins 0.000 claims description 23
- 239000004366 Glucose oxidase Substances 0.000 claims description 22
- 229940116332 glucose oxidase Drugs 0.000 claims description 22
- 235000019420 glucose oxidase Nutrition 0.000 claims description 22
- 229910052697 platinum Inorganic materials 0.000 claims description 21
- 239000000463 material Substances 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 9
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 8
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 8
- 229910052703 rhodium Inorganic materials 0.000 claims description 8
- 239000010948 rhodium Substances 0.000 claims description 8
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 239000002609 medium Substances 0.000 claims description 7
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 10
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 10
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- 229910021607 Silver chloride Inorganic materials 0.000 description 8
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
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- 229910003446 platinum oxide Inorganic materials 0.000 description 6
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
- 235000012000 cholesterol Nutrition 0.000 description 5
- 239000004020 conductor Substances 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 4
- 108090000854 Oxidoreductases Proteins 0.000 description 4
- 102000004316 Oxidoreductases Human genes 0.000 description 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 4
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- 238000000576 coating method Methods 0.000 description 4
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- 229910052741 iridium Inorganic materials 0.000 description 4
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 4
- 229940001447 lactate Drugs 0.000 description 4
- 238000011068 loading method Methods 0.000 description 4
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 4
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
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- HBEQXAKJSGXAIQ-UHFFFAOYSA-N oxopalladium Chemical compound [Pd]=O HBEQXAKJSGXAIQ-UHFFFAOYSA-N 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910003445 palladium oxide Inorganic materials 0.000 description 3
- 229920000515 polycarbonate Polymers 0.000 description 3
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- 238000005245 sintering Methods 0.000 description 3
- 229920002498 Beta-glucan Polymers 0.000 description 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- 241001235534 Graphis <ascomycete fungus> Species 0.000 description 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
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- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- WOCIAKWEIIZHES-UHFFFAOYSA-N ruthenium(iv) oxide Chemical compound O=[Ru]=O WOCIAKWEIIZHES-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
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- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 108700033069 EC 1.97.-.- Proteins 0.000 description 1
- 108010015133 Galactose oxidase Proteins 0.000 description 1
- 108010008292 L-Amino Acid Oxidase Proteins 0.000 description 1
- 102000007070 L-amino-acid oxidase Human genes 0.000 description 1
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- 229910019142 PO4 Inorganic materials 0.000 description 1
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- 235000002355 Ribes spicatum Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- MKRNVBXERAPZOP-UHFFFAOYSA-N Starch acetate Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)OC(C)=O)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 MKRNVBXERAPZOP-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
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- 239000012491 analyte Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 102000005936 beta-Galactosidase Human genes 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
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- MGNCLNQXLYJVJD-UHFFFAOYSA-N cyanuric chloride Chemical compound ClC1=NC(Cl)=NC(Cl)=N1 MGNCLNQXLYJVJD-UHFFFAOYSA-N 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
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- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
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- 235000013305 food Nutrition 0.000 description 1
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- 230000004927 fusion Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 238000010339 medical test Methods 0.000 description 1
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- 239000003960 organic solvent Substances 0.000 description 1
- SJLOMQIUPFZJAN-UHFFFAOYSA-N oxorhodium Chemical compound [Rh]=O SJLOMQIUPFZJAN-UHFFFAOYSA-N 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 229910003450 rhodium oxide Inorganic materials 0.000 description 1
- 238000007761 roller coating Methods 0.000 description 1
- 229910001925 ruthenium oxide Inorganic materials 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
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- 239000011550 stock solution Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
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- 239000003232 water-soluble binding agent Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D5/00—Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/30—Hydrogen technology
- Y02E60/50—Fuel cells
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/817—Enzyme or microbe electrode
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Inert Electrodes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888817997A GB8817997D0 (en) | 1988-07-28 | 1988-07-28 | Enzyme electrodes & improvements in manufacture thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL90983A0 IL90983A0 (en) | 1990-02-09 |
| IL90983A true IL90983A (en) | 1994-01-25 |
Family
ID=10641263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9098389A IL90983A (en) | 1988-07-28 | 1989-07-14 | Enzyme electrodes and improvements in the maufacture thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5160418A (de) |
| EP (1) | EP0352925B1 (de) |
| JP (1) | JP3056221B2 (de) |
| KR (1) | KR0128159B1 (de) |
| AU (1) | AU621913B2 (de) |
| CA (1) | CA1311522C (de) |
| DE (1) | DE68920223T2 (de) |
| DK (1) | DK171603B1 (de) |
| FI (1) | FI96517C (de) |
| GB (2) | GB8817997D0 (de) |
| HU (1) | HU209704B (de) |
| IE (1) | IE60578B1 (de) |
| IL (1) | IL90983A (de) |
| MX (1) | MX170142B (de) |
| NO (1) | NO300144B1 (de) |
| RU (1) | RU1836428C (de) |
Families Citing this family (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4027728A1 (de) * | 1990-08-31 | 1992-03-05 | Bayer Ag | Immobilisierung von organischen makromolekuelen oder biopolymeren in einer polymermembran |
| TW279133B (de) * | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
| US5468366A (en) * | 1992-01-15 | 1995-11-21 | Andcare, Inc. | Colloidal-gold electrosensor measuring device |
| US5217594A (en) * | 1992-01-15 | 1993-06-08 | Enzyme Technology Research Group, Inc. | Convenient determination of trace lead in whole blood and other fluids |
| US5227042A (en) * | 1992-05-15 | 1993-07-13 | The United States Of America As Represented By The United States Department Of Energy | Catalyzed enzyme electrodes |
| DE4427363A1 (de) * | 1993-08-03 | 1995-03-09 | A & D Co Ltd | Chemischer Einmalsensor |
| US5643721A (en) * | 1994-02-09 | 1997-07-01 | Abbott Laboratories | Bioreagent immobilization medium |
| US5494562A (en) * | 1994-06-27 | 1996-02-27 | Ciba Corning Diagnostics Corp. | Electrochemical sensors |
| IE72524B1 (en) * | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
| US5696314A (en) * | 1996-07-12 | 1997-12-09 | Chiron Diagnostics Corporation | Multilayer enzyme electrode membranes and methods of making same |
| US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
| US9155496B2 (en) | 1997-03-04 | 2015-10-13 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US8527026B2 (en) | 1997-03-04 | 2013-09-03 | Dexcom, Inc. | Device and method for determining analyte levels |
| US7192450B2 (en) | 2003-05-21 | 2007-03-20 | Dexcom, Inc. | Porous membranes for use with implantable devices |
| US6862465B2 (en) | 1997-03-04 | 2005-03-01 | Dexcom, Inc. | Device and method for determining analyte levels |
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| US4044193A (en) * | 1971-06-16 | 1977-08-23 | Prototech Company | Finely particulated colloidal platinum compound and sol for producing the same, and method of preparation of fuel cell electrodes and the like employing the same |
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-
1988
- 1988-07-28 GB GB888817997A patent/GB8817997D0/en active Pending
-
1989
- 1989-07-07 GB GB8915605A patent/GB2221300B/en not_active Expired - Lifetime
- 1989-07-07 EP EP89306923A patent/EP0352925B1/de not_active Expired - Lifetime
- 1989-07-07 DE DE68920223T patent/DE68920223T2/de not_active Expired - Lifetime
- 1989-07-14 IL IL9098389A patent/IL90983A/en unknown
- 1989-07-17 CA CA000605817A patent/CA1311522C/en not_active Expired - Lifetime
- 1989-07-18 US US07/381,580 patent/US5160418A/en not_active Expired - Lifetime
- 1989-07-18 AU AU38216/89A patent/AU621913B2/en not_active Expired
- 1989-07-24 FI FI893542A patent/FI96517C/fi active IP Right Grant
- 1989-07-24 NO NO893019A patent/NO300144B1/no not_active IP Right Cessation
- 1989-07-27 HU HU893822A patent/HU209704B/hu unknown
- 1989-07-27 DK DK371489A patent/DK171603B1/da not_active IP Right Cessation
- 1989-07-27 RU SU894614801A patent/RU1836428C/ru active
- 1989-07-27 IE IE245189A patent/IE60578B1/en not_active IP Right Cessation
- 1989-07-28 KR KR1019890010694A patent/KR0128159B1/ko not_active Expired - Lifetime
- 1989-07-28 MX MX016979A patent/MX170142B/es unknown
- 1989-07-28 JP JP1194433A patent/JP3056221B2/ja not_active Expired - Lifetime
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|---|---|
| AU3821689A (en) | 1990-02-01 |
| NO893019D0 (no) | 1989-07-24 |
| FI96517C (fi) | 1996-07-10 |
| GB2221300B (en) | 1991-12-18 |
| US5160418A (en) | 1992-11-03 |
| DE68920223T2 (de) | 1995-07-13 |
| KR910002519A (ko) | 1991-02-25 |
| AU621913B2 (en) | 1992-03-26 |
| HUT51326A (en) | 1990-04-28 |
| NO300144B1 (no) | 1997-04-14 |
| RU1836428C (ru) | 1993-08-23 |
| IE60578B1 (en) | 1994-07-27 |
| IL90983A0 (en) | 1990-02-09 |
| IE892451L (en) | 1990-01-28 |
| FI893542A0 (fi) | 1989-07-24 |
| GB8915605D0 (en) | 1989-08-23 |
| EP0352925A3 (en) | 1990-04-18 |
| FI893542L (fi) | 1990-01-29 |
| DK371489D0 (da) | 1989-07-27 |
| CA1311522C (en) | 1992-12-15 |
| JPH0299849A (ja) | 1990-04-11 |
| FI96517B (fi) | 1996-03-29 |
| KR0128159B1 (ko) | 1998-04-01 |
| NO893019L (no) | 1990-01-29 |
| DE68920223D1 (de) | 1995-02-09 |
| EP0352925A2 (de) | 1990-01-31 |
| GB8817997D0 (en) | 1988-09-01 |
| DK371489A (da) | 1990-01-29 |
| HU209704B (en) | 1994-10-28 |
| GB2221300A (en) | 1990-01-31 |
| JP3056221B2 (ja) | 2000-06-26 |
| DK171603B1 (da) | 1997-02-17 |
| MX170142B (es) | 1993-08-09 |
| EP0352925B1 (de) | 1994-12-28 |
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