IL91712A - Recombinant DNA containing sequences encoding genes A, B, G or I of the Tylosin production of EAIDARF SECYMOTPERTS Vectors and surrogate cells are converted - Google Patents

Recombinant DNA containing sequences encoding genes A, B, G or I of the Tylosin production of EAIDARF SECYMOTPERTS Vectors and surrogate cells are converted

Info

Publication number: IL91712A
Authority: IL; Israel
Prior art keywords: plasmid; dna; fragment; antibiotic; gene
Prior art date: 1988-09-29

Application number

IL9171289A

Other languages

English (en)

Hebrew (he)

Other versions

IL91712A0 (en

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-29

Filing date

1989-09-21

Publication date

1996-01-31

1989-09-21 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1990-06-10 Publication of IL91712A0 publication Critical patent/IL91712A0/xx

1996-01-31 Publication of IL91712A publication Critical patent/IL91712A/en

Links

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241000187438 Streptomyces fradiae Species 0.000 title claims abstract description 61
239000004182 Tylosin Substances 0.000 title claims abstract description 61
229930194936 Tylosin Natural products 0.000 title claims abstract description 61
235000019375 tylosin Nutrition 0.000 title claims abstract description 61
229960004059 tylosin Drugs 0.000 title claims abstract description 61
WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 title claims abstract description 59
230000001851 biosynthetic effect Effects 0.000 title claims abstract description 54
108020004511 Recombinant DNA Proteins 0.000 title claims abstract description 21
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230000000694 effects Effects 0.000 claims abstract description 30
239000013612 plasmid Substances 0.000 claims description 150
239000012634 fragment Substances 0.000 claims description 66
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ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces

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Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)

IL9171289A 1988-09-29 1989-09-21 Recombinant DNA containing sequences encoding genes A, B, G or I of the Tylosin production of EAIDARF SECYMOTPERTS Vectors and surrogate cells are converted IL91712A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25171888A	1988-09-29	1988-09-29

Publications (2)

Publication Number	Publication Date
IL91712A0 IL91712A0 (en)	1990-06-10
IL91712A true IL91712A (en)	1996-01-31

Family

ID=22953112

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9171289A IL91712A (en)	1988-09-29	1989-09-21	Recombinant DNA containing sequences encoding genes A, B, G or I of the Tylosin production of EAIDARF SECYMOTPERTS Vectors and surrogate cells are converted

Country Status (12)

Country	Link
EP (1)	EP0364130B1 (de)
JP (1)	JPH02182189A (de)
AT (1)	ATE125868T1 (de)
AU (1)	AU615344B2 (de)
DE (1)	DE68923672T2 (de)
DK (1)	DK175943B1 (de)
ES (1)	ES2076967T3 (de)
GR (1)	GR3017030T3 (de)
HK (1)	HK186695A (de)
HU (1)	HUT52155A (de)
IE (1)	IE67870B1 (de)
IL (1)	IL91712A (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2197524A1 (en) *	1996-02-22	1997-08-22	Bradley Stuart Dehoff	Polyketide synthase genes
ES2155342B1 (es) *	1998-08-05	2001-12-01	Antibioticos Sau	Mejoras de cepas de streptomyces mediante la utilizacion de genes biosinteticos de tilosina.
CN116286581A (zh) *	2023-04-01	2023-06-23	中国科学院微生物研究所	菌株及其在发酵产泰乐菌素中的应用
CN116426450A (zh) *	2023-04-01	2023-07-14	中国科学院微生物研究所	菌株及其在制备泰乐菌素a中的应用

1989
- 1989-09-21 IL IL9171289A patent/IL91712A/en not_active IP Right Cessation
- 1989-09-25 DK DK198904705A patent/DK175943B1/da not_active IP Right Cessation
- 1989-09-27 ES ES89309852T patent/ES2076967T3/es not_active Expired - Lifetime
- 1989-09-27 AU AU42341/89A patent/AU615344B2/en not_active Expired
- 1989-09-27 DE DE68923672T patent/DE68923672T2/de not_active Expired - Lifetime
- 1989-09-27 AT AT89309852T patent/ATE125868T1/de not_active IP Right Cessation
- 1989-09-27 EP EP89309852A patent/EP0364130B1/de not_active Expired - Lifetime
- 1989-09-27 HU HU895093A patent/HUT52155A/hu unknown
- 1989-09-28 IE IE310589A patent/IE67870B1/en not_active IP Right Cessation
- 1989-09-28 JP JP1256891A patent/JPH02182189A/ja active Pending
1995
- 1995-08-03 GR GR950402026T patent/GR3017030T3/el unknown
- 1995-12-07 HK HK186695A patent/HK186695A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU4234189A (en)	1990-04-05
JPH02182189A (ja)	1990-07-16
AU615344B2 (en)	1991-09-26
IL91712A0 (en)	1990-06-10
EP0364130B1 (de)	1995-08-02
DK175943B1 (da)	2005-08-01
GR3017030T3 (en)	1995-11-30
HK186695A (en)	1995-12-15
DE68923672D1 (de)	1995-09-07
IE67870B1 (en)	1996-05-01
IE893105L (en)	1990-03-29
EP0364130A2 (de)	1990-04-18
DE68923672T2 (de)	1996-02-22
EP0364130A3 (de)	1991-06-12
DK470589A (da)	1990-03-30
DK470589D0 (da)	1989-09-25
ATE125868T1 (de)	1995-08-15
ES2076967T3 (es)	1995-11-16
HUT52155A (en)	1990-06-28

Legal Events

Date	Code	Title
1996-07-23	FF	Patent granted
1996-10-16	KB	Patent renewed
2000-01-31	KB	Patent renewed
2003-11-23	KB	Patent renewed
2007-10-31	KB	Patent renewed
2010-05-31	EXP	Patent expired

Publication	Publication Date	Title
US4935340A (en)	1990-06-19	Method of isolating antibiotic biosynthetic genes
US5672497A (en)	1997-09-30	Method for increasing the antibiotic-producing ability of antibiotic-producing microorganisms
US5098837A (en)	1992-03-24	Macrolide biosynthetic genes for use in streptomyces and other organisms
EP0238323B1 (de)	1994-12-28	Tylosin Antibiotika produzierende Mikroorganismen
US5149638A (en)	1992-09-22	Tylosin biosynthetic genes tylA, tylB and tylI
US5190871A (en)	1993-03-02	Use of the site-specific integrating function of phage φC31
EP0085548A2 (de)	1983-08-10	Klonierungsvektoren
IE922435A1 (en)	1993-01-27	Activator gene for macrolide biosynthesis
US5786181A (en)	1998-07-28	Process for producing high purity 6, 12-dideoxyerythromycin A by fermentation
US5589385A (en)	1996-12-31	Cloning of the biosynthetic pathway for chlortetracycline and tetracycline formation and cosmids useful therein
EP0115173A2 (de)	1984-08-08	Klonierungsvektoren für Streptomyces
EP0364130B1 (de)	1995-08-02	Neue Tylosin-Biosynthese-Gene
CA1336693C (en)	1995-08-15	Recombinant dna vectors encoding a 4"-0-isovaleryl acylase derived from a carbomycin biosynthetic gene, designated care, for use in streptomyces and other organisms
EP0391594A2 (de)	1990-10-10	Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung
HU197354B (en)	1989-03-28	Process for selecting streptomyces containing recombinant dna
HU208551B (en)	1993-11-29	Process for producing recombinant dns shuttle vector and chromosomal gene-bank
KR100193208B1 (ko)	1999-06-15	테트라사이클린 및 클로르테트라사이클린의 생합성 경로를 암호화하는 유전자 집락을 함유한 코스미드 및 이를 사용하여 상기 단백질의 수율을 증가 시키는 방법
AU602954B2 (en)	1990-11-01	Carbomycin biosynthetic gene, designated carg, for use in streptomyces and other organisms
US4886757A (en)	1989-12-12	Spiramycin resistance-conferring cloning vectors
US4889809A (en)	1989-12-26	Tylosin resistance-conferring gene, designated tlrC, for use in streptomyces fradiae
Lampel	1988	Transformation and cloning in anthracycline-producing streptomycetes
NZ232685A (en)	1992-01-29	Tylosin biosynthetic pathway and genetically engineered organisms