IL91814A - Pharmaceutical compositions comprising 6-phenyl (methyl)-2,7-bis (cyclic amino)-4- pteridinamines, certain novel such pteridines and their preparation - Google Patents

Pharmaceutical compositions comprising 6-phenyl (methyl)-2,7-bis (cyclic amino)-4- pteridinamines, certain novel such pteridines and their preparation

Info

Publication number
IL91814A
IL91814A IL9181489A IL9181489A IL91814A IL 91814 A IL91814 A IL 91814A IL 9181489 A IL9181489 A IL 9181489A IL 9181489 A IL9181489 A IL 9181489A IL 91814 A IL91814 A IL 91814A
Authority
IL
Israel
Prior art keywords
methyl
group
morpholino
pteridine
phenyl
Prior art date
Application number
IL9181489A
Other languages
English (en)
Other versions
IL91814A0 (en
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of IL91814A0 publication Critical patent/IL91814A0/xx
Publication of IL91814A publication Critical patent/IL91814A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL9181489A 1988-10-01 1989-09-28 Pharmaceutical compositions comprising 6-phenyl (methyl)-2,7-bis (cyclic amino)-4- pteridinamines, certain novel such pteridines and their preparation IL91814A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3833393A DE3833393A1 (de) 1988-10-01 1988-10-01 Verwendung von pteridinen zur verhinderung der primaeren und sekundaeren resistenz bei der chemotherapie und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
IL91814A0 IL91814A0 (en) 1990-06-10
IL91814A true IL91814A (en) 1994-02-27

Family

ID=6364156

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9181489A IL91814A (en) 1988-10-01 1989-09-28 Pharmaceutical compositions comprising 6-phenyl (methyl)-2,7-bis (cyclic amino)-4- pteridinamines, certain novel such pteridines and their preparation

Country Status (19)

Country Link
EP (1) EP0362645B1 (fr)
JP (1) JPH02256676A (fr)
KR (1) KR910006289A (fr)
AT (1) ATE106728T1 (fr)
AU (1) AU620645B2 (fr)
DD (1) DD299062A5 (fr)
DE (2) DE3833393A1 (fr)
DK (1) DK480489A (fr)
ES (1) ES2056174T3 (fr)
FI (1) FI92699C (fr)
HU (1) HU205761B (fr)
IL (1) IL91814A (fr)
MX (1) MX9203034A (fr)
NO (1) NO175979C (fr)
NZ (1) NZ230833A (fr)
PT (1) PT91836B (fr)
SU (1) SU1720491A3 (fr)
UA (1) UA8028A1 (fr)
ZA (1) ZA897414B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000039129A1 (fr) * 1998-12-28 2000-07-06 K.U. Leuven Research & Development Effets immunosuppresseurs de derives de la pteridine
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
DE10202468A1 (de) * 2002-01-23 2004-09-30 Faustus Forschungs Cie. Translational Cancer Research Gmbh Pteridinderivate, Verfahren zu deren Herstellung und ihre Verwendung
ATE369861T1 (de) * 2003-09-12 2007-09-15 4 Aza Ip Nv Pteridin-derivate zur behandlung von erkrankungen im zusammenhang mit tnf-alpha
DE602004008312T2 (de) * 2003-10-17 2008-04-17 4 Aza Ip Nv Heterocyclus-substituierte pteridin-derivate und ihre verwendung in der therapie
RU2447074C2 (ru) * 2005-05-12 2012-04-10 Тиботек Фармасьютикалз Лтд. Птеридины, полезные в качестве ингибиторов hcv, и способы получения птеридинов
WO2008009078A2 (fr) 2006-07-20 2008-01-24 Gilead Sciences, Inc. Dérivés de la quinazoline tri-substitués en 4,6-dl et en 2,4,6 utilisables pour traiter les infections virales
US10144736B2 (en) 2006-07-20 2018-12-04 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
DK3097102T3 (en) 2015-03-04 2018-01-22 Gilead Sciences Inc TOLL-LIKE RECEPTOR MODULATING 4,6-DIAMINO-PYRIDO [3,2-D] PYRIMIDINE COMPOUNDS
KR20160003575A (ko) 2015-11-09 2016-01-11 정민시 발전기용 동력전달장치
WO2018045150A1 (fr) 2016-09-02 2018-03-08 Gilead Sciences, Inc. Dérivés de 4,6-diamino-pyrido [3,2-d] pyrimidine en tant que modulateurs du récepteur de type toll
MA46093A (fr) 2016-09-02 2021-05-19 Gilead Sciences Inc Composés modulateurs du recepteur de type toll
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3574206A (en) * 1965-04-15 1971-04-06 Boehringer Sohn Ingelheim 2,7-dimorpholino-4-amino-6-phenyl-pteridines
NL129630C (fr) * 1966-10-14
DE1617336C2 (de) * 1966-11-25 1982-07-01 C.H. Boehringer Sohn, 6507 Ingelheim Arzneimittel gegen Angina pectoris
DE1795515A1 (de) * 1967-08-18 1972-03-30 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen Pteridinen
DE1795516A1 (de) * 1967-12-15 1972-01-27 Thomae Gmbh Dr K 4-AEthanolisopropanolamino-2-(2'-methylmorpholino)-7-morpholino-6-phenyl-pteridin
DE1921308A1 (de) * 1969-04-25 1971-01-07 Boehringer Sohn Ingelheim Herzwirksame Zubereitungen
US4767761A (en) * 1987-11-04 1988-08-30 Dana-Farber Cancer Institute, Inc. Ornithine derivatives and their use as methotrexate-resistant cell inhibitors

Also Published As

Publication number Publication date
FI92699C (fi) 1994-12-27
NO175979C (no) 1995-01-11
FI92699B (fi) 1994-09-15
EP0362645A3 (fr) 1992-03-25
EP0362645B1 (fr) 1994-06-08
DE3833393A1 (de) 1990-04-05
EP0362645A2 (fr) 1990-04-11
PT91836B (pt) 1995-07-18
ATE106728T1 (de) 1994-06-15
DK480489D0 (da) 1989-09-29
NZ230833A (en) 1991-05-28
ES2056174T3 (es) 1994-10-01
ZA897414B (en) 1991-06-26
FI894615A7 (fi) 1990-04-02
DK480489A (da) 1990-04-02
NO893879L (no) 1990-04-02
PT91836A (pt) 1990-04-30
KR910006289A (ko) 1991-04-29
JPH02256676A (ja) 1990-10-17
NO893879D0 (no) 1989-09-29
AU4174989A (en) 1990-04-05
IL91814A0 (en) 1990-06-10
FI894615A0 (fi) 1989-09-29
UA8028A1 (uk) 1995-12-26
SU1720491A3 (ru) 1992-03-15
HUT52504A (en) 1990-07-28
MX9203034A (es) 1992-07-01
DE58907824D1 (de) 1994-07-14
HU205761B (en) 1992-06-29
AU620645B2 (en) 1992-02-20
DD299062A5 (de) 1992-03-26
NO175979B (no) 1994-10-03

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RH Patent void