IL91886A - An antidote to blood anticoagulants - Google Patents

An antidote to blood anticoagulants

Info

Publication number: IL91886A
Authority: IL; Israel
Prior art keywords: hirudin; factor viii; blood; desulphatohirudin; dna
Prior art date: 1988-10-06

Application number

IL9188689A

Other languages

English (en)

Hebrew (he)

Other versions

IL91886A0 (en

Original Assignee

Ciba Geigy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-06

Filing date

1989-10-04

Publication date

1995-07-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10644806&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL91886(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1989-10-04 Application filed by Ciba Geigy filed Critical Ciba Geigy

1990-06-10 Publication of IL91886A0 publication Critical patent/IL91886A0/xx

1995-07-31 Publication of IL91886A publication Critical patent/IL91886A/en

Links

239000003146 anticoagulant agent Substances 0.000 title claims abstract description 46
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210000004369 blood Anatomy 0.000 title claims abstract description 41
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239000000729 antidote Substances 0.000 title claims abstract description 20
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108010054218 Factor VIII Proteins 0.000 claims abstract description 78
102000001690 Factor VIII Human genes 0.000 claims abstract description 78
239000012634 fragment Substances 0.000 claims abstract description 39
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108010055341 glutamyl-glutamic acid Proteins 0.000 description 1
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DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Tropical Medicine & Parasitology (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Materials For Medical Uses (AREA)
Dental Preparations (AREA)
Materials Applied To Surfaces To Minimize Adherence Of Mist Or Water (AREA)
Saccharide Compounds (AREA)
External Artificial Organs (AREA)

IL9188689A 1988-10-06 1989-10-04 An antidote to blood anticoagulants IL91886A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888823480A GB8823480D0 (en)	1988-10-06	1988-10-06	Antidote

Publications (2)

Publication Number	Publication Date
IL91886A0 IL91886A0 (en)	1990-06-10
IL91886A true IL91886A (en)	1995-07-31

Family

ID=10644806

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9188689A IL91886A (en)	1988-10-06	1989-10-04	An antidote to blood anticoagulants

Country Status (13)

Country	Link
EP (1)	EP0367713B2 (fr)
JP (1)	JPH02145526A (fr)
KR (1)	KR0147294B1 (fr)
AT (1)	ATE77752T1 (fr)
AU (1)	AU624635B2 (fr)
CA (1)	CA2000153C (fr)
DE (1)	DE68901964T2 (fr)
DK (1)	DK491289A (fr)
GB (1)	GB8823480D0 (fr)
IE (1)	IE61361B1 (fr)
IL (1)	IL91886A (fr)
NZ (1)	NZ230899A (fr)
ZA (1)	ZA897586B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL99527A (en) *	1990-09-28	1997-08-14	Lilly Co Eli	Tripeptide antithrombotic agents
WO1994008034A1 (fr) *	1992-09-28	1994-04-14	Japan Energy Corporation	Nouvelle variante d'hirudine, son procede de production, et anticoagulant la contenant comme ingredient actif
US5972648A (en) *	1993-09-28	1999-10-26	Japan Energy Corporation	Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients
DE4430205A1 (de) *	1994-08-26	1996-02-29	Behringwerke Ag	Zusammensetzungen, die als Gegenmittel für Blut-Antikoagulanzien geeignet sind und deren Verwendung
DE4437544A1 (de)	1994-10-20	1996-04-25	Behringwerke Ag	Einsatz von vWF-enthaltenden Konzentraten als Kombinationstherapie bei Therapie mit Antithrombotika und Fibrinolytika
WO2025262265A1 (fr)	2024-06-21	2025-12-26	Etablissement Francais Du Sang	Molécules chimériques comprenant un anticorps anti-fibrine et une molécule antithrombotique

1988
- 1988-10-06 GB GB888823480A patent/GB8823480D0/en active Pending
1989
- 1989-09-27 AT AT89810733T patent/ATE77752T1/de not_active IP Right Cessation
- 1989-09-27 EP EP89810733A patent/EP0367713B2/fr not_active Expired - Lifetime
- 1989-09-27 DE DE68901964T patent/DE68901964T2/de not_active Expired - Fee Related
- 1989-10-04 NZ NZ230899A patent/NZ230899A/xx unknown
- 1989-10-04 IL IL9188689A patent/IL91886A/en not_active IP Right Cessation
- 1989-10-04 JP JP1257982A patent/JPH02145526A/ja active Pending
- 1989-10-04 KR KR1019890014200A patent/KR0147294B1/ko not_active Expired - Fee Related
- 1989-10-04 CA CA002000153A patent/CA2000153C/fr not_active Expired - Fee Related
- 1989-10-05 DK DK491289A patent/DK491289A/da not_active Application Discontinuation
- 1989-10-05 ZA ZA897586A patent/ZA897586B/xx unknown
- 1989-10-05 IE IE321289A patent/IE61361B1/en not_active IP Right Cessation
- 1989-10-06 AU AU42662/89A patent/AU624635B2/en not_active Ceased

Also Published As

Publication number	Publication date
IE893212L (en)	1990-04-06
GB8823480D0 (en)	1988-11-16
DE68901964T2 (de)	1995-06-14
DK491289A (da)	1990-04-07
ATE77752T1 (de)	1992-07-15
CA2000153C (fr)	1999-07-13
CA2000153A1 (fr)	1990-04-06
EP0367713B1 (fr)	1992-07-01
IE61361B1 (en)	1994-11-02
AU4266289A (en)	1990-04-12
EP0367713B2 (fr)	1995-01-04
AU624635B2 (en)	1992-06-18
ZA897586B (en)	1990-05-30
KR900005992A (ko)	1990-05-07
DE68901964D1 (de)	1992-08-06
DK491289D0 (da)	1989-10-05
IL91886A0 (en)	1990-06-10
KR0147294B1 (ko)	1998-08-17
EP0367713A1 (fr)	1990-05-09
JPH02145526A (ja)	1990-06-05
NZ230899A (en)	1991-10-25

Legal Events

Date	Code	Title
1998-02-08	HC	Change of name of proprietor(s)
2000-02-17	KB	Patent renewed
2004-06-20	RH1	Patent not in force

Publication	Publication Date	Title
US5204323A (en)	1993-04-20	Heparin and hirudin antidotal compositions and methods
CA1336493C (fr)	1995-08-01	Combinaison pharmacologiquement active renfermant un activateur du plasminogene et un inhibiteur de la thrombine
AU735427B2 (en)	2001-07-05	Bi- or multifunctional molecules based on a dendroaspin scaffold
AU617989B2 (en)	1991-12-12	Variants of hirudin, their use and their preparation
US5583111A (en)	1996-12-10	Thrombin inhibitors
AU624635B2 (en)	1992-06-18	Antidote
US5876971A (en)	1999-03-02	Thrombin inhibitor from the saliva of protostomia
US5482923A (en)	1996-01-09	Heparin neutralization with platelet factor 4 fragments
EP0710285B1 (fr)	2001-04-11	Analogues d'un polypeptide antithrombine et leur procede de preparation
JP2001519442A (ja)	2001-10-23	三価のトロンビン阻害剤
HK1130209A1 (en)	2009-12-24	Therapeutic and/or ameliorating agent for disseminated intravascular coagulation