IL92146A - Aqueous solution of water-soluble adsorption salt of ibopamine for ophthalmic use - Google Patents

Aqueous solution of water-soluble adsorption salt of ibopamine for ophthalmic use

Info

Publication number: IL92146A
Authority: IL; Israel
Prior art keywords: solution; ibopamine; solution according; water soluble; acid addition
Prior art date: 1988-11-09

Application number

IL9214689A

Other languages

English (en)

Hebrew (he)

Other versions

IL92146A0 (en

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-09

Filing date

1989-10-30

Publication date

1994-06-24

1989-10-30 Application filed by Zambon Spa filed Critical Zambon Spa

1990-07-12 Publication of IL92146A0 publication Critical patent/IL92146A0/xx

1994-06-24 Publication of IL92146A publication Critical patent/IL92146A/en

Links

WDKXLLJDNUBYCY-UHFFFAOYSA-N ibopamine Chemical compound CNCCC1=CC=C(OC(=O)C(C)C)C(OC(=O)C(C)C)=C1 WDKXLLJDNUBYCY-UHFFFAOYSA-N 0.000 title claims abstract description 44
229960004370 ibopamine Drugs 0.000 title claims abstract description 20
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 16
150000003839 salts Chemical class 0.000 title claims abstract description 13
239000002253 acid Substances 0.000 title claims abstract description 12
239000007864 aqueous solution Substances 0.000 title claims description 12
239000000243 solution Substances 0.000 claims description 35
ALIXRWKJZYLBJI-UHFFFAOYSA-N [4-[2-(methylamino)ethyl]-2-(2-methylpropanoyloxy)phenyl] 2-methylpropanoate;hydrochloride Chemical compound Cl.CNCCC1=CC=C(OC(=O)C(C)C)C(OC(=O)C(C)C)=C1 ALIXRWKJZYLBJI-UHFFFAOYSA-N 0.000 claims description 8
229960001216 ibopamine hydrochloride Drugs 0.000 claims description 8
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 6
229930195725 Mannitol Natural products 0.000 claims description 6
229920003091 Methocel™ Polymers 0.000 claims description 6
229960000686 benzalkonium chloride Drugs 0.000 claims description 6
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 6
239000000594 mannitol Substances 0.000 claims description 6
235000010355 mannitol Nutrition 0.000 claims description 6
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
229920000609 methyl cellulose Polymers 0.000 claims description 2
239000001923 methylcellulose Substances 0.000 claims description 2
235000010981 methylcellulose Nutrition 0.000 claims description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract description 9
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract description 9
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract description 9
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract description 9
238000011282 treatment Methods 0.000 description 5
239000000203 mixture Substances 0.000 description 4
YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
229960002303 citric acid monohydrate Drugs 0.000 description 3
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 3
239000000843 powder Substances 0.000 description 3
210000001747 pupil Anatomy 0.000 description 3
239000008223 sterile water Substances 0.000 description 3
229940061607 dibasic sodium phosphate Drugs 0.000 description 2
NGKZFDYBISXGGS-UHFFFAOYSA-N epinine Chemical compound CNCCC1=CC=C(O)C(O)=C1 NGKZFDYBISXGGS-UHFFFAOYSA-N 0.000 description 2
-1 epinine 3 Chemical compound 0.000 description 2
230000002911 mydriatic effect Effects 0.000 description 2
239000002904 solvent Substances 0.000 description 2
241000919811 Collyria Species 0.000 description 1
206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
230000003139 buffering effect Effects 0.000 description 1
229960004106 citric acid Drugs 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
DGLRDKLJZLEJCY-UHFFFAOYSA-L disodium hydrogenphosphate dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O DGLRDKLJZLEJCY-UHFFFAOYSA-L 0.000 description 1
229910000397 disodium phosphate Inorganic materials 0.000 description 1
235000019800 disodium phosphate Nutrition 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
238000007619 statistical method Methods 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL9214689A 1988-11-09 1989-10-30 Aqueous solution of water-soluble adsorption salt of ibopamine for ophthalmic use IL92146A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8822558A IT1231488B (it)	1988-11-09	1988-11-09	Soluzione acquosa farmaceutica tamponata a ph 4,5 per uso oftalmico contenente ibopamina e idrossipropilmetilcellulosa

Publications (2)

Publication Number	Publication Date
IL92146A0 IL92146A0 (en)	1990-07-12
IL92146A true IL92146A (en)	1994-06-24

Family

ID=11197818

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9214689A IL92146A (en)	1988-11-09	1989-10-30	Aqueous solution of water-soluble adsorption salt of ibopamine for ophthalmic use

Country Status (15)

Country	Link
EP (1)	EP0442958B1 (ja)
JP (1)	JP2842689B2 (ja)
KR (1)	KR0137647B1 (ja)
AU (1)	AU628114B2 (ja)
CA (1)	CA2002552C (ja)
DE (1)	DE68912947T2 (ja)
DK (1)	DK175270B1 (ja)
ES (1)	ES2018939A6 (ja)
FI (1)	FI94389C (ja)
GR (1)	GR1002474B (ja)
IE (1)	IE62756B1 (ja)
IL (1)	IL92146A (ja)
IT (1)	IT1231488B (ja)
WO (1)	WO1990004964A1 (ja)
ZA (1)	ZA898325B (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995000143A1 (en) *	1993-06-24	1995-01-05	Leiras Oy	Composition for ophthalmic use
ITMI20040146A1 (it) *	2004-01-30	2004-04-30	Acraf	Ibopamina maleato metodo per prepararlo e composizioni farmaceutiche che lo comprendono
US20240065999A1 (en) *	2020-11-09	2024-02-29	The Board Of Trustees Of The Leland Stanford Junior University	Ophthalmic Formulation Containing a Dopaminergic Prodrug that may be Combined with One or More Agents
WO2025181000A1 (en) *	2024-02-26	2025-09-04	Emagine Sa	Composition for the treatment of keratoconus

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US421470A (en) *		1890-02-18		alden
IT1178800B (it) *	1984-12-27	1987-09-16	Simes	Composizioni farmaceutiche e loro uso come midriatici

1988
- 1988-11-09 IT IT8822558A patent/IT1231488B/it active
1989
- 1989-10-13 KR KR1019900701461A patent/KR0137647B1/ko not_active Expired - Fee Related
- 1989-10-30 IL IL9214689A patent/IL92146A/en unknown
- 1989-10-31 AU AU46297/89A patent/AU628114B2/en not_active Expired
- 1989-10-31 JP JP2500034A patent/JP2842689B2/ja not_active Expired - Lifetime
- 1989-10-31 EP EP89913132A patent/EP0442958B1/en not_active Expired - Lifetime
- 1989-10-31 WO PCT/EP1989/001304 patent/WO1990004964A1/en not_active Ceased
- 1989-10-31 DE DE68912947T patent/DE68912947T2/de not_active Expired - Lifetime
- 1989-11-01 ZA ZA898325A patent/ZA898325B/xx unknown
- 1989-11-07 GR GR890100737A patent/GR1002474B/el not_active IP Right Cessation
- 1989-11-07 ES ES8903769A patent/ES2018939A6/es not_active Expired - Fee Related
- 1989-11-08 IE IE359689A patent/IE62756B1/en not_active IP Right Cessation
- 1989-11-08 CA CA002002552A patent/CA2002552C/en not_active Expired - Lifetime
1991
- 1991-04-29 DK DK199100780A patent/DK175270B1/da not_active IP Right Cessation
- 1991-05-02 FI FI912131A patent/FI94389C/fi active

Also Published As

Publication number	Publication date
CA2002552C (en)	1999-12-07
DK175270B1 (da)	2004-08-02
AU4629789A (en)	1990-05-28
JPH04501563A (ja)	1992-03-19
DE68912947D1 (de)	1994-03-17
EP0442958A1 (en)	1991-08-28
DK78091D0 (da)	1991-04-29
KR900701263A (ko)	1990-12-01
IL92146A0 (en)	1990-07-12
DK78091A (da)	1991-04-29
FI94389C (fi)	1995-09-11
CA2002552A1 (en)	1990-05-09
ZA898325B (en)	1990-09-26
IE893596L (en)	1990-05-09
KR0137647B1 (ko)	1998-05-15
GR1002474B (el)	1996-11-26
DE68912947T2 (de)	1994-08-25
IT8822558A0 (it)	1988-11-09
IT1231488B (it)	1991-12-07
JP2842689B2 (ja)	1999-01-06
AU628114B2 (en)	1992-09-10
WO1990004964A1 (en)	1990-05-17
FI912131A0 (fi)	1991-05-02
GR890100737A (el)	1990-12-31
IE62756B1 (en)	1995-02-22
FI94389B (fi)	1995-05-31
ES2018939A6 (es)	1991-05-16
EP0442958B1 (en)	1994-02-02

Legal Events

Date	Code	Title
1997-07-13	HP	Change in proprietorship
2000-08-31	KB	Patent renewed
2004-01-04	KB	Patent renewed
2008-01-06	KB	Patent renewed

Publication	Publication Date	Title
US20240307305A1 (en)	2024-09-19	Atropine-containing aqueous composition
AU2002310461B2 (en)	2006-05-18	Olopatadine formulations for topical administation
AU642210B2 (en)	1993-10-14	Therapeutic use of indole-3-yl-carboxylic acid endo-8- methyl-8-aza-bicyclo(3,2,1)oct-3-yl ester
AU2002310461A1 (en)	2003-05-15	Olopatadine formulations for topical administation
JPH0696521B2 (ja)	1994-11-30	眼局所投与用眼圧降下剤
MXPA04009735A (es)	2005-01-11	Formulaciones liquidas de baja dosis de entecavir y uso.
CA2002552C (en)	1999-12-07	Pharmaceutical aqueous solution for ophthalmic use comprising a water solube pharmaceutically acceptable acid addition salt of ibopamine
KR20100014858A (ko)	2010-02-11	국소 비강 투여용 올로파타딘 제제
PL191767B1 (pl)	2006-06-30	Stabilizowane przed racemizacją stałe lub ciekłe preparaty farmaceutyczne zawierające jako składnik czynny cilansetron, sposób wytwarzania stabilizowanych przed racemizacją stałych preparatów farmaceutycznych zawierających jako składnik czynny cilansetron oraz zastosowanie dopuszczalnych fizjologicznie rozpuszczalnych w wodzie kwaśnych dodatków
IE900733L (en)	1990-09-03	Pharmaceutical treatment
KR100776579B1 (ko)	2007-11-15	수성 액제
US4764530A (en)	1988-08-16	Pharmaceutical compositions and their use as mydriatics
WO2003086346A1 (en)	2003-10-23	Diphenhydramine tannate compositions and methods of use
EP0279121A2 (en)	1988-08-24	Pharmaceutical compositions comprising an aqueous solution of a pyranoquinoline derivative
US5093348A (en)	1992-03-03	Pharmaceutical composition for topical ophthalmic use having improved local tolerability
NZ782902B2 (en)	2025-01-22	Oxymetazoline compositions and methods for treating ocular disorders
WO1995017190A1 (en)	1995-06-29	Pharmaceuticals
HK40004290A (en)	2020-04-24	Atropine-containing aqueous composition
HK40004290B (en)	2023-05-05	Atropine-containing aqueous composition
HK1059573B (en)	2005-07-22	Olopatadine formulations for topical administration