IL92211A - Technium complex - M99, its preparation and radiopharmaceutical preparations containing it - Google Patents

Technium complex - M99, its preparation and radiopharmaceutical preparations containing it

Info

Publication number
IL92211A
IL92211A IL9221189A IL9221189A IL92211A IL 92211 A IL92211 A IL 92211A IL 9221189 A IL9221189 A IL 9221189A IL 9221189 A IL9221189 A IL 9221189A IL 92211 A IL92211 A IL 92211A
Authority
IL
Israel
Prior art keywords
symbols
technetium
complex
acooh
unsubstituted
Prior art date
Application number
IL9221189A
Other languages
English (en)
Hebrew (he)
Other versions
IL92211A0 (en
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Priority to IL10756089A priority Critical patent/IL107560A/en
Publication of IL92211A0 publication Critical patent/IL92211A0/xx
Publication of IL92211A publication Critical patent/IL92211A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
IL9221189A 1988-11-16 1989-11-03 Technium complex - M99, its preparation and radiopharmaceutical preparations containing it IL92211A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL10756089A IL107560A (en) 1988-11-16 1989-11-03 Kit for making radiopharmaceutical preparations containing the Technium-M99 complex

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/272,177 US4925650A (en) 1988-11-16 1988-11-16 Technetium -99m complex for examining the renal function

Publications (2)

Publication Number Publication Date
IL92211A0 IL92211A0 (en) 1990-07-26
IL92211A true IL92211A (en) 1995-01-24

Family

ID=23038736

Family Applications (3)

Application Number Title Priority Date Filing Date
IL9221189A IL92211A (en) 1988-11-16 1989-11-03 Technium complex - M99, its preparation and radiopharmaceutical preparations containing it
IL10756089A IL107560A (en) 1988-11-16 1989-11-03 Kit for making radiopharmaceutical preparations containing the Technium-M99 complex
IL10756093A IL107560A0 (en) 1988-11-16 1993-11-10 Kit for preparing radiopharmaceutical compositions containing a technetium-99m complex

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL10756089A IL107560A (en) 1988-11-16 1989-11-03 Kit for making radiopharmaceutical preparations containing the Technium-M99 complex
IL10756093A IL107560A0 (en) 1988-11-16 1993-11-10 Kit for preparing radiopharmaceutical compositions containing a technetium-99m complex

Country Status (9)

Country Link
US (1) US4925650A (fr)
EP (1) EP0444130B1 (fr)
JP (1) JP3129431B2 (fr)
AT (1) ATE167188T1 (fr)
AU (1) AU629880B2 (fr)
CA (1) CA2002850C (fr)
DE (1) DE68928705T2 (fr)
IL (3) IL92211A (fr)
WO (1) WO1990005733A1 (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980147A (en) * 1984-06-25 1990-12-25 University Of Utah Research Foundation Radiolabeled technetium chelates for use in renal function determinations
US5071636A (en) * 1987-12-29 1991-12-10 Nihon Medi-Physics Co., Ltd. Chelating compounds and their use
US5250666A (en) * 1989-06-16 1993-10-05 Neorx Corporation Radionuclide metal chelates for the radiolabeling of proteins
US5164176A (en) * 1989-06-16 1992-11-17 Neorx Corporation Radionuclide metal chelates for the radiolabeling of proteins
ATE130303T1 (de) * 1989-06-16 1995-12-15 Neorx Corp Radionukleid-chelatverbindungen zur radiomarkierung von proteinen.
CA2080685A1 (fr) * 1990-04-17 1991-10-18 Alfons Verbruggen Methode et trousse pour la preparation de complexes marques au technetium-99
US5143713A (en) * 1990-05-30 1992-09-01 Board Of Regents, The University Of Texas System 99m Tc labeled liposomes
US5158760A (en) * 1990-05-30 1992-10-27 Board Of Regents, The University Of Texas System 99m TC labeled liposomes
US5116598A (en) * 1990-10-29 1992-05-26 Mallinckrodt Medical, Inc. N4 technetium-99 m complexes for use as radiopharmaceuticals
US5037631A (en) * 1990-10-29 1991-08-06 Mallinckrodt Medical, Inc. Technetium-99M complex for examinating the renal function
US5104638A (en) * 1990-10-29 1992-04-14 Mallinckrodt Medical, Inc. Method of making a radiopharmaceutical complex from a kit
JP2860157B2 (ja) * 1990-10-31 1999-02-24 日本メジフィジックス株式会社 腎機能測定用の既放射能標識テクネチウムキレート注射剤の製造方法
US5243073A (en) * 1990-12-14 1993-09-07 Mallinckrodt Medical, Inc. Hexadentate ligands useful in radiographic imaging agents
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
WO1992019274A1 (fr) * 1991-05-08 1992-11-12 Mallinckrodt Medical, Inc. Chelates de technetium utilisables pour l'examen de la fonction renale
US5562894A (en) * 1991-08-09 1996-10-08 Regents Of The University Of California Amino-acyl-type and catecholamine-type contrast agents for MRI
NZ244613A (en) * 1991-10-29 1996-05-28 Bracco International B V Subst A ligand containing a hypoxia-localising moiety, preparation thereof; a kit (optionally multivial) for preparing a metal complex containing the ligand
US5808091A (en) * 1991-10-29 1998-09-15 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia localizing moiety
EP0542216A1 (fr) * 1991-11-13 1993-05-19 Hoechst Aktiengesellschaft Diaminomercapto (thio)éthers comme complexants pour nucléides applicable en médicine nucléaire, procédé pour la préparation de ces complèxes et "kits" de marquage les contenant
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
AU658310B2 (en) * 1992-07-31 1995-04-06 Australian Nuclear Science & Technology Organisation Rhenium complexes
US5496533A (en) * 1992-07-31 1996-03-05 Australian Nuclear Science & Technology Organisation Rhenium complexes
US5688485A (en) * 1992-12-31 1997-11-18 The Dupont Merck Pharmaceutical Company Radiolabelled complexes of ester-substituted diaminethiols
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
HU222574B1 (hu) * 1993-03-31 2003-08-28 Mallinckrodt Medical Inc. Redukálószerként foszfinokat tartalmazó radioaktív gyógyászati készítmények és az ezeket tartalmazó készletek
EP0618191A1 (fr) * 1993-04-02 1994-10-05 AMERSHAM INTERNATIONAL plc Composés chelateurs pour les métaux
US5464934A (en) * 1993-05-14 1995-11-07 Mallinckrodt Medical, Inc. Metal chelates as spacer compounds in biologically active peptides
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
CA2190727C (fr) * 1994-05-19 2006-07-18 Sudhakar Kasina Ligands d'atomes donneurs d'azote et de soufre pontes et substitues par amines aromatiques, utilises en imagerie
WO1996007629A1 (fr) * 1994-09-08 1996-03-14 Mallinckrodt Medical, Inc. Chelates au technetium utilises pour evaluer la fonction renale
US5955053A (en) * 1996-05-06 1999-09-21 Emory University Metal chelates as pharmaceutical imaging agents, processes of making such and uses thereof
US5986074A (en) * 1996-05-06 1999-11-16 Emory University Metal chelates as pharmaceutical imaging agents, processes of making such and uses thereof
US5919934A (en) * 1997-02-19 1999-07-06 The George Washington University Compounds, compositions, and methods for cancer imaging and therapy
US6005083A (en) * 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
US7067111B1 (en) * 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
DK1286704T3 (da) 2000-06-02 2014-09-22 Univ Texas Ethylendicystein (EC)-glucose analoge konjugater
WO2003072142A1 (fr) * 2002-02-26 2003-09-04 Amato Pharmaceutical Products, Ltd. Procede d'encapsulation de complexes metalliques dans des liposomes
JP2006522100A (ja) * 2003-03-10 2006-09-28 バイオジェン アイデック インク 標的化ペプチドに対するチオール媒介性薬物結合
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
US7414137B2 (en) 2006-03-23 2008-08-19 Inspire Pharmaceuticals, Inc. Process for the preparation of 3,4-disubstituted-thiazolidin-2-ones
US8758723B2 (en) 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
US10925977B2 (en) * 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
EP2830666B1 (fr) * 2012-03-26 2020-01-08 Board of Regents, The University of Texas System Synthèse efficace de conjugués éthylènedicystéine-sucre pour des applications d'imagerie et de thérapie

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2810753A (en) * 1954-05-24 1957-10-22 Dow Chemical Co Metal ion chelating agents
US4673562A (en) * 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
US4670545A (en) * 1984-05-11 1987-06-02 University Patents, Inc. Chelating agents for technetium-99M
EP0188256B1 (fr) * 1985-01-14 1991-08-21 NeoRx Protéines marquées par un radionuclide d'un métal pour diagnostic et thérapie
ATE52516T1 (de) * 1986-05-28 1990-05-15 Mallinckrodt Inc Technetiumchelate fuer die bestimmung der nierenfunktion.
US5279811A (en) * 1987-02-18 1994-01-18 The Du Pont Merck Pharmaceutical Company Ester-substituted diaminedithiols and radiolabeled complexes thereof

Also Published As

Publication number Publication date
EP0444130B1 (fr) 1998-06-10
IL92211A0 (en) 1990-07-26
JPH04505152A (ja) 1992-09-10
CA2002850A1 (fr) 1990-05-16
EP0444130A1 (fr) 1991-09-04
DE68928705T2 (de) 1998-10-15
IL107560A (en) 1996-11-14
DE68928705D1 (de) 1998-07-16
AU629880B2 (en) 1992-10-15
CA2002850C (fr) 2000-01-25
IL107560A0 (en) 1994-02-27
AU4648989A (en) 1990-06-12
ATE167188T1 (de) 1998-06-15
JP3129431B2 (ja) 2001-01-29
WO1990005733A1 (fr) 1990-05-31
US4925650A (en) 1990-05-15

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