IL92537A - Topical preparations and dermal systems containing 1-isobutyl-H1-imidazo [C-4,5] quinoline-4-amine - Google Patents
Topical preparations and dermal systems containing 1-isobutyl-H1-imidazo [C-4,5] quinoline-4-amineInfo
- Publication number
- IL92537A IL92537A IL9253789A IL9253789A IL92537A IL 92537 A IL92537 A IL 92537A IL 9253789 A IL9253789 A IL 9253789A IL 9253789 A IL9253789 A IL 9253789A IL 92537 A IL92537 A IL 92537A
- Authority
- IL
- Israel
- Prior art keywords
- percent
- formulation
- weight
- total weight
- amine
- Prior art date
Links
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- 239000000463 material Substances 0.000 claims abstract description 23
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
- 230000000699 topical effect Effects 0.000 claims abstract description 4
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims description 59
- 239000000178 monomer Substances 0.000 claims description 37
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 claims description 36
- FQYRLEXKXQRZDH-UHFFFAOYSA-N 4-aminoquinoline Chemical compound C1=CC=C2C(N)=CC=NC2=C1 FQYRLEXKXQRZDH-UHFFFAOYSA-N 0.000 claims description 35
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- 235000014113 dietary fatty acids Nutrition 0.000 claims description 30
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- OMNKZBIFPJNNIO-UHFFFAOYSA-N n-(2-methyl-4-oxopentan-2-yl)prop-2-enamide Chemical class CC(=O)CC(C)(C)NC(=O)C=C OMNKZBIFPJNNIO-UHFFFAOYSA-N 0.000 claims description 4
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 3
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- 229920006243 acrylic copolymer Polymers 0.000 claims 2
- FZZMTSNZRBFGGU-UHFFFAOYSA-N 2-chloro-7-fluoroquinazolin-4-amine Chemical compound FC1=CC=C2C(N)=NC(Cl)=NC2=C1 FZZMTSNZRBFGGU-UHFFFAOYSA-N 0.000 claims 1
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- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 1
- 229920001567 vinyl ester resin Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 20
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 abstract description 8
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- 230000000144 pharmacologic effect Effects 0.000 abstract 1
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- 238000010521 absorption reaction Methods 0.000 description 1
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- 229930195733 hydrocarbon Natural products 0.000 description 1
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- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
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- 239000004707 linear low-density polyethylene Substances 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical class O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 229940042472 mineral oil Drugs 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- QYZFTMMPKCOTAN-UHFFFAOYSA-N n-[2-(2-hydroxyethylamino)ethyl]-2-[[1-[2-(2-hydroxyethylamino)ethylamino]-2-methyl-1-oxopropan-2-yl]diazenyl]-2-methylpropanamide Chemical compound OCCNCCNC(=O)C(C)(C)N=NC(C)(C)C(=O)NCCNCCO QYZFTMMPKCOTAN-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- FPLYNRPOIZEADP-UHFFFAOYSA-N octylsilane Chemical compound CCCCCCCC[SiH3] FPLYNRPOIZEADP-UHFFFAOYSA-N 0.000 description 1
- 150000001451 organic peroxides Chemical class 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
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- 150000003254 radicals Chemical class 0.000 description 1
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- 238000005070 sampling Methods 0.000 description 1
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- 238000010345 tape casting Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28493388A | 1988-12-15 | 1988-12-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL92537A0 IL92537A0 (en) | 1990-08-31 |
| IL92537A true IL92537A (en) | 1994-04-12 |
Family
ID=23092090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9253789A IL92537A (en) | 1988-12-15 | 1989-12-04 | Topical preparations and dermal systems containing 1-isobutyl-H1-imidazo [C-4,5] quinoline-4-amine |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0376534B1 (es) |
| JP (1) | JP2915034B2 (es) |
| KR (1) | KR0150445B1 (es) |
| AU (1) | AU631585B2 (es) |
| CA (1) | CA2004597C (es) |
| DE (2) | DE68911499T2 (es) |
| DK (1) | DK176121B1 (es) |
| ES (1) | ES2062043T3 (es) |
| HK (1) | HK1006275A1 (es) |
| IE (1) | IE62569B1 (es) |
| IL (1) | IL92537A (es) |
| NL (1) | NL980042I1 (es) |
| NZ (1) | NZ231655A (es) |
| ZA (1) | ZA899450B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ232740A (en) * | 1989-04-20 | 1992-06-25 | Riker Laboratories Inc | Solution for parenteral administration comprising a 1h-imidazo(4,5-c) quinolin-4-amine derivative, an acid and a tonicity adjuster |
| IL105325A (en) * | 1992-04-16 | 1996-11-14 | Minnesota Mining & Mfg | Immunogen/vaccine adjuvant composition |
| WO1995004551A1 (en) * | 1993-08-10 | 1995-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Percutaneously absorbable preparation |
| DE4434775A1 (de) * | 1994-09-29 | 1996-04-04 | Beiersdorf Ag | Dermatologische Zubereitungen mit einem Gehalt an Fettsäureglyceriden gegen Superinfektionen |
| US5939090A (en) * | 1996-12-03 | 1999-08-17 | 3M Innovative Properties Company | Gel formulations for topical drug delivery |
| IT1294748B1 (it) * | 1997-09-17 | 1999-04-12 | Permatec Tech Ag | Formulazione per un dispositivo transdermico |
| TR200101943T2 (tr) * | 1999-01-08 | 2002-04-22 | 3M Innovative Properties Company | Bir immun cevap modifayeri ile mukoza ile ilgili durumların tedavisine yönelik formülasyonlar ve metodlar. |
| US8119159B2 (en) | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| EP1390383B1 (en) | 2001-05-11 | 2012-02-29 | Isis Pharmaceuticals, Inc. | Antisense permeation enhancers |
| WO2002092070A1 (en) * | 2001-05-11 | 2002-11-21 | Elan Corporation, Plc | Isostearic acid salts as permeation enhancers |
| CN1292751C (zh) * | 2002-04-23 | 2007-01-03 | 四川大学 | 皮肤局部用咪喹莫特或其衍生物脂质体及其制备方法和用途 |
| MXPA05009694A (es) * | 2003-03-13 | 2005-10-20 | 3M Innovative Properties Co | Metodos para mejorar la calidad de la piel. |
| KR101191322B1 (ko) | 2006-04-07 | 2012-10-16 | 메리온 리서치 Ⅲ 리미티드 | 증진제를 함유하는 고형 경구용 투여 제형 |
| US9023863B2 (en) | 2006-07-14 | 2015-05-05 | Stiefel Research Australia Pty Ltd | Fatty acid pharmaceutical foam |
| US20100092401A1 (en) * | 2006-07-18 | 2010-04-15 | Graceway Pharmaceuticals, Llc | Immune response modifier formulations |
| CN107096012A (zh) | 2008-05-07 | 2017-08-29 | 诺和诺德股份有限公司 | 肽的组合物及其制备方法 |
| WO2011120033A1 (en) | 2010-03-26 | 2011-09-29 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor xa inhibitors for oral administration |
| EP2661273A4 (en) | 2011-01-07 | 2014-06-04 | Merrion Res Iii Ltd | IRON PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION |
| US10265384B2 (en) | 2015-01-29 | 2019-04-23 | Novo Nordisk A/S | Tablets comprising GLP-1 agonist and enteric coating |
| ES2940736B2 (es) | 2021-11-09 | 2023-09-19 | Ntd Labs S L U | Uso combinado de imiquimod y de un hidrolizado de caseina para el tratamiento de condilomas |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL73534A (en) * | 1983-11-18 | 1990-12-23 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds |
| ATE77962T1 (de) * | 1985-02-25 | 1992-07-15 | Univ Rutgers | Dosierungssystem fuer transdermale absorption von arzneimittelwirkstoffen. |
| CA1288698C (en) * | 1985-08-30 | 1991-09-10 | Rutgers, The State University Of New Jersey | Transdermal anti-anginal pharmaceutical dosage |
-
1989
- 1989-12-04 IL IL9253789A patent/IL92537A/en not_active IP Right Cessation
- 1989-12-05 CA CA002004597A patent/CA2004597C/en not_active Expired - Lifetime
- 1989-12-05 IE IE388889A patent/IE62569B1/en not_active IP Right Cessation
- 1989-12-06 DK DK198906138A patent/DK176121B1/da not_active IP Right Cessation
- 1989-12-06 NZ NZ231655A patent/NZ231655A/en unknown
- 1989-12-11 EP EP89312885A patent/EP0376534B1/en not_active Expired - Lifetime
- 1989-12-11 ZA ZA899450A patent/ZA899450B/xx unknown
- 1989-12-11 ES ES89312885T patent/ES2062043T3/es not_active Expired - Lifetime
- 1989-12-11 DE DE68911499T patent/DE68911499T2/de not_active Expired - Lifetime
- 1989-12-11 DE DE19975026C patent/DE19975026I2/de active Active
- 1989-12-13 AU AU46706/89A patent/AU631585B2/en not_active Expired
- 1989-12-14 KR KR1019890018506A patent/KR0150445B1/ko not_active Expired - Lifetime
- 1989-12-14 JP JP1324874A patent/JP2915034B2/ja not_active Expired - Lifetime
-
1998
- 1998-06-16 HK HK98105434A patent/HK1006275A1/en not_active IP Right Cessation
- 1998-12-14 NL NL980042C patent/NL980042I1/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR0150445B1 (ko) | 1998-10-15 |
| IL92537A0 (en) | 1990-08-31 |
| CA2004597C (en) | 2000-02-08 |
| DK176121B1 (da) | 2006-09-11 |
| DE68911499D1 (de) | 1994-01-27 |
| NZ231655A (en) | 1992-06-25 |
| AU4670689A (en) | 1990-06-21 |
| EP0376534A1 (en) | 1990-07-04 |
| IE62569B1 (en) | 1995-02-08 |
| EP0376534B1 (en) | 1993-12-15 |
| KR900009084A (ko) | 1990-07-02 |
| DK613889D0 (da) | 1989-12-06 |
| DK613889A (da) | 1990-06-16 |
| AU631585B2 (en) | 1992-12-03 |
| JP2915034B2 (ja) | 1999-07-05 |
| IE893888L (en) | 1990-06-15 |
| JPH02282327A (ja) | 1990-11-19 |
| HK1006275A1 (en) | 1999-02-19 |
| CA2004597A1 (en) | 1990-06-15 |
| DE19975026I2 (de) | 2010-07-08 |
| ZA899450B (en) | 1990-09-26 |
| ES2062043T3 (es) | 1994-12-16 |
| NL980042I1 (nl) | 1999-02-01 |
| DE68911499T2 (de) | 1994-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |