IL92580A - Aryl-substituted cyclic ether derivatives, their preparation and pharmaceutical compositions containnig them - Google Patents

Aryl-substituted cyclic ether derivatives, their preparation and pharmaceutical compositions containnig them

Info

Publication number
IL92580A
IL92580A IL9258089A IL9258089A IL92580A IL 92580 A IL92580 A IL 92580A IL 9258089 A IL9258089 A IL 9258089A IL 9258089 A IL9258089 A IL 9258089A IL 92580 A IL92580 A IL 92580A
Authority
IL
Israel
Prior art keywords
containnig
aryl
preparation
pharmaceutical compositions
cyclic ether
Prior art date
Application number
IL9258089A
Other languages
English (en)
Other versions
IL92580A0 (en
Original Assignee
Ici Pharma
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Pharma, Ici Plc filed Critical Ici Pharma
Publication of IL92580A0 publication Critical patent/IL92580A0/xx
Publication of IL92580A publication Critical patent/IL92580A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL9258089A 1988-12-23 1989-12-06 Aryl-substituted cyclic ether derivatives, their preparation and pharmaceutical compositions containnig them IL92580A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88403311 1988-12-23

Publications (2)

Publication Number Publication Date
IL92580A0 IL92580A0 (en) 1990-08-31
IL92580A true IL92580A (en) 1994-04-12

Family

ID=8200452

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9258089A IL92580A (en) 1988-12-23 1989-12-06 Aryl-substituted cyclic ether derivatives, their preparation and pharmaceutical compositions containnig them

Country Status (17)

Country Link
US (1) US5098932A (de)
EP (1) EP0375457B1 (de)
JP (1) JPH03135976A (de)
AU (1) AU622965B2 (de)
CA (1) CA2006095A1 (de)
DE (1) DE68913940T2 (de)
DK (1) DK665089A (de)
ES (1) ES2063149T3 (de)
FI (1) FI896015A7 (de)
GB (1) GB8927287D0 (de)
HU (1) HUT52494A (de)
IE (1) IE63211B1 (de)
IL (1) IL92580A (de)
NO (1) NO895087L (de)
NZ (1) NZ231666A (de)
PT (1) PT92701A (de)
ZA (1) ZA899688B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE902113A1 (en) * 1989-07-18 1991-06-19 Ici Plc Diaryl ether cyclic ethers
US5254581A (en) * 1990-06-21 1993-10-19 Imperial Chemical Industries Plc Pyran derivatives and their use as inhibitors of 5-lipoxygenase
IE914005A1 (en) * 1990-12-14 1992-06-17 Zeneca Ltd Novel intermediates
CA2058254A1 (en) * 1991-01-15 1992-07-16 John Francis Kingston Benzodioxole derivatives
IL100483A0 (en) * 1991-01-17 1992-09-06 Ici Plc Sulphonamide derivatives
US5258399A (en) * 1991-01-17 1993-11-02 Imperial Chemical Industries Plc Sulphonamide derivatives
EP0505122A1 (de) * 1991-03-21 1992-09-23 Zeneca Limited Alpha, Alpha-Dialkylbenzylderivate
EP0532239B1 (de) * 1991-09-10 1995-12-13 Zeneca Limited Benzolsulfonamidderivate als 5-Lipoxygenasehemmer
GB9300894D0 (en) * 1992-02-07 1993-03-10 Zeneca Ltd Oxime derivatives
EP0555067A1 (de) * 1992-02-07 1993-08-11 Zeneca Limited Hydroxylaminderivate als 5-Lipoxygenasehemmer
CA2094465A1 (en) * 1992-04-23 1993-10-24 Pierre Andre Raymond Bruneau Cycloalkane derivatives
CA2095005A1 (en) * 1992-05-12 1993-11-13 Philip Neil Edwards Hydroxylamine derivatives
CA2095006A1 (en) * 1992-05-12 1993-11-13 Philip Neil Edwards Oxime derivatives
US5231197A (en) * 1992-06-01 1993-07-27 General Electric Company Method for producing ethylenically unsaturated graftable orthoesters
DE4228201A1 (de) * 1992-08-25 1994-03-03 Schering Ag Neue Leukotrien-B¶4¶-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AU4444393A (en) * 1992-09-01 1994-03-10 Zeneca Limited Pyrrolidine derivatives
WO1994005638A1 (en) * 1992-09-02 1994-03-17 Abbott Laboratories Trans 1,4-diether cyclohexane inhibitors of 5-lipoxygenase
US5446062A (en) * 1993-11-12 1995-08-29 Abbott Laboratories ((4-alkoxypyran-4-yl) substituted) ether, arylalkyl-, arylalkenyl-, and arylalkynyl)urea inhibitors of 5-lipoxygenase
US5407959A (en) * 1993-11-12 1995-04-18 Abbott Laboratories (Trans-1,4-dialkoxycyclohexyl) substituted arylalkylaryl-arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase
US6512121B2 (en) 1998-09-14 2003-01-28 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US5643933A (en) * 1995-06-02 1997-07-01 G. D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US6515014B2 (en) 1995-06-02 2003-02-04 G. D. Searle & Co. Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
CA2223154A1 (en) 1995-06-02 1996-12-05 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
ATE301457T1 (de) * 1995-06-12 2005-08-15 Searle & Co Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor
WO1997029776A1 (en) 1996-02-13 1997-08-21 G.D. Searle & Co. Combinations having immunosuppressive effects, containing cyclooxygenase-2-inhibitors and 5-lipoxygenase inhibitors
AU1952597A (en) 1996-02-13 1997-09-02 G.D. Searle & Co. Combinations, having immunosuppressive effects, containing cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor
US6677364B2 (en) * 1998-04-20 2004-01-13 G.D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
CN1468055A (zh) * 2000-10-03 2004-01-14 �����ɷ� 苯基丙炔基羟吡啶除草剂
ES2732293T3 (es) 2007-02-22 2019-11-21 Childrens Hospital & Res Center At Oakland Formulaciones de ácidos grasos y métodos para el uso de las mismas
EP3423429B1 (de) 2016-03-03 2023-07-12 Universite De Moncton Modulatoren der lypoxygenase- und cyclooxygenaseenzymaktivität

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3743737A (en) * 1970-05-21 1973-07-03 Smith Kline French Lab 3-sulfonamido-4-hydroxyphenyl-2-piperindinylcarbinol compositions
US3661917A (en) * 1970-05-21 1972-05-09 Smith Kline French Lab 3-sulfonamido-4-hydroxyphenyl-2-piperidylcarbinols
CA960676A (en) * 1970-05-21 1975-01-07 Smith Kline And French Canada Ltd. 3-sulfonamido-4-hydroxyphenyl-2-piperidinylcarbinols
IE56702B1 (en) * 1982-12-01 1991-11-06 Usv Pharma Corp Antiinflammatory antiallergic compounds
NO174506B (no) * 1984-10-30 1994-02-07 Usv Pharma Corp Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser
US4625034A (en) * 1985-02-04 1986-11-25 Usv Pharmaceutical Corp. 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4876346A (en) * 1985-05-02 1989-10-24 American Home Products Corporation Quinoline compounds
EP0271287A3 (de) * 1986-12-11 1990-06-13 Merck Frosst Canada Inc. Chinolindicarbonsäuren und ihre Amide
US4920133A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920130A (en) * 1987-11-02 1990-04-24 Rorer Pharamceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4918081A (en) * 1988-06-20 1990-04-17 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene d4
EP0349062A1 (de) * 1988-06-27 1990-01-03 Merck Frosst Canada Inc. Chinolinetheralkansäuren

Also Published As

Publication number Publication date
NO895087D0 (no) 1989-12-18
EP0375457A2 (de) 1990-06-27
AU622965B2 (en) 1992-04-30
DE68913940D1 (de) 1994-04-21
EP0375457B1 (de) 1994-03-16
IE63211B1 (en) 1995-04-05
HUT52494A (en) 1990-07-28
EP0375457A3 (de) 1991-01-09
DK665089A (da) 1990-06-24
AU4714789A (en) 1990-06-28
IE893881L (en) 1990-06-23
PT92701A (pt) 1990-06-29
US5098932A (en) 1992-03-24
ZA899688B (en) 1990-08-29
GB8927287D0 (en) 1990-01-31
ES2063149T3 (es) 1995-01-01
NZ231666A (en) 1992-01-29
CA2006095A1 (en) 1990-06-23
FI896015A0 (fi) 1989-12-15
IL92580A0 (en) 1990-08-31
FI896015A7 (fi) 1990-06-24
NO895087L (no) 1990-06-25
JPH03135976A (ja) 1991-06-10
DK665089D0 (da) 1989-12-22
DE68913940T2 (de) 1994-07-14

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Legal Events

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RH Patent void