IL93105A - Imidazole derivatives their preparation and pharmaceutical compositions containing them - Google Patents
Imidazole derivatives their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL93105A IL93105A IL9310590A IL9310590A IL93105A IL 93105 A IL93105 A IL 93105A IL 9310590 A IL9310590 A IL 9310590A IL 9310590 A IL9310590 A IL 9310590A IL 93105 A IL93105 A IL 93105A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- carbon atoms
- formula
- alkyl
- coome
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/299,709 US4916129A (en) | 1989-01-19 | 1989-01-19 | Combination β-blocking/angiotensin II blocking antihypertensives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL93105A0 IL93105A0 (en) | 1990-11-05 |
| IL93105A true IL93105A (en) | 1994-02-27 |
Family
ID=23155938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9310590A IL93105A (en) | 1989-01-19 | 1990-01-18 | Imidazole derivatives their preparation and pharmaceutical compositions containing them |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4916129A (ja) |
| EP (1) | EP0380959A1 (ja) |
| JP (1) | JPH032169A (ja) |
| KR (1) | KR920001672B1 (ja) |
| AU (1) | AU618503B2 (ja) |
| CA (1) | CA2006604A1 (ja) |
| FI (1) | FI900294A7 (ja) |
| HU (1) | HU205352B (ja) |
| IL (1) | IL93105A (ja) |
| MY (1) | MY104864A (ja) |
| NO (1) | NO900264L (ja) |
| NZ (1) | NZ232140A (ja) |
| PT (1) | PT92897A (ja) |
| ZA (1) | ZA90402B (ja) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR940006950B1 (ko) * | 1989-05-02 | 1994-07-30 | 후지꾸라 가부시끼가이샤 | 압전형 가속도센서 및 압전형 가속도센서장치 |
| IE70593B1 (en) * | 1989-09-29 | 1996-12-11 | Eisai Co Ltd | Biphenylmethane derivative the use of it and pharmacological compositions containing same |
| CA2028925A1 (en) * | 1989-11-06 | 1991-05-07 | Gerald R. Girard | Substituted n-(imidazolyl)alkyl alanine derivatives |
| US5073566A (en) * | 1989-11-30 | 1991-12-17 | Eli Lilly And Company | Angiotensin ii antagonist 1,3-imidazoles and use thereas |
| DE122007000050I1 (de) * | 1990-02-19 | 2007-11-08 | Novartis Ag | Acylverbindungen |
| US5179113A (en) * | 1990-03-20 | 1993-01-12 | E. I. Du Pont De Nemours And Company | Treatment of central nervous disorders with imidazole compounds |
| US5210092A (en) * | 1990-09-25 | 1993-05-11 | Fujisawa Pharmaceutical Co., Ltd. | Angiotensin ii antagonizing heterocyclic derivatives |
| DE4036706A1 (de) * | 1990-11-17 | 1992-05-21 | Hoechst Ag | Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie |
| IS1756B (is) | 1991-02-21 | 2000-12-28 | Sankyo Company Limited | Hliðstæðuaðferð til framleiðslu 1-Biphenylmethylimidazole afleiða |
| US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
| FR2673427B1 (fr) * | 1991-03-01 | 1993-06-18 | Sanofi Elf | Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant. |
| GB9110636D0 (en) * | 1991-05-16 | 1991-07-03 | Glaxo Group Ltd | Chemical compounds |
| FR2677984B1 (fr) * | 1991-06-21 | 1994-02-25 | Elf Sanofi | Derives d'imidazoline n-substitues, leur preparation, les compositions pharmaceutiques en contenant. |
| AU2494792A (en) * | 1991-08-19 | 1993-03-16 | E.I. Du Pont De Nemours And Company | Angiotensin ii receptor blocking imidazolinone derivatives |
| WO1993004045A1 (en) * | 1991-08-19 | 1993-03-04 | E.I. Du Pont De Nemours And Company | Angiotensin ii receptor blocking imidazolinone derivatives |
| US5256654A (en) * | 1991-10-24 | 1993-10-26 | American Home Products Corporation | Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists |
| US5149699A (en) * | 1991-10-24 | 1992-09-22 | American Home Products Corporation | Substituted pyridopyrimidines useful as antgiotensin II antagonists |
| US5612360A (en) * | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
| US5401851A (en) * | 1992-06-03 | 1995-03-28 | Eli Lilly And Company | Angiotensin II antagonists |
| RU2109736C1 (ru) * | 1992-12-17 | 1998-04-27 | Санкио Компани Лимитед | Производные бифенила и способ их получения |
| CZ284395B6 (cs) * | 1994-03-16 | 1998-11-11 | Sankyo Company Limited | Prostředek pro snižování očního tlaku |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3705907A (en) * | 1970-02-19 | 1972-12-12 | Sandoz Ltd | 4-(2-hydroxy)-3-aminopropoxy)-indole derivatives |
| JPS54148788A (en) * | 1978-05-15 | 1979-11-21 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative and its preparation |
| JPS5671073A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | Imidazole derivative |
| JPS5671074A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
| JPS58157768A (ja) * | 1982-03-16 | 1983-09-19 | Takeda Chem Ind Ltd | ４−クロロ−２−フエニルイミダゾ−ル−５−酢酸誘導体 |
| PT78388B (en) * | 1983-04-12 | 1986-09-15 | Smithkline Beckman Corp | Dopamine-beta-hydroxylase inhibitors |
| GB8422165D0 (en) * | 1984-09-01 | 1984-10-03 | Wellcome Found | Compounds |
| CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| ZA902794B (en) * | 1989-04-18 | 1991-04-24 | Duphar Int Res | New 3-n substituted carbamoyl-indole derivatives |
-
1989
- 1989-01-19 US US07/299,709 patent/US4916129A/en not_active Expired - Fee Related
- 1989-12-22 CA CA002006604A patent/CA2006604A1/en not_active Abandoned
-
1990
- 1990-01-17 NZ NZ232140A patent/NZ232140A/en unknown
- 1990-01-17 EP EP90100874A patent/EP0380959A1/en not_active Withdrawn
- 1990-01-18 PT PT92897A patent/PT92897A/pt not_active Application Discontinuation
- 1990-01-18 HU HU90184A patent/HU205352B/hu not_active IP Right Cessation
- 1990-01-18 IL IL9310590A patent/IL93105A/en not_active IP Right Cessation
- 1990-01-18 FI FI900294A patent/FI900294A7/fi not_active Application Discontinuation
- 1990-01-18 NO NO90900264A patent/NO900264L/no unknown
- 1990-01-18 JP JP2007287A patent/JPH032169A/ja active Pending
- 1990-01-18 KR KR1019900000556A patent/KR920001672B1/ko not_active Expired
- 1990-01-19 MY MYPI90000092A patent/MY104864A/en unknown
- 1990-01-19 ZA ZA90402A patent/ZA90402B/xx unknown
- 1990-01-19 AU AU48545/90A patent/AU618503B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| HU205352B (en) | 1992-04-28 |
| AU618503B2 (en) | 1991-12-19 |
| KR920001672B1 (ko) | 1992-02-22 |
| ZA90402B (en) | 1991-09-25 |
| KR900011739A (ko) | 1990-08-02 |
| FI900294A0 (fi) | 1990-01-18 |
| PT92897A (pt) | 1990-07-31 |
| FI900294A7 (fi) | 1990-07-20 |
| HUT53618A (en) | 1990-11-28 |
| MY104864A (en) | 1994-06-30 |
| IL93105A0 (en) | 1990-11-05 |
| NZ232140A (en) | 1991-06-25 |
| AU4854590A (en) | 1990-07-26 |
| HU900184D0 (en) | 1990-03-28 |
| NO900264D0 (no) | 1990-01-18 |
| EP0380959A1 (en) | 1990-08-08 |
| NO900264L (no) | 1990-07-20 |
| JPH032169A (ja) | 1991-01-08 |
| CA2006604A1 (en) | 1990-07-19 |
| US4916129A (en) | 1990-04-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL93105A (en) | Imidazole derivatives their preparation and pharmaceutical compositions containing them | |
| TW397825B (en) | Aroyl-piperidine derivatives | |
| RU2160736C2 (ru) | Производные индола и их физиологически приемлемые соли и сольваты, способы их получения, лекарственное средство для лечения или профилактики клинических состояний, для которых показан прием агониста "5-нт1-подобного" рецептора, и способ его получения | |
| US5352788A (en) | N-substituted heterocyclic derivatives | |
| US5541209A (en) | Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative | |
| HU221188B1 (en) | N-substituted imidazole and pyrimidine derivatives, pharmaceutical compositions comprising such compounds as active ingredients and process for producing them | |
| RU2107062C1 (ru) | N-замещенные производные имидазола или их соли, способ их получения, промежуточное соединение и фармацевтическая композиция, являющаяся антагонистом ангиотенсина ii | |
| CA2328878A1 (en) | Thienylazolylalcoxyethanamines, their preparation and their application as medicaments | |
| JP2002509930A (ja) | ベンゾ複素環ジスタマイシン誘導体、その製造方法および抗腫瘍薬としてのそれの使用 | |
| IE51946B1 (en) | Imidazolylphenyl amidines | |
| JPH0338269B2 (ja) | ||
| CA1107287A (en) | Antidepressant carbazoles and intermediates thereto | |
| JP2921760B2 (ja) | フタルイミド誘導体及びそれら誘導体を含んでなる医薬 | |
| KR100382998B1 (ko) | 6-메톡시-1h-벤조트리아졸-5-카르복사미드유도체,그제조방법및그것을함유하는의약조성물 | |
| HUT72075A (en) | Improved process for the preparation of substituted indolone derivatives | |
| KR101725292B1 (ko) | 항암 활성을 갖는 신규 피리미딘-4-카르복시산 유도체 | |
| EP0946517A1 (fr) | Derives de n-(imidazolylbutyle) benzenesulfonamide ayant une activite antithrombotique | |
| US6458821B1 (en) | N-substituted azabicycloheptane derivatives, production and use thereof | |
| RU2444516C2 (ru) | Способ синтеза производных имидазоламинокислот и родственных соединений | |
| JP3222051B2 (ja) | ６−メトキシ−１ｈ−ベンゾトリアゾール−５−カルボキサミド誘導体 | |
| JP4866905B2 (ja) | イミダゾール−アミノ酸誘導体及び関連化合物の合成方法 | |
| CZ20004018A3 (cs) | Způsob výroby inhibitoru sodíko-vodíkových měničů typu 1 | |
| HUT55358A (en) | Process for producing benzylpyrrolidine derivatives with dopamin antagonist effect and pharmaceutical compositions comprising such compounds | |
| FR2761065A1 (fr) | Derives de n-(arginyle)benzenesulfonamide, leur preparation et leur application en therapeutique | |
| HK1171756B (zh) | 咪唑-氨基酸衍生物和相关化合物的合成方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |