IL93324A - Release means for administering pharmaceutical preparations orally - Google Patents
Release means for administering pharmaceutical preparations orallyInfo
- Publication number
- IL93324A IL93324A IL9332490A IL9332490A IL93324A IL 93324 A IL93324 A IL 93324A IL 9332490 A IL9332490 A IL 9332490A IL 9332490 A IL9332490 A IL 9332490A IL 93324 A IL93324 A IL 93324A
- Authority
- IL
- Israel
- Prior art keywords
- tube
- therapeutic agent
- grid
- dose
- outlet end
- Prior art date
Links
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- SGXXNSQHWDMGGP-IZZDOVSWSA-N nizatidine Chemical compound [O-][N+](=O)\C=C(/NC)NCCSCC1=CSC(CN(C)C)=N1 SGXXNSQHWDMGGP-IZZDOVSWSA-N 0.000 description 1
- 229960001180 norfloxacin Drugs 0.000 description 1
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 description 1
- 229960001158 nortriptyline Drugs 0.000 description 1
- 235000020939 nutritional additive Nutrition 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229960004535 oxazepam Drugs 0.000 description 1
- ADIMAYPTOBDMTL-UHFFFAOYSA-N oxazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(O)N=C1C1=CC=CC=C1 ADIMAYPTOBDMTL-UHFFFAOYSA-N 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 229960002035 penbutolol Drugs 0.000 description 1
- KQXKVJAGOJTNJS-HNNXBMFYSA-N penbutolol Chemical compound CC(C)(C)NC[C@H](O)COC1=CC=CC=C1C1CCCC1 KQXKVJAGOJTNJS-HNNXBMFYSA-N 0.000 description 1
- 229940056367 penicillin v Drugs 0.000 description 1
- 239000008014 pharmaceutical binder Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 1
- 229960002508 pindolol Drugs 0.000 description 1
- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 1
- 229960001289 prazosin Drugs 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 229940001470 psychoactive drug Drugs 0.000 description 1
- 239000004089 psychotropic agent Substances 0.000 description 1
- 230000000506 psychotropic effect Effects 0.000 description 1
- 229960000620 ranitidine Drugs 0.000 description 1
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000021317 sensory perception Effects 0.000 description 1
- 229940126589 solid medicine Drugs 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000006068 taste-masking agent Substances 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- JOFWLTCLBGQGBO-UHFFFAOYSA-N triazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl JOFWLTCLBGQGBO-UHFFFAOYSA-N 0.000 description 1
- 229960003386 triazolam Drugs 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0015—Devices specially adapted for taking medicines
- A61J7/0038—Straws
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47G—HOUSEHOLD OR TABLE EQUIPMENT
- A47G21/00—Table-ware
- A47G21/18—Drinking straws or the like
- A47G21/183—Drinking straws or the like with means for changing the flavour of the liquid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31263689A | 1989-02-17 | 1989-02-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL93324A0 IL93324A0 (en) | 1990-11-29 |
| IL93324A true IL93324A (en) | 1994-02-27 |
Family
ID=23212351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9332490A IL93324A (en) | 1989-02-17 | 1990-02-08 | Release means for administering pharmaceutical preparations orally |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4981468A (de) |
| EP (1) | EP0383503B1 (de) |
| JP (1) | JPH02274252A (de) |
| KR (1) | KR900012591A (de) |
| AT (1) | ATE91878T1 (de) |
| AU (1) | AU625179B2 (de) |
| CA (1) | CA2009858A1 (de) |
| DE (1) | DE69002345T2 (de) |
| DK (1) | DK0383503T3 (de) |
| ES (1) | ES2043268T3 (de) |
| HU (1) | HUT57573A (de) |
| IE (1) | IE63590B1 (de) |
| IL (1) | IL93324A (de) |
| NZ (1) | NZ232482A (de) |
| ZA (1) | ZA90945B (de) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5900250A (en) * | 1992-05-13 | 1999-05-04 | Alza Corporation | Monoglyceride/lactate ester permeation enhancer for oxybutnin |
| US5318520A (en) * | 1992-10-16 | 1994-06-07 | Nakao Naomi L | Safety method and device for intravenous feed systems |
| ATE183926T1 (de) * | 1993-09-29 | 1999-09-15 | Alza Corp | Hautpermeabilitaetserhöher bestehend aus monoglycerid/laktat estern |
| US5780058A (en) | 1995-07-21 | 1998-07-14 | Alza Corporation | Oral delivery of discrete units |
| AU742022B2 (en) * | 1995-07-21 | 2001-12-13 | Alza Corporation | Oral delivery of discrete units |
| BR9609696A (pt) * | 1995-07-21 | 1999-03-23 | Alza Corp | Administração oral unidades separadas |
| US5707353A (en) * | 1995-12-21 | 1998-01-13 | Abbott Laboratories | Oral administration of beneficial agents |
| EP0942656B1 (de) * | 1996-10-10 | 2003-05-21 | Peter Baron | Vorrichtung zur herstellung eines aromatisierten getränkes |
| AUPS270602A0 (en) * | 2002-05-31 | 2002-06-20 | Baron, Peter | Drink flavouring straw |
| US20030087005A1 (en) * | 1996-10-10 | 2003-05-08 | Peter Baron | Drink flavouring straw |
| AU729769B2 (en) * | 1996-10-18 | 2001-02-08 | Alza Corporation | Closure system for an active agent delivery device |
| DK0936893T3 (da) * | 1996-10-18 | 2001-09-03 | Alza Corp | Indretning med flere strømningsbaner til oral afgivelse af diskrete enheder |
| US6024721A (en) | 1996-10-18 | 2000-02-15 | Alza Corporation | Mixing system for an active agent delivery device |
| WO1998034598A2 (en) * | 1997-02-07 | 1998-08-13 | Gist-Brocades B.V. | Homogeneous granulated formulations for dose sipping technology |
| ES2182303T3 (es) | 1997-05-16 | 2003-03-01 | Alza Corp | Configuraciones reguladoras del flujo para un dispositivo de administracion de agents activos. |
| US5945123A (en) * | 1998-04-02 | 1999-08-31 | K-V Pharmaceutical Company | Maximizing effectiveness of substances used to improve health and well being |
| US20040062802A1 (en) * | 1998-04-02 | 2004-04-01 | Hermelin Victor M. | Maximizing effectiveness of substances used to improve health and well being |
| WO2000025744A1 (en) * | 1998-10-30 | 2000-05-11 | Mcneil-Ppc, Inc. | Granular, free-flowing pharmaceutical composition, and straw-like dosage form for oral administration thereof |
| US6217545B1 (en) | 1999-02-08 | 2001-04-17 | Porex Technologies Corp. | Filter with varying density which is responsive to fluid flow |
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| HUP0300491A2 (en) | 2000-02-28 | 2003-07-28 | Vectura Ltd | Improvements in or relating to the delivery of oral drugs |
| US20020068078A1 (en) * | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| DE10228173A1 (de) * | 2002-03-27 | 2003-10-09 | Gruenenthal Gmbh | System zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen |
| DE10228175A1 (de) * | 2002-03-27 | 2003-10-09 | Gruenenthal Gmbh | Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen |
| US20050118245A1 (en) * | 2002-03-27 | 2005-06-02 | Wilsmann Klaus M. | Assembled unit consisting of individually separable, transdermal, therapeutic systems |
| DE10228192A1 (de) * | 2002-06-24 | 2004-01-15 | Grünenthal GmbH | Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen |
| DE10228179A1 (de) * | 2002-06-24 | 2004-01-22 | Grünenthal GmbH | Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen |
| DE10228176A1 (de) * | 2002-06-24 | 2004-01-22 | Grünenthal GmbH | Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen |
| DE10228171A1 (de) * | 2002-06-24 | 2004-01-22 | Grünenthal GmbH | Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen |
| US7524515B2 (en) * | 2003-01-10 | 2009-04-28 | Mutual Pharmaceuticals, Inc. | Pharmaceutical safety dosage forms |
| DE10308175A1 (de) * | 2003-02-25 | 2004-09-02 | Grünenthal GmbH | Darreichungsform und Kit zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen |
| US6966252B2 (en) * | 2003-03-31 | 2005-11-22 | Mcneil-Ppc, Inc. | Hydrophilic substance dispensing device |
| RU2005138854A (ru) * | 2003-05-14 | 2006-07-27 | Куреха Корпорейшн (Jp) | Размещающий корпус для проглатывания твердой формы для перорального приема, контейнер для размещающего корпуса и способ проглатывания |
| US20040253351A1 (en) * | 2003-06-11 | 2004-12-16 | Killips Lynn Ramblas | Apparatus and method for mixing confectionary with fluids |
| DE10342513A1 (de) * | 2003-09-12 | 2005-05-12 | Gruenenthal Gmbh | Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen, Kit und Verwendung |
| DE10342514A1 (de) * | 2003-09-12 | 2005-04-07 | Grünenthal GmbH | Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen, Kit und Verwendung |
| US20050103879A1 (en) * | 2003-11-19 | 2005-05-19 | Robinson Ted R. | Straw |
| US20050116057A1 (en) * | 2003-12-01 | 2005-06-02 | Hamer Douglas T. | Novelty beverages straw |
| US7431175B2 (en) * | 2004-07-16 | 2008-10-07 | Roger Heilos | Drinking cup lid for assisting in ingestion of medication |
| US20070051741A1 (en) * | 2005-09-02 | 2007-03-08 | Kraft Foods Holdings, Inc. | Methods for the application of ingredients to the inside of a straw |
| NL1031129C2 (nl) * | 2005-12-01 | 2007-06-04 | Asepticstraw Internat B V | Artikel voor het bewegen van een medium voor te eten en/of drinken. |
| AR060029A1 (es) | 2006-03-02 | 2008-05-21 | Unistraw Patent Holdings Ltd | Pajilla para beber adaptada para acondicionar progresivamente un ingrediente activo y metodo de fabricar dicha pajilla |
| US20080075809A1 (en) * | 2006-09-21 | 2008-03-27 | Anderson Michael R | Drinking straw for dispensing substances with one-way valve |
| KR101445891B1 (ko) * | 2007-01-05 | 2014-10-02 | 아셀알엑스 파마슈티컬스 인코퍼레이티드 | 경구 경점막 제형의 투여를 위한 저장 및 분배 장치 |
| US20080181932A1 (en) * | 2007-01-30 | 2008-07-31 | Drugtech Corporation | Compositions for oral delivery of pharmaceuticals |
| US20080197141A1 (en) * | 2007-02-20 | 2008-08-21 | Felfoldi Edesseggyarto Kft. | Drinking Straw |
| WO2008112388A1 (en) | 2007-03-14 | 2008-09-18 | Drugtech Corporation | Spatial arrangement of particles in a drinking device for oral delivery of pharmaceuticals |
| CA2683499A1 (en) * | 2007-04-10 | 2008-10-16 | Sandoz Ag | Device for the oral application of a substance |
| FR2920308B1 (fr) * | 2007-09-05 | 2011-02-25 | Unither Dev | Forme pharmaceutique pour l'administration par voie orale de principes actifs. |
| US7997509B2 (en) * | 2008-04-08 | 2011-08-16 | Dana Karklins | Portion-controlled dispensing straw assembly |
| EP2349222B1 (de) * | 2008-09-10 | 2016-08-24 | Sandoz AG | Kapsel mit löslichem blockierelement |
| GB2480827B (en) * | 2010-06-01 | 2012-06-06 | Kraft Foods R & D Inc | Improvements in the preparation of beverages and liquid food products |
| KR102078044B1 (ko) | 2011-09-19 | 2020-02-17 | 오렉쏘 에이비 | 오피오이드 의존증의 치료를 위한 남용-방지성 약학 조성물 |
| US9017749B2 (en) | 2011-12-21 | 2015-04-28 | Babatope Sewande Ayeni | Flavored straw with a flavor delivery system |
| US9751056B2 (en) | 2012-01-23 | 2017-09-05 | Merit Medical Systems, Inc. | Mixing syringe |
| US8834449B2 (en) * | 2012-01-23 | 2014-09-16 | Ikomed Technologies, Inc. | Mixing syringe |
| DK2870072T3 (en) | 2012-07-05 | 2017-12-04 | P C O A Devices Ltd | medicine dispensers |
| BR112015002014B1 (pt) * | 2012-07-30 | 2020-12-15 | P.C.O.A. Devices Ltd | Receptáculo para conter e distribuir pílulas medicinais sólidas e uso do mesmo |
| US20140343487A1 (en) * | 2013-05-14 | 2014-11-20 | Semion Hlebnikov | Drinking straw that contains substances for treating the side effects of alcohol consumption |
| CA2936746C (en) | 2014-10-31 | 2017-06-27 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
| WO2016193242A1 (en) * | 2015-06-01 | 2016-12-08 | Unistraw Holdings Pte. Ltd. | Formulations of cns-stimulants and vitamins |
| AU2016274646A1 (en) * | 2015-06-10 | 2017-12-07 | Unistraw Holdings Pte. Ltd. | Drinking straw with internal coating |
| CN109068871B (zh) * | 2015-12-22 | 2021-09-28 | 西斯泰克斯有限责任公司 | 两端具有十字狭缝阀门封闭件的预填充饮用吸管 |
| HUE048549T2 (hu) | 2017-06-20 | 2020-08-28 | Sisteks D O O | Elõre megtöltött szívószál mindkét végén keresztbemetszett membránszeleppel |
| WO2020021111A1 (en) * | 2018-07-27 | 2020-01-30 | Sisteks D.O.O. | Straw for oral administration of pharmaceutical formulation |
| US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
| CN111407663B (zh) | 2019-01-07 | 2026-01-02 | 上海汉都医药科技有限公司 | 一种口服给药递送装置 |
| WO2021062987A1 (zh) | 2019-09-30 | 2021-04-08 | 上海汉都医药科技有限公司 | 固体口服制剂的药物容置装置及含其的口服给药递送装置 |
| IL298255A (en) | 2020-05-18 | 2023-01-01 | air up group GmbH | An aroma container and a drinking device with an aroma container |
| US11272799B2 (en) | 2020-05-29 | 2022-03-15 | Unistraw Corp. | Drinking straw with internal coating |
| EP3944792A1 (de) * | 2020-07-30 | 2022-02-02 | air up group GmbH | Trinkvorrichtung und trinkgefäss |
| US20230414454A1 (en) * | 2022-06-23 | 2023-12-28 | Michael William Babb | Medication or vitamin swallowing aid |
| US20250302218A1 (en) * | 2024-03-30 | 2025-10-02 | Red River Tea Company | Container straw, beverage kit, method for preparing the beverage kit, and method of using the beverage kit |
| WO2025221761A2 (en) * | 2024-04-17 | 2025-10-23 | Genzyme Corporation | Medicament container and kit for reconstituting a lyophilized medicament |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US580527A (en) * | 1897-04-13 | Drinking-tube | ||
| US121684A (en) * | 1871-12-05 | Improvement in devices for administering pills | ||
| US430928A (en) * | 1890-06-24 | Device for administering medicine to animals | ||
| US697209A (en) * | 1901-07-24 | 1902-04-08 | Benno Koppenhagen | Device for facilitating taking pills. |
| US1236029A (en) * | 1916-08-10 | 1917-08-07 | George H Williams | Drinking device. |
| US1685280A (en) * | 1927-07-16 | 1928-09-25 | Lester L Findley | Powder-placing syringe |
| US2436505A (en) * | 1945-08-24 | 1948-02-24 | Rall John H Du | Pill douser |
| US2753267A (en) * | 1954-02-08 | 1956-07-03 | Jere Bayard | Flavored drinking straw machine and method |
| US2846313A (en) * | 1956-04-23 | 1958-08-05 | Jere Bayard | Flavored drinking straw |
| US3517884A (en) * | 1968-08-05 | 1970-06-30 | Stephen D Horvath | Spiral drinking straw |
| US3615595A (en) * | 1969-04-08 | 1971-10-26 | Nat Patent Dev Corp | Flavored drinking straw |
| US3905477A (en) * | 1972-03-14 | 1975-09-16 | Union Carbide Corp | Tamperproof pouch label |
| US3980074A (en) * | 1973-07-18 | 1976-09-14 | Beecham Group Limited | Device for the administration of powders |
| US4581013A (en) * | 1982-04-19 | 1986-04-08 | Jane C. A. Hayes | Doser for orally administering medicine |
| US4440207A (en) * | 1982-05-14 | 1984-04-03 | Baxter Travenol Laboratories, Inc. | Antibacterial protective cap for connectors |
| DE3245711A1 (de) * | 1982-12-10 | 1984-06-14 | Deutsche Granini Gmbh & Co Kg, 4800 Bielefeld | Trinkvorrichtung fuer erfrischungsgetraenke |
| US4792333A (en) * | 1986-11-04 | 1988-12-20 | Strawdose, Inc. | Unit dose drug package and administering device |
-
1990
- 1990-01-12 US US07/464,481 patent/US4981468A/en not_active Expired - Fee Related
- 1990-02-08 IL IL9332490A patent/IL93324A/en not_active IP Right Cessation
- 1990-02-08 ZA ZA90945A patent/ZA90945B/xx unknown
- 1990-02-09 DE DE90301427T patent/DE69002345T2/de not_active Expired - Fee Related
- 1990-02-09 AT AT90301427T patent/ATE91878T1/de active
- 1990-02-09 EP EP90301427A patent/EP0383503B1/de not_active Expired - Lifetime
- 1990-02-09 DK DK90301427.2T patent/DK0383503T3/da active
- 1990-02-09 ES ES90301427T patent/ES2043268T3/es not_active Expired - Lifetime
- 1990-02-12 CA CA002009858A patent/CA2009858A1/en not_active Abandoned
- 1990-02-12 NZ NZ232482A patent/NZ232482A/en unknown
- 1990-02-13 KR KR1019900001734A patent/KR900012591A/ko not_active Ceased
- 1990-02-14 AU AU49822/90A patent/AU625179B2/en not_active Ceased
- 1990-02-15 JP JP2035080A patent/JPH02274252A/ja active Pending
- 1990-02-15 IE IE55990A patent/IE63590B1/en not_active IP Right Cessation
- 1990-02-16 HU HU90842A patent/HUT57573A/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69002345D1 (de) | 1993-09-02 |
| CA2009858A1 (en) | 1990-08-17 |
| ATE91878T1 (de) | 1993-08-15 |
| DK0383503T3 (da) | 1993-09-20 |
| EP0383503B1 (de) | 1993-07-28 |
| NZ232482A (en) | 1992-12-23 |
| IE900559L (en) | 1990-08-17 |
| HUT57573A (en) | 1991-12-30 |
| AU625179B2 (en) | 1992-07-02 |
| EP0383503A1 (de) | 1990-08-22 |
| ZA90945B (en) | 1991-10-30 |
| ES2043268T3 (es) | 1993-12-16 |
| IL93324A0 (en) | 1990-11-29 |
| IE63590B1 (en) | 1995-05-17 |
| US4981468A (en) | 1991-01-01 |
| DE69002345T2 (de) | 1993-12-09 |
| JPH02274252A (ja) | 1990-11-08 |
| HU900842D0 (en) | 1990-04-28 |
| AU4982290A (en) | 1990-08-23 |
| KR900012591A (ko) | 1990-09-01 |
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| Date | Code | Title | Description |
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| KB | Patent renewed | ||
| KB | Patent renewed | ||
| RH1 | Patent not in force |