IL93754A - יחידה גנטית לעיכוב anr - Google Patents

יחידה גנטית לעיכוב anr

Info

Publication number: IL93754A
Authority: IL; Israel
Prior art keywords: rna; dna; dna molecule; ribozyme; inhibiting
Prior art date: 1989-03-16

Application number

IL9375490A

Other languages

English (en)

Other versions

IL93754A0 (en

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-16

Filing date

1990-03-15

Publication date

1995-12-31

1990-03-15 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

1990-12-23 Publication of IL93754A0 publication Critical patent/IL93754A0/xx

1995-12-31 Publication of IL93754A publication Critical patent/IL93754A/he

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead

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Organic Chemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

IL9375490A 1989-03-16 1990-03-15 יחידה גנטית לעיכוב anr IL93754A (he)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AT60989		1989-03-16

Publications (2)

Publication Number	Publication Date
IL93754A0 IL93754A0 (en)	1990-12-23
IL93754A true IL93754A (he)	1995-12-31

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ID=3495118

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IL9375490A IL93754A (he)	1989-03-16	1990-03-15	יחידה גנטית לעיכוב anr

Country Status (20)

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EP (1)	EP0387775B1 (he)
JP (1)	JP3330930B2 (he)
KR (1)	KR900014591A (he)
AT (1)	ATE140961T1 (he)
AU (1)	AU637354B2 (he)
CA (1)	CA2012312C (he)
DD (1)	DD297838A5 (he)
DE (1)	DE59010432D1 (he)
DK (1)	DK0387775T3 (he)
ES (1)	ES2090049T3 (he)
FI (1)	FI105103B (he)
GR (1)	GR3020935T3 (he)
HU (2)	HU215187B (he)
IE (1)	IE74850B1 (he)
IL (1)	IL93754A (he)
NO (1)	NO306623B1 (he)
NZ (1)	NZ232917A (he)
PT (1)	PT93440B (he)
RU (1)	RU2136751C1 (he)
ZA (1)	ZA901973B (he)

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WO1990013641A1 (en) *	1989-05-10	1990-11-15	Sloan-Kettering Institute For Cancer Research	Stably transformed eucaryotic cells comprising a foreign transcribable dna under the control of a pol iii promoter
DE4091533T (he) *	1989-08-31	1992-01-30
JP2507895B2 (ja) *	1989-12-19	1996-06-19	工業技術院長	リボザイムの新規合成系
ATE150789T1 (de) *	1990-06-19	1997-04-15	Gene Shears Pty Ltd	Endonukleasen
US6008343A (en) *	1990-06-19	1999-12-28	Gene Shears Pty. Ltd.	Nucleotide based endonucleases
JP3257675B2 (ja) *	1990-10-12	2002-02-18	マックス−プランク−ゲゼルシャフトツールフェルデルングデルビッセンシャフテンエー．ファウ．	修飾リボザイム
DE4104186A1 (de) *	1991-02-12	1992-08-13	Genentech Inc	Neue, ueber endozytose in hoehere eukaryotische zellen aufnehmbare, nukleinsaeure enthaltende komplexe
FR2687411A1 (fr) *	1992-02-13	1993-08-20	Nice Sophia Antipolis Universi	Vecteur comportant un gene viral transcrit par l'arn polymerase iii, et procede de production intracellulaire d'arn.
AU4259193A (en) *	1992-04-28	1993-11-29	Frank Andreas Harald Meyer	Medicament for the gene-therapeutic treatment of human beings, animals and plants, especially to block virus multiplication and carcinogenes and process for producing the medicament
JPH08502950A (ja) *	1992-05-14	1996-04-02	リボザイム・ファーマシューティカルズ・インコーポレイテッド	癌増殖を抑制する方法及び試薬
US5610052A (en) *	1992-08-26	1997-03-11	Ribozyme Pharmaceuticals Inc.	Enzymatic RNA with activity to ras
US5989906A (en) *	1992-05-14	1999-11-23	Ribozyme Pharmaceuticals, Inc.	Method and reagent for inhibiting P-glycoprotein (mdr-1-gene)
CA2114312A1 (en) *	1992-05-27	1993-12-09	John J. Rossi	Chimeric trnalys-ribozyme molecules
US5827935A (en) *	1992-05-27	1998-10-27	City Of Hope	Chimeric tRNAlys -ribozyme molecules
PT652705E (pt) *	1992-06-29	2006-05-31	Gene Shears Pty Ltd	Acidos nucleicos e metodos para a sua utilizacao para combater patogenios virais
AU5968994A (en) *	1992-12-16	1994-07-04	Johanna E. Bergmann	Agents for the prevention and treatment of human alzheimer's disease
ATE250670T1 (de) *	1993-07-06	2003-10-15	Univ Nice Sophia Antipolis	Vektor, enthält ein bei arn-polymerase-iii transcriptes virus-gen
US5837503A (en) *	1993-07-07	1998-11-17	Universite De Nice-Sophia-Antipolis	Vector containing viral gene transcribed by RNA polymerase III and methods for use
US5817635A (en) *	1993-08-09	1998-10-06	Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V.	Modified ribozymes
AU692208B2 (en) *	1994-01-24	1998-06-04	City Of Hope	Inhibitors and target molecule co-localization
DE4424761C1 (de) *	1994-07-04	1995-06-08	Max Planck Gesellschaft	Expressionskassette für die Antisense- und die Ribozym-Expression
JPH11506914A (ja)	1995-06-07	1999-06-22	コモンウェルス・サイエンティフィック・アンド・インダストリアル・リサーチ・オーガニゼーション	最適化ミニザイムおよびミニリボザイムおよびその使用
FR2755976B1 (fr) *	1996-11-15	1999-01-15	Idm Immuno Designed Molecules	Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires
US6057156A (en) *	1997-01-31	2000-05-02	Robozyme Pharmaceuticals, Inc.	Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors
AU1187099A (en) *	1997-10-21	1999-05-10	Ribozyme Pharmaceuticals, Inc.	Peptide bond formation using nucleic acid catalysts
US6506559B1 (en)	1997-12-23	2003-01-14	Carnegie Institute Of Washington	Genetic inhibition by double-stranded RNA
AUPP249298A0 (en)	1998-03-20	1998-04-23	Ag-Gene Australia Limited	Synthetic genes and genetic constructs comprising same I
WO1999049029A1 (en)	1998-03-20	1999-09-30	Benitec Australia Ltd	Control of gene expression
EP2314700A1 (en)	1999-01-28	2011-04-27	Medical College of Georgia Research Institute, Inc	Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA
US6423885B1 (en)	1999-08-13	2002-07-23	Commonwealth Scientific And Industrial Research Organization (Csiro)	Methods for obtaining modified phenotypes in plant cells
EP1229134A3 (en)	2001-01-31	2004-01-28	Nucleonics, Inc	Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
AUPR621501A0 (en)	2001-07-06	2001-08-02	Commonwealth Scientific And Industrial Research Organisation	Delivery of ds rna
IL273245B2 (he)	2017-09-15	2025-03-01	Commw Scient Ind Res Org	מולקולות rna
WO2025111506A1 (en) *	2023-11-22	2025-05-30	Tevard Biosciences, Inc.	Modified transfer rnas and methods of use

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US4987071A (en) *	1986-12-03	1991-01-22	University Patents, Inc.	RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
SU1759873A1 (ru) *	1990-08-14	1992-09-07	Новосибирский государственный университет им.Ленинского комсомола	Фрагмент дезоксирибонуклиновой кислоты, кодирующий промотор SP6 РНК-полимеразы

1990
- 1990-03-13 ES ES90104701T patent/ES2090049T3/es not_active Expired - Lifetime
- 1990-03-13 AT AT90104701T patent/ATE140961T1/de not_active IP Right Cessation
- 1990-03-13 DE DE59010432T patent/DE59010432D1/de not_active Expired - Lifetime
- 1990-03-13 DK DK90104701.9T patent/DK0387775T3/da active
- 1990-03-13 EP EP90104701A patent/EP0387775B1/de not_active Expired - Lifetime
- 1990-03-14 DD DD90338709A patent/DD297838A5/de not_active IP Right Cessation
- 1990-03-14 NZ NZ232917A patent/NZ232917A/en unknown
- 1990-03-14 HU HU901584A patent/HU215187B/hu unknown
- 1990-03-15 AU AU51301/90A patent/AU637354B2/en not_active Expired
- 1990-03-15 IL IL9375490A patent/IL93754A/he not_active IP Right Cessation
- 1990-03-15 ZA ZA901973A patent/ZA901973B/xx unknown
- 1990-03-15 FI FI901296A patent/FI105103B/fi active IP Right Grant
- 1990-03-15 JP JP06549390A patent/JP3330930B2/ja not_active Expired - Lifetime
- 1990-03-15 PT PT93440A patent/PT93440B/pt not_active IP Right Cessation
- 1990-03-15 IE IE93190A patent/IE74850B1/en not_active IP Right Cessation
- 1990-03-15 NO NO901213A patent/NO306623B1/no not_active IP Right Cessation
- 1990-03-15 CA CA002012312A patent/CA2012312C/en not_active Expired - Lifetime
- 1990-03-15 KR KR1019900003438A patent/KR900014591A/ko not_active Ceased
- 1990-03-16 RU SU5010032A patent/RU2136751C1/ru active
1995
- 1995-06-30 HU HU95P/P00692P patent/HU211868A9/hu unknown
1996
- 1996-09-03 GR GR960402292T patent/GR3020935T3/el unknown

Also Published As

Publication number	Publication date
CA2012312C (en)	2001-08-14
JPH03130080A (ja)	1991-06-03
PT93440A (pt)	1990-11-07
EP0387775A1 (de)	1990-09-19
HU211868A9 (en)	1995-12-28
GR3020935T3 (en)	1996-12-31
FI105103B (fi)	2000-06-15
HU215187B (hu)	1998-10-28
RU2136751C1 (ru)	1999-09-10
HUT54206A (en)	1991-01-28
NO901213L (no)	1990-09-17
FI901296A0 (fi)	1990-03-15
IE900931L (en)	1990-09-16
IL93754A0 (en)	1990-12-23
NZ232917A (en)	1997-07-27
ES2090049T3 (es)	1996-10-16
CA2012312A1 (en)	1990-09-16
DD297838A5 (de)	1992-01-23
AU637354B2 (en)	1993-05-27
ATE140961T1 (de)	1996-08-15
ZA901973B (en)	1991-11-27
NO901213D0 (no)	1990-03-15
AU5130190A (en)	1990-11-01
KR900014591A (ko)	1990-10-24
DE59010432D1 (de)	1996-09-05
HU901584D0 (en)	1990-06-28
NO306623B1 (no)	1999-11-29
DK0387775T3 (da)	1996-11-04
JP3330930B2 (ja)	2002-10-07
EP0387775B1 (de)	1996-07-31
IE74850B1 (en)	1997-08-13
PT93440B (pt)	2001-07-31

Legal Events

Date	Code	Title
1996-06-18	FF	Patent granted
1996-10-16	KB	Patent renewed
2004-06-01	KB	Patent renewed
2008-04-13	KB	Patent renewed
2011-04-28	EXP	Patent expired

Publication	Publication Date	Title
CA2012312C (en)	2001-08-14	Genetic units for inhibiting the function of rna
CA2012311C (en)	2003-06-24	New protein-polycation-conjugate
US5874414A (en)	1999-02-23	Trans-splicing ribozymes
JP3316216B2 (ja)	2002-08-19	安定化外部ガイド配列
US5989906A (en)	1999-11-23	Method and reagent for inhibiting P-glycoprotein (mdr-1-gene)
US5667969A (en)	1997-09-16	Alteration of sequence of a deleterious target molecule by ribozyme catalyzed trans-splicing
US5750390A (en)	1998-05-12	Method and reagent for treatment of diseases caused by expression of the bcl-2 gene
CA2135499A1 (en)	1993-11-25	Method and reagent for inhibiting cancer development
JPH10500309A (ja)	1998-01-13	リボザイムを用いて再狭窄および癌を治療するための方法および組成物
US6183959B1 (en)	2001-02-06	Method for target site selection and discovery
CA2148368A1 (en)	1994-05-11	Tnf-.alpha. ribozymes and degradation resistant mrna derivatives linked to tnf-.alpha. ribozymes
US5599704A (en)	1997-02-04	ErbB2/neu targeted ribozymes
US6830923B1 (en)	2004-12-14	Genetics units for inhibiting the function of RNA
US20040072783A1 (en)	2004-04-15	Nucleozymes with endonuclease activity
Phylactou et al.	2000	Utilization of properties of natural catalytic RNA to design and synthesize functional ribozymes
Qiu	1996	Cellular ribonucleases and the design of hammerhead ribozymes
IE83273B1 (en)		New protein-polycation-conjugates