IL97446A - Medicinal product for the improvement of down-regulation of autoimmune diseases - Google Patents

Medicinal product for the improvement of down-regulation of autoimmune diseases

Info

Publication number: IL97446A
Authority: IL; Israel
Prior art keywords: suppressive; autoantigens; disease; agent; pharmaceutical composition
Prior art date: 1990-03-02

Application number

IL9744691A

Other languages

English (en)

Hebrew (he)

Other versions

IL97446A0 (en

Original Assignee

Brigham & Womens Hospital

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-02

Filing date

1991-03-05

Publication date

1996-03-31

1991-03-05 Application filed by Brigham & Womens Hospital filed Critical Brigham & Womens Hospital

1992-06-21 Publication of IL97446A0 publication Critical patent/IL97446A0/xx

1996-03-31 Publication of IL97446A publication Critical patent/IL97446A/en

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Microbiology (AREA)
Mycology (AREA)
Marine Sciences & Fisheries (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)

IL9744691A 1990-03-02 1991-03-05 Medicinal product for the improvement of down-regulation of autoimmune diseases IL97446A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48773290A	1990-03-02	1990-03-02

Publications (2)

Publication Number	Publication Date
IL97446A0 IL97446A0 (en)	1992-06-21
IL97446A true IL97446A (en)	1996-03-31

Family

ID=23936898

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9744691A IL97446A (en)	1990-03-02	1991-03-05	Medicinal product for the improvement of down-regulation of autoimmune diseases

Country Status (13)

Country	Link
EP (2)	EP0782859A1 (de)
JP (1)	JPH05508621A (de)
AT (1)	ATE157257T1 (de)
AU (1)	AU651097B2 (de)
BR (1)	BR9106114A (de)
CA (1)	CA2077340A1 (de)
DE (1)	DE69127470T2 (de)
DK (1)	DK0594607T3 (de)
ES (1)	ES2107459T3 (de)
HU (2)	HUT61896A (de)
IL (1)	IL97446A (de)
NO (1)	NO923395D0 (de)
WO (1)	WO1991012816A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6645504B1 (en)	1987-06-24	2003-11-11	Autoimmune Inc.	Bystander suppression of type I diabetes by oral administration of glucagon
US5268454A (en) *	1991-02-08	1993-12-07	La Jolla Pharmaceutical Company	Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier
IL99699A (en)	1990-10-10	2002-04-21	Autoimmune Inc	Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
HUT69942A (en) *	1990-10-15	1995-09-28	Brigham & Womens Hospital	Treatment of autoimmun diseases by oral administration of autoantigenes
HU220357B (hu) *	1992-02-28	2001-12-28	Autoimmune Inc.	Eljárás és készítmények autoimmun betegségek kezelésére bystander antigén alkalmazásával
US5891435A (en) *	1993-04-16	1999-04-06	Research Corporation Technologies, Inc.	Methods and compositions for delaying or preventing the onset of autoimmune disease
EP0705108A4 (de) *	1993-06-02	1997-08-06	Tvw Telethon Inst Child Health	Verwendung von kryptischen peptiden zur induktion immunologisches toleranz
GB9319429D0 (en)	1993-09-21	1993-11-03	London Health Ass	Methods and products for controlling immune responses in mammals
IL115766A0 (en) *	1994-10-25	1996-01-19	Immulogic Pharma Corp	Composition and treatment for multiple sclerosis
US6329499B1 (en)	1994-11-18	2001-12-11	Neurocrine Biosciences, Inc.	Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein
US6251396B1 (en)	1994-11-18	2001-06-26	Neurocrine Biosciences, Inc.	Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
EP1172376A1 (de)	1994-11-18	2002-01-16	Neurocrine Biosciences, Inc.	Peptidanaloge des menschlichen, basischen myelinproteins mit substitution an position 91 zur behandlung der multiplen sklerose
US6379670B1 (en)	1994-11-18	2002-04-30	Neurocrine Biosciences, Inc.	Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
DK0831877T3 (da) *	1995-06-07	2005-02-14	Telik Inc	Metabolske virkninger af visse glutathionanaloge
US6488933B2 (en)	1995-07-05	2002-12-03	Yeda Research And Development Co. Ltd.	Preparations for the treatment of T cell mediated diseases
JP3935938B2 (ja) *	1996-01-05	2007-06-27	オートイミューンインク	▲ｉｉ▼型コラーゲンの調製法
US5849886A (en) *	1996-07-10	1998-12-15	Oy Aboatech Ab	Extraction of myelin basic protein
US6211160B1 (en)	1996-09-06	2001-04-03	The Trustees Of The University Of Pennsylvania	Method for tolerizing a mammalian patient to administration of gene therapy virus vectors
JP4086928B2 (ja) *	1997-02-13	2008-05-14	大日本住友製薬株式会社	タイプ２ヘルパーｔ細胞型サイトカイン産生選択的抑制剤
US7097845B2 (en)	1997-04-23	2006-08-29	Jacob Sten Petersen	Combinations of antigen and mucosal binding component for inducing specific immunological tolerance
TWI239847B (en)	1997-12-02	2005-09-21	Elan Pharm Inc	N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US6750324B1 (en)	1997-12-02	2004-06-15	Neuralab Limited	Humanized and chimeric N-terminal amyloid beta-antibodies
US6761888B1 (en)	2000-05-26	2004-07-13	Neuralab Limited	Passive immunization treatment of Alzheimer's disease
US7588766B1 (en)	2000-05-26	2009-09-15	Elan Pharma International Limited	Treatment of amyloidogenic disease
US6905686B1 (en)	1997-12-02	2005-06-14	Neuralab Limited	Active immunization for treatment of alzheimer's disease
US6923964B1 (en)	1997-12-02	2005-08-02	Neuralab Limited	Active immunization of AScr for prion disorders
US6913745B1 (en)	1997-12-02	2005-07-05	Neuralab Limited	Passive immunization of Alzheimer's disease
US6710226B1 (en)	1997-12-02	2004-03-23	Neuralab Limited	Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics
US6787523B1 (en)	1997-12-02	2004-09-07	Neuralab Limited	Prevention and treatment of amyloidogenic disease
US7179892B2 (en)	2000-12-06	2007-02-20	Neuralab Limited	Humanized antibodies that recognize beta amyloid peptide
US7790856B2 (en)	1998-04-07	2010-09-07	Janssen Alzheimer Immunotherapy	Humanized antibodies that recognize beta amyloid peptide
US20080050367A1 (en)	1998-04-07	2008-02-28	Guriq Basi	Humanized antibodies that recognize beta amyloid peptide
US20030147882A1 (en)	1998-05-21	2003-08-07	Alan Solomon	Methods for amyloid removal using anti-amyloid antibodies
US6787637B1 (en)	1999-05-28	2004-09-07	Neuralab Limited	N-Terminal amyloid-β antibodies
UA81216C2 (en)	1999-06-01	2007-12-25		Prevention and treatment of amyloid disease
US7897575B2 (en)	2000-05-24	2011-03-01	The United States Of America As Represented By The Department Of Health And Human Services	Treatment and prevention of vascular dementia
US7261896B2 (en)	2000-05-24	2007-08-28	United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health	Methods for preventing strokes by inducing tolerance to e-selectin
PE20020574A1 (es)	2000-12-06	2002-07-02	Wyeth Corp	Anticuerpos humanizados que reconocen el peptido amiloideo beta
US7700751B2 (en)	2000-12-06	2010-04-20	Janssen Alzheimer Immunotherapy	Humanized antibodies that recognize β-amyloid peptide
MY139983A (en)	2002-03-12	2009-11-30	Janssen Alzheimer Immunotherap	Humanized antibodies that recognize beta amyloid peptide
TWI306458B (en)	2003-05-30	2009-02-21	Elan Pharma Int Ltd	Humanized antibodies that recognize beta amyloid peptide
EP1838348B1 (de)	2004-12-15	2013-06-26	Janssen Alzheimer Immunotherapy	Humanisierte amyloid-beta-antikörper zur verbesserung der kognition
US7625560B2 (en)	2004-12-15	2009-12-01	Janssen Alzheimer Immunotherapy	Humanized antibodies that recognize beta amyloid peptide
US8784810B2 (en)	2006-04-18	2014-07-22	Janssen Alzheimer Immunotherapy	Treatment of amyloidogenic diseases
US8003097B2 (en)	2007-04-18	2011-08-23	Janssen Alzheimer Immunotherapy	Treatment of cerebral amyloid angiopathy
DK2182983T3 (da)	2007-07-27	2014-07-14	Janssen Alzheimer Immunotherap	Behandling af amyloidogene sygdomme med humaniserede anti-abeta antistoffer
JO3076B1 (ar)	2007-10-17	2017-03-15	Janssen Alzheimer Immunotherap	نظم العلاج المناعي المعتمد على حالة apoe
US9067981B1 (en)	2008-10-30	2015-06-30	Janssen Sciences Ireland Uc	Hybrid amyloid-beta antibodies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4309406A (en)	1979-07-10	1982-01-05	American Home Products Corporation	Sustained release pharmaceutical compositions
US4309404A (en)	1979-08-09	1982-01-05	American Home Products Corporation	Sustained release pharmaceutical compositions
US4556552A (en)	1983-09-19	1985-12-03	Colorcon, Inc.	Enteric film-coating compositions
US4704295A (en)	1983-09-19	1987-11-03	Colorcon, Inc.	Enteric film-coating compositions
JPS60149386A (ja) *	1984-01-17	1985-08-06	Dainippon Pharmaceut Co Ltd	インタ−ロイキン１をコ−ドする伝令リボ核酸及びその調製法
US4695459A (en) *	1984-12-26	1987-09-22	The Board Of Trustees Of Leland Stanford Junior University	Method of treating autoimmune diseases that are mediated by Leu3/CD4 phenotype T cells
DE19848246A1 (de)	1998-10-20	2000-04-27	Krauss Maffei Kunststofftech	Thermoplastteil mit eingespritzter Elastomerdichtung
US8802139B2 (en)	2003-06-26	2014-08-12	Intellipharmaceutics Corp.	Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient

1991
- 1991-03-04 AU AU75789/91A patent/AU651097B2/en not_active Ceased
- 1991-03-04 HU HU9202808A patent/HUT61896A/hu unknown
- 1991-03-04 DE DE69127470T patent/DE69127470T2/de not_active Expired - Fee Related
- 1991-03-04 ES ES91906685T patent/ES2107459T3/es not_active Expired - Lifetime
- 1991-03-04 CA CA002077340A patent/CA2077340A1/en not_active Abandoned
- 1991-03-04 EP EP97100981A patent/EP0782859A1/de not_active Withdrawn
- 1991-03-04 DK DK91906685.2T patent/DK0594607T3/da active
- 1991-03-04 AT AT91906685T patent/ATE157257T1/de not_active IP Right Cessation
- 1991-03-04 EP EP91906685A patent/EP0594607B1/de not_active Expired - Lifetime
- 1991-03-04 WO PCT/US1991/001466 patent/WO1991012816A1/en not_active Ceased
- 1991-03-04 JP JP91507166A patent/JPH05508621A/ja active Pending
- 1991-03-04 BR BR919106114A patent/BR9106114A/pt not_active Application Discontinuation
- 1991-03-05 IL IL9744691A patent/IL97446A/en not_active IP Right Cessation
1992
- 1992-08-31 NO NO923395A patent/NO923395D0/no unknown
1995
- 1995-03-07 HU HU95P/P00088P patent/HU210813A9/hu unknown

Also Published As

Publication number	Publication date
AU7578991A (en)	1991-09-18
BR9106114A (pt)	1993-03-09
ES2107459T3 (es)	1997-12-01
NO923395L (no)	1992-08-31
ATE157257T1 (de)	1997-09-15
EP0594607A4 (de)	1993-04-20
DE69127470T2 (de)	1998-02-19
IL97446A0 (en)	1992-06-21
HUT61896A (en)	1993-03-29
EP0594607B1 (de)	1997-08-27
EP0782859A1 (de)	1997-07-09
EP0594607A1 (de)	1994-05-04
HU9202808D0 (en)	1992-12-28
CA2077340A1 (en)	1991-09-03
NO923395D0 (no)	1992-08-31
DK0594607T3 (da)	1998-04-14
AU651097B2 (en)	1994-07-14
JPH05508621A (ja)	1993-12-02
HU210813A9 (en)	1995-08-28
WO1991012816A1 (en)	1991-09-05
DE69127470D1 (de)	1997-10-02

Legal Events

Date	Code	Title
1996-08-04	FF	Patent granted
1997-03-18	KB	Patent renewed
1997-06-10	KB	Patent renewed
2002-02-10	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
EP0594607B1 (de)	1997-08-27	Verstärkung der unterdrückungsregulation von autoimmunkrankheiten durch orale oder enterale verabreichung von autoantigenen
EP0359783B2 (de)	2002-04-17	Behandlung von autoimmun-erkrankungen durch orale verabreichung von autoantigenen
KR0185747B1 (ko)	1999-05-01	자기항원의 에어로졸 투여에 의한 자기면역질환의 개선된 치료방법
JP3712260B2 (ja)	2005-11-02	自己免疫疾患のバイスタンダー抑制
US5571500A (en)	1996-11-05	Treatment of autoimmune diseases through administration by inhalation of autoantigens
US5641474A (en)	1997-06-24	Prevention of autoimmune diseases by aerosol administration of autoantigens
EP0553291B1 (de)	2006-03-08	Behandlung von autoimmunkrankheiten durch orale verabreichung von autoantigenen
US5571499A (en)	1996-11-05	Treatment of autoimmune diseases by aerosol administration of autoantigens
US5645820A (en)	1997-07-08	Treatment of autoimmune diseases by aerosol administration of autoantigens
US5720955A (en)	1998-02-24	Method of treating rheumatoid arthritis with soluble collagen
WO1994007520A9 (en)	1994-07-07	Method of treating rheumatoid arthritis with type ii collagen
US5961977A (en)	1999-10-05	Method of treating or preventing autoimmune uveoretinitis in mammals
JPH09511990A (ja)	1997-12-02	経口寛容および／またはＴｈ２増強サイトカインを用いた自己免疫疾患の治療
AU686797B2 (en)	1998-02-12	Treatment of autoimmune disease using oral tolerization and/or type I interferon