IL97644A - Corticotropin releasing factor (crf) analogs and compositions comprising them - Google Patents

Corticotropin releasing factor (crf) analogs and compositions comprising them

Info

Publication number: IL97644A
Authority: IL; Israel
Prior art keywords: leu; glu; ala; gln; ser
Prior art date: 1990-03-23

Application number

IL9764491A

Other languages

English (en)

Other versions

IL97644A0 (en

Original Assignee

Salk Inst For Biological Studi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-23

Filing date

1991-03-22

Publication date

1995-03-30

1991-03-22 Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi

1992-06-21 Publication of IL97644A0 publication Critical patent/IL97644A0/xx

1995-03-30 Publication of IL97644A publication Critical patent/IL97644A/en

Links

239000000055 Corticotropin-Releasing Hormone Substances 0.000 title claims abstract description 62
239000000203 mixture Substances 0.000 title claims description 8
108010022152 Corticotropin-Releasing Hormone Proteins 0.000 title description 29
102000012289 Corticotropin-Releasing Hormone Human genes 0.000 title description 28
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 185
101800000414 Corticotropin Proteins 0.000 claims abstract description 34
IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 claims abstract description 34
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COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 claims description 6
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DEFJQIDDEAULHB-IMJSIDKUSA-N L-alanyl-L-alanine Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(O)=O DEFJQIDDEAULHB-IMJSIDKUSA-N 0.000 claims description 2
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LJGOZJHDEQHJRI-SITYYSIOSA-N α-helical crf Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(C)C)C1=CNC=N1 LJGOZJHDEQHJRI-SITYYSIOSA-N 0.000 abstract description 4
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Toxicology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Heart & Thoracic Surgery (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Control Of Eletrric Generators (AREA)
Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Vehicle Body Suspensions (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
Amplifiers (AREA)
Details Of Television Scanning (AREA)
Polymerisation Methods In General (AREA)
Compositions Of Macromolecular Compounds (AREA)

IL9764491A 1990-03-23 1991-03-22 Corticotropin releasing factor (crf) analogs and compositions comprising them IL97644A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US49823090A	1990-03-23	1990-03-23

Publications (2)

Publication Number	Publication Date
IL97644A0 IL97644A0 (en)	1992-06-21
IL97644A true IL97644A (en)	1995-03-30

Family

ID=23980142

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9764491A IL97644A (en)	1990-03-23	1991-03-22	Corticotropin releasing factor (crf) analogs and compositions comprising them

Country Status (14)

Country	Link
EP (1)	EP0521963B1 (de)
JP (1)	JP3243250B2 (de)
KR (1)	KR0174564B1 (de)
AT (1)	ATE169639T1 (de)
AU (1)	AU638823B2 (de)
CA (1)	CA2075718C (de)
DE (1)	DE69129985T2 (de)
DK (1)	DK0521963T3 (de)
ES (1)	ES2121778T3 (de)
FI (1)	FI105013B (de)
IE (1)	IE62607B1 (de)
IL (1)	IL97644A (de)
NO (1)	NO923672L (de)
WO (1)	WO1991014446A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6354364B1 (en)	1994-03-30	2002-03-12	Nichols Aluminum-Golden, Inc.	Apparatus for cooling and coating a mold in a continuous caster
US6039956A (en) *	1994-09-12	2000-03-21	Pennsylvania, Trustees Of The University Of, The	Corticotropin release inhibiting factor and methods of using same for treating behavioral symptoms in an anxiety disorder
EP0781140A4 (de) *	1994-09-12	1999-11-03	Univ Pennsylvania	Die corticotropinfreisetzung inhibierender faktor und verfahren zu seiner nutzung
CN1361180A (zh) *	2000-12-26	2002-07-31	上海博德基因开发有限公司	一种新的多肽——促肾上腺皮质激素释放因子8.8和编码这种多肽的多核苷酸
GB0119920D0 (en) *	2001-08-15	2001-10-10	Pfizer Ltd	New use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH467246A (de) *	1965-08-24	1969-01-15	Sandoz Ag	Verfahren zur Herstellung eines neuen Polypeptids
EP0153845B1 (de) *	1984-02-23	1993-04-21	The Salk Institute For Biological Studies	CRF-Analoga
CA1335227C (en) *	1987-06-22	1995-04-11	Wylie W. Vale, Jr.	Crf analog conjugates
IE64788B1 (en) *	1988-06-21	1995-09-06	Salk Inst For Biological Studi	CRF analogs
CA1341051C (en) *	1988-09-23	2000-07-11	Jean Edouard Frederic Rivier	Crf antagonists
CA1340964C (en) *	1988-09-30	2000-04-18	Jean E. F. Rivier	Crf analogs

1991
- 1991-03-21 AT AT91906643T patent/ATE169639T1/de not_active IP Right Cessation
- 1991-03-21 AU AU75517/91A patent/AU638823B2/en not_active Expired
- 1991-03-21 IE IE94491A patent/IE62607B1/en not_active IP Right Cessation
- 1991-03-21 DK DK91906643T patent/DK0521963T3/da active
- 1991-03-21 JP JP50730291A patent/JP3243250B2/ja not_active Expired - Lifetime
- 1991-03-21 DE DE69129985T patent/DE69129985T2/de not_active Expired - Lifetime
- 1991-03-21 CA CA002075718A patent/CA2075718C/en not_active Expired - Lifetime
- 1991-03-21 EP EP91906643A patent/EP0521963B1/de not_active Expired - Lifetime
- 1991-03-21 WO PCT/US1991/001896 patent/WO1991014446A1/en not_active Ceased
- 1991-03-21 KR KR1019920702299A patent/KR0174564B1/ko not_active Expired - Lifetime
- 1991-03-21 ES ES91906643T patent/ES2121778T3/es not_active Expired - Lifetime
- 1991-03-22 IL IL9764491A patent/IL97644A/en not_active IP Right Cessation
1992
- 1992-08-28 FI FI923863A patent/FI105013B/fi active
- 1992-09-22 NO NO92923672A patent/NO923672L/no unknown

Also Published As

Publication number	Publication date
ES2121778T3 (es)	1998-12-16
FI923863A0 (fi)	1992-08-28
JPH05505821A (ja)	1993-08-26
KR930700137A (ko)	1993-03-13
IE910944A1 (en)	1991-09-25
DE69129985D1 (de)	1998-09-17
FI105013B (fi)	2000-05-31
AU7551791A (en)	1991-10-21
AU638823B2 (en)	1993-07-08
ATE169639T1 (de)	1998-08-15
DE69129985T2 (de)	1999-03-25
JP3243250B2 (ja)	2002-01-07
WO1991014446A1 (en)	1991-10-03
FI923863L (fi)	1992-08-28
CA2075718A1 (en)	1991-09-24
IE62607B1 (en)	1995-02-22
EP0521963A1 (de)	1993-01-13
NO923672L (no)	1992-11-12
IL97644A0 (en)	1992-06-21
EP0521963B1 (de)	1998-08-12
NO923672D0 (no)	1992-09-22
CA2075718C (en)	2001-08-07
KR0174564B1 (ko)	1999-02-01
EP0521963A4 (en)	1993-06-02
DK0521963T3 (da)	1999-05-10

Legal Events

Date	Code	Title
1997-07-13	KB	Patent renewed
2001-07-24	KB	Patent renewed
2005-06-19	KB	Patent renewed
2009-09-15	KB	Patent renewed
2011-12-29	EXP	Patent expired

Publication	Publication Date	Title
US4605642A (en)	1986-08-12	CRF antagonists
US5510458A (en)	1996-04-23	CRF antagonists
EP0122798B1 (de)	1993-11-03	rCRF und ähnliche Verbindungen
US4594329A (en)	1986-06-10	CRF analogs
US4415558A (en)	1983-11-15	CRF And analogs
US5109111A (en)	1992-04-28	CRF antagonists
IL92172A (en)	1995-05-26	FRC of fish, pharmaceutical preparations containing it and AND encoder for it
US5278146A (en)	1994-01-11	CRF analogs
US5235036A (en)	1993-08-10	Crf analogs
US4908352A (en)	1990-03-13	Urotensin peptides
CA1340964C (en)	2000-04-18	Crf analogs
WO1990003392A1 (en)	1990-04-05	Crf antagonists
EP0067608A1 (de)	1982-12-22	CRF und Analoge
CA2075718C (en)	2001-08-07	Crf analogs
FI94421C (fi)	1995-09-11	Menetelmä terapeuttisesti käyttökelpoisten peptidien valmistamiseksi
IE63601B1 (en)	1995-05-17	CRF analogs
US5112809A (en)	1992-05-12	CRF analogs
EP0369664B1 (de)	1994-02-23	CRF vom Fisch