IL97819A0 - Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases - Google Patents
Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseasesInfo
- Publication number
- IL97819A0 IL97819A0 IL97819A IL9781991A IL97819A0 IL 97819 A0 IL97819 A0 IL 97819A0 IL 97819 A IL97819 A IL 97819A IL 9781991 A IL9781991 A IL 9781991A IL 97819 A0 IL97819 A0 IL 97819A0
- Authority
- IL
- Israel
- Prior art keywords
- folates
- treatment
- neoplastic diseases
- acid conjugates
- difluoroglutamic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/508,874 US5066828A (en) | 1990-04-12 | 1990-04-12 | Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL97819A0 true IL97819A0 (en) | 1992-06-21 |
Family
ID=24024432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL97819A IL97819A0 (en) | 1990-04-12 | 1991-04-10 | Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5066828A (de) |
| EP (1) | EP0451835B1 (de) |
| JP (1) | JP2970698B2 (de) |
| KR (1) | KR910018344A (de) |
| CN (1) | CN1055740A (de) |
| AT (1) | ATE127778T1 (de) |
| AU (1) | AU635628B2 (de) |
| CA (1) | CA2040059A1 (de) |
| DE (1) | DE69112885T2 (de) |
| ES (1) | ES2079507T3 (de) |
| FI (1) | FI911778L (de) |
| HU (1) | HU911195D0 (de) |
| IE (1) | IE911230A1 (de) |
| IL (1) | IL97819A0 (de) |
| NO (1) | NO911418L (de) |
| NZ (1) | NZ237735A (de) |
| PT (1) | PT97338A (de) |
| ZA (1) | ZA912590B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5286726A (en) * | 1990-04-12 | 1994-02-15 | The Regents Of The University Of Michigan | Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases |
| AU4220193A (en) * | 1992-04-29 | 1993-11-29 | Sri International | Deazaaminopterins for treatment of inflammation |
| US6323205B1 (en) * | 1996-07-17 | 2001-11-27 | Sloan-Kettering Institute For Cancer Research | Combinations of 10-propargyl-10-deazaaminopterin and taxols and methods of using same in the treatment of tumors |
| DE19904812A1 (de) | 1999-02-05 | 2000-08-10 | Basf Ag | Verfahren zur Herstellung von Folsäure |
| CN101646639A (zh) | 2007-04-11 | 2010-02-10 | 默克阿泼洛发股份公司 | 18f-标记的叶酸 |
| WO2008125615A1 (en) * | 2007-04-11 | 2008-10-23 | Merck Eprova Ag | 18 f-labelled folates |
| US9901578B2 (en) | 2007-08-17 | 2018-02-27 | Allos Therapeutics, Inc. | Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer |
| US20090048262A1 (en) * | 2007-08-17 | 2009-02-19 | Allos Therapeutics, Inc. | Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer |
| US20100248249A1 (en) * | 2007-08-17 | 2010-09-30 | Allos Therapeutics, Inc. | Methods for Assessing Cancer for Increased Sensitivity to 10-Propargyl-10-Deazaaminopterin by Assessing Egfr Levels |
| CA2736861C (en) | 2008-10-10 | 2017-11-14 | Roger Schibli | 18f-labelled folates as pet radiotracers |
| WO2011096947A1 (en) * | 2010-02-02 | 2011-08-11 | Allos Therapeutics, Inc. | Optically pure diastereomers of 10-propargyl-10-deazaaminopterin and methods of using same |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH630380A5 (de) * | 1977-08-12 | 1982-06-15 | Lonza Ag | Verfahren zur herstellung von l-methotrexat. |
| US4136101A (en) * | 1978-02-03 | 1979-01-23 | American Cyanamid Company | Process for preparing dialkyl (p-aminobenzoyl) glutamates |
| US4247453A (en) * | 1978-09-13 | 1981-01-27 | Abbott Laboratories | Folic acid derivatives for use in radioimmunoassay |
| IT1215169B (it) * | 1985-12-17 | 1990-01-31 | Rotta Research Lab | Derivati alchil ossigenati degli acidi glutammico ed aspartico ad attivita antagonista su polipeptidi bioattivi e procedimento per la loro preparazione |
| NZ219971A (en) * | 1986-06-06 | 1989-08-29 | Univ Princeton | Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions |
| EP0341837A3 (de) * | 1988-04-15 | 1990-08-16 | The Wellcome Foundation Limited | Glutamsäurederivate |
-
1990
- 1990-04-12 US US07/508,874 patent/US5066828A/en not_active Expired - Fee Related
-
1991
- 1991-04-08 AU AU74165/91A patent/AU635628B2/en not_active Ceased
- 1991-04-08 CA CA002040059A patent/CA2040059A1/en not_active Abandoned
- 1991-04-08 NZ NZ237735A patent/NZ237735A/xx unknown
- 1991-04-08 ZA ZA912590A patent/ZA912590B/xx unknown
- 1991-04-10 IL IL97819A patent/IL97819A0/xx unknown
- 1991-04-11 HU HU911195A patent/HU911195D0/hu unknown
- 1991-04-11 IE IE123091A patent/IE911230A1/en unknown
- 1991-04-11 ES ES91105767T patent/ES2079507T3/es not_active Expired - Lifetime
- 1991-04-11 DE DE69112885T patent/DE69112885T2/de not_active Expired - Fee Related
- 1991-04-11 PT PT97338A patent/PT97338A/pt not_active Application Discontinuation
- 1991-04-11 AT AT91105767T patent/ATE127778T1/de not_active IP Right Cessation
- 1991-04-11 EP EP91105767A patent/EP0451835B1/de not_active Expired - Lifetime
- 1991-04-11 CN CN91102288A patent/CN1055740A/zh active Pending
- 1991-04-11 NO NO91911418A patent/NO911418L/no unknown
- 1991-04-12 JP JP3106387A patent/JP2970698B2/ja not_active Expired - Fee Related
- 1991-04-12 FI FI911778A patent/FI911778L/fi unknown
- 1991-04-12 KR KR1019910005826A patent/KR910018344A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04235144A (ja) | 1992-08-24 |
| JP2970698B2 (ja) | 1999-11-02 |
| PT97338A (pt) | 1992-01-31 |
| IE911230A1 (en) | 1991-10-23 |
| NZ237735A (en) | 1993-08-26 |
| FI911778A7 (fi) | 1991-10-13 |
| ATE127778T1 (de) | 1995-09-15 |
| HU911195D0 (en) | 1991-10-28 |
| NO911418D0 (no) | 1991-04-11 |
| CN1055740A (zh) | 1991-10-30 |
| US5066828A (en) | 1991-11-19 |
| DE69112885D1 (de) | 1995-10-19 |
| FI911778A0 (fi) | 1991-04-12 |
| DE69112885T2 (de) | 1996-02-15 |
| CA2040059A1 (en) | 1991-10-13 |
| ZA912590B (en) | 1992-01-29 |
| EP0451835A1 (de) | 1991-10-16 |
| ES2079507T3 (es) | 1996-01-16 |
| KR910018344A (ko) | 1991-11-30 |
| EP0451835B1 (de) | 1995-09-13 |
| AU635628B2 (en) | 1993-03-25 |
| AU7416591A (en) | 1991-10-17 |
| FI911778L (fi) | 1991-10-13 |
| NO911418L (no) | 1991-10-14 |
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