IL98681A - Pharmaceutical compositions comprising hydroxamate derivatives for iron removal from mammalian cells and from pathogenic organisms and some novel hydroxamate derivatives - Google Patents

Pharmaceutical compositions comprising hydroxamate derivatives for iron removal from mammalian cells and from pathogenic organisms and some novel hydroxamate derivatives

Info

Publication number: IL98681A
Authority: IL; Israel
Prior art keywords: alkyl; hydroxamate derivatives; aralkyl; aryl; heteroaryl
Prior art date: 1991-06-30

Application number

IL98681A

Other languages

English (en)

Other versions

IL98681A0 (en

Inventor

Shanzer Abraham

Cabantchik Ioav

Libman Jacqueline

Original Assignee

Yeda Rehovot And Dev Company L

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-30

Filing date

1991-06-30

Publication date

1997-06-10

1991-06-30 Application filed by Yeda Rehovot And Dev Company L filed Critical Yeda Rehovot And Dev Company L

1991-06-30 Priority to IL98681A priority Critical patent/IL98681A/xx

1992-06-30 Priority to ES92914455T priority patent/ES2123560T3/es

1992-06-30 Priority to EP92914455A priority patent/EP0550716B1/en

1992-06-30 Priority to CA002090426A priority patent/CA2090426A1/en

1992-06-30 Priority to PCT/EP1992/001474 priority patent/WO1993000082A1/en

1992-06-30 Priority to AU22288/92A priority patent/AU2228892A/en

1992-06-30 Priority to DE69226936T priority patent/DE69226936T2/de

1992-06-30 Priority to JP5501341A priority patent/JPH06503097A/ja

1992-06-30 Priority to US07/977,403 priority patent/US5430058A/en

1992-07-15 Publication of IL98681A0 publication Critical patent/IL98681A0/xx

1997-06-10 Publication of IL98681A publication Critical patent/IL98681A/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title 2
229910052742 iron Inorganic materials 0.000 title 1
210000004962 mammalian cell Anatomy 0.000 title 1
244000052769 pathogen Species 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 7
125000003710 aryl alkyl group Chemical group 0.000 abstract 5
125000003118 aryl group Chemical group 0.000 abstract 5
125000001072 heteroaryl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000003302 alkenyloxy group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
101100134925 Gallus gallus COR6 gene Proteins 0.000 abstract 1
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
YMEHWISYYMKMFO-WOMRJYOTSA-N methyl N-[(12E,15S)-15-[(4S)-4-(3-chlorophenyl)-2-oxopiperidin-1-yl]-9-oxo-8,17,19-triazatricyclo[14.2.1.02,7]nonadeca-1(18),2(7),3,5,12,16-hexaen-5-yl]carbamate Chemical compound COC(=O)Nc1ccc2-c3cnc([nH]3)[C@H](C\C=C\CCC(=O)Nc2c1)N1CC[C@@H](CC1=O)c1cccc(Cl)c1 YMEHWISYYMKMFO-WOMRJYOTSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pyrrole Compounds (AREA)

IL98681A 1991-06-30 1991-06-30 Pharmaceutical compositions comprising hydroxamate derivatives for iron removal from mammalian cells and from pathogenic organisms and some novel hydroxamate derivatives IL98681A (en)

Priority Applications (9)

Application Number	Priority Date	Filing Date	Title
IL98681A IL98681A (en)	1991-06-30	1991-06-30	Pharmaceutical compositions comprising hydroxamate derivatives for iron removal from mammalian cells and from pathogenic organisms and some novel hydroxamate derivatives
ES92914455T ES2123560T3 (es)	1991-06-30	1992-06-30	Composiciones farmaceuticas que comprenden derivados de hidroxamato para la eliminacion del hierro.
EP92914455A EP0550716B1 (en)	1991-06-30	1992-06-30	Pharmaceutical compositions comprising hydroxamate derivatives for iron removal
CA002090426A CA2090426A1 (en)	1991-06-30	1992-06-30	Pharmaceutical compositions comprising hydroxamate derivatives for iron removal
PCT/EP1992/001474 WO1993000082A1 (en)	1991-06-30	1992-06-30	Pharmaceutical compositions comprising hydroxamate derivatives for iron removal
AU22288/92A AU2228892A (en)	1991-06-30	1992-06-30	Pharmaceutical compositions comprising hydroxamate derivatives for iron removal
DE69226936T DE69226936T2 (de)	1991-06-30	1992-06-30	Hydroxamatderivate enthaltende pharmazeutische Zusammensetzungen zur Eisenentfernung
JP5501341A JPH06503097A (ja)	1991-06-30	1992-06-30	鉄除去のためのヒドロキサメート誘導体を含む製薬組成物
US07/977,403 US5430058A (en)	1991-06-30	1992-06-30	Pharmaceutical compositions comprising hydroxamate derivatives for iron removal

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IL98681A IL98681A (en)	1991-06-30	1991-06-30	Pharmaceutical compositions comprising hydroxamate derivatives for iron removal from mammalian cells and from pathogenic organisms and some novel hydroxamate derivatives

Publications (2)

Publication Number	Publication Date
IL98681A0 IL98681A0 (en)	1992-07-15
IL98681A true IL98681A (en)	1997-06-10

Family

ID=11062594

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL98681A IL98681A (en)	1991-06-30	1991-06-30	Pharmaceutical compositions comprising hydroxamate derivatives for iron removal from mammalian cells and from pathogenic organisms and some novel hydroxamate derivatives

Country Status (9)

Country	Link
US (1)	US5430058A (ja)
EP (1)	EP0550716B1 (ja)
JP (1)	JPH06503097A (ja)
AU (1)	AU2228892A (ja)
CA (1)	CA2090426A1 (ja)
DE (1)	DE69226936T2 (ja)
ES (1)	ES2123560T3 (ja)
IL (1)	IL98681A (ja)
WO (1)	WO1993000082A1 (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5639746A (en) *	1994-12-29	1997-06-17	The Procter & Gamble Company	Hydroxamic acid-containing inhibitors of matrix metalloproteases
US5672598A (en) *	1995-03-21	1997-09-30	The Procter & Gamble Company	Lactam-containing hydroxamic acids
KR100339296B1 (ko) *	1996-08-28	2002-06-03	데이비드 엠 모이어	헤테로고리성 메탈로프로테아제 억제제
BR9713182A (pt) *	1996-08-28	1999-11-03	Procter & Gamble	Amidas de ácido fosfìnico como inibidores de metalo protease de matriz
ATE226573T1 (de)	1996-08-28	2002-11-15	Procter & Gamble	Heterozyklische metalloproteaseinhibitoren
DE69716934T2 (de) *	1996-08-28	2003-07-31	The Procter & Gamble Company, Cincinnati	1,3-diheterozyklische metalloprotease inhibitoren
RU2203274C2 (ru) *	1996-08-28	2003-04-27	Дзе Проктер Энд Гэмбл Компани	Спироциклические ингибиторы металлопротеаз
US5922761A (en) *	1996-09-06	1999-07-13	Medinox, Inc.	Methods for in vivo reduction of iron levels and compositions useful therefor
CA2298617A1 (en)	1997-07-31	1999-02-11	Yetunde Olabisi Taiwo	Acyclic metalloprotease inhibitors
AU3192499A (en) *	1998-03-18	1999-10-11	United States Of America, Represented By The Secretary, Department Of Health And Human Services, The	Cytotoxic metal chelators and methods for making and using same
MXPA01008857A (es)	1999-03-03	2002-07-02	Procter & Gamble	Inhibidores de metaloproteasa dihetero sustituidos.
BR0008716A (pt)	1999-03-03	2002-09-24	Procter & Gamble	Inibidores de metaloprotease contendo alquenil ou alquinil
US6767741B1 (en) *	1999-08-27	2004-07-27	Invitrogen Corporation	Metal binding compounds and their use in cell culture medium compositions
US6623721B2 (en)	2000-12-18	2003-09-23	Draximage, Inc.	Bifunctional chelating compounds containing hydroxamic acid residues
US7160855B2 (en) *	2002-03-14	2007-01-09	Children's Hospital & Research Center At Oakland	Enhancement of iron chelation therapy
US8628812B2 (en)	2008-12-30	2014-01-14	Pepsico, Inc.	Preservative system for acidic beverages based on sequestrants
US8425968B2 (en)	2009-06-19	2013-04-23	Pepsico., Inc.	Beverage preservative system containing pimaricin-cyclodextrin complex
AU2011282983A1 (en) *	2010-07-28	2013-02-21	Smartcells, Inc.	Drug-ligand conjugates, synthesis thereof, and intermediates thereto
WO2012104204A1 (en)	2011-01-31	2012-08-09	Vifor (International) Ag	Iron-carbohydrate complex compounds for the intravenous therapy of malaria

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH438351A (de) *	1959-09-25	1967-06-30	Ciba Geigy	Verfahren zur Herstellung neuer Wuchsstoffe
US4966997A (en) *	1988-10-11	1990-10-30	Yeda Research And Development Co., Ltd.	Trishydroxamic acids
US5149845A (en) *	1988-11-25	1992-09-22	Yeda Research And Development Co. Ltd.	Extractants for the separation of transition and related metal ions

1991
- 1991-06-30 IL IL98681A patent/IL98681A/xx not_active IP Right Cessation
1992
- 1992-06-30 CA CA002090426A patent/CA2090426A1/en not_active Abandoned
- 1992-06-30 ES ES92914455T patent/ES2123560T3/es not_active Expired - Lifetime
- 1992-06-30 DE DE69226936T patent/DE69226936T2/de not_active Expired - Fee Related
- 1992-06-30 EP EP92914455A patent/EP0550716B1/en not_active Expired - Lifetime
- 1992-06-30 WO PCT/EP1992/001474 patent/WO1993000082A1/en not_active Ceased
- 1992-06-30 AU AU22288/92A patent/AU2228892A/en not_active Abandoned
- 1992-06-30 US US07/977,403 patent/US5430058A/en not_active Expired - Fee Related
- 1992-06-30 JP JP5501341A patent/JPH06503097A/ja active Pending

Also Published As

Publication number	Publication date
DE69226936D1 (de)	1998-10-15
US5430058A (en)	1995-07-04
EP0550716A1 (en)	1993-07-14
ES2123560T3 (es)	1999-01-16
AU2228892A (en)	1993-01-25
DE69226936T2 (de)	1999-05-12
CA2090426A1 (en)	1992-12-31
IL98681A0 (en)	1992-07-15
JPH06503097A (ja)	1994-04-07
WO1993000082A1 (en)	1993-01-07
EP0550716B1 (en)	1998-09-09

Legal Events

Date	Code	Title
1998-01-04	FF	Patent granted
1998-04-05	KB	Patent renewed
2001-07-24	KB	Patent renewed
2006-03-12	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL98681A (en)	1997-06-10	Pharmaceutical compositions comprising hydroxamate derivatives for iron removal from mammalian cells and from pathogenic organisms and some novel hydroxamate derivatives
ES8800150A1 (es)	1987-10-16	Un procedimiento para la preparacion de derivados de indol
HUT52059A (en)	1990-06-28	Process for producing pharmaceutical compositions and new quinoline derivatives as a group of active components
IL146326A0 (en)	2002-07-25	Quinoline derivatives as inhibitors of mek enzymes
ES8500902A1 (es)	1984-11-01	Un procedimiento para la preparacion de un derivado del indol.
EP0322738A3 (en)	1991-05-08	Benzylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells
EP0100189A3 (en)	1984-05-23	Dihydropyridine anti-ischaemic and antihypertensive agents
EP0632031A4 (ja)	1995-02-08
IE40511B1 (en)	1979-06-20	N-(1-(-phenylalkyl)-piperidyl-j)-(-(-pyridyl)-carbonic acid amides
AU703163B2 (en)	1999-03-18	Anti-ischaemic hydroxylamine derivatives and pharmaceutical compositions
CA2089366A1 (en)	1992-02-21	Penem compounds
HUT69392A (en)	1995-09-28	Alkylenediamine derivatives, pharmaceutical compositions containing them and process for their preparation
ES8302718A1 (es)	1983-02-01	"procedimiento para la preparacion de cetohidroxi-iminocefalosporinas".
NZ234450A (en)	1991-10-25	Substituted pyrrolo(2,1-b)thiazole derivatives, intermediates and pharmaceutical compositions
TW326439B (en)	1998-02-11	Octahydornaphthalene oxime derivatives for cholesterol biosynthesis inhibition, their preparation and use
ES2009283A6 (es)	1989-09-16	Procedimiento para preparar nuevos aminoacilatos de glicerol-acetal.
ES8301482A1 (es)	1982-05-01	Un procedimiento para la preparacion de un derivado del aci-do clavulanico