IL98935A - Liposomal immunogenic carriers - Google Patents

Liposomal immunogenic carriers

Info

Publication number: IL98935A
Authority: IL; Israel
Prior art keywords: liposomal; immunogenic carrier; target antigen; immune response; eliciting
Prior art date: 1990-07-27

Application number

IL9893591A

Other languages

English (en)

Other versions

IL98935A0 (en

Original Assignee

Res Dev Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-27

Filing date

1991-07-23

Publication date

1994-01-24

1991-07-23 Application filed by Res Dev Foundation filed Critical Res Dev Foundation

1992-07-15 Publication of IL98935A0 publication Critical patent/IL98935A0/xx

1994-01-24 Publication of IL98935A publication Critical patent/IL98935A/en

Links

230000002163 immunogen Effects 0.000 title claims description 34
239000000969 carrier Substances 0.000 title description 2
239000000427 antigen Substances 0.000 claims abstract description 75
102000036639 antigens Human genes 0.000 claims abstract description 75
108091007433 antigens Proteins 0.000 claims abstract description 75
239000002502 liposome Substances 0.000 claims abstract description 73
150000002632 lipids Chemical class 0.000 claims abstract description 22
230000002209 hydrophobic effect Effects 0.000 claims abstract description 9
210000004698 lymphocyte Anatomy 0.000 claims abstract description 6
230000003993 interaction Effects 0.000 claims abstract description 3
101800000324 Immunoglobulin A1 protease translocator Proteins 0.000 claims description 34
230000028993 immune response Effects 0.000 claims description 23
238000000034 method Methods 0.000 claims description 21
108090000765 processed proteins & peptides Proteins 0.000 claims description 19
102000004196 processed proteins & peptides Human genes 0.000 claims description 14
239000000203 mixture Substances 0.000 claims description 11
210000003719 b-lymphocyte Anatomy 0.000 claims description 7
210000002443 helper t lymphocyte Anatomy 0.000 claims description 7
229920001184 polypeptide Polymers 0.000 claims description 7
-1 phosphatidyl ether Chemical compound 0.000 claims description 6
WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 6
230000005859 cell recognition Effects 0.000 claims description 5
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
150000003431 steroids Chemical class 0.000 claims description 4
241000712461 unidentified influenza virus Species 0.000 claims description 4
JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims description 3
229930183167 cerebroside Natural products 0.000 claims description 3
150000002270 gangliosides Chemical class 0.000 claims description 3
125000005456 glyceride group Chemical group 0.000 claims description 3
206010022000 influenza Diseases 0.000 claims description 3
125000001095 phosphatidyl group Chemical group 0.000 claims description 3
150000008104 phosphatidylethanolamines Chemical class 0.000 claims description 3
241000588724 Escherichia coli Species 0.000 claims description 2
201000005702 Pertussis Diseases 0.000 claims description 2
241000191940 Staphylococcus Species 0.000 claims description 2
241000194017 Streptococcus Species 0.000 claims description 2
206010043376 Tetanus Diseases 0.000 claims description 2
235000012000 cholesterol Nutrition 0.000 claims description 2
206010013023 diphtheria Diseases 0.000 claims description 2
239000003053 toxin Substances 0.000 claims description 2
231100000765 toxin Toxicity 0.000 claims description 2
241000124008 Mammalia Species 0.000 claims 10
JSPNNZKWADNWHI-PNANGNLXSA-N (2r)-2-hydroxy-n-[(2s,3r,4e,8e)-3-hydroxy-9-methyl-1-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]heptadecanamide Chemical compound CCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@H]([C@H](O)\C=C\CC\C=C(/C)CCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JSPNNZKWADNWHI-PNANGNLXSA-N 0.000 claims 1
101710114192 Elicitin Proteins 0.000 claims 1
RIZIAUKTHDLMQX-UHFFFAOYSA-N cerebroside D Natural products CCCCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=C(C)CCCCCCCCC)COC1OC(CO)C(O)C(O)C1O RIZIAUKTHDLMQX-UHFFFAOYSA-N 0.000 claims 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
230000005875 antibody response Effects 0.000 abstract description 7
239000000463 material Substances 0.000 abstract description 6
239000000470 constituent Substances 0.000 abstract description 3
241000699670 Mus sp. Species 0.000 description 30
125000001917 2,4-dinitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C(=C1*)[N+]([O-])=O)[N+]([O-])=O 0.000 description 25
230000004044 response Effects 0.000 description 22
238000002360 preparation method Methods 0.000 description 18
102000004169 proteins and genes Human genes 0.000 description 14
108090000623 proteins and genes Proteins 0.000 description 14
108010067755 dinitrophenyl-bovine serum albumin Proteins 0.000 description 10
101710154606 Hemagglutinin Proteins 0.000 description 9
101710093908 Outer capsid protein VP4 Proteins 0.000 description 9
101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 9
101710176177 Protein A56 Proteins 0.000 description 9
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 9
239000000185 hemagglutinin Substances 0.000 description 9
239000002953 phosphate buffered saline Substances 0.000 description 9
210000001744 T-lymphocyte Anatomy 0.000 description 8
210000002966 serum Anatomy 0.000 description 8
238000002965 ELISA Methods 0.000 description 7
238000002474 experimental method Methods 0.000 description 7
238000010348 incorporation Methods 0.000 description 7
230000001419 dependent effect Effects 0.000 description 6
230000000694 effects Effects 0.000 description 6
230000003053 immunization Effects 0.000 description 6
238000004519 manufacturing process Methods 0.000 description 6
238000002649 immunization Methods 0.000 description 5
230000001965 increasing effect Effects 0.000 description 5
229960005486 vaccine Drugs 0.000 description 5
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
241001465754 Metazoa Species 0.000 description 4
239000007864 aqueous solution Substances 0.000 description 4
231100000673 dose–response relationship Toxicity 0.000 description 4
230000016784 immunoglobulin production Effects 0.000 description 4
238000002347 injection Methods 0.000 description 4
239000007924 injection Substances 0.000 description 4
238000011081 inoculation Methods 0.000 description 4
238000012360 testing method Methods 0.000 description 4
108010004032 Bromelains Proteins 0.000 description 3
241000283707 Capra Species 0.000 description 3
102000018697 Membrane Proteins Human genes 0.000 description 3
108010052285 Membrane Proteins Proteins 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
241001529936 Murinae Species 0.000 description 3
239000004365 Protease Substances 0.000 description 3
241000700605 Viruses Species 0.000 description 3
150000001413 amino acids Chemical class 0.000 description 3
238000003556 assay Methods 0.000 description 3
235000019835 bromelain Nutrition 0.000 description 3
238000010790 dilution Methods 0.000 description 3
239000012895 dilution Substances 0.000 description 3
230000009851 immunogenic response Effects 0.000 description 3
238000011534 incubation Methods 0.000 description 3
230000001629 suppression Effects 0.000 description 3
210000003462 vein Anatomy 0.000 description 3
LRYZPFWEZHSTHD-HEFFAWAOSA-O 2-[[(e,2s,3r)-2-formamido-3-hydroxyoctadec-4-enoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium Chemical class CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](NC=O)COP(O)(=O)OCC[N+](C)(C)C LRYZPFWEZHSTHD-HEFFAWAOSA-O 0.000 description 2
102000002260 Alkaline Phosphatase Human genes 0.000 description 2
108020004774 Alkaline Phosphatase Proteins 0.000 description 2
108060003951 Immunoglobulin Proteins 0.000 description 2
102000012750 Membrane Glycoproteins Human genes 0.000 description 2
108010090054 Membrane Glycoproteins Proteins 0.000 description 2
241000283973 Oryctolagus cuniculus Species 0.000 description 2
230000000890 antigenic effect Effects 0.000 description 2
230000001580 bacterial effect Effects 0.000 description 2
239000000872 buffer Substances 0.000 description 2
210000004899 c-terminal region Anatomy 0.000 description 2
150000001784 cerebrosides Chemical class 0.000 description 2
230000001268 conjugating effect Effects 0.000 description 2
238000000502 dialysis Methods 0.000 description 2
102000018358 immunoglobulin Human genes 0.000 description 2
239000012528 membrane Substances 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
231100000252 nontoxic Toxicity 0.000 description 2
230000003000 nontoxic effect Effects 0.000 description 2
230000003287 optical effect Effects 0.000 description 2
230000008569 process Effects 0.000 description 2
239000000243 solution Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
229940126577 synthetic vaccine Drugs 0.000 description 2
230000002992 thymic effect Effects 0.000 description 2
231100000419 toxicity Toxicity 0.000 description 2
230000001988 toxicity Effects 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
XZKIHKMTEMTJQX-UHFFFAOYSA-N 4-Nitrophenyl Phosphate Chemical compound OP(O)(=O)OC1=CC=C([N+]([O-])=O)C=C1 XZKIHKMTEMTJQX-UHFFFAOYSA-N 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
206010008631 Cholera Diseases 0.000 description 1
238000012286 ELISA Assay Methods 0.000 description 1
102000002322 Egg Proteins Human genes 0.000 description 1
108010000912 Egg Proteins Proteins 0.000 description 1
208000032843 Hemorrhage Diseases 0.000 description 1
239000000232 Lipid Bilayer Substances 0.000 description 1
241000609499 Palicourea Species 0.000 description 1
208000002606 Paramyxoviridae Infections Diseases 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
241000725643 Respiratory syncytial virus Species 0.000 description 1
241000282898 Sus scrofa Species 0.000 description 1
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
238000010171 animal model Methods 0.000 description 1
238000013459 approach Methods 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
208000034158 bleeding Diseases 0.000 description 1
231100000319 bleeding Toxicity 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
230000008859 change Effects 0.000 description 1
230000007402 cytotoxic response Effects 0.000 description 1
238000013461 design Methods 0.000 description 1
238000001514 detection method Methods 0.000 description 1
238000011161 development Methods 0.000 description 1
ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
229960003983 diphtheria toxoid Drugs 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
235000013345 egg yolk Nutrition 0.000 description 1
210000002969 egg yolk Anatomy 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
235000013305 food Nutrition 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
208000002672 hepatitis B Diseases 0.000 description 1
125000001165 hydrophobic group Chemical group 0.000 description 1
230000036039 immunity Effects 0.000 description 1
230000005847 immunogenicity Effects 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
230000006054 immunological memory Effects 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
108700010900 influenza virus proteins Proteins 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
210000004779 membrane envelope Anatomy 0.000 description 1
230000015654 memory Effects 0.000 description 1
229940068196 placebo Drugs 0.000 description 1
239000000902 placebo Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
210000001541 thymus gland Anatomy 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
239000003981 vehicle Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/829—Liposomes, e.g. encapsulation

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Dispersion Chemistry (AREA)
Immunology (AREA)
Microbiology (AREA)
Mycology (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Manufacturing Of Micro-Capsules (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL9893591A 1990-07-27 1991-07-23 Liposomal immunogenic carriers IL98935A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US55896090A	1990-07-27	1990-07-27

Publications (2)

Publication Number	Publication Date
IL98935A0 IL98935A0 (en)	1992-07-15
IL98935A true IL98935A (en)	1994-01-24

Family

ID=24231699

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9893591A IL98935A (en)	1990-07-27	1991-07-23	Liposomal immunogenic carriers

Country Status (21)

Country	Link
US (1)	US5464630A (de)
EP (1)	EP0542923B1 (de)
JP (1)	JP3518866B2 (de)
KR (1)	KR100213851B1 (de)
CN (1)	CN1032236C (de)
AT (1)	ATE157537T1 (de)
AU (1)	AU650299B2 (de)
CA (1)	CA2088163C (de)
DE (1)	DE69127545T2 (de)
DK (1)	DK0542923T3 (de)
ES (1)	ES2106088T3 (de)
FI (1)	FI107515B (de)
GR (1)	GR3025377T3 (de)
IE (1)	IE912535A1 (de)
IL (1)	IL98935A (de)
NO (1)	NO311167B1 (de)
NZ (1)	NZ239072A (de)
PT (1)	PT98470B (de)
RU (1)	RU2107493C1 (de)
WO (1)	WO1992002243A1 (de)
ZA (1)	ZA915755B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5879685A (en) *	1991-05-08	1999-03-09	Schweiz, Serum- & Impfinstitut Bern	Immunostimulating and immunopotentiating reconstituted influenza virosomes and vaccines containing them
US6004534A (en) *	1993-07-23	1999-12-21	Massachusetts Institute Of Technology	Targeted polymerized liposomes for improved drug delivery
AU3541495A (en) *	1994-09-01	1996-03-22	Wisconsin Alumni Research Foundation	Therapeutic remodeling in aids
US6060082A (en) *	1997-04-18	2000-05-09	Massachusetts Institute Of Technology	Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
AUPO732997A0 (en)	1997-06-12	1997-07-03	Csl Limited	Ganglioside immunostimulating complexes and uses thereof
US5993852A (en) *	1997-08-29	1999-11-30	Pharmaderm Laboratories Ltd.	Biphasic lipid vesicle composition for transdermal administration of an immunogen
US6027731A (en) *	1998-11-17	2000-02-22	Wisconsin Alumni Research Foundation	Pertussis toxin induced lymphocytosis
CN102294023A (zh) *	2001-07-26	2011-12-28	奥塔戈创新公司	抗原组合物
GB0118517D0 (en) *	2001-07-30	2001-09-19	Mitsubishi Tokyo Pharm Inc	Compound
JP2009510032A (ja) *	2005-09-30	2009-03-12	リポクセンテクノロジーズリミテッド	多糖抗原及びタンパク質アジュバントを含む多価リポソームワクチン組成物
RU2480479C1 (ru) *	2011-11-01	2013-04-27	Елена Викторовна Свирщевская	Гетерологичный пептидный мини-антиген в составе полимерной частицы для создания противоаллергенной вакцины
WO2013103658A1 (en)	2012-01-03	2013-07-11	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Native and agonist ctl epitopes of the muc1 tumor antigen
AU2014340201B2 (en)	2013-10-23	2019-02-21	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	HLA-A24 agonist epitopes of MUC1-C oncoprotein and compositions and methods of use
JP7048482B2 (ja)	2015-08-03	2022-04-05	アメリカ合衆国	Ｂｒａｃｈｙｕｒｙ欠失変異体、Ｂｒａｃｈｙｕｒｙ欠失変異体をコードする非酵母ベクター、及びそれらの使用
EP3535284B1 (de)	2016-11-07	2021-04-21	The United States of America as represented by The Secretary Department of Health and Human Services	Entwicklung von agonistenepitopen des humanen papillomavirus
EP3880694A1 (de)	2018-11-14	2021-09-22	The United States of America, as represented by the Secretary, Department of Health and Human Services	Tp5, ein peptid-inhibitor von aberrantem und hyperaktivem cdk5/p25 als behandlung von krebs
WO2021150713A2 (en)	2020-01-21	2021-07-29	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Human immunogenic epitopes of h, k, and e human endogenous retroviruses (hervs)
US20230287067A1 (en)	2020-01-21	2023-09-14	The United States Of America,As Represented By The Secretary,Department Of Health And Human Services	Human immunogenic epitopes of hemo and hhla2 human endogenous retroviruses (hervs)
AU2024296108A1 (en)	2023-07-20	2026-02-26	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Identification of sequence variants of the ervmer34-1 sequence family and use in anti-cancer therapies

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2009343C3 (de) *	1970-02-27	1980-10-23	Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen	Verwendung von Lysolecithinen als immunologische Adjuvantien
GB1502774A (en) *	1974-06-25	1978-03-01	Nat Res Dev	Immunological preparations
US4196191A (en) *	1975-09-29	1980-04-01	Burroughs Wellcome Co.	Biological preparations
US4235871A (en) *	1978-02-24	1980-11-25	Papahadjopoulos Demetrios P	Method of encapsulating biologically active materials in lipid vesicles
GB2026340B (en) *	1978-07-03	1982-12-22	Ash P	Stabilising microvesicles
US4199565A (en) *	1979-03-26	1980-04-22	Merck & Co., Inc.	Liposome particle containing viral or bacterial antigenic subunit
HU184141B (en) *	1979-12-27	1984-07-30	Human Oltoanyagtermelo	Adjuvant particles compositions containing said particles and biologically active substances adsorbed thereon and a process for the preparation thereof
US4673574A (en) *	1981-08-31	1987-06-16	Anderson Porter W	Immunogenic conjugates
US4902506A (en) *	1983-07-05	1990-02-20	The University Of Rochester	Immunogenic conjugates
US4761283A (en) *	1983-07-05	1988-08-02	The University Of Rochester	Immunogenic conjugates
US4565696A (en) *	1983-08-03	1986-01-21	The Regents Of The University Of California	Production of immunogens by antigen conjugation to liposomes
US4708933A (en) *	1984-06-12	1987-11-24	Leaf Huang	Immunoliposome assay-methods and products
JPH0832637B2 (ja) *	1985-02-14	1996-03-29	アクゾ・エヌ・ヴエー	合成免疫原
US4797285A (en) *	1985-12-06	1989-01-10	Yissum Research And Development Company Of The Hebrew University Of Jerusalem	Lipsome/anthraquinone drug composition and method
US4882145A (en) *	1986-12-09	1989-11-21	Scripps Clinic And Research Foundation	T cell epitopes of the hepatitis B virus nucleocapsid protein
EP0306912A3 (de) *	1987-09-08	1989-07-05	Albany Medical College	Zur selektiven Anregung der Antikörperbildung befähigte immunogene Produkte und ihre Verwendung in pharmazeutischen Zusammensetzungen.

1991
- 1991-07-18 IE IE253591A patent/IE912535A1/en not_active IP Right Cessation
- 1991-07-22 NZ NZ239072A patent/NZ239072A/en not_active IP Right Cessation
- 1991-07-23 IL IL9893591A patent/IL98935A/en not_active IP Right Cessation
- 1991-07-23 ZA ZA915755A patent/ZA915755B/xx unknown
- 1991-07-24 EP EP91918697A patent/EP0542923B1/de not_active Expired - Lifetime
- 1991-07-24 DE DE69127545T patent/DE69127545T2/de not_active Expired - Fee Related
- 1991-07-24 JP JP51779191A patent/JP3518866B2/ja not_active Expired - Fee Related
- 1991-07-24 CA CA002088163A patent/CA2088163C/en not_active Expired - Fee Related
- 1991-07-24 RU RU93004915A patent/RU2107493C1/ru not_active IP Right Cessation
- 1991-07-24 AU AU87597/91A patent/AU650299B2/en not_active Ceased
- 1991-07-24 KR KR1019930700231A patent/KR100213851B1/ko not_active Expired - Fee Related
- 1991-07-24 AT AT91918697T patent/ATE157537T1/de not_active IP Right Cessation
- 1991-07-24 ES ES91918697T patent/ES2106088T3/es not_active Expired - Lifetime
- 1991-07-24 WO PCT/US1991/005231 patent/WO1992002243A1/en not_active Ceased
- 1991-07-24 DK DK91918697.3T patent/DK0542923T3/da active
- 1991-07-26 PT PT98470A patent/PT98470B/pt not_active IP Right Cessation
- 1991-07-27 CN CN91105793A patent/CN1032236C/zh not_active Expired - Fee Related
1993
- 1993-01-21 NO NO19930202A patent/NO311167B1/no unknown
- 1993-01-26 FI FI930319A patent/FI107515B/fi active
1995
- 1995-01-30 US US08/380,213 patent/US5464630A/en not_active Expired - Lifetime
1997
- 1997-11-13 GR GR970403020T patent/GR3025377T3/el unknown

Also Published As

Publication number	Publication date
JPH06502630A (ja)	1994-03-24
NZ239072A (en)	1997-06-24
NO930202L (no)	1993-01-21
ATE157537T1 (de)	1997-09-15
ES2106088T3 (es)	1997-11-01
EP0542923B1 (de)	1997-09-03
AU8759791A (en)	1992-03-02
EP0542923A1 (de)	1993-05-26
NO311167B1 (no)	2001-10-22
PT98470B (pt)	1998-02-27
CN1032236C (zh)	1996-07-10
AU650299B2 (en)	1994-06-16
FI930319A0 (fi)	1993-01-26
NO930202D0 (no)	1993-01-21
FI930319L (fi)	1993-01-26
FI107515B (fi)	2001-08-31
CN1059279A (zh)	1992-03-11
DE69127545D1 (de)	1997-10-09
RU2107493C1 (ru)	1998-03-27
EP0542923A4 (de)	1994-04-13
KR100213851B1 (ko)	1999-08-02
DK0542923T3 (da)	1997-10-13
GR3025377T3 (en)	1998-02-27
CA2088163C (en)	2003-06-17
PT98470A (pt)	1992-06-30
HK1008304A1 (en)	1999-05-07
DE69127545T2 (de)	1998-01-08
IL98935A0 (en)	1992-07-15
ZA915755B (en)	1993-02-24
WO1992002243A1 (en)	1992-02-20
JP3518866B2 (ja)	2004-04-12
CA2088163A1 (en)	1992-01-28
US5464630A (en)	1995-11-07
IE912535A1 (en)	1992-01-29

Legal Events

Date	Code	Title
1998-01-04	KB	Patent renewed
2001-10-31	KB	Patent renewed
2005-09-25	KB	Patent renewed
2010-10-31	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
CA2088163C (en)	2003-06-17	Liposomes that provide thymic dependent help to weak vaccine antigens
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AU631377B2 (en)	1992-11-26	Affinity associated vaccine
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US4565696A (en)	1986-01-21	Production of immunogens by antigen conjugation to liposomes
US4950480A (en)	1990-08-21	Enhancement of antigen immunogenicity
Boeckler et al.	1996	Immunogenicity of new heterobifunctional cross-linking reagents used in the conjugation of synthetic peptides to liposomes
Boeckler et al.	1999	Design of highly immunogenic liposomal constructs combining structurally independent B cell and T helper cell peptide epitopes
Frisch et al.	1991	Parameters affecting the immunogenicity of a liposome‐associated synthetic hexapeptide antigen
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JP2004513897A (ja)	2004-05-13	特定交叉反応性を高める抗原構造を得る方法
WO1990001947A1 (en)	1990-03-08	Affinity associated vaccine
HK1008304B (en)	2000-07-07	Liposomes that provide thymic dependent help to weak vaccine antigens
Leibl et al.	1998	Adjuvant/carrier activity of inactivated tick-borne encephalitis virus
AU667028B2 (en)	1996-03-07	Lipid A composition as immunogenic agents to prevent or treat gram-negative bacterial infections
Pietrobon et al.	1994	Liposomes that provide T-dependent help to weak antigens (T-independent antigens)
EP0517743A1 (de)	1992-12-16	Verbesserte immunogene zusammensetzungen
Frisch et al.	2003	Synthetic Peptide–Based Highly Immunogenic Liposomal Constructs
CA1327523C (en)	1994-03-08	Antigen immunogenicity
CA1334165C (en)	1995-01-31	Affinity associated vaccine
Garçon et al.	1996	Liposomes to Induce Potent Humorale Responses to T-Independent Antigens