ATE157537T1 - Liposomen, die versorgt werden mit t-helfer lympozyten zur unterstützung schwacher antigene als impfstoffe - Google Patents

Liposomen, die versorgt werden mit t-helfer lympozyten zur unterstützung schwacher antigene als impfstoffe

Info

Publication number
ATE157537T1
ATE157537T1 AT91918697T AT91918697T ATE157537T1 AT E157537 T1 ATE157537 T1 AT E157537T1 AT 91918697 T AT91918697 T AT 91918697T AT 91918697 T AT91918697 T AT 91918697T AT E157537 T1 ATE157537 T1 AT E157537T1
Authority
AT
Austria
Prior art keywords
helper
liposomes
lympocytes
vaccines
supplied
Prior art date
Application number
AT91918697T
Other languages
English (en)
Inventor
Howard R Six
Nathalie Garcon
Original Assignee
Res Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Dev Foundation filed Critical Res Dev Foundation
Application granted granted Critical
Publication of ATE157537T1 publication Critical patent/ATE157537T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
AT91918697T 1990-07-27 1991-07-24 Liposomen, die versorgt werden mit t-helfer lympozyten zur unterstützung schwacher antigene als impfstoffe ATE157537T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55896090A 1990-07-27 1990-07-27

Publications (1)

Publication Number Publication Date
ATE157537T1 true ATE157537T1 (de) 1997-09-15

Family

ID=24231699

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91918697T ATE157537T1 (de) 1990-07-27 1991-07-24 Liposomen, die versorgt werden mit t-helfer lympozyten zur unterstützung schwacher antigene als impfstoffe

Country Status (21)

Country Link
US (1) US5464630A (de)
EP (1) EP0542923B1 (de)
JP (1) JP3518866B2 (de)
KR (1) KR100213851B1 (de)
CN (1) CN1032236C (de)
AT (1) ATE157537T1 (de)
AU (1) AU650299B2 (de)
CA (1) CA2088163C (de)
DE (1) DE69127545T2 (de)
DK (1) DK0542923T3 (de)
ES (1) ES2106088T3 (de)
FI (1) FI107515B (de)
GR (1) GR3025377T3 (de)
IE (1) IE912535A1 (de)
IL (1) IL98935A (de)
NO (1) NO311167B1 (de)
NZ (1) NZ239072A (de)
PT (1) PT98470B (de)
RU (1) RU2107493C1 (de)
WO (1) WO1992002243A1 (de)
ZA (1) ZA915755B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879685A (en) * 1991-05-08 1999-03-09 Schweiz, Serum- & Impfinstitut Bern Immunostimulating and immunopotentiating reconstituted influenza virosomes and vaccines containing them
US6004534A (en) * 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
AU3541495A (en) * 1994-09-01 1996-03-22 Wisconsin Alumni Research Foundation Therapeutic remodeling in aids
US6060082A (en) 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
AUPO732997A0 (en) 1997-06-12 1997-07-03 Csl Limited Ganglioside immunostimulating complexes and uses thereof
US5993852A (en) * 1997-08-29 1999-11-30 Pharmaderm Laboratories Ltd. Biphasic lipid vesicle composition for transdermal administration of an immunogen
US6027731A (en) * 1998-11-17 2000-02-22 Wisconsin Alumni Research Foundation Pertussis toxin induced lymphocytosis
JP4685350B2 (ja) * 2001-07-26 2011-05-18 オタゴ イノベイション リミティド 抗原性組成物
GB0118517D0 (en) * 2001-07-30 2001-09-19 Mitsubishi Tokyo Pharm Inc Compound
EP1928418B1 (de) 2005-09-30 2011-12-21 Lipoxen Technologies Limited Liposomale impfstoff-zusammensetzung aus einem polysaccharid-antigen und einem protein-adjuvans
RU2480479C1 (ru) * 2011-11-01 2013-04-27 Елена Викторовна Свирщевская Гетерологичный пептидный мини-антиген в составе полимерной частицы для создания противоаллергенной вакцины
EP2800762B1 (de) 2012-01-03 2018-01-03 The United States of America, as represented by the Secretary, Department of Health and Human Services Native und agonistische ctl-epitope des muc1-tumorantigens
WO2015061416A2 (en) 2013-10-23 2015-04-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla-a24 agonist epitopes of muc1-c oncoprotein and compositions and methods of use
EP4137150A1 (de) 2015-08-03 2023-02-22 The United States of America, as represented by the Secretary, Department of Health and Human Services Brachyury-deletionsmutanten, nichthefevektoren zur codierung von brachyury-deletionsmutanten und verwendung davon
EP3535284B1 (de) 2016-11-07 2021-04-21 The United States of America as represented by The Secretary Department of Health and Human Services Entwicklung von agonistenepitopen des humanen papillomavirus
EP3880694A1 (de) 2018-11-14 2021-09-22 The United States of America, as represented by the Secretary, Department of Health and Human Services Tp5, ein peptid-inhibitor von aberrantem und hyperaktivem cdk5/p25 als behandlung von krebs
US20230287067A1 (en) 2020-01-21 2023-09-14 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Human immunogenic epitopes of hemo and hhla2 human endogenous retroviruses (hervs)
WO2021150713A2 (en) 2020-01-21 2021-07-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human immunogenic epitopes of h, k, and e human endogenous retroviruses (hervs)
WO2025019872A2 (en) 2023-07-20 2025-01-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Identification of novel sequences of the ervmer34-1 human endogenous retroviral sequence family, and modification of those sequences for a more effective anti-cancer vaccine and other potential anti-cancer therapies

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2009343C3 (de) * 1970-02-27 1980-10-23 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen Verwendung von Lysolecithinen als immunologische Adjuvantien
GB1502774A (en) * 1974-06-25 1978-03-01 Nat Res Dev Immunological preparations
US4196191A (en) * 1975-09-29 1980-04-01 Burroughs Wellcome Co. Biological preparations
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
GB2026340B (en) * 1978-07-03 1982-12-22 Ash P Stabilising microvesicles
US4199565A (en) * 1979-03-26 1980-04-22 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
HU184141B (en) * 1979-12-27 1984-07-30 Human Oltoanyagtermelo Adjuvant particles compositions containing said particles and biologically active substances adsorbed thereon and a process for the preparation thereof
US4673574A (en) * 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4902506A (en) * 1983-07-05 1990-02-20 The University Of Rochester Immunogenic conjugates
US4761283A (en) * 1983-07-05 1988-08-02 The University Of Rochester Immunogenic conjugates
US4565696A (en) * 1983-08-03 1986-01-21 The Regents Of The University Of California Production of immunogens by antigen conjugation to liposomes
US4708933A (en) * 1984-06-12 1987-11-24 Leaf Huang Immunoliposome assay-methods and products
JPH0832637B2 (ja) * 1985-02-14 1996-03-29 アクゾ・エヌ・ヴエー 合成免疫原
US4797285A (en) * 1985-12-06 1989-01-10 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Lipsome/anthraquinone drug composition and method
US4882145A (en) * 1986-12-09 1989-11-21 Scripps Clinic And Research Foundation T cell epitopes of the hepatitis B virus nucleocapsid protein
AU626797B2 (en) * 1987-09-08 1992-08-13 Albany Medical College Immunogenic composites capable of selectively inducing antibody production, pharmaceutical compositions employing the same and method of selectively inducing antibody production

Also Published As

Publication number Publication date
EP0542923A1 (de) 1993-05-26
CA2088163A1 (en) 1992-01-28
HK1008304A1 (en) 1999-05-07
ZA915755B (en) 1993-02-24
AU650299B2 (en) 1994-06-16
PT98470B (pt) 1998-02-27
FI930319A0 (fi) 1993-01-26
IL98935A (en) 1994-01-24
EP0542923B1 (de) 1997-09-03
NO930202D0 (no) 1993-01-21
GR3025377T3 (en) 1998-02-27
WO1992002243A1 (en) 1992-02-20
CA2088163C (en) 2003-06-17
EP0542923A4 (de) 1994-04-13
RU2107493C1 (ru) 1998-03-27
FI930319L (fi) 1993-01-26
NZ239072A (en) 1997-06-24
ES2106088T3 (es) 1997-11-01
DE69127545T2 (de) 1998-01-08
DE69127545D1 (de) 1997-10-09
JPH06502630A (ja) 1994-03-24
JP3518866B2 (ja) 2004-04-12
NO311167B1 (no) 2001-10-22
AU8759791A (en) 1992-03-02
CN1059279A (zh) 1992-03-11
KR100213851B1 (ko) 1999-08-02
FI107515B (fi) 2001-08-31
DK0542923T3 (da) 1997-10-13
NO930202L (no) 1993-01-21
IE912535A1 (en) 1992-01-29
PT98470A (pt) 1992-06-30
CN1032236C (zh) 1996-07-10
IL98935A0 (en) 1992-07-15
US5464630A (en) 1995-11-07

Similar Documents

Publication Publication Date Title
ATE157537T1 (de) Liposomen, die versorgt werden mit t-helfer lympozyten zur unterstützung schwacher antigene als impfstoffe
EP1333858B8 (de) Impfstoffe mit erhöhter immunantwort und verfahren zur deren herstellung
RU93004915A (ru) Липосомы, осуществляющие тимус-зависимую помощь "слабым" антигенам, используемым для приготовления вакцины
HU9500571D0 (en) Retro-, inverso-, and retro-inverso synthetic peptide analogues
ES2115626T3 (es) Anticuerpo monoclonal humano especifico al antigeno de superficie de la membrana de las celulas cancerosas.
DE3852054D1 (de) Monoklonale Antikörper gegen Glycolipid-Antigene und ihre Verwendung.
ES2185705T3 (es) Proteina bifuncional, preparacion y uso.
ES2124533T3 (es) Anticuerpos monoclonales inmunoestimulantes.
BR9809656A (pt) Composição imunopotencializante
ATE62254T1 (de) Multispezifische immunogene proteine.
DE69029134D1 (de) Monoklonale antikörper zur induzierung von toleranz
ES2196150T3 (es) Induccion de tolerancia inmunologica por el uso de anticuerpos anti-cd4 que no inducen deplecion.
GB9406492D0 (en) Malaria peptides
ATE193534T1 (de) Benzodiazepin-derivate sowie deren konjugate mit proteinen und polypeptiden
ATE2048T1 (de) Isolierung von hepatitis be-antigen.
DE3850993D1 (de) Monoklonaler Antikörper spezifisch gegen humane Pankreas-Phospholipase-A2.
EP0652769A1 (de) Impfstoffe gegen MetazoonParasiten.
ATE109004T1 (de) Toleranzinduktion gegenüber einem fremdantigen.
ATE132267T1 (de) Immuntest unter verwendung von antigenen, produziert in heterologen organismen
ES2090331T3 (es) Ctaa 28a32, antigeno reconocido por mca 28a32.
ITRM910385A0 (it) Vaccini utilizzanti eritrociti come veicoli di antigeni.
EP0854727A4 (de) Durch hla-b44 moleküle präsentierte tumor-abstossungsantigene und ihre verwendung
IT1254570B (it) Antigeni legati alla superfice esterna di eritrociti e procedimento per la loro preparazione.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee