IL99146A - 3-(3-substituted 1, 2, 5-thia (or oxa) diazol-4-yl)-1, 2, 5, 6-tetrahydropyridine derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

3-(3-substituted 1, 2, 5-thia (or oxa) diazol-4-yl)-1, 2, 5, 6-tetrahydropyridine derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL99146A
IL99146A IL99146A IL9914691A IL99146A IL 99146 A IL99146 A IL 99146A IL 99146 A IL99146 A IL 99146A IL 9914691 A IL9914691 A IL 9914691A IL 99146 A IL99146 A IL 99146A
Authority
IL
Israel
Prior art keywords
compound
thiadiazol
dimethylpyridine
tetrahydro
formula
Prior art date
Application number
IL99146A
Other languages
English (en)
Other versions
IL99146A0 (en
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IL99146A0 publication Critical patent/IL99146A0/xx
Publication of IL99146A publication Critical patent/IL99146A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Lubricants (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL99146A 1990-08-21 1991-08-09 3-(3-substituted 1, 2, 5-thia (or oxa) diazol-4-yl)-1, 2, 5, 6-tetrahydropyridine derivatives, their preparation and pharmaceutical compositions containing them IL99146A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK198490A DK198490D0 (da) 1990-08-21 1990-08-21 Heterocykliske forbindelser, deres fremstilling og anvendelse

Publications (2)

Publication Number Publication Date
IL99146A0 IL99146A0 (en) 1992-07-15
IL99146A true IL99146A (en) 1998-01-04

Family

ID=8109268

Family Applications (1)

Application Number Title Priority Date Filing Date
IL99146A IL99146A (en) 1990-08-21 1991-08-09 3-(3-substituted 1, 2, 5-thia (or oxa) diazol-4-yl)-1, 2, 5, 6-tetrahydropyridine derivatives, their preparation and pharmaceutical compositions containing them

Country Status (18)

Country Link
US (2) US5328923A (de)
EP (1) EP0544714B1 (de)
JP (1) JP3100159B2 (de)
AT (1) ATE130611T1 (de)
AU (1) AU660938B2 (de)
CA (1) CA2089770A1 (de)
DE (1) DE69114848T2 (de)
DK (2) DK198490D0 (de)
ES (1) ES2079075T3 (de)
FI (1) FI930746L (de)
GR (1) GR3018479T3 (de)
IE (1) IE73873B1 (de)
IL (1) IL99146A (de)
NO (1) NO302415B1 (de)
NZ (1) NZ239475A (de)
PT (1) PT98735B (de)
WO (1) WO1992003431A1 (de)
ZA (1) ZA916580B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
DK198390D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5376668A (en) * 1990-08-21 1994-12-27 Novo Nordisk A/S Heterocyclic compounds
JPH07502529A (ja) * 1991-12-31 1995-03-16 藤沢薬品工業株式会社 アセチルコリンエステラーゼ阻害およびムスカリン様のアゴニスト活性を有するオキサジアゾール誘導体
EP0734259B1 (de) * 1993-08-19 2002-06-12 Novo Nordisk A/S Verwendung von Piperidin-Derivaten in der Behandlung von Schizophrenie
US5753683A (en) * 1993-08-19 1998-05-19 Novo Nordisk A/S Antipsychotic method
US5545638A (en) * 1993-12-21 1996-08-13 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
IL112024A (en) * 1993-12-21 1999-07-14 Novo Nordisk As Pharmaceutical compositions comprising tetrahydropyridine derivatives substituted with oxadiazole or thiadiazole for treating gastrointestinal motility disorders
US5605908A (en) * 1994-10-24 1997-02-25 Eli Lilly And Company Heterocyclic compounds and their use
US5821370A (en) * 1994-10-24 1998-10-13 Eli Lilly And Company Heterocyclic compounds and their preparation and use
US5998404A (en) 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
US5488056A (en) * 1994-10-31 1996-01-30 Eli Lilly And Company Method for treating anxiety
US5574028A (en) * 1994-10-31 1996-11-12 Eli Lilly And Company Method for treating anxiety
US5726193A (en) * 1994-10-31 1998-03-10 Eli Lilly And Company Method for treating anxiety
US5565475A (en) * 1994-11-08 1996-10-15 Muhlhauser; Mark A. Method of treating urinary bladder dysfunctions with 3-tetrahydropyridine derivatives
CA2252563A1 (en) * 1996-04-24 1997-10-30 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US6043258A (en) * 1996-08-01 2000-03-28 Eli Lilly And Company Method for treating disruptive behavior disorders with xanomeline
US6090829A (en) * 1996-08-01 2000-07-18 Eli Lilly And Company Method for treating excessive aggression
US6117890A (en) * 1996-08-01 2000-09-12 Eli Lilly And Company Method for treating bipolar disorder
US6034108A (en) * 1997-07-28 2000-03-07 Eli Lilly And Company Method for treating mental retardation
AU2307899A (en) * 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
EP1983560A2 (de) * 2001-07-10 2008-10-22 Shin-Etsu Handotai Company Limited Herstellungsverfahren eines Silizium-Epitaxialwafers
CN1821243B (zh) * 2005-08-30 2010-12-08 北京大学 取代的吡啶类m1受体激动剂、其制备方法及其用途
WO2021097427A1 (en) 2019-11-15 2021-05-20 Karuna Therapeutics, Inc. Xanomeline derivatives and methods for treating neurological disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
GB8610432D0 (en) * 1986-04-29 1986-06-04 Akzo Nv Amino-thiazole & oxazole derivatives
IL83275A (en) * 1986-09-08 1994-02-27 Novo Nordisk As Substituted 1, 2, 4- oxadiazolyl piperidine compounds, their preparation and pharmaceutical compositions containing them
US5017618A (en) * 1987-03-16 1991-05-21 University Of Florida Labile derivatives of ketone analogs of 3-substituted-1-alkylamino-2-propanols and their use as beta-adrenergic blockers
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
GB8717446D0 (en) * 1987-07-23 1987-08-26 Merck Sharp & Dohme Chemical compounds
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
EP0322182A3 (de) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclische-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
DK162892C (da) * 1988-07-04 1992-05-11 Novo Nordisk As 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
DK198390D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse

Also Published As

Publication number Publication date
WO1992003431A1 (en) 1992-03-05
JP3100159B2 (ja) 2000-10-16
US5591755A (en) 1997-01-07
JPH06500541A (ja) 1994-01-20
IE912959A1 (en) 1992-02-26
FI930746A7 (fi) 1993-03-26
PT98735A (pt) 1992-08-31
ATE130611T1 (de) 1995-12-15
DK198490D0 (da) 1990-08-21
DK0544714T3 (da) 1996-04-09
GR3018479T3 (en) 1996-03-31
US5328923A (en) 1994-07-12
DE69114848D1 (de) 1996-01-04
AU8422991A (en) 1992-03-17
PT98735B (pt) 1999-01-29
ZA916580B (en) 1992-05-27
NO930600L (no) 1993-04-16
NZ239475A (en) 1994-08-26
AU660938B2 (en) 1995-07-13
CA2089770A1 (en) 1992-02-22
IE73873B1 (en) 1997-07-02
IL99146A0 (en) 1992-07-15
FI930746A0 (fi) 1993-02-19
FI930746L (fi) 1993-03-26
DE69114848T2 (de) 1996-07-18
EP0544714B1 (de) 1995-11-22
NO930600D0 (no) 1993-02-19
ES2079075T3 (es) 1996-01-01
NO302415B1 (no) 1998-03-02
EP0544714A1 (de) 1993-06-09

Similar Documents

Publication Publication Date Title
IL99146A (en) 3-(3-substituted 1, 2, 5-thia (or oxa) diazol-4-yl)-1, 2, 5, 6-tetrahydropyridine derivatives, their preparation and pharmaceutical compositions containing them
EP0687265B1 (de) Heterocyclische verbindungen und ihre herstellung und verwendung
US5043345A (en) Piperidine compounds and their preparation and use
EP0544756B1 (de) 1,2,5,6-tetrahydro-1-methylpyridine, ihre herstellung und anwendung
AU662105B2 (en) Derivatives and azabicyclic oxadiazole or thiadiazole compounds
EP0628041B1 (de) Heterocyclische verbindungen, deren herstellung und verwendung
JPH11508540A (ja) 新規の置換アザ環式またはアザ二環式化合物
US5994373A (en) Substituted azacyclic compounds
USRE35822E (en) Heterocyclic compounds
JP2000344765A (ja) アザシクロ化合物又はアザビシクロ化合物及びその製造方法

Legal Events

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KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees