IL99759A - Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them - Google Patents

Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them

Info

Publication number: IL99759A
Authority: IL; Israel
Prior art keywords: aminoindan; propargyl; mono; preparation; pharmaceutical compositions
Prior art date: 1991-10-16

Application number

IL99759A

Other languages

English (en)

Other versions

IL99759A0 (en

Inventor

Sterling Jeff

Levy Ruth

Veinberg Alex

Goldenberg Willy

Finberg John

Youdim Musa

Gutman Arieh

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-16

Filing date

1991-10-16

Publication date

1997-06-10

1991-10-16 Priority to IL11281991A priority Critical patent/IL112819A/en

1991-10-16 Priority to IL99759A priority patent/IL99759A/xx

1991-10-16 Application filed by Teva Pharma filed Critical Teva Pharma

1992-08-18 Publication of IL99759A0 publication Critical patent/IL99759A0/xx

1992-09-30 Priority to AU26063/92A priority patent/AU649565B2/en

1992-10-01 Priority to ZA927570A priority patent/ZA927570B/xx

1992-10-02 Priority to FI924458A priority patent/FI113262B/fi

1992-10-05 Priority to NZ244616A priority patent/NZ244616A/en

1992-10-06 Priority to HU9203162A priority patent/HU217589B/hu

1992-10-06 Priority to CA002079968A priority patent/CA2079968C/en

1992-10-14 Priority to CN92113070A priority patent/CN1038928C/zh

1992-10-15 Priority to ES92402821T priority patent/ES2101063T3/es

1992-10-15 Priority to DK92402821.0T priority patent/DK0538134T3/da

1992-10-15 Priority to DE69218101T priority patent/DE69218101T2/de

1992-10-15 Priority to JP27731492A priority patent/JP3247165B2/ja

1992-10-15 Priority to EP92402821A priority patent/EP0538134B1/de

1992-10-15 Priority to AT92402821T priority patent/ATE149999T1/de

1994-09-22 Priority to US08/310,480 priority patent/US5486541A/en

1997-05-26 Priority to GR970401207T priority patent/GR3023556T3/el

1997-06-10 Publication of IL99759A publication Critical patent/IL99759A/xx

Links

RUOKEQAAGRXIBM-UHFFFAOYSA-N n-prop-2-ynyl-2,3-dihydro-1h-inden-1-amine Chemical class C1=CC=C2C(NCC#C)CCC2=C1 RUOKEQAAGRXIBM-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
REMZONJIIBEOHN-UHFFFAOYSA-N 4-fluoro-n-prop-2-ynyl-2,3-dihydro-1h-inden-1-amine Chemical compound FC1=CC=CC2=C1CCC2NCC#C REMZONJIIBEOHN-UHFFFAOYSA-N 0.000 abstract 1
RAWRWXXSRQSLRX-UHFFFAOYSA-N 5-fluoro-n-prop-2-ynyl-2,3-dihydro-1h-inden-1-amine Chemical compound FC1=CC=C2C(NCC#C)CCC2=C1 RAWRWXXSRQSLRX-UHFFFAOYSA-N 0.000 abstract 1
SJGUUGICXKISGE-UHFFFAOYSA-N 6-fluoro-n-prop-2-ynyl-2,3-dihydro-1h-inden-1-amine Chemical compound FC1=CC=C2CCC(NCC#C)C2=C1 SJGUUGICXKISGE-UHFFFAOYSA-N 0.000 abstract 1
102000010909 Monoamine Oxidase Human genes 0.000 abstract 1
108010062431 Monoamine oxidase Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
- C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL99759A 1991-10-16 1991-10-16 Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them IL99759A (en)

Priority Applications (17)

Application Number	Priority Date	Filing Date	Title
IL11281991A IL112819A (en)	1991-10-16	1991-10-16	Fluorinated 1-aminoindan compounds and a process for their preparation
IL99759A IL99759A (en)	1991-10-16	1991-10-16	Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them
AU26063/92A AU649565B2 (en)	1991-10-16	1992-09-30	Mono-fluorinated derivatives of N-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase
ZA927570A ZA927570B (en)	1991-10-16	1992-10-01	Mono-fluorinated derivatives of N-propagyl-1-aminoindan and their use as inhibitors of monoamine oxidase.
FI924458A FI113262B (fi)	1991-10-16	1992-10-02	Menetelmä N-propargyyli-1-aminoindaanin fluorattujen johdannaisten valmistamiseksi
NZ244616A NZ244616A (en)	1991-10-16	1992-10-05	Mono-fluorinated derivatives of n-propargyl-1-aminoindan, preparation and pharmaceutical compositions thereof
HU9203162A HU217589B (hu)	1991-10-16	1992-10-06	N-propargil-1-amino-indán monofluorszármazékai és ezeket tartalmazó gyógyászati készítmények, valamint eljárás a vegyületek és a gyógyászati készítmények előállítására
CA002079968A CA2079968C (en)	1991-10-16	1992-10-06	Mono-fluorinated derivatives of n-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase
CN92113070A CN1038928C (zh)	1991-10-16	1992-10-14	制备单氟化的n－炔丙基－1－氨基茚满衍生物的方法
ES92402821T ES2101063T3 (es)	1991-10-16	1992-10-15	Derivados monofluorados de n-propargil-1-amino-indano y su utilizacion como inhibidores de la monoamin-oxidasa.
AT92402821T ATE149999T1 (de)	1991-10-16	1992-10-15	Monofluorierte derivate von n-propargyl-1- aminoindan und deren verwendung als monoamino- oxidaseinhibitoren
DK92402821.0T DK0538134T3 (da)	1991-10-16	1992-10-15	Monofluorerede derivater af N-propargyl-1-aminoindan og deres anvendelse som inhibitorer for monoaminoxidase
DE69218101T DE69218101T2 (de)	1991-10-16	1992-10-15	Monofluorierte Derivate von N-Propargyl-1-Aminoindan und deren Verwendung als Monoamino-Oxidaseinhibitoren
JP27731492A JP3247165B2 (ja)	1991-10-16	1992-10-15	Ｎ−プロパルギル−１−アミノインダンのモノ−弗素化誘導体、これを有効成分とする薬剤およびその製造方法
EP92402821A EP0538134B1 (de)	1991-10-16	1992-10-15	Monofluorierte Derivate von N-Propargyl-1-Aminoindan und deren Verwendung als Monoamino-Oxidaseinhibitoren
US08/310,480 US5486541A (en)	1991-10-16	1994-09-22	Monofluorinated derivatives of N-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase
GR970401207T GR3023556T3 (en)	1991-10-16	1997-05-26	Mono-fluorinated derivatives of N-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IL99759A IL99759A (en)	1991-10-16	1991-10-16	Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number	Publication Date
IL99759A0 IL99759A0 (en)	1992-08-18
IL99759A true IL99759A (en)	1997-06-10

Family

ID=11062970

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL99759A IL99759A (en)	1991-10-16	1991-10-16	Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them
IL11281991A IL112819A (en)	1991-10-16	1991-10-16	Fluorinated 1-aminoindan compounds and a process for their preparation

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL11281991A IL112819A (en)	1991-10-16	1991-10-16	Fluorinated 1-aminoindan compounds and a process for their preparation

Country Status (16)

Country	Link
US (1)	US5486541A (de)
EP (1)	EP0538134B1 (de)
JP (1)	JP3247165B2 (de)
CN (1)	CN1038928C (de)
AT (1)	ATE149999T1 (de)
AU (1)	AU649565B2 (de)
CA (1)	CA2079968C (de)
DE (1)	DE69218101T2 (de)
DK (1)	DK0538134T3 (de)
ES (1)	ES2101063T3 (de)
FI (1)	FI113262B (de)
GR (1)	GR3023556T3 (de)
HU (1)	HU217589B (de)
IL (2)	IL99759A (de)
NZ (1)	NZ244616A (de)
ZA (1)	ZA927570B (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5744500A (en)	1990-01-03	1998-04-28	Teva Pharmaceutical Industries, Ltd.	Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof
JP3342491B2 (ja) *	1993-08-06	2002-11-11	ファルマシア・アンド・アップジョン・カンパニー	選択的ドーパミンｄ３リガンドとしての２−アミノインダン類
IL111240A (en) *	1993-10-18	2001-10-31	Teva Pharma	Salts of r(+) - enantiomers of n- propargyl-1-aminoindan and pharmaceutical compositions comprising them
US5914349A (en)	1994-01-10	1999-06-22	Teva Pharmaceutical Industries, Ltd.	Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
DE69535315T2 (de) *	1994-01-10	2007-06-28	Teva Pharmaceutical Industries Ltd.	1-aminoindanderivate und zusammensetzungen hiervon
IL115357A (en) *	1995-09-20	2000-01-31	Teva Pharma	Stable compositions containing N-propargyl-1-aminoindan and polyhydric alcohols
IL118836A (en)	1996-07-11	2001-01-11	Teva Pharma	Pharmaceutical compositions comprising s-(-)-n-propargyl-1-aminoindan
US6211235B1 (en)	1996-11-22	2001-04-03	Elan Pharmaceuticals, Inc.	Compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6191166B1 (en)	1997-11-21	2001-02-20	Elan Pharmaceuticals, Inc.	Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis
DE69738275T2 (de)	1996-12-18	2008-08-28	Teva Pharmaceutical Industries Ltd.	Aminoindanderivate
US6683075B1 (en)	1996-12-23	2004-01-27	Athena Neurosciences, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6635632B1 (en)	1996-12-23	2003-10-21	Athena Neurosciences, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
GB9715082D0 (en) *	1997-07-17	1997-09-24	Scherer Ltd R P	Treatment of attention deficit hyperactivity disorder and narcolepsy
US6552013B1 (en)	1998-06-22	2003-04-22	Elan Pharmaceuticals, Inc.	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) *	1998-06-22	2003-05-27	Elan Pharmaceutials, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en)	1998-06-22	2003-03-04	Elan Pharmaceuticals, Inc.	Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) *	1998-06-22	2004-08-10	Elan Pharmaceuticals, Inc.	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en)	1998-06-22	2003-01-21	Elan Pharmaceuticals, Inc.	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
IL149308A0 (en)	1999-10-27	2002-11-10	Teva Pharma	Use of 1-aminoindan derivatives for treatment of manic disorders
DE60113407T2 (de) *	2000-05-04	2006-06-29	Warner-Lambert Co. Llc	Verfahren zur hemmung von amyloidprotein aggregation und zur diagnostischen nachweis von amyloidablagerung unter verwendung von aminoindanderivaten
AR028110A1 (es) *	2000-06-02	2003-04-23	Astrazeneca Ab	Nuevo proceso
US20020151526A1 (en) *	2000-10-06	2002-10-17	Gallop Mark A.	Bile-acid prodrugs of L-dopa and their use in the sustained treatment of parkinsonism
US6956129B2 (en) *	2001-02-16	2005-10-18	Bayer Aktiengesellschaft	Polyhalogen-substituted cinnamic acids and cinnamic acid derivatives and a process for the preparation of polyhalogen-substituted cinnamic acids and cinnamic acid derivatives
US20040010038A1 (en) *	2002-02-27	2004-01-15	Eran Blaugrund	Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
SI1567152T1 (sl) *	2002-11-15	2013-10-30	Teva Pharmaceutical Industries Ltd.	Uporaba rasagilina z riluzolom za zdravljenje amiotrofične lateralne skleroze
US20050192265A1 (en) *	2003-03-20	2005-09-01	Thompson Richard C.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
US8097608B2 (en)	2003-11-25	2012-01-17	Technion Research And Development Foundation Ltd.	Methods for treatment of cardiovascular disorders and diseases
US20080090915A1 (en) *	2003-11-25	2008-04-17	Technion Research And Development Foundation Ltd.	Method for preventing or attenuating anthracycline-induced cardiotoxicity
WO2005051371A1 (en) *	2003-11-25	2005-06-09	Technion Research & Development Foundation Ltd.	Compositions and methods for treatment of cardiovascular disorders and diseases
WO2006014973A2 (en) *	2004-07-26	2006-02-09	Teva Pharmaceutical Industries, Ltd.	Pharmaceutical dosage forms including rasagiline
US20060025446A1 (en) *	2004-07-27	2006-02-02	Jeffrey Sterling	Propargyl nitroxides and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders
US20100167983A1 (en) *	2007-10-22	2010-07-01	Teva Pharmaceutical Industries, Ltd.	Combination therapy with glatiramer acetate and rasagiline for the treatment of multiple sclerosis
WO2006089164A1 (en) *	2005-02-17	2006-08-24	Teva Pharmaceutical Industries, Ltd.	Combination therapy with glatiramer acetate and rasagiline for the treatment of multiple sclerosis
CA2901244A1 (en)	2005-02-23	2006-08-31	Teva Pharmaceutical Industries, Ltd.	Rasagiline formulations of improved content uniformity
CN101300006B (zh) *	2005-06-02	2012-07-25	叶林发现公司	用于治疗肥胖的mao-b抑制剂
US8263655B2 (en)	2005-10-06	2012-09-11	Technion Research And Development Foundation Ltd	Methods for treatment of renal failure
EP1954667B1 (de)	2005-11-17	2017-02-08	Teva Pharmaceutical Industries Ltd	Verfahren zur isolierung propargylierter aminoindane
US7572834B1 (en)	2005-12-06	2009-08-11	Teva Pharmaceutical Industries, Ltd.	Rasagiline formulations and processes for their preparation
AU2006326642B2 (en)	2005-12-09	2012-05-03	Technion Research And Development Foundation Ltd.	Use of low-dose ladostigil for neuroprotection
JP5701485B2 (ja)	2006-02-21	2015-04-15	テバファーマシューティカルインダストリーズリミティド	多系統萎縮症の治療のためのラサギリンの使用
TW200744576A (en)	2006-02-24	2007-12-16	Teva Pharma	Propargylated aminoindans, processes for preparation, and uses thereof
CA2646250A1 (en) *	2006-04-03	2007-10-18	Teva Pharmaceutical Industries Ltd.	Use of rasagiline for the treatment of restless legs syndrome
EP1892233A1 (de) *	2006-08-18	2008-02-27	Ratiopharm GmbH	Neue Salze des Wirkstoffs Rasagilin
JP5356248B2 (ja) *	2006-12-14	2013-12-04	テバファーマシューティカルインダストリーズリミティド	ラサギリンのタンニン酸塩
ZA200903903B (en) *	2006-12-14	2010-08-25	Teva Pharma	Crystalline solid rasagiline base
EP1987816A1 (de) *	2007-04-30	2008-11-05	Ratiopharm GmbH	Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff
AU2008296908B2 (en) *	2007-09-05	2014-01-09	Teva Pharmaceutical Industries, Ltd.	Method of treating glaucoma using rasagiline
US8188149B2 (en) *	2007-09-17	2012-05-29	Teva Pharmaceutical Industries, Ltd.	Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss
EP2053033A1 (de) *	2007-10-26	2009-04-29	Bayer Schering Pharma AG	Verbindungen zur Verwendung bei der Abbildung, Diagnose und/oder Behandlung von Erkrankungen des zentralen Nervensystems oder von Tumoren
US20090181086A1 (en) *	2008-01-11	2009-07-16	Muhammad Safadi	Rasagiline formulations, their preparation and use
WO2009151594A1 (en) *	2008-06-10	2009-12-17	Teva Pharmaceutical Industries, Ltd.	Rasagiline soft gelatin capsules
JP2011522892A (ja) *	2008-06-13	2011-08-04	テバファーマシューティカルインダストリーズリミティド	パーキンソン病緩和のためのラサギリン
AU2009260733B2 (en) *	2008-06-19	2015-01-29	Teva Pharmaceutical Industries, Ltd.	Process for purifying rasagiline base
MX2010013875A (es)	2008-06-19	2011-01-20	Teva Pharma	Proceso para preparar y secar base de rasagilina solida.
ES2402765T3 (es) *	2008-12-22	2013-05-08	Krka, D.D., Novo Mesto	Procedimiento de preparación de ivabradina
US20100189790A1 (en) *	2009-01-23	2010-07-29	Teva Pharmaceutical Industries, Ltd.	Delayed release rasagiline formulation
SI2451771T1 (sl)	2009-07-09	2014-10-30	Ratiopharm Gmbh	Soli rasagilina in njihovi farmacevtski pripravki
AU2010341499A1 (en) *	2009-12-22	2012-08-09	Teva Pharmaceutical Industries Ltd.	3-keto-N-propargyl-1-aminoindan
RU2607595C2 (ru)	2010-02-03	2017-01-10	Фарма Ту Б Лтд.	Составы разагилина с пролонгированным высвобождением и их применение
CA2806740A1 (en)	2010-07-27	2012-02-02	Teva Pharmaceutical Industries Ltd.	Use of rasagiline for the treatment of olfactory dysfunction
AU2011282716A1 (en)	2010-07-27	2013-03-14	Teva Pharmaceutical Industries Ltd.	Dispersions of rasagiline citrate
WO2013055687A2 (en)	2011-10-10	2013-04-18	Teva Pharmaceutical Industries Ltd.	R(+)-n-formyl-propargyl-aminoindan
JP2014534197A (ja)	2011-10-10	2014-12-18	テバファーマシューティカルインダストリーズリミティド	Ｒ（＋）−ｎ−メチル−プロパルギルアミノインダン
US9308182B2 (en)	2012-08-17	2016-04-12	Teva Pharmaceutical Industries, Ltd.	Parenteral formulations of rasagiline

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3201470A (en) *		1965-08-17		Chsx c cech
US3253037A (en) *	1962-06-19	1966-05-24	Ciba Geigy Corp	N-2-alkynyl-amino-benzocylo-alkanes
GB1187017A (en) *	1966-07-16	1970-04-08	Aspro Nicholas Ltd	Substituted 1-Amino Indanes and Tetrahydronaphthalens
GB1033686A (en) *	1965-05-10	1966-06-22	Maximilian Heller	Improvements in convertible double bed settees
HU207282B (en) *	1984-05-31	1993-03-29	Chinoin Gyogyszer Es Vegyeszet	Process for producing phenyl-alkyl-amine derivatives and pharmaceutical compositions containing them
HU208484B (en) *	1988-08-17	1993-11-29	Chinoin Gyogyszer Es Vegyeszet	Process for producing pharmaceutical composition containing acid additional salt of selegilin as active component for treating schisofrenia
IL92952A (en) *	1990-01-03	1994-06-24	Teva Pharma	R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them

1991
- 1991-10-16 IL IL99759A patent/IL99759A/xx not_active IP Right Cessation
- 1991-10-16 IL IL11281991A patent/IL112819A/en not_active IP Right Cessation
1992
- 1992-09-30 AU AU26063/92A patent/AU649565B2/en not_active Ceased
- 1992-10-01 ZA ZA927570A patent/ZA927570B/xx unknown
- 1992-10-02 FI FI924458A patent/FI113262B/fi active
- 1992-10-05 NZ NZ244616A patent/NZ244616A/en not_active IP Right Cessation
- 1992-10-06 HU HU9203162A patent/HU217589B/hu not_active IP Right Cessation
- 1992-10-06 CA CA002079968A patent/CA2079968C/en not_active Expired - Fee Related
- 1992-10-14 CN CN92113070A patent/CN1038928C/zh not_active Expired - Fee Related
- 1992-10-15 DK DK92402821.0T patent/DK0538134T3/da active
- 1992-10-15 ES ES92402821T patent/ES2101063T3/es not_active Expired - Lifetime
- 1992-10-15 EP EP92402821A patent/EP0538134B1/de not_active Expired - Lifetime
- 1992-10-15 JP JP27731492A patent/JP3247165B2/ja not_active Expired - Fee Related
- 1992-10-15 AT AT92402821T patent/ATE149999T1/de not_active IP Right Cessation
- 1992-10-15 DE DE69218101T patent/DE69218101T2/de not_active Expired - Fee Related
1994
- 1994-09-22 US US08/310,480 patent/US5486541A/en not_active Expired - Lifetime
1997
- 1997-05-26 GR GR970401207T patent/GR3023556T3/el unknown

Also Published As

Publication number	Publication date
FI113262B (fi)	2004-03-31
ZA927570B (en)	1993-04-14
EP0538134B1 (de)	1997-03-12
DE69218101T2 (de)	1997-09-25
CN1073427A (zh)	1993-06-23
CA2079968C (en)	2004-12-21
DK0538134T3 (da)	1997-04-01
EP0538134A2 (de)	1993-04-21
JP3247165B2 (ja)	2002-01-15
IL112819A (en)	2001-11-25
JPH05262701A (ja)	1993-10-12
ES2101063T3 (es)	1997-07-01
HU217589B (hu)	2000-02-28
IL99759A0 (en)	1992-08-18
GR3023556T3 (en)	1997-08-29
NZ244616A (en)	1995-04-27
AU2606392A (en)	1993-04-22
DE69218101D1 (de)	1997-04-17
HU9203162D0 (en)	1992-12-28
US5486541A (en)	1996-01-23
FI924458L (fi)	1993-04-17
EP0538134A3 (en)	1993-06-16
FI924458A0 (fi)	1992-10-02
AU649565B2 (en)	1994-05-26
CA2079968A1 (en)	1993-04-17
CN1038928C (zh)	1998-07-01
HUT67218A (en)	1995-03-28
ATE149999T1 (de)	1997-03-15

Legal Events

Date	Code	Title
1998-01-04	FF	Patent granted
1998-02-22	KB	Patent renewed
2002-02-10	KB	Patent renewed
2006-01-15	KB	Patent renewed
2010-11-30	MM9K	Patent not in force due to non-payment of renewal fees

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HU9401159D0 (en)	1994-07-28	New compound leustroducsin h, its preparation and pharmaceutical compositions containing them